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GSE58827: Dynamics of the Mouse Liver

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Results for Tbx21

Z-value: 1.40

Motif logo

Transcription factors associated with Tbx21

Gene Symbol Gene ID Gene Info
ENSMUSG00000001444.3 T-box 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx21mm39_v1_chr11_-_97006153_970061580.372.6e-02Click!

Activity profile of Tbx21 motif

Sorted Z-values of Tbx21 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_110248815 26.00 ENSMUST00000035061.9
neutrophilic granule protein
chr10_+_43455919 15.85 ENSMUST00000214476.2
CD24a antigen
chr12_-_4924341 14.83 ENSMUST00000137337.8
ENSMUST00000045921.14
major facilitator superfamily domain containing 2B
chr7_-_126641593 12.74 ENSMUST00000032915.8
kinesin family member 22
chr3_-_98247237 12.49 ENSMUST00000065793.12
3-phosphoglycerate dehydrogenase
chr6_-_60806810 11.89 ENSMUST00000163779.8
synuclein, alpha
chr17_+_48554786 10.95 ENSMUST00000048065.6
triggering receptor expressed on myeloid cells 3
chr7_-_126641565 9.56 ENSMUST00000205806.2
kinesin family member 22
chr11_+_103061905 8.69 ENSMUST00000042286.12
ENSMUST00000218163.2
formin-like 1
chr7_+_127661835 7.92 ENSMUST00000106242.10
ENSMUST00000120355.8
ENSMUST00000106240.9
ENSMUST00000098015.10
integrin alpha M
predicted gene, 49368
chr5_-_138169253 7.78 ENSMUST00000139983.8
minichromosome maintenance complex component 7
chr17_+_36172210 7.62 ENSMUST00000074259.15
ENSMUST00000174873.2
nurim (nuclear envelope membrane protein)
chr10_+_77366086 7.45 ENSMUST00000000299.14
ENSMUST00000131023.8
integrin beta 2
chr5_-_120915693 6.91 ENSMUST00000044833.9
2'-5' oligoadenylate synthetase 3
chr2_-_164198427 6.69 ENSMUST00000109367.10
secretory leukocyte peptidase inhibitor
chr17_+_33774681 6.63 ENSMUST00000087605.13
ENSMUST00000174695.2
myosin IF
chr11_+_120499295 6.52 ENSMUST00000106194.8
ENSMUST00000106195.3
ENSMUST00000061309.5
neuropeptide B
chr9_+_69360902 6.52 ENSMUST00000034756.15
ENSMUST00000123470.8
annexin A2
chr11_+_24030663 6.31 ENSMUST00000118955.2
B cell CLL/lymphoma 11A (zinc finger protein)
chr15_+_98972850 6.17 ENSMUST00000039665.8
trophinin associated protein
chr10_+_77366195 6.00 ENSMUST00000130059.8
integrin beta 2
chr9_+_69361348 5.95 ENSMUST00000134907.8
annexin A2
chr7_+_79944198 5.54 ENSMUST00000163812.9
ENSMUST00000047558.14
ENSMUST00000174199.8
ENSMUST00000173824.8
ENSMUST00000174172.8
protein regulator of cytokinesis 1
chr6_+_90596123 5.41 ENSMUST00000032177.10
solute carrier family 41, member 3
chr4_+_115420876 5.09 ENSMUST00000126645.8
ENSMUST00000030480.4
cytochrome P450, family 4, subfamily a, polypeptide 31
chr4_+_115420817 4.77 ENSMUST00000141033.8
ENSMUST00000030486.15
cytochrome P450, family 4, subfamily a, polypeptide 31
chr7_+_127661807 4.61 ENSMUST00000064821.14
integrin alpha M
chr12_+_73333641 4.56 ENSMUST00000153941.8
ENSMUST00000122920.8
ENSMUST00000101313.4
solute carrier family 38, member 6
chr7_-_44775961 4.41 ENSMUST00000210931.3
ribosomal protein L13A
chr17_+_43327412 4.40 ENSMUST00000024708.6
tumor necrosis factor receptor superfamily, member 21
chr2_-_51824656 4.34 ENSMUST00000165313.2
RNA binding motif protein 43
chr6_+_129374441 4.03 ENSMUST00000112081.9
ENSMUST00000112079.3
C-type lectin domain family 1, member b
chr8_+_85428391 3.78 ENSMUST00000238338.2
lymphoblastomic leukemia 1
chr4_+_154954042 3.74 ENSMUST00000079269.14
ENSMUST00000163732.8
ENSMUST00000080559.13
membrane metallo-endopeptidase-like 1
chr3_-_54642450 3.64 ENSMUST00000153224.2
exosome component 8
chr6_+_129374260 3.62 ENSMUST00000032262.14
C-type lectin domain family 1, member b
chr17_-_24746804 3.56 ENSMUST00000176353.8
ENSMUST00000176237.8
TNF receptor-associated factor 7
chr17_-_24746911 3.51 ENSMUST00000176652.8
TNF receptor-associated factor 7
chr7_+_126461117 3.48 ENSMUST00000037248.10
HIRA interacting protein 3
chr1_+_74193138 3.37 ENSMUST00000027372.8
ENSMUST00000106899.4
chemokine (C-X-C motif) receptor 2
chr7_+_43896146 3.34 ENSMUST00000055858.14
ENSMUST00000137702.8
ENSMUST00000188111.7
ENSMUST00000185481.7
ENSMUST00000146155.8
ENSMUST00000107949.8
ENSMUST00000084937.11
ENSMUST00000107950.9
ENSMUST00000107948.8
ENSMUST00000187524.7
ENSMUST00000137742.8
ENSMUST00000125318.3
RIKEN cDNA 2410002F23 gene
predicted gene 28496
chr4_-_117013396 3.31 ENSMUST00000102696.5
ribosomal protein S8
chr6_+_120813162 3.29 ENSMUST00000203584.3
ENSMUST00000203037.3
BCL2-like 13 (apoptosis facilitator)
chr4_-_132080916 3.25 ENSMUST00000155129.2
ENSMUST00000151374.2
regulator of chromosome condensation 1
small nucleolar RNA host gene 3
chr19_+_53298906 3.24 ENSMUST00000003870.15
MAX interactor 1, dimerization protein
chr1_-_16174387 3.23 ENSMUST00000149566.2
ribosomal protein L7
chr5_-_148988110 3.18 ENSMUST00000110505.8
high mobility group box 1
chr14_-_54754810 3.03 ENSMUST00000023873.12
protein arginine N-methyltransferase 5
chr15_+_79784365 2.97 ENSMUST00000230135.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr11_+_116421923 2.93 ENSMUST00000138840.8
sphingosine kinase 1
chr3_-_103698391 2.87 ENSMUST00000106845.9
ENSMUST00000029438.15
homeodomain interacting protein kinase 1
chr15_+_80017315 2.83 ENSMUST00000023050.9
TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr9_+_59198829 2.81 ENSMUST00000217570.2
ENSMUST00000026266.9
ADP-dependent glucokinase
chr7_-_126461000 2.74 ENSMUST00000106343.3
ENSMUST00000205349.2
ENSMUST00000206349.2
INO80 complex subunit E
chr12_+_116369017 2.71 ENSMUST00000084828.5
ENSMUST00000222469.2
ENSMUST00000221114.2
ENSMUST00000221970.2
non-SMC condensin II complex, subunit G2
chr8_-_57940834 2.70 ENSMUST00000034022.4
sin3 associated polypeptide
chr15_+_34495441 2.68 ENSMUST00000052290.14
ENSMUST00000079028.6
processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
chr4_+_132366298 2.57 ENSMUST00000135299.8
ENSMUST00000020197.14
ENSMUST00000180250.8
ENSMUST00000081726.13
ENSMUST00000079157.11
EYA transcriptional coactivator and phosphatase 3
chr7_-_126460820 2.55 ENSMUST00000129812.2
ENSMUST00000106342.8
INO80 complex subunit E
chr5_-_121045568 2.51 ENSMUST00000080322.8
2'-5' oligoadenylate synthetase 1A
chr8_+_89015705 2.48 ENSMUST00000171456.9
adenylate cyclase 7
chr1_-_97589365 2.42 ENSMUST00000153115.8
ENSMUST00000142234.2
macrophage immunometabolism regulator
chr16_-_58319696 2.38 ENSMUST00000148061.2
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr16_-_20245071 2.35 ENSMUST00000115547.9
ENSMUST00000096199.5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chrX_+_152506577 2.33 ENSMUST00000140575.8
ENSMUST00000208373.2
ENSMUST00000185492.7
ENSMUST00000149514.8
negative regulator of P-body association
chr2_-_151815307 2.28 ENSMUST00000109863.2
family with sequence similarity 110, member A
chr16_-_20245138 2.23 ENSMUST00000079158.13
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr3_-_107145968 2.18 ENSMUST00000197758.5
prokineticin 1
chrX_+_73298342 2.16 ENSMUST00000096424.11
emerin
chrX_+_36891636 2.16 ENSMUST00000184866.10
ENSMUST00000179626.3
reproductive homeobox 5
chr19_+_34169629 2.12 ENSMUST00000239240.2
ENSMUST00000054956.15
STAM binding protein like 1
chr19_+_40600836 2.12 ENSMUST00000134063.8
ectonucleoside triphosphate diphosphohydrolase 1
chr11_-_74480870 2.10 ENSMUST00000145524.2
ENSMUST00000102521.9
RAP1 GTPase activating protein 2
chrX_+_73298285 2.09 ENSMUST00000002029.13
emerin
chr19_-_5416339 2.08 ENSMUST00000170010.3
BAF nuclear assembly factor 1
chr17_-_27247891 2.07 ENSMUST00000078691.12
BCL2-antagonist/killer 1
chr16_-_3821614 2.05 ENSMUST00000171658.2
ENSMUST00000171762.2
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr8_-_106427696 1.98 ENSMUST00000042608.8
adrenocortical dysplasia
chr7_-_99477551 1.98 ENSMUST00000036331.7
neuraminidase 3
chr7_-_126461522 1.97 ENSMUST00000206968.2
INO80 complex subunit E
chr12_-_113843161 1.93 ENSMUST00000103451.5
immunoglobulin heavy variable 2-9
chr1_+_171667259 1.89 ENSMUST00000155802.9
CD84 antigen
chr8_-_71349927 1.78 ENSMUST00000212709.2
ENSMUST00000212796.2
ENSMUST00000212378.2
ENSMUST00000054220.10
ENSMUST00000212494.2
ribosomal protein L18A
chrX_+_73298388 1.77 ENSMUST00000119197.8
ENSMUST00000088313.5
emerin
chr15_+_54274151 1.69 ENSMUST00000036737.4
collectin sub-family member 10
chr14_-_60488922 1.68 ENSMUST00000225311.2
ENSMUST00000041905.8
predicted gene, 49336
chr11_-_6217718 1.67 ENSMUST00000004507.11
ENSMUST00000151446.2
DEAD box helicase 56
chr3_+_137624231 1.63 ENSMUST00000197064.5
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
chr14_-_40728839 1.60 ENSMUST00000152837.2
ENSMUST00000134715.8
peroxiredoxin like 2A
chr3_+_88204418 1.52 ENSMUST00000001452.14
chaperonin containing Tcp1, subunit 3 (gamma)
chr6_+_83114020 1.49 ENSMUST00000121093.8
rhotekin
chr6_-_128803182 1.47 ENSMUST00000204756.3
ENSMUST00000204394.3
ENSMUST00000204423.3
ENSMUST00000204677.2
ENSMUST00000205130.3
ENSMUST00000174544.2
ENSMUST00000172887.8
ENSMUST00000032472.11
predicted gene 44511
killer cell lectin-like receptor subfamily B member 1B
chr11_-_70873773 1.41 ENSMUST00000078528.7
complement component 1, q subcomponent binding protein
chr2_-_151815759 1.37 ENSMUST00000109865.8
ENSMUST00000109864.8
family with sequence similarity 110, member A
chr19_-_5416626 1.35 ENSMUST00000237167.2
BAF nuclear assembly factor 1
chr13_-_6686686 1.34 ENSMUST00000136585.2
phosphofructokinase, platelet
chr19_-_5660057 1.34 ENSMUST00000236229.2
ENSMUST00000235701.2
ENSMUST00000236264.2
K(lysine) acetyltransferase 5
chr15_+_74586682 1.33 ENSMUST00000023265.5
prostate stem cell antigen
chr11_-_45846291 1.30 ENSMUST00000011398.13
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr14_-_56472102 1.25 ENSMUST00000015585.4
granzyme C
chr9_-_112015007 1.25 ENSMUST00000070218.12
cyclic AMP-regulated phosphoprotein, 21
chr1_-_135615831 1.24 ENSMUST00000190298.8
neuron navigator 1
chr7_+_35148188 1.20 ENSMUST00000118383.8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
chr12_-_102406069 1.06 ENSMUST00000021607.9
legumain
chr10_+_69055215 1.05 ENSMUST00000172261.3
Rho-related BTB domain containing 1
chr16_-_35951553 1.01 ENSMUST00000161638.2
ENSMUST00000096090.3
cystatin A1
chr2_-_111400026 1.00 ENSMUST00000217772.2
ENSMUST00000207283.3
olfactory receptor 1295
chr9_+_65370077 0.99 ENSMUST00000215170.2
SPG21, maspardin
chr2_+_3119442 0.97 ENSMUST00000091505.11
family with sequence similarity 171, member A1
chr1_-_181985663 0.96 ENSMUST00000169123.4
vomeronasal 1 receptor 1
chr18_+_37875135 0.94 ENSMUST00000003599.9
protocadherin gamma subfamily B, 6
chr4_-_117772163 0.92 ENSMUST00000036156.6
importin 13
chr14_-_60488894 0.89 ENSMUST00000225111.2
predicted gene, 49336
chr6_-_70237939 0.85 ENSMUST00000103386.3
immunoglobulin kappa variable 6-23
chr19_-_60215097 0.83 ENSMUST00000238054.2
ENSMUST00000065286.2
family with sequence similarity 204, member A
chr1_+_59952131 0.83 ENSMUST00000036540.12
family with sequence similarity 117, member B
chr7_+_35148579 0.81 ENSMUST00000032703.10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
chr13_-_74956640 0.77 ENSMUST00000231578.2
calpastatin
chr7_+_35148461 0.77 ENSMUST00000118969.8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
chr11_-_65053710 0.74 ENSMUST00000093002.12
ENSMUST00000047463.15
Rho GTPase activating protein 44
chr1_-_192812509 0.70 ENSMUST00000085555.7
UTP25 small subunit processome component
chr2_+_28590159 0.70 ENSMUST00000074156.7
adenylate kinase 8
chr6_-_148797648 0.69 ENSMUST00000072324.12
ENSMUST00000111569.9
caprin family member 2
chr16_-_4698148 0.68 ENSMUST00000037843.7
UBA-like domain containing 1
chr19_-_4976844 0.68 ENSMUST00000236496.2
dipeptidylpeptidase 3
chr7_-_26878260 0.67 ENSMUST00000093040.13
RAB4B, member RAS oncogene family
chr4_-_102883905 0.67 ENSMUST00000084382.6
ENSMUST00000106869.3
insulin-like 5
chr6_-_38101503 0.66 ENSMUST00000040259.8
ATPase, H+ transporting, lysosomal V0 subunit A4
chr1_+_133058881 0.63 ENSMUST00000052529.4
protein phosphatase 1, regulatory subunit 15B
chr6_+_68414401 0.62 ENSMUST00000103324.3
immunoglobulin kappa chain variable 15-103
chr2_+_164664920 0.60 ENSMUST00000132282.2
zinc finger SWIM-type containing 1
chr6_+_113355076 0.59 ENSMUST00000156898.5
ENSMUST00000203578.3
ENSMUST00000171058.8
actin related protein 2/3 complex, subunit 4
chrX_-_73412078 0.55 ENSMUST00000155676.8
ubiquitin-like 4A
chr6_-_50238926 0.54 ENSMUST00000167893.2
gasdermin E
chr2_-_23045876 0.53 ENSMUST00000028119.7
microtubule associated serine/threonine kinase-like
chr6_-_50238723 0.52 ENSMUST00000101405.10
ENSMUST00000165099.8
ENSMUST00000170142.8
gasdermin E
chr13_-_36301466 0.51 ENSMUST00000053265.8
LYR motif containing 4
chrX_+_73340703 0.51 ENSMUST00000019231.12
ENSMUST00000147900.8
ENSMUST00000147275.8
ENSMUST00000114171.10
ATPase, H+ transporting, lysosomal accessory protein 1
chr16_-_20244631 0.51 ENSMUST00000077867.10
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr8_-_85549452 0.50 ENSMUST00000065539.6
DAN domain family member 5, BMP antagonist
chr8_-_69187708 0.47 ENSMUST00000136060.8
ENSMUST00000130214.8
ENSMUST00000078350.13
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr11_-_45845992 0.46 ENSMUST00000109254.2
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr2_-_166885414 0.45 ENSMUST00000067584.7
zinc finger, NFX1-type containing 1
chr10_+_7668655 0.43 ENSMUST00000015901.11
peptidylprolyl isomerase (cyclophilin)-like 4
chr1_+_9615619 0.43 ENSMUST00000072079.9
ribosome biogenesis regulator 1
chr19_+_12438125 0.36 ENSMUST00000081035.9
macrophage expressed gene 1
chr12_-_8589545 0.35 ENSMUST00000095863.10
ENSMUST00000165657.3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
chr12_-_31704766 0.32 ENSMUST00000020977.4
dihydrouridine synthase 4-like (S. cerevisiae)
chr11_-_61610772 0.31 ENSMUST00000151780.8
ENSMUST00000148584.2
solute carrier family 5 (sodium/glucose cotransporter), member 10
chr13_+_100806206 0.27 ENSMUST00000170347.4
ENSMUST00000057325.15
coiled-coil domain containing 125
chr8_+_26339646 0.27 ENSMUST00000098858.11
potassium channel, subfamily U, member 1
chr17_-_32491339 0.25 ENSMUST00000237008.2
bromodomain containing 4
chr13_-_100787481 0.25 ENSMUST00000177848.3
ENSMUST00000022136.14
RAD17 checkpoint clamp loader component
chr18_+_67221287 0.24 ENSMUST00000025402.15
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr14_+_54664359 0.23 ENSMUST00000010550.12
ENSMUST00000199195.3
ENSMUST00000196273.2
mitochondrial ribosomal protein L52
chr14_-_51287620 0.23 ENSMUST00000076106.4
ribonuclease, RNase A family, 11 (non-active)
chr2_-_62404195 0.22 ENSMUST00000174234.8
ENSMUST00000000402.16
ENSMUST00000174448.8
ENSMUST00000102732.10
fibroblast activation protein
chr13_-_74956030 0.21 ENSMUST00000065629.6
calpastatin
chr19_+_38043506 0.21 ENSMUST00000237408.2
centrosomal protein 55
chr3_+_142236086 0.20 ENSMUST00000171263.8
ENSMUST00000045097.11
guanylate binding protein 7
chr7_+_121464254 0.19 ENSMUST00000033161.7
sodium channel, nonvoltage-gated 1 beta
chr10_+_129610507 0.18 ENSMUST00000203598.3
olfactory receptor 809
chr17_+_84819260 0.14 ENSMUST00000047206.7
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr6_-_113354468 0.14 ENSMUST00000099118.8
transcriptional adaptor 3
chr11_+_70342731 0.13 ENSMUST00000151013.8
ENSMUST00000019067.8
mediator complex subunit 11
chr7_+_4340708 0.11 ENSMUST00000006792.6
ENSMUST00000126417.3
natural cytotoxicity triggering receptor 1
chr13_+_22129246 0.11 ENSMUST00000176511.8
ENSMUST00000102978.8
ENSMUST00000152258.9
zinc finger protein 184 (Kruppel-like)
chr6_+_36364990 0.10 ENSMUST00000172278.8
cholinergic receptor, muscarinic 2, cardiac
chr18_+_9957906 0.09 ENSMUST00000025137.9
THO complex 1
chrX_-_94488394 0.08 ENSMUST00000084535.6
APC membrane recruitment 1
chr7_+_134870237 0.07 ENSMUST00000210697.2
ENSMUST00000097983.5
neuropeptide S
chr19_+_5475149 0.05 ENSMUST00000159759.3
ENSMUST00000054477.8
expressed sequence AI837181
chr7_+_25959759 0.05 ENSMUST00000227232.2
ENSMUST00000228145.2
ENSMUST00000228369.2
ENSMUST00000227790.2
ENSMUST00000227534.2
ENSMUST00000227230.2
vomeronasal 1 receptor, 184
chr5_-_39801940 0.04 ENSMUST00000152057.2
ENSMUST00000053116.7
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr18_-_42712717 0.04 ENSMUST00000054738.5
G protein-coupled receptor 151
chr3_-_15892807 0.03 ENSMUST00000148194.8
signal-regulatory protein beta 1C
chr7_+_12034357 0.03 ENSMUST00000072801.5
ENSMUST00000227672.2
vomeronasal 1 receptor 82
chr2_-_166902307 0.02 ENSMUST00000155281.8
zinc finger, NFX1-type containing 1
chr5_-_5713264 0.02 ENSMUST00000148193.2
cilia and flagella associated protein 69
chr13_+_23317325 0.01 ENSMUST00000227050.2
ENSMUST00000227160.2
ENSMUST00000227741.2
ENSMUST00000226692.2
vomeronasal 1 receptor 218
chr18_+_57605525 0.01 ENSMUST00000209786.2
cortexin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 26.0 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
5.3 15.8 GO:0034118 erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
4.0 11.9 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
2.5 12.5 GO:0006566 threonine metabolic process(GO:0006566)
2.1 12.5 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
1.6 6.3 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
1.6 12.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
1.4 10.9 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
1.2 3.6 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
1.1 3.4 GO:0019043 establishment of viral latency(GO:0019043)
1.1 4.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
1.1 3.2 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
1.0 3.0 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.9 2.7 GO:0016078 tRNA catabolic process(GO:0016078)
0.9 6.9 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.7 9.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.7 2.8 GO:0015811 L-cystine transport(GO:0015811)
0.7 2.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429) positive regulation of t-circle formation(GO:1904431)
0.7 13.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.7 2.0 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.6 7.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 1.9 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.5 2.1 GO:0010046 response to mycotoxin(GO:0010046)
0.5 22.7 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.5 8.7 GO:0051014 actin filament severing(GO:0051014)
0.4 2.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.4 2.1 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.3 6.0 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.3 6.6 GO:0043312 neutrophil degranulation(GO:0043312)
0.3 3.8 GO:0001955 blood vessel maturation(GO:0001955)
0.3 3.4 GO:0042119 neutrophil activation(GO:0042119)
0.3 1.4 GO:2000510 positive regulation of trophoblast cell migration(GO:1901165) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.3 3.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.3 1.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.3 4.4 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.3 1.3 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.2 2.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.2 6.7 GO:0019731 antibacterial humoral response(GO:0019731)
0.2 2.2 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.2 2.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.2 2.9 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.2 2.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.2 7.6 GO:0030220 platelet formation(GO:0030220)
0.1 0.7 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 3.0 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1 0.5 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.1 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.3 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 1.5 GO:1904869 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1 0.5 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 6.6 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 0.5 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.6 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.1 3.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.2 GO:0010710 regulation of collagen catabolic process(GO:0010710) melanocyte proliferation(GO:0097325)
0.1 2.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 0.5 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 1.5 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
0.1 1.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.5 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 6.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.0 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 2.7 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.7 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.4 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 1.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 2.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 1.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.3 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 2.5 GO:0048525 negative regulation of viral process(GO:0048525)
0.0 0.1 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.0 2.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 3.2 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 1.7 GO:0006400 tRNA modification(GO:0006400)
0.0 1.7 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 2.2 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.0 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0072161 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
3.0 11.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
2.7 13.5 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.7 4.4 GO:0097452 GAIT complex(GO:0097452)
0.6 13.6 GO:0005652 nuclear lamina(GO:0005652)
0.6 15.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 7.8 GO:0042555 MCM complex(GO:0042555)
0.4 2.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 2.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.3 7.3 GO:0031011 Ino80 complex(GO:0031011)
0.3 3.4 GO:0042629 mast cell granule(GO:0042629)
0.3 3.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 12.5 GO:0008305 integrin complex(GO:0008305)
0.3 1.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.3 22.3 GO:0005871 kinesin complex(GO:0005871)
0.2 5.5 GO:0070938 contractile ring(GO:0070938)
0.2 3.0 GO:0034709 methylosome(GO:0034709)
0.2 2.7 GO:0000796 condensin complex(GO:0000796)
0.2 1.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 1.6 GO:0071986 Ragulator complex(GO:0071986)
0.2 2.0 GO:0070187 telosome(GO:0070187)
0.2 2.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 6.6 GO:0031941 filamentous actin(GO:0031941)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 2.1 GO:0005605 basal lamina(GO:0005605)
0.1 0.5 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 4.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 9.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.2 GO:0043194 axon initial segment(GO:0043194)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 2.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 2.8 GO:0031526 brush border membrane(GO:0031526)
0.0 7.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.2 GO:0005769 early endosome(GO:0005769)
0.0 27.1 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 1.7 GO:0005581 collagen trimer(GO:0005581)
0.0 4.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 6.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.1 GO:0005770 late endosome(GO:0005770)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.4 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 26.0 GO:0001851 complement component C3b binding(GO:0001851)
1.4 9.9 GO:0050051 alkane 1-monooxygenase activity(GO:0018685) leukotriene-B4 20-monooxygenase activity(GO:0050051)
1.4 12.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.2 10.9 GO:0070891 lipoteichoic acid binding(GO:0070891)
1.1 3.4 GO:0019959 interleukin-8 binding(GO:0019959)
1.1 11.9 GO:1903136 cuprous ion binding(GO:1903136)
1.1 3.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.9 2.7 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.8 9.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7 2.8 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.6 3.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.6 13.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.6 1.8 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.5 8.7 GO:0005522 profilin binding(GO:0005522)
0.5 3.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.5 3.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.4 2.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.4 2.0 GO:0052794 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.3 2.4 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.3 2.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 1.4 GO:0030984 kininogen binding(GO:0030984)
0.3 1.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 3.7 GO:0008097 5S rRNA binding(GO:0008097)
0.2 1.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 1.9 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.2 21.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 22.3 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 7.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 0.7 GO:0004127 cytidylate kinase activity(GO:0004127)
0.2 0.5 GO:0016015 morphogen activity(GO:0016015)
0.2 2.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.5 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 3.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 6.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 6.6 GO:0003774 motor activity(GO:0003774)
0.1 0.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 6.8 GO:0051287 NAD binding(GO:0051287)
0.1 1.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 5.5 GO:0019894 kinesin binding(GO:0019894)
0.1 2.7 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.1 1.7 GO:0005537 mannose binding(GO:0005537)
0.1 0.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.3 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.0 2.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 9.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 6.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 2.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 8.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 1.7 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 6.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 3.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.6 GO:0019209 kinase activator activity(GO:0019209)
0.0 7.5 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 3.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 3.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.7 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 26.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 11.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 8.0 PID ATR PATHWAY ATR signaling pathway
0.1 6.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 2.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 17.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 1.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 4.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 4.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 22.3 REACTOME KINESINS Genes involved in Kinesins
0.5 3.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.5 7.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 12.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 11.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 3.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 2.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.3 2.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 3.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 12.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 3.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 12.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.7 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 12.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 7.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 4.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 2.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 11.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.9 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 2.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 3.3 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.0 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 3.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression