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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for alx4a+alx4b

Z-value: 0.52

Motif logo

Transcription factors associated with alx4a+alx4b

Gene Symbol Gene ID Gene Info
ENSDARG00000074442 ALX homeobox 4b
ENSDARG00000088332 ALX homeobox 4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
alx4adr11_v1_chr7_-_26924903_269249030.205.8e-02Click!
alx4bdr11_v1_chr18_+_38321039_38321039-0.131.9e-01Click!

Activity profile of alx4a+alx4b motif

Sorted Z-values of alx4a+alx4b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_31713239 3.99 ENSDART00000122379
hyaluronan binding protein 2
chr13_-_20381485 3.81 ENSDART00000131351
si:ch211-270n8.1
chr5_+_2815021 3.67 ENSDART00000020472
4-hydroxyphenylpyruvate dioxygenase a
chr12_-_35830625 3.65 ENSDART00000180028

chr15_-_5815006 3.40 ENSDART00000102459
retinol binding protein 2a, cellular
chr9_+_34127005 3.06 ENSDART00000167384
ENSDART00000078065
coagulation factor V
chr19_-_5699703 2.94 ENSDART00000082050
zgc:174904
chr6_-_607063 2.94 ENSDART00000189900
lectin, galactoside-binding, soluble, 2b
chr14_+_32430982 2.77 ENSDART00000017179
ENSDART00000123382
ENSDART00000075593
coagulation factor IXa
chr22_-_23748284 2.73 ENSDART00000162005
complement factor H like 2
chr20_+_53441935 2.69 ENSDART00000175214
apolipoprotein Bb, tandem duplicate 2
chr7_+_6652967 2.64 ENSDART00000102681
purine nucleoside phosphorylase 5a
chr15_-_462783 2.59 ENSDART00000161049
Danio rerio uncharacterized LOC100002960 (LOC100002960), mRNA.
chr1_+_127250 2.54 ENSDART00000003463
coagulation factor VIIi
chr25_-_13569234 2.35 ENSDART00000189645
fatty acid 2-hydroxylase
chr21_-_19314618 2.31 ENSDART00000188744
glycerol-3-phosphate acyltransferase 3
chr21_+_45841731 2.25 ENSDART00000038657
fatty acid hydroxylase domain containing 2
chr10_+_21867307 2.19 ENSDART00000126629
cerebellin 17
chr2_-_17392799 2.19 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr22_+_19552987 2.15 ENSDART00000105315
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr4_-_9891874 1.95 ENSDART00000067193
adrenomedullin 2a
chr8_-_30979494 1.87 ENSDART00000138959
si:ch211-251j10.3
chr20_-_33566640 1.87 ENSDART00000159729
si:dkey-65b13.9
chr10_+_11261576 1.86 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr10_+_26747755 1.85 ENSDART00000100329
coagulation factor IXb
chr7_-_71531846 1.85 ENSDART00000111797
alkaline ceramidase 2
chr8_+_24745041 1.76 ENSDART00000148872
solute carrier family 16, member 4
chr6_-_58764672 1.58 ENSDART00000154322
sterol O-acyltransferase 2
chr18_-_25568994 1.56 ENSDART00000133029
si:ch211-13k12.2
chr3_+_3681116 1.56 ENSDART00000109618
ADP-ribosyltransferase 4 (Dombrock blood group)
chr18_+_7073130 1.56 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
chr2_-_17393216 1.55 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr17_+_51627209 1.49 ENSDART00000056886
zgc:113142
chr14_-_4145594 1.48 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr13_+_646700 1.48 ENSDART00000006892
tumor protein p53 binding protein, 2a
chr13_-_22862133 1.47 ENSDART00000138563
phenazine biosynthesis-like protein domain containing 2
chr20_-_23439011 1.46 ENSDART00000022887
solute carrier family 10, member 4
chr24_-_32582378 1.44 ENSDART00000066590
retinol dehydrogenase 12, like
chr1_-_7951002 1.43 ENSDART00000138187
si:dkey-79f11.8
chr12_-_4243268 1.43 ENSDART00000131275
zgc:92313
chr16_+_40563533 1.40 ENSDART00000190368
tumor protein p53 inducible nuclear protein 1
chr8_+_43340995 1.39 ENSDART00000038566
refilin A
chr13_-_50565338 1.32 ENSDART00000062684
B cell linker
chr17_-_37395460 1.32 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr15_-_47848544 1.29 ENSDART00000098711
eukaryotic translation initiation factor 3, subunit K
chr24_-_40860603 1.28 ENSDART00000188032

chr15_-_25527580 1.27 ENSDART00000167005
ENSDART00000157498
hypoxia-inducible factor 1, alpha subunit, like
chr10_+_6013076 1.27 ENSDART00000167613
ENSDART00000159216
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr6_+_612594 1.27 ENSDART00000150903
kynureninase
chr6_-_7720332 1.26 ENSDART00000135945
ribosomal protein SA
chr17_-_49412313 1.23 ENSDART00000152100
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr11_-_669558 1.22 ENSDART00000173450
peroxisome proliferator-activated receptor gamma
chr10_+_17776981 1.21 ENSDART00000141693
chemokine (C-C motif) ligand 19b
chr24_-_32582880 1.19 ENSDART00000186307
retinol dehydrogenase 12, like
chr10_-_13343831 1.19 ENSDART00000135941
interleukin 11 receptor, alpha
chr23_+_4709607 1.17 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr15_-_21014270 1.16 ENSDART00000154019
si:ch211-212c13.10
chr21_+_25236297 1.14 ENSDART00000112783
transmembrane protein 45B
chr19_-_5669122 1.14 ENSDART00000112211
si:ch211-264f5.2
chr17_-_2039511 1.13 ENSDART00000160223
serine peptidase inhibitor, Kunitz type 1 a
chr3_-_3798755 1.12 ENSDART00000170535
guanylate cyclase 2C
chr11_-_45138857 1.12 ENSDART00000166501
calcium activated nucleotidase 1b
chr11_+_31609481 1.11 ENSDART00000124830
ENSDART00000162768
zgc:162816
chr25_+_10811551 1.10 ENSDART00000167730
alanyl (membrane) aminopeptidase b
chr8_-_12867128 1.10 ENSDART00000142201
solute carrier family 2 (facilitated glucose transporter), member 6
chr7_-_66877058 1.09 ENSDART00000155954
adrenomedullin a
chr14_-_5817039 1.09 ENSDART00000131820
Kazal-type serine peptidase inhibitor domain 2
chr15_-_1885247 1.08 ENSDART00000149703
P450 (cytochrome) oxidoreductase b
chr11_-_45141309 1.08 ENSDART00000181736
calcium activated nucleotidase 1b
chr4_+_77971104 1.07 ENSDART00000188609
zgc:113921
chr9_+_28598577 1.03 ENSDART00000142623
ENSDART00000135947
si:ch73-7i4.1
chr19_+_19988869 1.03 ENSDART00000151024
oxysterol binding protein-like 3a
chr16_-_28658341 1.03 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr1_+_32054159 1.03 ENSDART00000181442
steroid sulfatase (microsomal), isozyme S
chr2_-_24407933 1.03 ENSDART00000088584
si:dkey-208k22.6
chr4_-_1908179 1.02 ENSDART00000139586
anoctamin 6
chr13_-_31008275 1.02 ENSDART00000139394
WDFY family member 4
chr6_-_43677125 1.01 ENSDART00000150128
forkhead box P1b
chr4_+_25692277 1.00 ENSDART00000047113
acyl-CoA thioesterase 18
chr18_-_5527050 0.99 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
chr24_-_25166720 0.99 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr21_-_29197700 0.98 ENSDART00000172614
si:ch211-57b15.2
chr2_+_25315591 0.97 ENSDART00000161386
fibronectin type III domain containing 3Ba
chr12_+_20641471 0.97 ENSDART00000133654
calcium binding and coiled-coil domain 2
chr12_+_47081783 0.93 ENSDART00000158568
5-methyltetrahydrofolate-homocysteine methyltransferase
chr3_-_49925313 0.93 ENSDART00000164361
glucagon receptor a
chr10_-_31015535 0.91 ENSDART00000146116
pannexin 3
chr23_+_26733232 0.91 ENSDART00000035080
zgc:158263
chr14_-_14659023 0.90 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr16_-_22544047 0.90 ENSDART00000131657
cingulin a
chr18_-_34549721 0.90 ENSDART00000137101
ENSDART00000021880
signal sequence receptor, gamma
chr1_+_52560549 0.90 ENSDART00000167514
ATP-binding cassette, sub-family A (ABC1), member 1A
chr12_-_18578218 0.88 ENSDART00000125803
zinc finger, DHHC-type containing 4
chr18_+_22109379 0.88 ENSDART00000147230
zgc:158868
chr24_-_11076400 0.87 ENSDART00000003195
charged multivesicular body protein 4C
chr4_+_16715267 0.86 ENSDART00000143849
plakophilin 2
chr25_-_21031007 0.86 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr23_+_39695827 0.86 ENSDART00000113893
ENSDART00000186679
transmembrane and coiled-coil domains 4
chr15_+_32398921 0.85 ENSDART00000156125
ENSDART00000153806
si:ch211-162k9.6
chr18_+_14684115 0.83 ENSDART00000108469
spermatogenesis associated 2-like
chr8_-_12867434 0.83 ENSDART00000081657
solute carrier family 2 (facilitated glucose transporter), member 6
chr7_-_66868543 0.83 ENSDART00000149680
adenosine monophosphate deaminase 3a
chr22_-_10541372 0.83 ENSDART00000179708
si:dkey-42i9.4
chr7_-_8712148 0.82 ENSDART00000065488
testis expressed 261
chr2_-_57110477 0.81 ENSDART00000181132
solute carrier family 25, member 42
chr8_+_23738122 0.81 ENSDART00000062983
ribosomal protein L10a
chr18_+_2228737 0.81 ENSDART00000165301
RAB27A, member RAS oncogene family
chr12_+_20641102 0.81 ENSDART00000152964
calcium binding and coiled-coil domain 2
chr18_+_14619544 0.80 ENSDART00000010821
UTP4, small subunit processome component
chr16_-_16761164 0.80 ENSDART00000135872
si:dkey-27n14.1
chr15_+_5360407 0.79 ENSDART00000110420
odorant receptor, family A, subfamily 112, member 1
chr23_-_33350990 0.79 ENSDART00000144831
si:ch211-226m16.2
chr21_+_39941875 0.78 ENSDART00000190414
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr11_+_42474694 0.78 ENSDART00000056048
ENSDART00000184710
si:ch1073-165f9.2
chr4_+_18824959 0.78 ENSDART00000146141
ENSDART00000040424
solute carrier family 26 (anion exchanger), member 3
chr12_+_22580579 0.77 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr15_-_2519640 0.76 ENSDART00000047013
signal recognition particle receptor, B subunit
chr20_-_9095105 0.75 ENSDART00000140792
OMA1 zinc metallopeptidase
chr5_+_71802014 0.75 ENSDART00000124939
ENSDART00000097164
LIM homeobox 3
chr15_+_32798333 0.75 ENSDART00000162370
ENSDART00000166525
spartin b
chr12_+_5358409 0.75 ENSDART00000152632
phospholipase C, epsilon 1
chr24_+_5912635 0.74 ENSDART00000153736
Pim proto-oncogene, serine/threonine kinase, related 63
chr24_-_5911973 0.74 ENSDART00000077933
ENSDART00000077922
Pim proto-oncogene, serine/threonine kinase, related 64
chr10_-_42882215 0.72 ENSDART00000180580
ENSDART00000187374

chr23_-_20051369 0.72 ENSDART00000049836
biglycan b
chr1_+_55755304 0.72 ENSDART00000144983
trans-2,3-enoyl-CoA reductase b
chr7_+_57088920 0.71 ENSDART00000024076
secretory carrier membrane protein 2, like
chr22_-_10156581 0.71 ENSDART00000168304
RanBP-type and C3HC4-type zinc finger containing 1
chr3_+_29941777 0.71 ENSDART00000113889
interferon-induced protein 35
chr21_+_21195487 0.70 ENSDART00000181746
ENSDART00000184832
RPTOR independent companion of MTOR, complex 2b
chr16_+_23303859 0.69 ENSDART00000006093
solute carrier family 50 (sugar efflux transporter), member 1
chr22_+_7738966 0.69 ENSDART00000147073
si:ch73-44m9.5
chr14_+_33329420 0.69 ENSDART00000171090
ENSDART00000164062
sosondowah ankyrin repeat domain family d
chr10_+_41199660 0.66 ENSDART00000125314
adrenoceptor beta 3b
chr8_+_25034544 0.65 ENSDART00000123300
neugrin, neurite outgrowth associated
chr24_+_21621654 0.65 ENSDART00000002595
ribosomal protein L21
chr8_+_31435452 0.65 ENSDART00000145282
selenoprotein P
chr12_+_37401331 0.64 ENSDART00000125040
si:ch211-152f22.4
chr3_-_29941357 0.64 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
granulin a
chr7_-_34448076 0.64 ENSDART00000170935
nuclear receptor subfamily 1, group H, member 3
chr1_-_6085750 0.64 ENSDART00000138891
si:ch1073-345a8.1
chr5_+_66312359 0.64 ENSDART00000137534
MALT paracaspase 1
chr1_-_49250490 0.64 ENSDART00000150386
si:ch73-6k14.2
chr17_-_27048537 0.64 ENSDART00000050018
ENSDART00000193861
connector enhancer of kinase suppressor of Ras 1
chr3_-_34136368 0.63 ENSDART00000136900
ENSDART00000186125
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr8_-_31062811 0.63 ENSDART00000142528
solute carrier family 20, member 1a
chr25_+_20715950 0.63 ENSDART00000180223
ERGIC and golgi 2
chr20_-_49889111 0.63 ENSDART00000058858
kinesin family member 13Bb
chr8_-_45838277 0.63 ENSDART00000046064
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr15_-_3736773 0.63 ENSDART00000090624
lysophosphatidic acid receptor 6a
chr10_+_35358675 0.62 ENSDART00000193263
si:dkey-259j3.5
chr3_-_61494840 0.62 ENSDART00000101957
BAI1-associated protein 2-like 1b
chr8_-_8698607 0.62 ENSDART00000046712
zgc:86609
chr17_+_24821627 0.62 ENSDART00000112389
WD repeat domain 43
chr20_+_48116476 0.61 ENSDART00000043938
translocation associated membrane protein 2
chr20_+_36812368 0.61 ENSDART00000062931
ABRA C-terminal like
chr13_-_36798204 0.61 ENSDART00000012357
salvador family WW domain containing protein 1
chr8_+_28695914 0.61 ENSDART00000033386
osteoclast stimulatory transmembrane protein
chr9_-_38587275 0.60 ENSDART00000077446
si:dkey-101k6.5
chr2_-_28396993 0.60 ENSDART00000188170

chr15_-_19051152 0.60 ENSDART00000186453
Rho GTPase activating protein 32a
chr12_-_18578432 0.60 ENSDART00000122858
zinc finger, DHHC-type containing 4
chr16_+_50953842 0.60 ENSDART00000174709
si:dkeyp-97a10.1
chr8_-_45760087 0.59 ENSDART00000025620
peptidylprolyl isomerase Aa (cyclophilin A)
chr9_-_53666031 0.59 ENSDART00000126314
protocadherin 8
chr20_-_43663494 0.58 ENSDART00000144564

chr13_+_18321140 0.58 ENSDART00000180947
eukaryotic translation initiation factor 4E family member 1c
chr16_-_38118003 0.58 ENSDART00000058667
si:dkey-23o4.6
chr5_+_27898226 0.58 ENSDART00000098604
ENSDART00000180251
ADAM metallopeptidase domain 28
chr16_+_50953547 0.57 ENSDART00000157526
si:dkeyp-97a10.1
chr8_-_21091961 0.57 ENSDART00000100281
aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2
chr18_+_41527877 0.57 ENSDART00000146972
selenoprotein T, 1b
chr19_-_27858033 0.57 ENSDART00000103898
ENSDART00000144884
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr13_-_12602920 0.56 ENSDART00000102311
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr22_-_10541712 0.56 ENSDART00000013933
si:dkey-42i9.4
chr21_-_25801956 0.55 ENSDART00000101219
methyltransferase like 27
chr6_-_39270851 0.55 ENSDART00000148839
Rho guanine nucleotide exchange factor (GEF) 25b
chr7_-_8738827 0.55 ENSDART00000172807
ENSDART00000173026
si:ch211-1o7.3
chr12_+_47698356 0.55 ENSDART00000112010
leucine zipper, putative tumor suppressor 2b
chr2_-_56348727 0.55 ENSDART00000060745
ubiquitin A-52 residue ribosomal protein fusion product 1
chr23_-_33361425 0.55 ENSDART00000031638
solute carrier family 48 (heme transporter), member 1a
chr6_+_36821621 0.55 ENSDART00000104157
transmembrane protein 45a
chr11_+_44617021 0.54 ENSDART00000158887
RNA binding motif protein 34
chr13_+_7442023 0.54 ENSDART00000080975
tumor necrosis factor, alpha-induced protein 2b
chr20_+_51197758 0.54 ENSDART00000020084
heat shock protein 90, alpha (cytosolic), class B member 1
chr25_-_37191929 0.54 ENSDART00000128108
urate (5-hydroxyiso-) hydrolase b
chr18_+_8320165 0.54 ENSDART00000092053
choline kinase beta
chr6_-_55399214 0.53 ENSDART00000168367
cathepsin A
chr19_+_43780970 0.53 ENSDART00000063870
ribosomal protein L11
chr6_+_9427641 0.53 ENSDART00000022620
kalirin RhoGEF kinase b
chr2_+_2169337 0.53 ENSDART00000179939
HIG1 hypoxia inducible domain family, member 1A
chr12_-_28363111 0.52 ENSDART00000016283
ENSDART00000164156
proteasome 26S subunit, non-ATPase 11b
chr8_-_25034411 0.52 ENSDART00000135973
nuclear transcription factor Y, alpha, like
chr6_+_3717613 0.51 ENSDART00000184330
Sjogren syndrome antigen B (autoantigen La)
chr15_+_31820536 0.51 ENSDART00000045921
furry homolog a (Drosophila)
chr16_+_42471455 0.51 ENSDART00000166640
si:ch211-215k15.5
chr8_+_53064920 0.51 ENSDART00000164823
NAD kinase a
chr15_+_28318005 0.51 ENSDART00000175860
myosin Ic, paralog b
chr4_+_77943184 0.50 ENSDART00000159094
protein kinase C and casein kinase substrate in neurons 2
chr12_-_4532066 0.50 ENSDART00000092687
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2

Network of associatons between targets according to the STRING database.

First level regulatory network of alx4a+alx4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 2.7 GO:0006642 triglyceride mobilization(GO:0006642)
0.5 1.4 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.4 1.3 GO:0097237 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.4 1.3 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.4 1.3 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.4 2.5 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.3 1.0 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.2 2.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.9 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.2 0.6 GO:1904478 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.2 1.1 GO:0070178 D-amino acid catabolic process(GO:0019478) D-serine catabolic process(GO:0036088) D-amino acid metabolic process(GO:0046416) D-serine metabolic process(GO:0070178)
0.2 1.2 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.2 0.5 GO:0071634 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.2 1.6 GO:0034435 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.2 0.5 GO:0002369 T cell cytokine production(GO:0002369)
0.2 0.5 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.2 0.5 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 10.6 GO:0007599 hemostasis(GO:0007599)
0.1 0.7 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 1.6 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.1 1.2 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 1.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.5 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 0.4 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.7 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.9 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 0.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.3 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.1 0.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 1.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 0.9 GO:0002934 desmosome organization(GO:0002934)
0.1 0.8 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 2.4 GO:0072599 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.1 0.5 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.1 0.3 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.1 0.3 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.3 GO:0050999 regulation of nitric-oxide synthase activity(GO:0050999) positive regulation of nitric-oxide synthase activity(GO:0051000) beta-amyloid clearance(GO:0097242) regulation of beta-amyloid clearance(GO:1900221)
0.1 0.3 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 1.9 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.1 0.8 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 1.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.6 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.4 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.1 1.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.2 GO:0002513 tolerance induction(GO:0002507) tolerance induction to self antigen(GO:0002513)
0.1 0.5 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.8 GO:0006032 chitin catabolic process(GO:0006032)
0.1 0.6 GO:0051013 microtubule severing(GO:0051013)
0.1 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.9 GO:0009086 methionine biosynthetic process(GO:0009086)
0.1 0.3 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.1 0.7 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.3 GO:0014823 response to activity(GO:0014823)
0.1 0.3 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 2.2 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 1.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.8 GO:0032264 IMP salvage(GO:0032264)
0.1 1.3 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.6 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.8 GO:0061055 myotome development(GO:0061055)
0.1 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 0.9 GO:0009651 response to salt stress(GO:0009651)
0.1 0.5 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 1.5 GO:0009636 response to toxic substance(GO:0009636)
0.1 1.9 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0044857 membrane raft assembly(GO:0001765) membrane raft organization(GO:0031579) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 1.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.3 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.0 1.0 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 1.1 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 1.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.0 0.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 2.9 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.7 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0035019 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.0 0.4 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.5 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 1.2 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.1 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.1 GO:0071706 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.0 0.1 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.0 0.3 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.6 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 1.1 GO:0030199 collagen fibril organization(GO:0030199)
0.0 3.1 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.9 GO:0001878 response to yeast(GO:0001878)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.3 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.3 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 1.2 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.6 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.9 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.2 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.4 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 1.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.4 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518) steroid hormone mediated signaling pathway(GO:0043401)
0.0 0.5 GO:0072350 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) tricarboxylic acid metabolic process(GO:0072350)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.5 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.1 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.0 0.7 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.6 GO:0007548 sex differentiation(GO:0007548)
0.0 0.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 2.2 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 1.9 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.9 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.0 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.3 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.1 GO:0072584 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.2 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.4 GO:1901215 negative regulation of neuron death(GO:1901215)
0.0 0.5 GO:0007006 mitochondrial membrane organization(GO:0007006)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0034359 mature chylomicron(GO:0034359)
0.3 1.4 GO:0061689 tricellular tight junction(GO:0061689)
0.2 0.5 GO:0034515 proteasome storage granule(GO:0034515)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.6 GO:0001650 fibrillar center(GO:0001650)
0.1 0.7 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.5 GO:0030891 VCB complex(GO:0030891)
0.1 0.3 GO:0019815 B cell receptor complex(GO:0019815)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.9 GO:0014704 intercalated disc(GO:0014704)
0.1 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.1 1.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 1.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.1 0.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.2 GO:0072380 TRC complex(GO:0072380)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.0 GO:0045180 basal cortex(GO:0045180)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 1.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 2.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0005921 gap junction(GO:0005921)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.4 GO:0044545 NSL complex(GO:0044545)
0.0 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.9 GO:0030686 90S preribosome(GO:0030686)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 17.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 1.4 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 1.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.0 GO:0001726 ruffle(GO:0001726)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005903 brush border(GO:0005903)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.5 GO:0016459 myosin complex(GO:0016459)
0.0 15.8 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.8 2.3 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.5 3.7 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.4 1.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.4 1.6 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.3 1.4 GO:0031005 filamin binding(GO:0031005)
0.3 1.0 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.3 2.2 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.3 0.9 GO:0001729 ceramide kinase activity(GO:0001729)
0.3 2.7 GO:0070325 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.3 2.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.3 2.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.3 1.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 1.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 0.8 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.3 1.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.3 1.3 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 1.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 1.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.9 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.2 1.9 GO:0016936 galactoside binding(GO:0016936)
0.2 0.9 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.2 0.9 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 1.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 0.7 GO:0051380 norepinephrine binding(GO:0051380)
0.1 0.9 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 0.6 GO:0047105 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.1 0.6 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.1 0.4 GO:0072545 tyrosine binding(GO:0072545)
0.1 1.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.9 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.3 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 0.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 2.2 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 0.3 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.1 1.4 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.1 1.5 GO:0002039 p53 binding(GO:0002039)
0.1 0.3 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.1 0.3 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.1 0.6 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.4 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 0.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.8 GO:0004568 chitinase activity(GO:0004568)
0.1 1.5 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 1.3 GO:0043236 laminin binding(GO:0043236)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.6 GO:0015232 heme transporter activity(GO:0015232)
0.1 1.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.1 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.4 GO:1903924 estradiol binding(GO:1903924)
0.1 12.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1 0.5 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.2 GO:0008517 folic acid transporter activity(GO:0008517) FAD transmembrane transporter activity(GO:0015230)
0.0 0.8 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 2.8 GO:0005507 copper ion binding(GO:0005507)
0.0 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.6 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 1.0 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.0 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.9 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.7 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 0.4 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.3 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.0 0.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 1.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.4 GO:0008252 nucleotidase activity(GO:0008252)
0.0 1.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.1 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0002020 protease binding(GO:0002020) metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.1 GO:0038187 pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 5.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 3.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 3.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.7 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.5 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.6 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease