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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for SPDEF

Z-value: 1.38

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Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
ENSDARG00000029930 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFdr11_v1_chr6_-_54290227_542902270.223.6e-02Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_28438947 11.25 ENSDART00000006489
acyl-CoA synthetase long chain family member 4a
chr21_+_6751760 8.70 ENSDART00000135914
olfactomedin 1b
chr21_+_6751405 7.96 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr3_-_36440705 7.65 ENSDART00000162875
rogdi homolog (Drosophila)
chr8_-_49431939 7.48 ENSDART00000011453
ENSDART00000088240
ENSDART00000114173
synaptophysin b
chr1_-_44581937 6.95 ENSDART00000009858
thioredoxin-related transmembrane protein 2b
chr5_+_64732270 6.66 ENSDART00000134241
olfactomedin 1a
chr16_-_16212615 6.48 ENSDART00000059905
uridine phosphorylase 1
chr5_+_64732036 6.37 ENSDART00000073950
olfactomedin 1a
chr12_-_14211293 6.32 ENSDART00000158399
AVL9 homolog (S. cerevisiase)
chr13_-_12494575 6.08 ENSDART00000137761
si:dkey-20i10.7
chr4_-_12978925 5.92 ENSDART00000013839
transmembrane BAX inhibitor motif containing 4
chr16_-_45001842 5.91 ENSDART00000037797
sulfotransferase family 2, cytosolic sulfotransferase 3
chr1_+_46598764 5.76 ENSDART00000053240
calcium binding protein 39-like
chr5_+_26795465 5.44 ENSDART00000053001
transcobalamin II
chr25_+_7872135 5.44 ENSDART00000003042
midkine b
chr15_-_31043183 5.40 ENSDART00000100145
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1
chr20_-_5369105 5.18 ENSDART00000114316
serine palmitoyltransferase, long chain base subunit 2b
chr20_+_27087539 5.17 ENSDART00000062094
transmembrane protein 251
chr2_-_3044947 5.06 ENSDART00000192642
guanylate kinase 1a
chr19_-_1871415 5.03 ENSDART00000004585
CLPTM1-like
chr13_+_681628 4.99 ENSDART00000016604
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr5_+_26795773 4.71 ENSDART00000145631
transcobalamin II
chr20_-_5291012 4.60 ENSDART00000122892
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr18_+_3169579 4.58 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
p21 protein (Cdc42/Rac)-activated kinase 1
chr7_+_38762043 4.56 ENSDART00000036461
Rho GTPase activating protein 1
chr20_-_20611063 4.49 ENSDART00000063492
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr1_+_49435017 4.41 ENSDART00000124833
programmed cell death 11
chr12_-_14211067 4.36 ENSDART00000077903
AVL9 homolog (S. cerevisiase)
chr23_-_24234371 4.36 ENSDART00000124539
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr11_-_15296805 4.35 ENSDART00000124968
ribophorin II
chr9_-_23824290 4.29 ENSDART00000059209
WD repeat and FYVE domain containing 2
chr4_+_16885854 4.26 ENSDART00000017726
ethanolamine kinase 1
chr21_-_40938382 4.21 ENSDART00000008593
Yip1 domain family, member 5
chr19_-_27006764 4.17 ENSDART00000089540
SAC1 like phosphatidylinositide phosphatase a
chr5_+_44346691 4.16 ENSDART00000034523
threonyl-tRNA synthetase
chr2_+_32846602 4.03 ENSDART00000056649
transmembrane protein 53
chr6_-_18531760 4.03 ENSDART00000167167
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr2_-_11662851 3.94 ENSDART00000145108
zgc:110130
chr15_+_17343319 3.87 ENSDART00000018461
vacuole membrane protein 1
chr15_-_15230264 3.87 ENSDART00000155400
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr24_-_8409641 3.84 ENSDART00000149662
ENSDART00000149025
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
chr1_+_46598502 3.83 ENSDART00000132861
calcium binding protein 39-like
chr14_+_25986895 3.79 ENSDART00000149087
solute carrier family 36 (proton/amino acid symporter), member 1
chr6_-_2222707 3.77 ENSDART00000022179
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr11_-_15297129 3.72 ENSDART00000167985
ENSDART00000163031
ENSDART00000165010
ENSDART00000171250
ENSDART00000010684
ENSDART00000191714
ENSDART00000191164
ribophorin II
chr22_-_20950448 3.71 ENSDART00000002029
FK506 binding protein 8
chr12_+_31422557 3.71 ENSDART00000153179
zinc finger, DHHC-type containing 6
chr6_-_18531349 3.69 ENSDART00000160693
ENSDART00000169780
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr23_+_31979602 3.66 ENSDART00000140351
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr6_-_51666739 3.62 ENSDART00000155549
chromodomain helicase DNA binding protein 6
chr7_-_34062301 3.60 ENSDART00000052404
mitogen-activated protein kinase kinase 5
chr10_+_36439293 3.58 ENSDART00000043802
ubiquitin specific peptidase like 1
chr19_-_17658160 3.57 ENSDART00000151766
ENSDART00000170790
ENSDART00000186678
ENSDART00000188045
ENSDART00000176980
ENSDART00000166313
ENSDART00000188589
thyroid hormone receptor beta
chr23_+_42304602 3.56 ENSDART00000166004
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr5_-_67292690 3.45 ENSDART00000062366
arginine/serine-rich coiled-coil 2
chr21_-_14762944 3.43 ENSDART00000114096
arrestin domain containing 1b
chr1_-_29758947 3.41 ENSDART00000049514
ENSDART00000183571
ENSDART00000140345
asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
chr8_-_14080534 3.40 ENSDART00000042867
death effector domain containing
chr15_+_7064819 3.39 ENSDART00000155268
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr9_+_14023386 3.36 ENSDART00000140199
ENSDART00000124267
si:ch211-67e16.4
chr24_-_7826489 3.36 ENSDART00000112777
si:dkey-197c15.6
chr2_-_42173834 3.32 ENSDART00000098357
ENSDART00000144707
solute carrier family 39 (zinc transporter), member 6
chr15_-_29114449 3.30 ENSDART00000145748
ENSDART00000109482
ENSDART00000179123
zgc:162698
chr7_+_50053339 3.29 ENSDART00000174308
si:dkey-6l15.1
chr1_-_28950366 3.26 ENSDART00000110270
PWP2 periodic tryptophan protein homolog (yeast)
chr20_-_30938184 3.24 ENSDART00000147359
ENSDART00000062552
WT1 associated protein
chr14_-_30897177 3.23 ENSDART00000087918
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3b
chr13_+_31545530 3.19 ENSDART00000164590
ENSDART00000178460
ENSDART00000185503
protein phosphatase, Mg2+/Mn2+ dependent, 1Aa
chr13_+_31545812 3.14 ENSDART00000076527
protein phosphatase, Mg2+/Mn2+ dependent, 1Aa
chr19_+_9455218 3.13 ENSDART00000139385
si:ch211-288g17.3
chr18_+_6638726 3.10 ENSDART00000142755
ENSDART00000167781
C2 calcium-dependent domain containing 5
chr15_+_19884242 3.09 ENSDART00000154437
ENSDART00000054416
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b
chr15_-_766015 3.05 ENSDART00000190648
si:dkey-7i4.15
chr6_-_34860574 3.04 ENSDART00000073957
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1a
chr15_+_25528290 3.03 ENSDART00000123143
nuclear protein, ataxia-telangiectasia locus
chr5_+_51833305 3.01 ENSDART00000165276
ENSDART00000166443
PAP associated domain containing 4
chr2_+_4383061 2.98 ENSDART00000163986
WW domain containing adaptor with coiled-coil b
chr3_+_59864872 2.98 ENSDART00000102014
MAPK regulated corepressor interacting protein 1
chr22_-_37611681 2.96 ENSDART00000028085
tetratricopeptide repeat domain 14
chr11_-_16975190 2.94 ENSDART00000122222
succinate-CoA ligase, GDP-forming, beta subunit
chr20_-_20610812 2.94 ENSDART00000181870
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr17_+_33375469 2.93 ENSDART00000032827
zgc:162964
chr4_+_5506952 2.92 ENSDART00000032857
ENSDART00000160222
mitogen-activated protein kinase 11
chr12_+_29240124 2.90 ENSDART00000053761
ENSDART00000130172
BMS1 ribosome biogenesis factor
chr16_+_22618620 2.89 ENSDART00000185728
ENSDART00000041625
cholinergic receptor, nicotinic, beta 2b
chr1_+_41596099 2.87 ENSDART00000111367
si:dkey-56e3.3
chr18_-_22735002 2.86 ENSDART00000023721
nudix hydrolase 21
chr5_+_28041967 2.81 ENSDART00000133641
2-oxoglutarate and iron-dependent oxygenase domain containing 2
chr25_-_3347418 2.79 ENSDART00000082385
golgi transport 1Bb
chr19_+_34742706 2.77 ENSDART00000103276
family with sequence similarity 206, member A
chr18_+_6638974 2.75 ENSDART00000162398
C2 calcium-dependent domain containing 5
chr11_-_16115804 2.74 ENSDART00000143436
ENSDART00000157928
ribosome production factor 1 homolog
chr20_-_23946296 2.73 ENSDART00000143005
midasin AAA ATPase 1
chr21_-_30994577 2.73 ENSDART00000065503
post-GPI attachment to proteins 2
chr17_+_49281597 2.72 ENSDART00000155599
zgc:113176
chr2_-_20052561 2.67 ENSDART00000100133
dihydropyrimidine dehydrogenase b
chr3_-_27066451 2.67 ENSDART00000156228
ENSDART00000156311
activating transcription factor 7 interacting protein 2
chr14_-_33521071 2.66 ENSDART00000052789
C1GALT1-specific chaperone 1
chr8_+_53388005 2.61 ENSDART00000171920
decapping mRNA 1A
chr16_+_38119004 2.59 ENSDART00000132087
pogo transposable element derived with ZNF domain b
chr8_-_17987547 2.57 ENSDART00000112699
ENSDART00000061747
fucose-1-phosphate guanylyltransferase
chr6_-_21988375 2.56 ENSDART00000161257
plexin b1b
chr13_+_14006118 2.54 ENSDART00000131875
ENSDART00000089528
attractin
chr15_+_37436430 2.52 ENSDART00000124779
IGF-like family receptor 1
chr24_-_32522587 2.50 ENSDART00000048968
ENSDART00000143781
zgc:56676
chr14_-_23684814 2.50 ENSDART00000024604
methionyl-tRNA synthetase 2, mitochondrial
chr3_-_40276057 2.49 ENSDART00000132225
ENSDART00000074737
serine hydroxymethyltransferase 1 (soluble)
chr2_+_16652238 2.47 ENSDART00000091351
glycerol kinase 5 (putative)
chr18_-_39321484 2.47 ENSDART00000077694
LEO1 homolog, Paf1/RNA polymerase II complex component
chr16_-_31824525 2.45 ENSDART00000058737
cell division cycle 42, like
chr21_-_19828423 2.44 ENSDART00000037664
nicotinamide nucleotide transhydrogenase
chr8_+_17143501 2.42 ENSDART00000061758
mesoderm induction early response 1, family member 3 b
chr11_+_24339377 2.41 ENSDART00000133679
ENSDART00000135435
ENSDART00000017973
ENSDART00000131365
ENSDART00000186418
RNA binding motif protein 39a
chr22_+_8753092 2.41 ENSDART00000140720
si:dkey-182g1.2
chr7_+_35191220 2.40 ENSDART00000110552
zinc finger, DHHC-type containing 1
chr17_-_7351488 2.36 ENSDART00000098731
syntaxin binding protein 5b (tomosyn)
chr25_+_15354095 2.35 ENSDART00000090397
KIAA1549-like a
chr21_-_22892124 2.34 ENSDART00000065563
coiled-coil domain containing 90B
chr20_+_715739 2.32 ENSDART00000136768
myosin VIa
chr17_+_20237727 2.31 ENSDART00000180115
survival motor neuron domain containing 1
chr9_-_296169 2.31 ENSDART00000165228
kinesin family member 5A, a
chr14_-_30724165 2.29 ENSDART00000020936
fibroblast growth factor (acidic) intracellular binding protein a
chr18_-_26797723 2.28 ENSDART00000008013
SEC11 homolog A, signal peptidase complex subunit
chr23_-_30764319 2.27 ENSDART00000075918
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr1_-_44048798 2.26 ENSDART00000073746
si:ch73-109d9.2
chr20_-_10118818 2.26 ENSDART00000033976
Meis homeobox 2b
chr7_+_17782436 2.25 ENSDART00000173793
ENSDART00000165110
si:dkey-28a3.2
chr5_+_41477954 2.24 ENSDART00000185871
protein inhibitor of activated STAT, 2
chr3_-_35554809 2.23 ENSDART00000010944
dynactin 5
chr20_-_48898560 2.20 ENSDART00000163071
5'-3' exoribonuclease 2
chr14_-_31856819 2.20 ENSDART00000003345
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_+_4276394 2.19 ENSDART00000038301
glucosamine-6-phosphate deaminase 2
chr1_-_23294753 2.19 ENSDART00000013263
UDP-glucose 6-dehydrogenase
chr20_+_52492192 2.17 ENSDART00000057986
zgc:100864
chr4_+_9612574 2.14 ENSDART00000150336
ENSDART00000041289
ENSDART00000150828
transmembrane protein 243, mitochondrial b
chr21_+_38033226 2.13 ENSDART00000085728
Kruppel-like factor 8
chr13_-_33654931 2.13 ENSDART00000020350
sorting nexin 5
chr22_-_8306743 2.13 ENSDART00000123982

chr8_-_41279326 2.13 ENSDART00000075491
POP5 homolog, ribonuclease P/MRP subunit
chr7_-_32629458 2.12 ENSDART00000001376
ADP-ribosylation factor-like 14 effector protein
chr25_+_3347461 2.11 ENSDART00000104888
solute carrier family 35, member B4
chr6_+_4387150 2.07 ENSDART00000181283
RNA binding motif protein 26
chr24_+_3478871 2.06 ENSDART00000111491
ENSDART00000134598
ENSDART00000142407
WD repeat domain 37
chr24_-_10897511 2.05 ENSDART00000145593
ENSDART00000102484
ENSDART00000066784
family with sequence similarity 49, member Bb
chr8_-_17184482 2.05 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr8_-_1267247 2.03 ENSDART00000150064
cell division cycle 14B
chr16_-_6944927 2.02 ENSDART00000149620
phosphomevalonate kinase
chr18_-_18584839 2.02 ENSDART00000159274
splicing factor 3b, subunit 3
chr2_+_3044992 2.02 ENSDART00000020463
zgc:63882
chr13_-_37519774 2.01 ENSDART00000141420
ENSDART00000185478
sphingosine-1-phosphate phosphatase 1
chr19_+_42770041 2.00 ENSDART00000150930
cytoplasmic linker associated protein 2
chr1_+_44582369 2.00 ENSDART00000003022
ENSDART00000137980
mediator complex subunit 19b
chr16_+_12812472 1.99 ENSDART00000008535
U2 small nuclear RNA auxiliary factor 2a
chr10_+_21722892 1.98 ENSDART00000162855
protocadherin 1 gamma 13
chr19_-_19025998 1.96 ENSDART00000186156
ENSDART00000163359
ENSDART00000167951
dynein, cytoplasmic 1, light intermediate chain 1
chr5_+_51833132 1.96 ENSDART00000167491
PAP associated domain containing 4
chr5_+_25084385 1.96 ENSDART00000134526
ENSDART00000111863
PAXX, non-homologous end joining factor
chr8_+_17184602 1.95 ENSDART00000050228
ENSDART00000140531
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr8_-_1266181 1.94 ENSDART00000148654
ENSDART00000149924
cell division cycle 14B
chr14_+_9583588 1.93 ENSDART00000164101
transmembrane protein 129, E3 ubiquitin protein ligase
chr23_+_16748806 1.92 ENSDART00000137737
ENSDART00000142556
F-box protein 44
chr5_-_26795438 1.92 ENSDART00000146124
si:ch211-102c2.7
chr22_-_16494406 1.90 ENSDART00000062727
syntaxin 6
chr13_+_24022963 1.90 ENSDART00000028285
piggyBac transposable element derived 5
chr20_-_48898371 1.89 ENSDART00000170617
5'-3' exoribonuclease 2
chr24_+_36392784 1.88 ENSDART00000134750
ADP-ribosylation factor 2b
chr5_-_28041715 1.88 ENSDART00000078660
zgc:113436
chr1_+_51407520 1.88 ENSDART00000074294
ARP2 actin related protein 2a homolog
chr8_-_21052371 1.87 ENSDART00000136561
si:dkeyp-82a1.6
chr6_+_37625787 1.87 ENSDART00000065122
tubulin, gamma complex associated protein 5
chr14_-_5407555 1.85 ENSDART00000001424
polycomb group ring finger 1
chr23_+_4260458 1.84 ENSDART00000103747
serine/arginine-rich splicing factor 6a
chr19_+_19241372 1.83 ENSDART00000184392
ENSDART00000165008
protein tyrosine phosphatase, non-receptor type 23, b
chr15_-_29556757 1.83 ENSDART00000060049
heat shock protein 70 family, member 13
chr12_-_31724198 1.82 ENSDART00000153056
ENSDART00000165299
ENSDART00000137464
ENSDART00000080173
serine/arginine-rich splicing factor 2a
chr16_-_29480335 1.81 ENSDART00000148930
leucine rich repeat and Ig domain containing 4b
chr14_-_43616572 1.81 ENSDART00000111189
GAR1 homolog, ribonucleoprotein
chr15_-_39820491 1.81 ENSDART00000097134
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr22_-_5663354 1.81 ENSDART00000081774
coiled-coil domain containing 51
chr21_+_26539157 1.81 ENSDART00000021121
syntaxin 5A, like
chr9_-_24218367 1.79 ENSDART00000135356
nucleic acid binding protein 1a
chr9_+_30108641 1.79 ENSDART00000060174
jagunal homolog 1a
chr25_+_8921425 1.78 ENSDART00000128591
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
chr2_+_21063660 1.77 ENSDART00000022765
RIO kinase 1 (yeast)
chr17_+_43468732 1.77 ENSDART00000055487
charged multivesicular body protein 3
chr1_+_47165842 1.76 ENSDART00000053152
ENSDART00000167051
carbonyl reductase 1
chr18_-_3552414 1.74 ENSDART00000163762
ENSDART00000165434
ENSDART00000161197
ENSDART00000166841
ENSDART00000170260
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr17_+_37253706 1.74 ENSDART00000076004
transmembrane protein 62
chr3_+_36617024 1.73 ENSDART00000189957
pyridoxal-dependent decarboxylase domain containing 1
chr16_+_11029762 1.73 ENSDART00000091183
Ets2 repressor factor like 3
chr25_-_10791437 1.73 ENSDART00000127054

chr6_-_54444929 1.72 ENSDART00000154121
Sys1 golgi trafficking protein
chr22_-_21176269 1.69 ENSDART00000112839
required for excision 1-B domain containing
chr7_-_57637779 1.69 ENSDART00000028017
MAD2 mitotic arrest deficient-like 1 (yeast)
chr16_+_32184485 1.69 ENSDART00000084009
zinc finger with UFM1-specific peptidase domain
chr3_-_30152836 1.68 ENSDART00000165920
nucleobindin 1
chr10_-_7671219 1.68 ENSDART00000159330
prenylcysteine oxidase 1
chr12_-_31422433 1.68 ENSDART00000186075
ENSDART00000153172
ENSDART00000066256
vesicle transport through interaction with t-SNAREs 1A
chr23_+_9867483 1.67 ENSDART00000023099
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.2 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
1.9 11.3 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
1.4 13.0 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
1.3 3.8 GO:0015808 L-alanine transport(GO:0015808) proline transport(GO:0015824)
1.2 5.8 GO:0010828 positive regulation of glucose transport(GO:0010828)
1.1 5.4 GO:2000562 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.0 2.9 GO:1990120 messenger ribonucleoprotein complex assembly(GO:1990120)
0.9 3.7 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.9 3.6 GO:0060220 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.9 2.7 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.8 2.5 GO:0019264 L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264)
0.8 4.6 GO:0003232 bulbus arteriosus development(GO:0003232)
0.7 2.2 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.7 3.6 GO:0030576 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.7 2.7 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.6 6.5 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.6 3.9 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.6 1.9 GO:0015074 DNA integration(GO:0015074)
0.6 2.4 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.6 2.4 GO:0006740 NADPH regeneration(GO:0006740)
0.6 1.8 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.6 2.3 GO:1990535 neuron projection maintenance(GO:1990535)
0.6 13.8 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.6 7.2 GO:0006670 sphingosine metabolic process(GO:0006670)
0.5 3.2 GO:0080009 mRNA methylation(GO:0080009)
0.5 3.2 GO:0089718 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.5 1.6 GO:0008344 adult locomotory behavior(GO:0008344)
0.5 1.6 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.5 2.0 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.5 1.5 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.5 15.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4 2.6 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.4 1.3 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.4 4.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 1.2 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.4 2.5 GO:0019563 glycerol catabolic process(GO:0019563)
0.4 2.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529)
0.4 4.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.4 2.0 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.4 1.1 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.4 1.5 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.4 3.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 1.4 GO:0021742 abducens nucleus development(GO:0021742)
0.3 2.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 3.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 1.7 GO:0030327 prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.3 2.2 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.3 7.5 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.3 6.5 GO:1901654 response to ketone(GO:1901654)
0.3 2.5 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.3 2.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.3 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.3 2.3 GO:0006465 signal peptide processing(GO:0006465)
0.2 4.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 1.0 GO:2000623 negative regulation of mRNA catabolic process(GO:1902373) regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 1.9 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.2 2.3 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.2 3.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 1.8 GO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation(GO:0003262)
0.2 1.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 2.9 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 3.9 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.2 1.2 GO:0006004 fucose metabolic process(GO:0006004)
0.2 7.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 2.1 GO:0021681 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 5.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 1.7 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 0.5 GO:0007529 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.2 0.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 1.4 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.2 3.0 GO:0010717 regulation of epithelial to mesenchymal transition(GO:0010717)
0.2 2.3 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.2 1.9 GO:0032196 transposition(GO:0032196)
0.2 3.9 GO:0007020 microtubule nucleation(GO:0007020)
0.2 5.4 GO:0014029 neural crest formation(GO:0014029)
0.2 1.8 GO:0016074 snoRNA metabolic process(GO:0016074)
0.2 3.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.2 1.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 0.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.6 GO:1903232 melanosome assembly(GO:1903232)
0.1 1.2 GO:0007220 Notch receptor processing(GO:0007220)
0.1 1.6 GO:0006903 vesicle targeting(GO:0006903)
0.1 2.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 2.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 4.5 GO:0032456 endocytic recycling(GO:0032456)
0.1 7.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 1.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 2.7 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.1 0.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.9 GO:0031167 rRNA methylation(GO:0031167)
0.1 1.8 GO:0042026 protein refolding(GO:0042026)
0.1 2.6 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 0.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 2.2 GO:0046660 female sex differentiation(GO:0046660)
0.1 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 8.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 2.5 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 1.7 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 1.4 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 2.9 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.1 1.5 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 1.2 GO:0035476 angioblast cell migration(GO:0035476)
0.1 1.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 1.0 GO:0032048 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.1 2.0 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 3.2 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 3.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.4 GO:0007032 endosome organization(GO:0007032)
0.1 2.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.4 GO:1903651 positive regulation of cytoplasmic transport(GO:1903651)
0.1 2.2 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.3 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 1.7 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.1 3.6 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 2.1 GO:0050870 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.1 1.7 GO:0016180 snRNA processing(GO:0016180)
0.1 0.6 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 3.6 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 2.4 GO:0050708 regulation of protein secretion(GO:0050708)
0.1 3.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 0.9 GO:0031060 regulation of histone methylation(GO:0031060)
0.1 0.4 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 1.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 4.3 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.1 2.0 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.9 GO:0016233 telomere capping(GO:0016233)
0.1 2.1 GO:0008643 carbohydrate transport(GO:0008643)
0.1 1.2 GO:0072599 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.5 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.7 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 3.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.8 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 1.7 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 1.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 1.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 1.5 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.9 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.2 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 1.1 GO:0043489 RNA stabilization(GO:0043489)
0.0 1.1 GO:0090148 membrane fission(GO:0090148)
0.0 1.5 GO:0048634 regulation of muscle organ development(GO:0048634)
0.0 2.5 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 16.5 GO:0006397 mRNA processing(GO:0006397)
0.0 1.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 1.7 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 1.8 GO:0006906 vesicle fusion(GO:0006906)
0.0 1.2 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.6 GO:0050821 protein stabilization(GO:0050821)
0.0 1.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.3 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.7 GO:0043291 RAVE complex(GO:0043291)
1.6 11.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
1.2 3.7 GO:0031251 PAN complex(GO:0031251)
1.0 2.9 GO:0042709 succinate-CoA ligase complex(GO:0042709)
1.0 2.9 GO:0042382 paraspeckles(GO:0042382)
0.9 12.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.8 3.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.8 3.9 GO:0033553 rDNA heterochromatin(GO:0033553)
0.6 2.3 GO:0005787 signal peptidase complex(GO:0005787)
0.5 2.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.5 5.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.5 3.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.5 1.9 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.4 1.6 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.4 2.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.4 1.6 GO:0032584 growth cone membrane(GO:0032584)
0.4 2.9 GO:0030686 90S preribosome(GO:0030686)
0.3 5.9 GO:0015030 Cajal body(GO:0015030)
0.3 3.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 7.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 1.8 GO:0070876 SOSS complex(GO:0070876)
0.3 2.0 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.3 1.4 GO:0071203 WASH complex(GO:0071203)
0.2 2.2 GO:0089701 U2AF(GO:0089701)
0.2 2.0 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 11.1 GO:0005811 lipid particle(GO:0005811)
0.2 1.2 GO:0071986 Ragulator complex(GO:0071986)
0.2 6.0 GO:0032040 small-subunit processome(GO:0032040)
0.2 1.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 1.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.2 0.6 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 1.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 3.0 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 1.3 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.5 GO:0070449 elongin complex(GO:0070449)
0.1 0.6 GO:0031085 BLOC-3 complex(GO:0031085)
0.1 2.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.1 1.8 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 2.9 GO:0035102 PRC1 complex(GO:0035102)
0.1 8.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.3 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.1 7.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 4.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 8.5 GO:0055037 recycling endosome(GO:0055037)
0.1 1.7 GO:0032039 integrator complex(GO:0032039)
0.1 5.9 GO:0031201 SNARE complex(GO:0031201)
0.1 0.7 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 1.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 4.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 3.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 6.6 GO:0005769 early endosome(GO:0005769)
0.1 33.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.4 GO:0016586 RSC complex(GO:0016586)
0.1 2.2 GO:0030496 midbody(GO:0030496)
0.0 0.2 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 5.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 31.0 GO:0045202 synapse(GO:0045202)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.0 3.5 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.2 GO:0030027 lamellipodium(GO:0030027)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.7 GO:0000776 kinetochore(GO:0000776)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0001725 stress fiber(GO:0001725) actomyosin(GO:0042641) contractile actin filament bundle(GO:0097517)
0.0 1.1 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.1 3.4 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
1.1 3.3 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
1.0 8.2 GO:0031419 cobalamin binding(GO:0031419)
1.0 11.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
1.0 4.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
1.0 5.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
1.0 5.1 GO:0004385 guanylate kinase activity(GO:0004385)
1.0 2.9 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.9 3.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.8 2.5 GO:0070905 glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905)
0.8 4.6 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.8 3.8 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.7 5.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.7 2.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.7 2.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.7 2.9 GO:0034511 U3 snoRNA binding(GO:0034511)
0.7 3.6 GO:0032183 SUMO binding(GO:0032183)
0.7 3.4 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.7 3.4 GO:0030620 U2 snRNA binding(GO:0030620)
0.7 2.7 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.6 2.4 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.6 2.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.5 2.2 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.5 5.4 GO:0016936 galactoside binding(GO:0016936)
0.5 2.7 GO:0017113 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.5 2.1 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.5 2.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.5 3.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.4 1.7 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.4 1.9 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.4 1.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.4 13.8 GO:0030145 manganese ion binding(GO:0030145)
0.4 1.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 1.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.3 1.7 GO:0001735 prenylcysteine oxidase activity(GO:0001735)
0.3 1.6 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.3 3.4 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3 2.5 GO:0045309 protein phosphorylated amino acid binding(GO:0045309) phosphoprotein binding(GO:0051219)
0.3 9.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 2.9 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 2.1 GO:0034452 dynactin binding(GO:0034452)
0.2 3.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 1.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.2 2.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.2 1.7 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.2 1.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 0.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 0.8 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.2 1.0 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.2 7.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 0.5 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 2.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 3.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 7.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 0.6 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 3.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 3.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 2.4 GO:0045159 myosin II binding(GO:0045159)
0.1 0.6 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 3.8 GO:0016208 AMP binding(GO:0016208)
0.1 1.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 3.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 3.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.8 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 1.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 2.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 5.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0030619 U1 snRNA binding(GO:0030619)
0.1 1.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 1.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 2.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 3.0 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.1 2.9 GO:0004707 MAP kinase activity(GO:0004707)
0.1 6.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 2.0 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 1.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 0.6 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 5.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 2.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.4 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 5.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 5.4 GO:0008201 heparin binding(GO:0008201)
0.1 0.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 3.6 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 2.6 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 4.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 1.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.9 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 1.4 GO:0019003 GDP binding(GO:0019003)
0.0 3.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.6 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 2.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0048039 ubiquinone binding(GO:0048039)
0.0 1.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 4.6 GO:0042802 identical protein binding(GO:0042802)
0.0 0.2 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.8 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 0.4 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.0 GO:0003774 motor activity(GO:0003774)
0.0 1.8 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.9 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0030515 snoRNA binding(GO:0030515)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.3 4.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.3 2.0 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 2.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 0.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 3.6 ST GA12 PATHWAY G alpha 12 Pathway
0.2 3.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 2.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 1.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 5.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 0.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 2.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 4.0 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 3.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 2.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.6 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 13.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
1.1 7.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.8 6.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.5 4.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 4.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 5.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 3.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 4.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 2.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 2.6 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.2 5.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 1.9 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 1.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 2.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 3.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 4.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.2 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 4.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.0 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 1.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 4.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 10.1 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 2.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 2.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 2.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.7 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 1.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 3.6 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 4.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.0 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins