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GSE58827: Dynamics of the Mouse Liver

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Results for Zfp128

Z-value: 0.66

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Transcription factors associated with Zfp128

Gene Symbol Gene ID Gene Info
Zfp128
ENSMUSG00000060397.7 zinc finger protein 128

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp128mm39_v1_chr7_+_12615091_126151320.492.4e-03Click!

Activity profile of Zfp128 motif

Sorted Z-values of Zfp128 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_45175570 8.71 ENSMUST00000167273.2
ENSMUST00000042105.11
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
chr11_-_11920540 5.25 ENSMUST00000109653.8
Grb10
growth factor receptor bound protein 10
chr5_-_138169509 4.57 ENSMUST00000153867.8
Mcm7
minichromosome maintenance complex component 7
chr5_-_138169253 4.43 ENSMUST00000139983.8
Mcm7
minichromosome maintenance complex component 7
chr6_+_128339882 4.00 ENSMUST00000073316.13
Foxm1
forkhead box M1
chrX_-_133483849 3.82 ENSMUST00000113213.2
ENSMUST00000033617.13
Btk
Bruton agammaglobulinemia tyrosine kinase
chr13_-_59917569 2.92 ENSMUST00000057115.7
Isca1
iron-sulfur cluster assembly 1
chr11_+_104441489 2.91 ENSMUST00000018800.9
Myl4
myosin, light polypeptide 4
chr6_-_128339775 2.53 ENSMUST00000112152.8
ENSMUST00000057421.15
ENSMUST00000112151.2
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr5_-_138169476 2.46 ENSMUST00000147920.2
Mcm7
minichromosome maintenance complex component 7
chr15_-_96540760 2.44 ENSMUST00000088452.11
Slc38a1
solute carrier family 38, member 1
chr7_+_45084257 2.26 ENSMUST00000003964.17
Gys1
glycogen synthase 1, muscle
chr8_+_84441806 2.25 ENSMUST00000019576.15
Ddx39a
DEAD box helicase 39a
chr8_+_84442133 2.11 ENSMUST00000109810.2
Ddx39a
DEAD box helicase 39a
chr4_+_126450728 2.04 ENSMUST00000048391.15
Clspn
claspin
chr15_-_76554065 1.91 ENSMUST00000037824.6
Foxh1
forkhead box H1
chr7_-_44578834 1.85 ENSMUST00000107857.11
ENSMUST00000167930.8
ENSMUST00000085399.13
ENSMUST00000166972.9
Ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr7_+_45084300 1.84 ENSMUST00000211150.2
Gys1
glycogen synthase 1, muscle
chr8_+_84441854 1.83 ENSMUST00000172396.8
Ddx39a
DEAD box helicase 39a
chr7_-_45084012 1.72 ENSMUST00000107771.12
ENSMUST00000211666.2
Ruvbl2
RuvB-like protein 2
chr8_-_127672590 1.16 ENSMUST00000179857.3
ENSMUST00000212771.2
Tomm20
translocase of outer mitochondrial membrane 20
chr9_+_21323120 1.12 ENSMUST00000002902.8
Qtrt1
queuine tRNA-ribosyltransferase catalytic subunit 1
chr3_+_37474422 1.12 ENSMUST00000029277.13
ENSMUST00000198968.2
Spata5
spermatogenesis associated 5
chr19_-_47525437 1.11 ENSMUST00000182808.8
ENSMUST00000182714.2
ENSMUST00000049369.16
Stn1
STN1, CST complex subunit
chr9_-_35087348 1.11 ENSMUST00000119847.2
ENSMUST00000034539.12
Dcps
decapping enzyme, scavenger
chr2_-_126985226 1.06 ENSMUST00000110386.2
ENSMUST00000132773.2
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr14_-_106134253 0.95 ENSMUST00000022709.6
Spry2
sprouty RTK signaling antagonist 2
chr4_+_138960687 0.95 ENSMUST00000042675.9
Capzb
capping protein (actin filament) muscle Z-line, beta
chr12_-_75596441 0.83 ENSMUST00000218716.2
Ppp2r5e
protein phosphatase 2, regulatory subunit B', epsilon
chr6_-_128339458 0.75 ENSMUST00000155573.3
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr18_-_37777238 0.75 ENSMUST00000066272.6
Taf7
TATA-box binding protein associated factor 7
chr17_+_34062059 0.73 ENSMUST00000002379.15
Cd320
CD320 antigen
chr2_-_30014466 0.72 ENSMUST00000044751.14
Zer1
zyg-11 related, cell cycle regulator
chr2_-_30014538 0.71 ENSMUST00000113677.3
Zer1
zyg-11 related, cell cycle regulator
chr9_+_3335469 0.66 ENSMUST00000053407.13
ENSMUST00000211933.2
ENSMUST00000212666.2
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr1_+_118409769 0.59 ENSMUST00000191823.6
Clasp1
CLIP associating protein 1
chr15_+_76763431 0.47 ENSMUST00000023179.7
Zfp7
zinc finger protein 7
chr11_-_116164928 0.40 ENSMUST00000106425.4
Srp68
signal recognition particle 68
chr3_+_97565528 0.38 ENSMUST00000045743.13
Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr11_-_116165024 0.37 ENSMUST00000021133.16
Srp68
signal recognition particle 68
chr5_-_121329385 0.34 ENSMUST00000054547.9
ENSMUST00000100770.9
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
chr3_-_79475078 0.27 ENSMUST00000133154.7
Fnip2
folliculin interacting protein 2
chr9_+_3335135 0.25 ENSMUST00000212294.2
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr17_-_82045800 0.20 ENSMUST00000235015.2
ENSMUST00000163123.3
Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_+_45175754 0.18 ENSMUST00000211227.2
ENSMUST00000051810.15
Plekha4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr2_+_70886073 0.16 ENSMUST00000154704.8
ENSMUST00000135357.8
ENSMUST00000064141.12
ENSMUST00000112159.9
ENSMUST00000102701.5
Dcaf17
DDB1 and CUL4 associated factor 17
chr7_-_21161866 0.03 ENSMUST00000177741.4
Gm6882
predicted gene 6882

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp128

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
1.3 3.8 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
1.0 11.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 1.9 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.5 5.2 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.4 1.9 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.4 1.1 GO:0036245 cellular response to menadione(GO:0036245)
0.4 2.9 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 2.4 GO:0006868 glutamine transport(GO:0006868)
0.3 1.7 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 1.2 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.2 4.0 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 1.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 1.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.3 GO:2000847 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1 0.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.1 0.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 3.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 3.2 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 2.8 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 0.7 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 1.4 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.0 0.9 GO:0006400 tRNA modification(GO:0006400)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.5 GO:0042555 MCM complex(GO:0042555)
0.6 8.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 1.9 GO:0032444 activin responsive factor complex(GO:0032444)
0.4 1.1 GO:1990879 CST complex(GO:1990879)
0.2 1.7 GO:0097255 R2TP complex(GO:0097255)
0.1 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.9 GO:0032433 filopodium tip(GO:0032433)
0.1 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.9 GO:0071203 F-actin capping protein complex(GO:0008290) WASH complex(GO:0071203)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 4.1 GO:0016234 inclusion body(GO:0016234)
0.0 2.6 GO:0031672 A band(GO:0031672)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 3.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.4 1.2 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.3 2.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 13.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 1.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 8.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.7 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 1.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.8 GO:0030942 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 5.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.3 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.1 1.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047)
0.1 1.9 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 3.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 1.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.1 PID ATR PATHWAY ATR signaling pathway
0.1 8.7 PID BMP PATHWAY BMP receptor signaling
0.1 5.6 PID IGF1 PATHWAY IGF1 pathway
0.1 3.8 ST GA12 PATHWAY G alpha 12 Pathway
0.1 3.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.9 PID ARF 3PATHWAY Arf1 pathway
0.1 1.7 PID MYC PATHWAY C-MYC pathway
0.0 1.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 8.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 5.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.9 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 3.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 2.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 4.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 2.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis