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GSE58827: Dynamics of the Mouse Liver

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Results for Zfp105

Z-value: 0.46

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Transcription factors associated with Zfp105

Gene Symbol Gene ID Gene Info
Zfp105
ENSMUSG00000057895.12 zinc finger protein 105

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp105mm39_v1_chr9_+_122752116_1227521570.618.8e-05Click!

Activity profile of Zfp105 motif

Sorted Z-values of Zfp105 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_103799873 3.72 ENSMUST00000123437.8
Lmo2
LIM domain only 2
chr10_-_111833138 2.08 ENSMUST00000074805.12
Glipr1
GLI pathogenesis-related 1 (glioma)
chr9_+_108437485 2.04 ENSMUST00000081111.14
ENSMUST00000193421.2
Impdh2
inosine monophosphate dehydrogenase 2
chr5_+_146769700 1.85 ENSMUST00000035983.12
Rpl21
ribosomal protein L21
chr11_+_44508137 1.79 ENSMUST00000109268.2
ENSMUST00000101326.10
ENSMUST00000081265.12
Ebf1
early B cell factor 1
chr11_+_101623836 1.45 ENSMUST00000129741.2
Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr10_-_30647836 1.45 ENSMUST00000215926.2
ENSMUST00000213836.2
Ncoa7
nuclear receptor coactivator 7
chr6_+_135339543 1.32 ENSMUST00000205156.3
Emp1
epithelial membrane protein 1
chr2_-_151586063 1.26 ENSMUST00000109869.2
Psmf1
proteasome (prosome, macropain) inhibitor subunit 1
chr8_-_57940834 1.15 ENSMUST00000034022.4
Sap30
sin3 associated polypeptide
chr15_+_6673167 0.99 ENSMUST00000163073.2
Fyb
FYN binding protein
chr6_-_30390996 0.96 ENSMUST00000152391.9
ENSMUST00000115184.2
ENSMUST00000080812.14
ENSMUST00000102992.10
Zc3hc1
zinc finger, C3HC type 1
chr6_-_127128007 0.89 ENSMUST00000000188.12
Ccnd2
cyclin D2
chr9_+_75093177 0.86 ENSMUST00000129281.8
ENSMUST00000148144.8
ENSMUST00000130384.2
Myo5a
myosin VA
chr6_+_135339929 0.79 ENSMUST00000032330.16
Emp1
epithelial membrane protein 1
chr11_+_99748741 0.78 ENSMUST00000107434.2
Gm11568
predicted gene 11568
chr6_-_127127959 0.74 ENSMUST00000201637.2
Ccnd2
cyclin D2
chr5_+_86219593 0.71 ENSMUST00000198435.5
ENSMUST00000031171.9
Stap1
signal transducing adaptor family member 1
chr10_-_30647881 0.67 ENSMUST00000215740.2
Ncoa7
nuclear receptor coactivator 7
chr12_+_3941728 0.58 ENSMUST00000172689.8
ENSMUST00000111186.8
Dnmt3a
DNA methyltransferase 3A
chr6_-_127127993 0.57 ENSMUST00000201066.2
Ccnd2
cyclin D2
chr7_-_15781838 0.51 ENSMUST00000210781.2
Bicra
BRD4 interacting chromatin remodeling complex associated protein
chrX_+_7656225 0.51 ENSMUST00000136930.8
ENSMUST00000115675.9
ENSMUST00000101694.10
Gripap1
GRIP1 associated protein 1
chr5_+_129875821 0.51 ENSMUST00000171300.8
ENSMUST00000201874.4
Sumf2
sulfatase modifying factor 2
chr7_-_132724889 0.51 ENSMUST00000166439.8
Ctbp2
C-terminal binding protein 2
chr10_-_23977810 0.48 ENSMUST00000170267.3
Taar8c
trace amine-associated receptor 8C
chr8_+_94537910 0.47 ENSMUST00000138659.9
Gnao1
guanine nucleotide binding protein, alpha O
chr12_-_52018072 0.45 ENSMUST00000040583.7
Heatr5a
HEAT repeat containing 5A
chr5_+_147456497 0.45 ENSMUST00000175807.8
Pan3
PAN3 poly(A) specific ribonuclease subunit
chr7_-_79974166 0.41 ENSMUST00000047362.11
ENSMUST00000121882.8
Rccd1
RCC1 domain containing 1
chr3_+_31150982 0.40 ENSMUST00000118204.2
Skil
SKI-like
chr7_-_66915756 0.36 ENSMUST00000207715.2
Mef2a
myocyte enhancer factor 2A
chr5_+_76288524 0.31 ENSMUST00000152642.8
ENSMUST00000127278.8
Srd5a3
steroid 5 alpha-reductase 3
chr15_-_79212400 0.30 ENSMUST00000173163.8
ENSMUST00000047816.15
ENSMUST00000172403.9
ENSMUST00000173632.8
Pla2g6
phospholipase A2, group VI
chr11_-_99742434 0.24 ENSMUST00000107437.2
Krtap4-16
keratin associated protein 4-16
chr19_+_41921903 0.24 ENSMUST00000224258.2
ENSMUST00000026154.9
ENSMUST00000224896.2
Zdhhc16
zinc finger, DHHC domain containing 16
chr2_-_87985537 0.23 ENSMUST00000216951.2
Olfr1167
olfactory receptor 1167
chr12_+_87921198 0.21 ENSMUST00000110145.12
ENSMUST00000181843.2
ENSMUST00000180706.8
ENSMUST00000181394.8
ENSMUST00000181326.8
ENSMUST00000181300.2
Gm2042
predicted gene 2042
chr18_-_14105591 0.20 ENSMUST00000234025.2
Zfp521
zinc finger protein 521
chr7_-_34012934 0.18 ENSMUST00000206399.2
Garre1
granule associated Rac and RHOG effector 1
chr10_-_78427721 0.17 ENSMUST00000040580.7
Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr3_+_138233004 0.17 ENSMUST00000196990.5
ENSMUST00000200239.5
ENSMUST00000200100.2
Eif4e
eukaryotic translation initiation factor 4E
chr11_+_83742961 0.15 ENSMUST00000146786.8
Hnf1b
HNF1 homeobox B
chr13_+_95012107 0.15 ENSMUST00000022195.13
Otp
orthopedia homeobox
chr12_-_84031622 0.12 ENSMUST00000164935.3
Heatr4
HEAT repeat containing 4
chr2_+_143388062 0.11 ENSMUST00000028905.10
Pcsk2
proprotein convertase subtilisin/kexin type 2
chr5_+_20112704 0.11 ENSMUST00000115267.7
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_+_97968737 0.11 ENSMUST00000043628.13
ENSMUST00000203938.2
Mitf
melanogenesis associated transcription factor
chr6_-_142910094 0.09 ENSMUST00000032421.4
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr6_-_53797748 0.08 ENSMUST00000127748.5
Tril
TLR4 interactor with leucine-rich repeats
chr15_-_50753061 0.08 ENSMUST00000165201.9
ENSMUST00000184458.8
Trps1
transcriptional repressor GATA binding 1
chr5_+_20112500 0.07 ENSMUST00000101558.10
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_+_20043315 0.05 ENSMUST00000173779.2
Cp
ceruloplasmin
chr6_-_99412306 0.03 ENSMUST00000113322.9
ENSMUST00000176850.8
ENSMUST00000176632.8
Foxp1
forkhead box P1
chr14_-_101846551 0.02 ENSMUST00000100340.4
Tbc1d4
TBC1 domain family, member 4
chr2_+_67004178 0.02 ENSMUST00000239009.2
ENSMUST00000238912.2
Xirp2
xin actin-binding repeat containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp105

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 0.7 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.2 3.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 0.9 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.1 2.2 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 2.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.3 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 0.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 2.1 GO:0032060 bleb assembly(GO:0032060)
0.1 0.5 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.3 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.6 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.2 GO:0061206 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.4 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 1.0 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 1.3 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 0.9 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 0.5 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 1.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.3 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.7 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.3 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 1.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 1.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.2 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 1.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 3.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.2 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.5 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.3 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation