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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for bach1a+bach1b+bach2a+bach2b

Z-value: 0.98

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Transcription factors associated with bach1a+bach1b+bach2a+bach2b

Gene Symbol Gene ID Gene Info
ENSDARG00000002196 BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
ENSDARG00000004074 BTB and CNC homology 1, basic leucine zipper transcription factor 2b
ENSDARG00000036569 BTB and CNC homology 1, basic leucine zipper transcription factor 2a
ENSDARG00000062553 BTB and CNC homology 1, basic leucine zipper transcription factor 1 a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bach2adr11_v1_chr17_+_15674052_156740520.788.7e-21Click!
bach2bdr11_v1_chr20_-_24122881_241228810.731.2e-16Click!
bach1adr11_v1_chr15_-_8177919_81779190.454.8e-06Click!
bach1bdr11_v1_chr10_+_25369859_25369859-0.066.0e-01Click!

Activity profile of bach1a+bach1b+bach2a+bach2b motif

Sorted Z-values of bach1a+bach1b+bach2a+bach2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_34486629 22.55 ENSDART00000131861
thymosin beta 2
chr19_-_21832441 21.16 ENSDART00000151272
ENSDART00000151442
ENSDART00000150168
ENSDART00000148797
ENSDART00000128196
ENSDART00000149259
ENSDART00000052556
ENSDART00000149658
ENSDART00000149639
ENSDART00000148424
myelin basic protein a
chr1_+_31113951 20.08 ENSDART00000129362
eukaryotic translation elongation factor 1 alpha 1b
chr20_+_34915945 16.41 ENSDART00000153064
synaptosomal-associated protein, 25a
chr2_+_47582681 16.40 ENSDART00000187579
secretogranin II (chromogranin C), b
chr2_+_47581997 16.22 ENSDART00000112579
secretogranin II (chromogranin C), b
chr21_-_30545121 14.19 ENSDART00000019199
RAB39B, member RAS oncogene family a
chr7_+_23875269 14.14 ENSDART00000101406
RAB39B, member RAS oncogene family b
chr1_+_12766351 13.86 ENSDART00000165785
protocadherin 10a
chr8_+_7359294 12.97 ENSDART00000121708
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr23_-_15878879 12.95 ENSDART00000010119
eukaryotic translation elongation factor 1 alpha 2
chr19_-_103289 11.90 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr19_-_5805923 11.86 ENSDART00000134340
si:ch211-264f5.8
chr25_+_21324588 11.33 ENSDART00000151842
leucine rich repeat neuronal 3a
chr2_+_24177006 10.70 ENSDART00000132582
microtubule associated protein 4 like
chr15_+_28989573 10.36 ENSDART00000076648
CAP-GLY domain containing linker protein 3
chr16_-_12984631 10.15 ENSDART00000184863
calcium channel, voltage-dependent, gamma subunit 7b
chr16_+_14033121 10.10 ENSDART00000135844
RUN and SH3 domain containing 1
chr1_-_53750522 9.96 ENSDART00000190755
v-akt murine thymoma viral oncogene homolog 3b
chr18_-_18850302 9.76 ENSDART00000131965
ENSDART00000167624
transglutaminase 2, like
chr1_-_40227166 9.62 ENSDART00000146680
si:ch211-113e8.3
chr5_-_22501663 9.39 ENSDART00000133174
si:dkey-27p18.5
chr17_-_7861219 9.30 ENSDART00000148604
spectrin repeat containing, nuclear envelope 1b
chr7_-_52963493 9.29 ENSDART00000052029
cocaine- and amphetamine-regulated transcript 3
chr8_+_24861264 8.98 ENSDART00000099607
solute carrier family 6 (neutral amino acid transporter), member 17
chr1_+_46598764 8.89 ENSDART00000053240
calcium binding protein 39-like
chr19_+_10396042 8.86 ENSDART00000028048
ENSDART00000151735
NECAP endocytosis associated 1
chr10_+_37145007 8.80 ENSDART00000131777
CUE domain containing 1a
chr14_-_34044369 8.73 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cytoplasmic FMR1 interacting protein 2
chr16_+_34479064 8.52 ENSDART00000159965
si:ch211-255i3.4
chr11_-_3334248 8.23 ENSDART00000154314
ENSDART00000121861
peripherin
chr3_+_7617353 7.92 ENSDART00000165551
zgc:109949
chr2_+_20430366 7.66 ENSDART00000155108
si:ch211-153l6.6
chr2_+_47582488 7.66 ENSDART00000149967
secretogranin II (chromogranin C), b
chr2_+_24177190 7.60 ENSDART00000099546
microtubule associated protein 4 like
chr19_-_36675023 7.40 ENSDART00000132471
CUB and Sushi multiple domains 2
chr21_-_42100471 7.29 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_-_9544161 7.09 ENSDART00000124425
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, like
chr7_+_26649319 6.93 ENSDART00000173823
ENSDART00000101053
tumor protein p53 inducible protein 11a
chr18_+_9635178 6.86 ENSDART00000183486
piccolo presynaptic cytomatrix protein b
chr8_+_24854600 6.84 ENSDART00000156570
solute carrier family 6 (neutral amino acid transporter), member 17
chr17_+_19626479 6.83 ENSDART00000044993
ENSDART00000131863
regulator of G protein signaling 7a
chr21_+_3093419 6.73 ENSDART00000162520
SHC adaptor protein 3
chr3_+_20156956 6.64 ENSDART00000125281
nerve growth factor receptor a (TNFR superfamily, member 16)
chr15_+_40188076 6.41 ENSDART00000063779
EF-hand domain family, member D1
chr19_+_24394560 6.38 ENSDART00000142506
si:dkey-81h8.1
chr24_-_21973365 6.38 ENSDART00000081204
ENSDART00000030592
acyl-CoA thioesterase 9, tandem duplicate 1
chr22_+_24220937 6.34 ENSDART00000165380
ubiquitin carboxyl-terminal hydrolase L5
chr10_+_4235998 6.28 ENSDART00000169328
phospholipid phosphatase related 1
chr5_+_20035284 6.22 ENSDART00000191808
small G protein signaling modulator 1a
chr25_-_7999756 6.11 ENSDART00000159908
calcium/calmodulin-dependent protein kinase 1Db
chr12_-_17147473 5.98 ENSDART00000106035
STAM binding protein-like 1
chr2_-_39759059 5.96 ENSDART00000007333
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr5_+_59534286 5.74 ENSDART00000189341
GTF2I repeat domain containing 1
chr18_+_3169579 5.68 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
p21 protein (Cdc42/Rac)-activated kinase 1
chr2_+_50862527 5.59 ENSDART00000169800
ENSDART00000158847
ENSDART00000160900
adenylate cyclase activating polypeptide 1a (pituitary) receptor type I
chr1_+_41849152 5.57 ENSDART00000053685
spermine oxidase
chr13_-_21701323 5.50 ENSDART00000164112
si:dkey-191g9.7
chr19_-_10395683 5.46 ENSDART00000109488
zgc:194578
chr13_-_37545487 5.41 ENSDART00000131269
synaptotagmin XVI
chr6_+_43903209 5.07 ENSDART00000006435
G protein-coupled receptor 27
chr10_-_32877348 4.95 ENSDART00000018977
ENSDART00000133421
RAB guanine nucleotide exchange factor (GEF) 1
chr5_+_20147830 4.91 ENSDART00000098727
SV2 related protein a
chr13_+_43247936 4.88 ENSDART00000126850
ENSDART00000165331
SPARC related modular calcium binding 2
chr3_+_45401472 4.78 ENSDART00000156693
BAI1-associated protein 3
chr22_-_11724563 4.68 ENSDART00000190796
ENSDART00000184744
keratin 222
chr19_-_7495006 4.67 ENSDART00000148836
regulatory factor X, 5
chr1_-_22726233 4.66 ENSDART00000140920
prominin 1 b
chr14_-_17588345 4.56 ENSDART00000143486
selenoprotein T, 2
chr22_-_3595439 4.50 ENSDART00000083308
protein tyrosine phosphatase, receptor type, s, a
chr14_-_6936731 4.43 ENSDART00000162196
CDC-like kinase 4a
chr3_-_24205339 4.42 ENSDART00000157135
si:dkey-110g7.8
chr14_-_44841503 4.27 ENSDART00000179114
si:dkey-109l4.6
chr5_-_14564878 4.24 ENSDART00000160511
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr20_-_16849306 4.23 ENSDART00000131395
ENSDART00000027582
breast cancer metastasis-suppressor 1-like b
chr3_+_24986145 4.20 ENSDART00000055428
chromobox homolog 7a
chr18_-_18849916 4.14 ENSDART00000142422
transglutaminase 2, like
chr1_+_41690402 4.09 ENSDART00000177298
F-box protein 41
chr11_+_11267829 4.08 ENSDART00000026814
ENSDART00000173346
ENSDART00000151926
protein tyrosine phosphatase type IVA, member 1
chr15_-_13254480 4.02 ENSDART00000190499
zgc:172282
chr19_+_33093395 4.02 ENSDART00000019459
family with sequence similarity 91, member A1
chr22_+_17399124 4.02 ENSDART00000145769
RAB GTPase activating protein 1-like
chr5_-_20678300 3.95 ENSDART00000088639
WSC domain containing 2
chr4_+_76431531 3.91 ENSDART00000174278

chr18_-_8396192 3.84 ENSDART00000193830
si:ch211-220f12.4
chr22_+_36547670 3.81 ENSDART00000125991
ENSDART00000186372
armadillo repeat containing 9
chr25_+_14697247 3.76 ENSDART00000180747
metallophosphoesterase domain containing 2b
chr17_-_45247332 3.71 ENSDART00000016815
tau tubulin kinase 2a
chr23_+_45339684 3.68 ENSDART00000149410
ENSDART00000102441
PC4 and SFRS1 interacting protein 1b
chr2_-_3038904 3.65 ENSDART00000186795
guanylate kinase 1a
chr5_+_21931124 3.64 ENSDART00000137627
si:ch73-92i20.1
chr2_-_155270 3.62 ENSDART00000131177
adenylate cyclase 1b
chr10_-_27566481 3.62 ENSDART00000078920
autism susceptibility candidate 2a
chr7_-_5487593 3.61 ENSDART00000136594
Rho guanine nucleotide exchange factor (GEF) 11
chr24_+_26039464 3.60 ENSDART00000131017
tyrosine kinase, non-receptor, 2a
chr20_-_32446406 3.52 ENSDART00000026635
nuclear receptor subfamily 2, group E, member 1
chr2_+_9821757 3.49 ENSDART00000018408
ENSDART00000141227
ENSDART00000144681
ENSDART00000148227
annexin A13, like
chr15_-_30832171 3.43 ENSDART00000152414
ENSDART00000152790
musashi RNA-binding protein 2b
chr12_-_3077395 3.39 ENSDART00000002867
ENSDART00000126315
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_+_2190714 3.39 ENSDART00000132126
muscleblind-like splicing regulator 2
chr1_+_46598502 3.37 ENSDART00000132861
calcium binding protein 39-like
chr1_+_58677434 3.36 ENSDART00000158488

chr17_-_45247151 3.35 ENSDART00000186230
tau tubulin kinase 2a
chr1_+_52137528 3.35 ENSDART00000007079
ENSDART00000074265
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr21_-_45613564 3.32 ENSDART00000160324

chr10_-_13239367 3.31 ENSDART00000001253
si:busm1-57f23.1
chr15_+_32867420 3.28 ENSDART00000159442
doublecortin-like kinase 1b
chr17_+_7595356 3.20 ENSDART00000130625
si:dkeyp-110a12.4
chr24_+_21973929 3.18 ENSDART00000042495
spermidine/spermine N1-acetyltransferase 1b
chr24_-_40009446 3.18 ENSDART00000087422
amine oxidase, copper containing 1
chr15_+_24704798 3.01 ENSDART00000192470
si:dkey-151p21.7
chr11_+_11267493 3.00 ENSDART00000148425
protein tyrosine phosphatase type IVA, member 1
chr22_-_5839686 2.96 ENSDART00000145406
si:rp71-36a1.5
chr5_+_34549845 2.89 ENSDART00000139317
allograft inflammatory factor 1-like
chr6_+_10534752 2.85 ENSDART00000090874
potassium channel, voltage gated eag related subfamily H, member 7
chr8_+_43053519 2.83 ENSDART00000147178
prion protein a
chr8_-_13211527 2.79 ENSDART00000090541
si:ch73-61d6.3
chr21_-_30254185 2.77 ENSDART00000101054
DnaJ (Hsp40) homolog, subfamily C, member 18
chr6_+_52350443 2.73 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
chr18_-_9046805 2.66 ENSDART00000134224
glutamate receptor, metabotropic 3
chr10_+_2529037 2.66 ENSDART00000123467
zmp:0000001301
chr13_+_1430094 2.66 ENSDART00000169888
si:ch211-165e15.1
chr6_+_40723554 2.63 ENSDART00000103833
solute carrier family 26, member 6, like
chr2_-_37837472 2.62 ENSDART00000165347
methyltransferase like 17
chr20_-_43723860 2.61 ENSDART00000122051
Mix paired-like homeobox
chr12_+_47280839 2.60 ENSDART00000187574
ryanodine receptor 2
chr5_-_55623443 2.60 ENSDART00000005671
ENSDART00000176341
heterogeneous nuclear ribonucleoprotein K, like
chr18_-_13360106 2.57 ENSDART00000091512
c-Maf inducing protein
chr18_+_15841449 2.56 ENSDART00000141800
ENSDART00000091349
early endosome antigen 1
chr2_+_48288461 2.54 ENSDART00000141495
hes family bHLH transcription factor 6
chr19_+_551963 2.53 ENSDART00000110495
A kinase (PRKA) anchor protein 9
chr9_-_2594410 2.53 ENSDART00000188306
ENSDART00000164276
sp9 transcription factor
chr15_+_25489406 2.51 ENSDART00000162482
zgc:152863
chr25_-_11378623 2.50 ENSDART00000166586
ectodermal-neural cortex 2
chr4_-_1801519 2.45 ENSDART00000188604
ENSDART00000135749
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr20_-_16548912 2.45 ENSDART00000137601
checkpoint suppressor 1
chr18_-_15155962 2.43 ENSDART00000111333
mitochondrial transcription termination factor 2
chr16_-_21181128 2.43 ENSDART00000133403
phosphodiesterase 11a, like
chr6_-_18960105 2.42 ENSDART00000185278
ENSDART00000162968
septin 9b
chr11_-_22371105 2.41 ENSDART00000146873
transmembrane protein 183A
chr4_+_68087932 2.37 ENSDART00000150494
zinc finger protein 1096
chr23_+_45200481 2.34 ENSDART00000004357
ENSDART00000111126
ENSDART00000193560
ENSDART00000190476
PC4 and SFRS1 interacting protein 1b
chr5_+_15350954 2.34 ENSDART00000140990
ENSDART00000137287
ENSDART00000061653
phosphatidylethanolamine binding protein 1
chr19_+_33093577 2.30 ENSDART00000180317
family with sequence similarity 91, member A1
chr9_+_41024973 2.30 ENSDART00000014660
ENSDART00000144467
ORMDL sphingolipid biosynthesis regulator 1
chr9_+_7030016 2.28 ENSDART00000148047
ENSDART00000148181
inositol polyphosphate-4-phosphatase type I Aa
chr4_-_4535189 2.26 ENSDART00000057519
zgc:194209
chr17_+_58211 2.24 ENSDART00000157642
si:ch1073-209e23.1
chr16_+_42829735 2.21 ENSDART00000014956
polymerase (RNA) III (DNA directed) polypeptide G like b
chr5_+_44805028 2.19 ENSDART00000141198
cathepsin La
chr12_-_35386910 2.18 ENSDART00000153453
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr9_-_33749556 2.16 ENSDART00000149383
Norrie disease (pseudoglioma)
chr2_-_26642831 2.14 ENSDART00000132854
ENSDART00000087714
ENSDART00000132651
U2 snRNP-associated SURP domain containing
chr20_-_21994901 2.12 ENSDART00000004984
dishevelled associated activator of morphogenesis 1b
chr13_+_22964868 2.12 ENSDART00000142129
tachykinin receptor 2
chr4_-_28958601 2.11 ENSDART00000111294
zgc:174315
chr2_-_37837056 2.09 ENSDART00000158179
ENSDART00000160317
ENSDART00000171409
methyltransferase like 17
chr11_+_34760628 2.09 ENSDART00000087216
si:dkey-202e22.2
chr2_+_9822319 2.09 ENSDART00000144078
ENSDART00000144371
annexin A13, like
chr13_+_7575563 2.05 ENSDART00000146592
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr25_+_336503 2.01 ENSDART00000160395

chr18_+_17537344 1.98 ENSDART00000025782
nucleoporin 93
chr16_+_27543893 1.97 ENSDART00000182421
si:ch211-197h24.6
chr3_+_24197934 1.97 ENSDART00000055609
activating transcription factor 4b
chr11_+_19370717 1.94 ENSDART00000165906
prickle homolog 2b
chr17_-_31044803 1.92 ENSDART00000185941
ENSDART00000152016
echinoderm microtubule associated protein like 1
chr4_+_69624049 1.92 ENSDART00000170052
zinc finger protein 1030
chr13_+_2357637 1.91 ENSDART00000017148
glutamate-cysteine ligase, catalytic subunit
chr19_-_40776608 1.84 ENSDART00000179941
calcitonin receptor
chr4_+_45274792 1.81 ENSDART00000150295
zinc finger protein 1138
chr24_-_21973163 1.78 ENSDART00000131406
acyl-CoA thioesterase 9, tandem duplicate 1
chr1_+_56447107 1.78 ENSDART00000091924

chr9_-_48370645 1.78 ENSDART00000140185
collagen, type XXVIII, alpha 2a
chr1_+_47165842 1.77 ENSDART00000053152
ENSDART00000167051
carbonyl reductase 1
chr4_-_73787702 1.77 ENSDART00000136328
ENSDART00000150546
si:dkey-262g12.3
chr4_+_1600034 1.76 ENSDART00000146779
solute carrier family 38, member 2
chr5_-_33298352 1.73 ENSDART00000015076
zgc:103692
chr5_-_42180205 1.70 ENSDART00000145247
family with sequence similarity 222, member Ba
chr16_+_48714048 1.69 ENSDART00000148709
ENSDART00000150121
bromodomain containing 2b
chr4_+_58057168 1.68 ENSDART00000161097
si:dkey-57k17.1
chr6_+_33885828 1.67 ENSDART00000179994
GC-rich promoter binding protein 1-like 1
chr12_-_27212596 1.66 ENSDART00000153101
proteasome activator subunit 3
chr18_+_3243292 1.65 ENSDART00000166580
p21 protein (Cdc42/Rac)-activated kinase 1
chr9_+_28140089 1.64 ENSDART00000046880
pleckstrin homology domain containing, family M, member 3
chr12_+_8074343 1.63 ENSDART00000124084
ciliary associated calcium binding coiled-coil 1
chr5_+_44804791 1.59 ENSDART00000122288
cathepsin La
chr10_+_38775408 1.56 ENSDART00000125045
Down syndrome cell adhesion molecule a
chr5_+_9037650 1.55 ENSDART00000158226
si:ch211-155m12.1
chr6_-_21534301 1.52 ENSDART00000126186
proteasome 26S subunit, non-ATPase 12
chr7_-_19638319 1.52 ENSDART00000163686
si:ch211-212k18.4
chr16_+_13818743 1.50 ENSDART00000090191
folliculin
chr5_-_42123794 1.50 ENSDART00000051135
ER membrane protein complex subunit 6
chr21_+_6328801 1.49 ENSDART00000163577
formin binding protein 1b
chr4_-_56157199 1.47 ENSDART00000169806
si:ch211-207e19.15
chr8_+_39511932 1.46 ENSDART00000113511
leucine zipper, putative tumor suppressor 1
chr8_-_14067517 1.44 ENSDART00000140948
death effector domain containing
chr3_+_19687217 1.43 ENSDART00000141937
tousled-like kinase 2
chr21_+_22892836 1.36 ENSDART00000065565
ALG8, alpha-1,3-glucosyltransferase
chr18_+_3052408 1.36 ENSDART00000181563
potassium channel tetramerization domain containing 14
chr24_-_5691956 1.34 ENSDART00000189112
deleted in autism 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of bach1a+bach1b+bach2a+bach2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.8 GO:0015824 proline transport(GO:0015824)
3.0 11.9 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
2.3 22.6 GO:0042989 sequestering of actin monomers(GO:0042989)
2.0 6.0 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
1.5 7.3 GO:0070208 protein heterotrimerization(GO:0070208)
1.4 8.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.2 7.3 GO:0003232 bulbus arteriosus development(GO:0003232)
1.2 9.3 GO:0008343 adult feeding behavior(GO:0008343)
0.9 37.0 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.9 28.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.8 3.2 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.8 13.9 GO:0097324 melanocyte migration(GO:0097324)
0.7 6.9 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.6 3.2 GO:0046677 response to antibiotic(GO:0046677)
0.6 13.9 GO:0018149 peptide cross-linking(GO:0018149)
0.6 10.1 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.6 16.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.6 8.7 GO:0001964 startle response(GO:0001964)
0.6 2.3 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.6 9.1 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.5 9.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.5 33.0 GO:0006414 translational elongation(GO:0006414)
0.5 2.5 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.5 2.5 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.5 2.4 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
0.5 1.9 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.4 2.6 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.4 2.0 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.4 9.3 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.3 2.2 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.3 3.4 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.3 2.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 2.1 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.3 3.8 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.3 3.6 GO:0016199 axon midline choice point recognition(GO:0016199)
0.3 1.3 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 1.0 GO:0033605 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.2 1.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.2 1.5 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.2 6.0 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.2 1.3 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.2 1.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.2 4.9 GO:0042476 odontogenesis(GO:0042476)
0.2 10.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.2 1.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 1.8 GO:0006868 glutamine transport(GO:0006868)
0.2 4.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 1.9 GO:0036368 cone photoresponse recovery(GO:0036368)
0.2 14.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.2 3.6 GO:0021884 forebrain neuron development(GO:0021884)
0.2 4.7 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.2 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.1 2.9 GO:0097178 ruffle assembly(GO:0097178)
0.1 0.8 GO:0030242 pexophagy(GO:0030242)
0.1 2.8 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 2.4 GO:0001966 thigmotaxis(GO:0001966)
0.1 23.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 3.8 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 3.8 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 0.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 2.9 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.1 1.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 6.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 2.9 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.1 10.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 8.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 3.3 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.1 2.1 GO:0070831 basement membrane assembly(GO:0070831)
0.1 2.2 GO:0072114 pronephros morphogenesis(GO:0072114)
0.1 2.2 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 4.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 4.2 GO:0016575 histone deacetylation(GO:0016575)
0.1 1.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 1.3 GO:0007631 feeding behavior(GO:0007631)
0.1 1.2 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 7.7 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 1.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 2.5 GO:0045104 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.1 0.8 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 1.5 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 2.6 GO:0001706 endoderm formation(GO:0001706)
0.0 0.8 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 2.1 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.4 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 10.2 GO:0006887 exocytosis(GO:0006887)
0.0 17.5 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 2.2 GO:0045010 actin nucleation(GO:0045010)
0.0 3.2 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.2 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0010002 cardioblast differentiation(GO:0010002)
0.0 3.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 3.2 GO:1990266 neutrophil migration(GO:1990266)
0.0 2.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)
0.0 1.7 GO:0001756 somitogenesis(GO:0001756)
0.0 0.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 2.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 16.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.2 21.2 GO:0043209 myelin sheath(GO:0043209)
0.7 2.9 GO:0008537 proteasome activator complex(GO:0008537)
0.7 6.9 GO:0098982 GABA-ergic synapse(GO:0098982)
0.6 4.7 GO:0071914 prominosome(GO:0071914)
0.6 2.3 GO:0035339 SPOTS complex(GO:0035339)
0.5 8.7 GO:0031209 SCAR complex(GO:0031209)
0.5 9.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 40.3 GO:0030141 secretory granule(GO:0030141)
0.4 11.3 GO:0035371 microtubule plus-end(GO:0035371)
0.4 6.7 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.3 14.3 GO:0030125 clathrin vesicle coat(GO:0030125)
0.3 2.1 GO:0097225 sperm midpiece(GO:0097225)
0.2 10.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 7.3 GO:0032590 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.2 7.1 GO:0035869 ciliary transition zone(GO:0035869)
0.2 4.2 GO:0070822 Sin3-type complex(GO:0070822)
0.2 1.7 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 0.8 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.0 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 2.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 2.1 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 15.8 GO:0008021 synaptic vesicle(GO:0008021)
0.1 2.4 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 2.0 GO:0034399 nuclear periphery(GO:0034399)
0.1 1.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 7.2 GO:0005882 intermediate filament(GO:0005882)
0.1 11.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 25.8 GO:0000139 Golgi membrane(GO:0000139)
0.1 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.8 GO:0005814 centriole(GO:0005814)
0.0 3.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 16.5 GO:0005874 microtubule(GO:0005874)
0.0 12.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.0 GO:0043204 perikaryon(GO:0043204)
0.0 3.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.5 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 4.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.4 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 17.2 GO:0005739 mitochondrion(GO:0005739)
0.0 9.4 GO:0043005 neuron projection(GO:0043005)
0.0 4.2 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
1.4 8.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
1.4 21.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.1 22.6 GO:0003785 actin monomer binding(GO:0003785)
1.1 5.6 GO:0046592 polyamine oxidase activity(GO:0046592)
0.9 6.6 GO:0005035 death receptor activity(GO:0005035)
0.9 5.6 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.8 3.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.8 4.7 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.7 33.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 3.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.7 13.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.6 3.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.6 1.8 GO:0097643 amylin receptor activity(GO:0097643)
0.6 19.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.5 8.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.5 6.3 GO:0070628 proteasome binding(GO:0070628)
0.5 4.6 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.5 2.5 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.5 2.4 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.5 2.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 3.2 GO:0019809 spermidine binding(GO:0019809)
0.4 16.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 6.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 1.2 GO:0017050 D-erythro-sphingosine kinase activity(GO:0017050)
0.4 12.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.4 6.9 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.4 2.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.4 2.8 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 8.2 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.3 1.3 GO:0035197 siRNA binding(GO:0035197)
0.3 2.3 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.3 1.9 GO:0043531 ADP binding(GO:0043531)
0.3 2.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.3 10.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 3.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 11.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 1.3 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.2 6.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 2.3 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.2 2.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 2.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 8.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.2 1.5 GO:0032977 membrane insertase activity(GO:0032977)
0.1 1.8 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 7.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.1 4.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 10.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 5.1 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.8 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 4.2 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 3.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 13.9 GO:0015293 symporter activity(GO:0015293)
0.1 2.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 4.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 21.5 GO:0008017 microtubule binding(GO:0008017)
0.1 5.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.7 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 5.5 GO:0030276 clathrin binding(GO:0030276)
0.0 15.1 GO:0003924 GTPase activity(GO:0003924)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 20.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 2.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 2.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 4.0 GO:0008168 methyltransferase activity(GO:0008168)
0.0 4.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.7 GO:0005525 GTP binding(GO:0005525)
0.0 4.2 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.4 10.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.3 7.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 3.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 5.0 PID RAS PATHWAY Regulation of Ras family activation
0.2 8.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 6.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.1 PID ARF 3PATHWAY Arf1 pathway
0.1 2.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 2.3 PID AURORA B PATHWAY Aurora B signaling
0.1 4.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
1.0 7.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.8 2.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 7.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 6.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.4 5.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 6.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 2.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 3.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 1.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 2.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 3.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 6.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 2.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.8 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 2.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.6 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism