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GSE58827: Dynamics of the Mouse Liver

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Results for Zfp282

Z-value: 0.72

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Transcription factors associated with Zfp282

Gene Symbol Gene ID Gene Info
Zfp282
ENSMUSG00000025821.10 zinc finger protein 282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp282mm39_v1_chr6_+_47854138_478541380.761.0e-07Click!

Activity profile of Zfp282 motif

Sorted Z-values of Zfp282 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_90576285 13.99 ENSMUST00000069927.10
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr14_+_80237691 8.70 ENSMUST00000228749.2
ENSMUST00000088735.4
Olfm4
olfactomedin 4
chr7_-_103492361 5.78 ENSMUST00000063957.6
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr7_-_45175570 4.99 ENSMUST00000167273.2
ENSMUST00000042105.11
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
chr7_+_142558783 4.97 ENSMUST00000009396.13
Tspan32
tetraspanin 32
chr14_-_70864448 4.74 ENSMUST00000110984.4
Dmtn
dematin actin binding protein
chr7_+_142558837 4.23 ENSMUST00000207211.2
Tspan32
tetraspanin 32
chrX_+_134894573 3.21 ENSMUST00000058119.9
Arxes2
adipocyte-related X-chromosome expressed sequence 2
chr8_+_95712151 3.20 ENSMUST00000212799.2
Adgrg1
adhesion G protein-coupled receptor G1
chr9_-_114610879 3.00 ENSMUST00000084867.9
ENSMUST00000216760.2
ENSMUST00000035009.16
Cmtm7
CKLF-like MARVEL transmembrane domain containing 7
chr1_+_134383247 2.84 ENSMUST00000112232.8
ENSMUST00000027725.11
ENSMUST00000116528.2
Klhl12
kelch-like 12
chr6_-_83504471 2.51 ENSMUST00000141904.8
Actg2
actin, gamma 2, smooth muscle, enteric
chr7_-_24705320 2.40 ENSMUST00000102858.10
ENSMUST00000196684.2
ENSMUST00000080882.11
Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr6_-_83504756 2.35 ENSMUST00000152029.2
Actg2
actin, gamma 2, smooth muscle, enteric
chr5_-_65548723 2.28 ENSMUST00000120094.5
ENSMUST00000127874.6
ENSMUST00000057885.13
Rpl9
ribosomal protein L9
chr8_-_23727639 2.13 ENSMUST00000033950.7
Gins4
GINS complex subunit 4 (Sld5 homolog)
chr11_-_68864666 2.10 ENSMUST00000038644.5
Rangrf
RAN guanine nucleotide release factor
chr16_+_10884156 2.00 ENSMUST00000089011.6
Snn
stannin
chr13_-_95661726 1.97 ENSMUST00000022185.10
F2rl1
coagulation factor II (thrombin) receptor-like 1
chr9_+_120400510 1.85 ENSMUST00000165532.3
Rpl14
ribosomal protein L14
chr10_+_93289264 1.84 ENSMUST00000016033.9
Lta4h
leukotriene A4 hydrolase
chr9_-_95727267 1.78 ENSMUST00000093800.9
Pls1
plastin 1 (I-isoform)
chr19_-_6835538 1.76 ENSMUST00000113440.2
Ccdc88b
coiled-coil domain containing 88B
chr17_-_50401305 1.76 ENSMUST00000113195.8
Rftn1
raftlin lipid raft linker 1
chr1_+_39407183 1.44 ENSMUST00000195123.6
Rpl31
ribosomal protein L31
chr1_-_125362321 1.42 ENSMUST00000191544.7
Actr3
ARP3 actin-related protein 3
chr10_-_19727165 1.41 ENSMUST00000059805.6
Slc35d3
solute carrier family 35, member D3
chr18_-_35855383 1.28 ENSMUST00000133064.8
Ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr4_-_126096376 1.22 ENSMUST00000106142.8
ENSMUST00000169403.8
ENSMUST00000130334.2
Thrap3
thyroid hormone receptor associated protein 3
chr1_+_74448535 1.18 ENSMUST00000027366.13
Vil1
villin 1
chr17_-_33904386 1.15 ENSMUST00000087582.13
Hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr17_-_33904345 1.13 ENSMUST00000234474.2
ENSMUST00000139302.8
ENSMUST00000114385.9
Hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr12_-_87490580 1.02 ENSMUST00000162961.8
ENSMUST00000185301.2
Alkbh1
alkB homolog 1, histone H2A dioxygenase
chr13_-_74882374 0.92 ENSMUST00000220738.2
Cast
calpastatin
chr7_-_105289515 0.91 ENSMUST00000133519.8
ENSMUST00000209550.2
ENSMUST00000210911.2
ENSMUST00000084782.10
ENSMUST00000131446.8
Arfip2
ADP-ribosylation factor interacting protein 2
chr4_-_126096551 0.89 ENSMUST00000080919.12
Thrap3
thyroid hormone receptor associated protein 3
chr4_+_14864076 0.89 ENSMUST00000029875.4
Pip4p2
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr2_-_24985137 0.88 ENSMUST00000114373.8
Noxa1
NADPH oxidase activator 1
chr2_-_24985161 0.86 ENSMUST00000044018.8
Noxa1
NADPH oxidase activator 1
chr16_-_85599994 0.84 ENSMUST00000023610.15
Adamts1
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
chr7_+_16472335 0.73 ENSMUST00000086112.8
ENSMUST00000205607.2
Ap2s1
adaptor-related protein complex 2, sigma 1 subunit
chr13_-_74882328 0.70 ENSMUST00000223309.2
Cast
calpastatin
chr3_-_88858465 0.66 ENSMUST00000173135.8
Dap3
death associated protein 3
chr3_-_88858402 0.63 ENSMUST00000173021.8
Dap3
death associated protein 3
chrX_+_105964224 0.62 ENSMUST00000060576.8
Lpar4
lysophosphatidic acid receptor 4
chr13_-_22289994 0.61 ENSMUST00000227357.2
ENSMUST00000228428.2
Vmn1r189
vomeronasal 1 receptor 189
chr17_-_46991709 0.58 ENSMUST00000233524.2
ENSMUST00000233733.2
ENSMUST00000071841.7
ENSMUST00000165007.9
Klhdc3
kelch domain containing 3
chr12_+_72583114 0.56 ENSMUST00000044352.8
Pcnx4
pecanex homolog 4
chr10_-_41894360 0.45 ENSMUST00000162405.8
ENSMUST00000095729.11
ENSMUST00000161081.2
ENSMUST00000160262.9
Armc2
armadillo repeat containing 2
chr2_-_125466985 0.45 ENSMUST00000089776.3
Cep152
centrosomal protein 152
chr7_-_143294051 0.41 ENSMUST00000119499.8
Osbpl5
oxysterol binding protein-like 5
chr12_+_111504450 0.35 ENSMUST00000166123.9
ENSMUST00000222441.2
Eif5
eukaryotic translation initiation factor 5
chr10_-_51507527 0.26 ENSMUST00000219286.2
ENSMUST00000020062.4
ENSMUST00000218684.2
Gprc6a
G protein-coupled receptor, family C, group 6, member A
chr18_-_78222349 0.25 ENSMUST00000237290.2
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr5_-_87638728 0.23 ENSMUST00000147854.6
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr16_+_7011580 0.22 ENSMUST00000231194.2
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_35011953 0.22 ENSMUST00000069837.4
Slit3
slit guidance ligand 3
chr9_-_85631361 0.21 ENSMUST00000039213.15
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_+_82933383 0.18 ENSMUST00000029630.15
ENSMUST00000166581.4
Fga
fibrinogen alpha chain
chr17_-_47169380 0.17 ENSMUST00000233455.2
Bicral
BRD4 interacting chromatin remodeling complex associated protein like
chr2_-_91274967 0.17 ENSMUST00000064652.14
ENSMUST00000102594.11
ENSMUST00000094835.9
1110051M20Rik
RIKEN cDNA 1110051M20 gene
chr12_+_9624437 0.17 ENSMUST00000057021.9
Osr1
odd-skipped related transcription factor 1
chr7_-_102507962 0.16 ENSMUST00000213481.2
ENSMUST00000209952.2
Olfr566
olfactory receptor 566
chr7_-_35255729 0.15 ENSMUST00000040962.6
Nudt19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr19_-_5135510 0.15 ENSMUST00000140389.8
ENSMUST00000151413.2
ENSMUST00000077066.8
Tmem151a
transmembrane protein 151A
chr7_-_29772226 0.13 ENSMUST00000183115.8
ENSMUST00000182919.8
ENSMUST00000183190.2
ENSMUST00000080834.15
Zfp82
zinc finger protein 82
chr19_-_5538370 0.13 ENSMUST00000124334.8
Mus81
MUS81 structure-specific endonuclease subunit
chr7_-_12552764 0.13 ENSMUST00000108546.2
ENSMUST00000072222.8
Zfp329
zinc finger protein 329
chr12_+_111504640 0.13 ENSMUST00000222375.2
ENSMUST00000222388.2
Eif5
eukaryotic translation initiation factor 5
chr12_+_87490666 0.12 ENSMUST00000161023.8
ENSMUST00000160488.8
ENSMUST00000077462.8
ENSMUST00000160880.2
Slirp
SRA stem-loop interacting RNA binding protein
chr16_-_34334454 0.11 ENSMUST00000089655.12
Kalrn
kalirin, RhoGEF kinase
chr2_+_24276545 0.09 ENSMUST00000127242.2
Psd4
pleckstrin and Sec7 domain containing 4
chr11_-_102120953 0.09 ENSMUST00000107150.8
ENSMUST00000156337.2
ENSMUST00000107151.9
ENSMUST00000107152.9
Hdac5
histone deacetylase 5
chr2_+_25179903 0.08 ENSMUST00000028337.7
Lrrc26
leucine rich repeat containing 26
chr7_+_26456567 0.08 ENSMUST00000077855.8
Cyp2b19
cytochrome P450, family 2, subfamily b, polypeptide 19
chr11_-_102120917 0.08 ENSMUST00000008999.12
Hdac5
histone deacetylase 5
chr17_+_47221377 0.07 ENSMUST00000024773.6
Prph2
peripherin 2
chr19_+_56814700 0.05 ENSMUST00000078723.11
ENSMUST00000121249.8
Tdrd1
tudor domain containing 1
chr2_+_28386895 0.03 ENSMUST00000163121.8
Gbgt1
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
chr7_-_46569662 0.03 ENSMUST00000143413.3
ENSMUST00000014546.15
Tsg101
tumor susceptibility gene 101
chr2_+_37666243 0.03 ENSMUST00000050372.10
Crb2
crumbs family member 2
chr6_-_39787813 0.03 ENSMUST00000114797.2
ENSMUST00000031978.9
Mrps33
mitochondrial ribosomal protein S33
chr7_-_108484213 0.02 ENSMUST00000217803.2
Olfr518
olfactory receptor 518
chr16_+_87251852 0.01 ENSMUST00000119504.8
ENSMUST00000131356.8
Usp16
ubiquitin specific peptidase 16

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp282

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.0 GO:0070488 neutrophil aggregation(GO:0070488)
1.6 4.7 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.8 9.2 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.8 4.7 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.8 3.0 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.7 3.0 GO:1902896 terminal web assembly(GO:1902896)
0.7 2.0 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) positive regulation of renin secretion into blood stream(GO:1900135) positive regulation of eosinophil activation(GO:1902568)
0.6 5.8 GO:0015671 oxygen transport(GO:0015671)
0.5 1.4 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.4 2.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 2.8 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 1.4 GO:1904171 negative regulation of bleb assembly(GO:1904171)
0.3 1.0 GO:0042245 tRNA wobble cytosine modification(GO:0002101) RNA repair(GO:0042245)
0.2 2.1 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.2 1.8 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 2.4 GO:0036376 sodium ion export from cell(GO:0036376)
0.1 8.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 3.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.6 GO:0007343 egg activation(GO:0007343)
0.1 1.7 GO:0060263 regulation of respiratory burst(GO:0060263)
0.1 1.8 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.1 0.2 GO:0072194 intermediate mesoderm development(GO:0048389) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098) kidney smooth muscle tissue development(GO:0072194)
0.1 0.2 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.1 0.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 1.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 1.8 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.4 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 3.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 3.9 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.9 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 1.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.6 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.1 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.2 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.7 5.8 GO:0005833 hemoglobin complex(GO:0005833)
0.7 2.1 GO:0000811 GINS complex(GO:0000811)
0.7 4.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 8.7 GO:0042581 specific granule(GO:0042581)
0.3 5.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 3.2 GO:0097451 glial limiting end-foot(GO:0097451)
0.2 2.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 2.3 GO:0042382 paraspeckles(GO:0042382)
0.2 1.8 GO:1990357 terminal web(GO:1990357)
0.2 2.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.0 GO:0031143 pseudopodium(GO:0031143)
0.1 1.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 14.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 5.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.4 GO:0098536 deuterosome(GO:0098536)
0.1 1.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.1 GO:0014704 intercalated disc(GO:0014704)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.8 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.4 5.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.5 2.0 GO:0015057 thrombin receptor activity(GO:0015057)
0.4 1.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.2 1.6 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 1.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 2.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 1.4 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 1.0 GO:0070579 DNA-N1-methyladenine dioxygenase activity(GO:0043734) methylcytosine dioxygenase activity(GO:0070579)
0.1 2.3 GO:1990405 protein antigen binding(GO:1990405)
0.1 1.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 2.1 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 5.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 4.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 2.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 3.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 6.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 8.7 GO:0045296 cadherin binding(GO:0045296)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.0 1.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.0 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 3.6 PID BMP PATHWAY BMP receptor signaling
0.1 2.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.6 PID TRAIL PATHWAY TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 4.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 5.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors