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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for CABZ01093502.2

Z-value: 0.67

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Transcription factors associated with CABZ01093502.2

Gene Symbol Gene ID Gene Info
CABZ01093502.2
ENSDARG00000105053 developing brain homeobox 2

Activity profile of CABZ01093502.2 motif

Sorted Z-values of CABZ01093502.2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_26145013 9.68 ENSDART00000162546
ENSDART00000129561
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr2_+_55984788 9.04 ENSDART00000183599
nmrk2
nicotinamide riboside kinase 2
chr22_-_24791505 8.47 ENSDART00000136837
vtg4
vitellogenin 4
chr22_-_24818066 5.48 ENSDART00000143443
vtg6
vitellogenin 6
chr20_-_40754794 5.30 ENSDART00000187251
cx32.3
connexin 32.3
chr19_+_46158078 4.97 ENSDART00000183933
ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr25_+_3318192 4.55 ENSDART00000146154
slc25a3b
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b
chr21_+_28478663 4.07 ENSDART00000077887
ENSDART00000134150
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr19_+_43780970 4.06 ENSDART00000063870
rpl11
ribosomal protein L11
chr20_-_43663494 3.83 ENSDART00000144564
BX470188.1

chr17_+_8799661 3.78 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr23_+_4709607 3.74 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
raf1a
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr12_-_10409961 3.54 ENSDART00000149521
ENSDART00000052001
eef2k
eukaryotic elongation factor 2 kinase
chr5_+_34623107 3.40 ENSDART00000184126
enc1
ectodermal-neural cortex 1
chr16_-_38118003 3.20 ENSDART00000058667
si:dkey-23o4.6
si:dkey-23o4.6
chr13_-_12602920 3.08 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr5_+_33498253 3.06 ENSDART00000140993
ms4a17c.2
membrane-spanning 4-domains, subfamily A, member 17c.2
chr5_+_71802014 2.95 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr2_+_19522082 2.70 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr10_-_13343831 2.63 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr8_-_30204650 2.52 ENSDART00000133209
zgc:162939
zgc:162939
chr22_-_14247276 2.50 ENSDART00000033332
si:ch211-246m6.5
si:ch211-246m6.5
chr8_-_20230559 2.47 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr7_-_7692723 2.46 ENSDART00000183352
aadat
aminoadipate aminotransferase
chr23_+_384850 2.41 ENSDART00000114000
zgc:101663
zgc:101663
chr2_-_7845110 2.32 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr15_-_17618800 2.27 ENSDART00000157185
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr17_+_20589553 2.26 ENSDART00000154447
si:ch73-288o11.4
si:ch73-288o11.4
chr3_-_59297532 2.26 ENSDART00000187991
CABZ01053748.1

chr20_-_3915770 2.25 ENSDART00000159322
si:ch73-111k22.3
si:ch73-111k22.3
chr8_+_6576940 2.21 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr7_-_17412559 2.20 ENSDART00000163020
nitr3a
novel immune-type receptor 3a
chr1_+_51721851 2.18 ENSDART00000040397
prdx2
peroxiredoxin 2
chr13_-_39736938 2.17 ENSDART00000141645
zgc:171482
zgc:171482
chr2_-_10877765 2.07 ENSDART00000100607
cdc7
cell division cycle 7 homolog (S. cerevisiae)
chr7_+_24573721 2.03 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
si:dkeyp-75h12.7
chr17_-_10122204 1.99 ENSDART00000160751
BX088587.1

chr9_+_24065855 1.99 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr2_+_14992879 1.95 ENSDART00000137546
pimr55
Pim proto-oncogene, serine/threonine kinase, related 55
chr20_-_46128590 1.92 ENSDART00000123744
taar1b
trace amine associated receptor 1b
chr12_-_28363111 1.87 ENSDART00000016283
ENSDART00000164156
psmd11b
proteasome 26S subunit, non-ATPase 11b
chr20_-_9095105 1.87 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr7_-_7692992 1.82 ENSDART00000192619
aadat
aminoadipate aminotransferase
chr5_-_42904329 1.79 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr2_+_20605925 1.72 ENSDART00000191510
olfml2bb
olfactomedin-like 2Bb
chr13_+_35528607 1.72 ENSDART00000075414
ENSDART00000112947
wdr27
WD repeat domain 27
chr5_-_30620625 1.70 ENSDART00000098273
tcnl
transcobalamin like
chr8_-_53044300 1.67 ENSDART00000191653
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr2_+_19578446 1.62 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr23_-_37113215 1.57 ENSDART00000146835
zgc:193690
zgc:193690
chr18_+_30847237 1.51 ENSDART00000012374
foxf1
forkhead box F1
chr5_+_9224051 1.45 ENSDART00000139265
si:ch211-12e13.12
si:ch211-12e13.12
chr13_+_31205439 1.40 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr11_+_17984167 1.40 ENSDART00000020283
ENSDART00000188329
rpusd4
RNA pseudouridylate synthase domain containing 4
chr23_+_22656477 1.36 ENSDART00000009337
ENSDART00000133322
eno1a
enolase 1a, (alpha)
chr1_+_58242498 1.34 ENSDART00000149091
ggt1l2.2
gamma-glutamyltransferase 1 like 2.2
chr21_-_38853737 1.26 ENSDART00000184100
tlr22
toll-like receptor 22
chr1_-_31171242 1.22 ENSDART00000190294
kcnq5b
potassium voltage-gated channel, KQT-like subfamily, member 5b
chr11_-_2838699 1.17 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr4_+_59845617 1.13 ENSDART00000167626
ENSDART00000123157
si:dkey-196n19.2
si:dkey-196n19.2
chr15_-_43284021 1.07 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_+_12527725 1.05 ENSDART00000149328
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr6_-_58764672 0.99 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr15_-_46779934 0.94 ENSDART00000085136
clcn2c
chloride channel 2c
chr14_-_34771371 0.94 ENSDART00000160598
ENSDART00000150413
ENSDART00000168910
ablim3
actin binding LIM protein family, member 3
chr23_-_37113396 0.93 ENSDART00000102886
ENSDART00000134461
zgc:193690
zgc:193690
chr4_-_9891874 0.93 ENSDART00000067193
adm2a
adrenomedullin 2a
chr9_-_9415000 0.93 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr2_+_10878406 0.89 ENSDART00000091497
tceanc2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr21_+_5926777 0.78 ENSDART00000121769
rexo4
REX4 homolog, 3'-5' exonuclease
chr23_-_6522099 0.75 ENSDART00000092214
ENSDART00000183380
ENSDART00000138020
bmp7b
bone morphogenetic protein 7b
chr6_+_7533601 0.75 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr3_+_25166805 0.67 ENSDART00000077493
TST
zgc:162544
chr10_-_5847655 0.53 ENSDART00000192773
ankrd55
ankyrin repeat domain 55
chr10_-_28513861 0.45 ENSDART00000177781
bbx
bobby sox homolog (Drosophila)
chr14_-_413273 0.44 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr23_+_21405201 0.43 ENSDART00000144409
iffo2a
intermediate filament family orphan 2a
chr23_-_16485190 0.41 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr4_-_49582758 0.38 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
si:dkey-159n16.2
chr4_-_46915962 0.33 ENSDART00000169555
si:ch211-134c10.1
si:ch211-134c10.1
chr20_+_11731039 0.26 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr9_-_51436377 0.24 ENSDART00000006612
tbr1b
T-box, brain, 1b
chr2_-_9818640 0.19 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr16_+_24733741 0.11 ENSDART00000155217
si:dkey-79d12.4
si:dkey-79d12.4
chr16_+_23303859 0.06 ENSDART00000006093
slc50a1
solute carrier family 50 (sugar efflux transporter), member 1
chr11_-_29737088 0.06 ENSDART00000159828
si:ch211-218g23.6
si:ch211-218g23.6
chr3_-_19368435 0.04 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr17_-_33412868 0.03 ENSDART00000187521
BX323819.1

Network of associatons between targets according to the STRING database.

First level regulatory network of CABZ01093502.2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0031448 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.4 2.3 GO:0005513 detection of calcium ion(GO:0005513)
0.4 14.3 GO:0032355 response to estradiol(GO:0032355)
0.2 3.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.2 3.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 1.9 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 1.4 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.2 2.2 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 4.6 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.2 2.2 GO:0001881 receptor recycling(GO:0001881)
0.2 3.8 GO:0031297 replication fork processing(GO:0031297)
0.2 2.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.2 5.0 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.2 4.1 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.2 1.4 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.2 0.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 1.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 1.8 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 1.0 GO:0034435 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1 0.9 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.2 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.2 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 1.7 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.5 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 6.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 3.7 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 4.3 GO:1901605 alpha-amino acid metabolic process(GO:1901605)
0.0 0.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.5 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.5 GO:0002040 sprouting angiogenesis(GO:0002040)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0031673 H zone(GO:0031673)
0.5 3.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.9 GO:0019815 B cell receptor complex(GO:0019815)
0.2 1.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 4.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 4.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 13.9 GO:0045735 nutrient reservoir activity(GO:0045735)
1.7 5.0 GO:0008179 adenylate cyclase binding(GO:0008179)
1.3 9.0 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.8 2.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.6 4.3 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.6 9.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 1.8 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.3 2.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 4.6 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 1.0 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.2 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.3 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.1 2.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 3.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 4.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.9 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 4.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.8 GO:0042393 histone binding(GO:0042393)
0.0 1.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 12.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 4.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.4 3.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.3 4.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 5.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.1 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 4.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism