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GSE58827: Dynamics of the Mouse Liver

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Results for Thrb

Z-value: 1.26

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Transcription factors associated with Thrb

Gene Symbol Gene ID Gene Info
Thrb
ENSMUSG00000021779.20 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrbmm39_v1_chr14_-_4488167_44881890.421.1e-02Click!

Activity profile of Thrb motif

Sorted Z-values of Thrb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_105775224 23.66 ENSMUST00000093222.13
ENSMUST00000093223.5
Ces3a
carboxylesterase 3A
chr3_+_14928561 23.47 ENSMUST00000029076.6
Car3
carbonic anhydrase 3
chr7_+_25597045 16.20 ENSMUST00000072438.13
ENSMUST00000005477.6
Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
chr2_+_58457370 15.04 ENSMUST00000071543.12
Upp2
uridine phosphorylase 2
chr7_-_105249308 9.95 ENSMUST00000210531.2
ENSMUST00000033185.10
Hpx
hemopexin
chr10_+_87357782 9.08 ENSMUST00000219813.2
Pah
phenylalanine hydroxylase
chr17_+_37253802 8.94 ENSMUST00000040498.12
Rnf39
ring finger protein 39
chr15_-_76193955 6.88 ENSMUST00000210024.2
Oplah
5-oxoprolinase (ATP-hydrolysing)
chr2_+_118998235 6.50 ENSMUST00000057454.4
Gchfr
GTP cyclohydrolase I feedback regulator
chr10_+_87357657 6.47 ENSMUST00000020241.17
Pah
phenylalanine hydroxylase
chr14_-_61597843 5.37 ENSMUST00000022494.10
Ebpl
emopamil binding protein-like
chr14_+_14475188 4.72 ENSMUST00000026315.8
Dnase1l3
deoxyribonuclease 1-like 3
chr11_-_113600346 4.66 ENSMUST00000173655.8
ENSMUST00000100248.6
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr12_+_108300599 4.41 ENSMUST00000021684.6
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr9_-_107546166 4.32 ENSMUST00000177567.8
Slc38a3
solute carrier family 38, member 3
chr4_+_41760454 4.17 ENSMUST00000108040.8
Il11ra1
interleukin 11 receptor, alpha chain 1
chr9_-_107546195 4.08 ENSMUST00000192990.6
Slc38a3
solute carrier family 38, member 3
chr2_-_25359752 3.83 ENSMUST00000114259.3
ENSMUST00000015234.13
Ptgds
prostaglandin D2 synthase (brain)
chr17_+_37253916 3.40 ENSMUST00000173072.2
Rnf39
ring finger protein 39
chr11_-_113600838 3.40 ENSMUST00000018871.8
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr9_+_44584523 3.29 ENSMUST00000034609.11
ENSMUST00000071219.12
Treh
trehalase (brush-border membrane glycoprotein)
chr10_+_77522403 2.91 ENSMUST00000092366.4
Tspear
thrombospondin type laminin G domain and EAR repeats
chr2_-_25360043 2.62 ENSMUST00000114251.8
Ptgds
prostaglandin D2 synthase (brain)
chr1_-_52539395 2.20 ENSMUST00000186764.7
Nab1
Ngfi-A binding protein 1
chr4_+_116078787 2.12 ENSMUST00000147292.8
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr4_+_20042045 2.12 ENSMUST00000098242.4
Ggh
gamma-glutamyl hydrolase
chr17_+_57297280 1.82 ENSMUST00000002735.9
Clpp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr13_+_34923589 1.61 ENSMUST00000221037.2
Fam50b
family with sequence similarity 50, member B
chr9_+_102503815 1.56 ENSMUST00000038673.14
ENSMUST00000186693.2
Anapc13
anaphase promoting complex subunit 13
chr5_+_95021656 1.45 ENSMUST00000180076.2
Gm3183
predicted gene 3183
chr5_-_74692327 1.38 ENSMUST00000072857.13
ENSMUST00000113542.9
ENSMUST00000151474.3
Scfd2
Sec1 family domain containing 2
chr9_+_102503476 1.38 ENSMUST00000190279.7
ENSMUST00000188398.7
Anapc13
anaphase promoting complex subunit 13
chrX_-_77627388 1.35 ENSMUST00000177904.8
Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr6_+_114435480 1.29 ENSMUST00000160780.2
Hrh1
histamine receptor H1
chr5_+_94365864 1.23 ENSMUST00000179743.3
Pramel38
PRAME like 38
chr3_-_79749949 1.21 ENSMUST00000029568.7
Tmem144
transmembrane protein 144
chr11_-_58516867 1.20 ENSMUST00000203173.2
ENSMUST00000070804.3
Olfr323
olfactory receptor 323
chr3_-_36529753 0.93 ENSMUST00000199478.2
Anxa5
annexin A5
chr19_-_46314945 0.89 ENSMUST00000225781.2
ENSMUST00000223903.2
Psd
pleckstrin and Sec7 domain containing
chr4_+_116078830 0.89 ENSMUST00000030464.14
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr16_-_16962256 0.86 ENSMUST00000115711.10
Ccdc116
coiled-coil domain containing 116
chr16_-_28571820 0.86 ENSMUST00000232352.2
Fgf12
fibroblast growth factor 12
chr11_+_70350436 0.81 ENSMUST00000039093.10
Zmynd15
zinc finger, MYND-type containing 15
chr2_+_152804405 0.80 ENSMUST00000099197.9
ENSMUST00000103155.10
Ttll9
tubulin tyrosine ligase-like family, member 9
chrX_-_77627486 0.78 ENSMUST00000114025.8
ENSMUST00000134602.8
ENSMUST00000114024.9
Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr14_+_53315909 0.76 ENSMUST00000103608.4
Trav14d-3-dv8
T cell receptor alpha variable 14D-3-DV8
chr16_+_8498618 0.72 ENSMUST00000201722.2
Gm5767
predicted gene 5767
chr1_-_24626492 0.68 ENSMUST00000051344.6
ENSMUST00000115244.9
Col19a1
collagen, type XIX, alpha 1
chr17_-_28908757 0.64 ENSMUST00000233398.2
Slc26a8
solute carrier family 26, member 8
chr10_-_18662526 0.56 ENSMUST00000216654.2
Gm4922
predicted gene 4922
chr11_+_70350252 0.53 ENSMUST00000108563.9
Zmynd15
zinc finger, MYND-type containing 15
chr17_-_14223966 0.50 ENSMUST00000189454.3
Gm7356
predicted gene 7356
chr8_-_120228434 0.49 ENSMUST00000133821.2
ENSMUST00000036748.15
Slc38a8
solute carrier family 38, member 8
chr14_+_54000594 0.40 ENSMUST00000103589.6
Trav14-3
T cell receptor alpha variable 14-3
chr11_+_109376432 0.38 ENSMUST00000106697.8
Arsg
arylsulfatase G
chr9_-_102503180 0.38 ENSMUST00000216281.2
ENSMUST00000093791.10
Cep63
centrosomal protein 63
chr13_-_92667321 0.36 ENSMUST00000022217.9
Zfyve16
zinc finger, FYVE domain containing 16
chr5_+_35971697 0.36 ENSMUST00000130233.8
Ablim2
actin-binding LIM protein 2
chr11_+_49094292 0.34 ENSMUST00000150284.8
ENSMUST00000109197.8
ENSMUST00000151228.2
Zfp62
zinc finger protein 62
chr13_-_59892731 0.30 ENSMUST00000180139.3
1700014D04Rik
RIKEN cDNA 1700014D04 gene
chr7_+_27222678 0.30 ENSMUST00000108353.9
Hipk4
homeodomain interacting protein kinase 4
chr16_-_16962279 0.29 ENSMUST00000232033.2
ENSMUST00000231597.2
ENSMUST00000232540.2
Ccdc116
coiled-coil domain containing 116
chr8_+_112262729 0.27 ENSMUST00000172856.8
Znrf1
zinc and ring finger 1
chr13_+_38041910 0.20 ENSMUST00000138110.8
Rreb1
ras responsive element binding protein 1
chr6_-_121450547 0.06 ENSMUST00000046373.8
ENSMUST00000151397.3
Iqsec3
IQ motif and Sec7 domain 3
chr14_+_54713703 0.05 ENSMUST00000164697.8
Rem2
rad and gem related GTP binding protein 2
chr1_-_83385911 0.01 ENSMUST00000160953.8
Sphkap
SPHK1 interactor, AKAP domain containing

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 GO:0009095 tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095)
2.8 8.4 GO:0006867 asparagine transport(GO:0006867) positive regulation of glutamine transport(GO:2000487)
2.3 16.2 GO:0042738 exogenous drug catabolic process(GO:0042738)
1.4 10.0 GO:0060332 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.1 6.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.7 8.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.7 3.3 GO:0005984 disaccharide metabolic process(GO:0005984)
0.5 2.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.4 23.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.3 4.4 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 1.3 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.2 4.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.2 4.2 GO:0046697 decidualization(GO:0046697)
0.2 0.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 0.9 GO:0070459 prolactin secretion(GO:0070459)
0.1 15.0 GO:0009166 nucleotide catabolic process(GO:0009166)
0.1 6.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.6 GO:0019532 oxalate transport(GO:0019532)
0.1 2.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 3.0 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 1.1 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.1 1.2 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 1.8 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 2.2 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 6.5 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 5.4 GO:0016125 sterol metabolic process(GO:0016125)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 2.5 GO:0007605 sensory perception of sound(GO:0007605)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 15.0 GO:0045098 type III intermediate filament(GO:0045098)
0.4 8.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 6.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 3.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 6.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 10.9 GO:0072562 blood microparticle(GO:0072562)
0.0 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 46.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 8.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.3 GO:0005903 brush border(GO:0005903)
0.0 0.9 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.5 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
2.5 15.0 GO:0004850 uridine phosphorylase activity(GO:0004850)
2.1 8.4 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
1.8 23.5 GO:0016151 nickel cation binding(GO:0016151)
1.7 10.0 GO:0015232 heme transporter activity(GO:0015232)
1.6 6.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.0 4.2 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.8 6.9 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.5 16.2 GO:0070330 aromatase activity(GO:0070330)
0.3 1.3 GO:0051381 histamine binding(GO:0051381)
0.3 3.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 5.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 6.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 8.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 23.7 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 2.1 GO:0008242 omega peptidase activity(GO:0008242)
0.1 4.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 4.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 1.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 3.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.2 GO:1901476 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 10.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.8 15.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 6.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 4.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 6.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 8.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 15.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 2.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation