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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 0.92

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Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Gene Symbol Gene ID Gene Info
bhlha15
ENSDARG00000045166 basic helix-loop-helix family, member a15
bhlhe23
ENSDARG00000037588 basic helix-loop-helix family, member e23
si_ch211-196c10.13
ENSDARG00000096756 si_ch211-196c10.13
bhlhe22
ENSDARG00000058039 basic helix-loop-helix family, member e22

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe23dr11_v1_chr23_-_17657348_176573480.791.3e-21Click!
bhlhe22dr11_v1_chr24_+_24461558_244615580.796.0e-21Click!
si:ch211-196c10.13dr11_v1_chr8_+_23142946_231429460.672.3e-13Click!
bhlha15dr11_v1_chr12_+_17754859_177548590.019.2e-01Click!

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_22012389 24.92 ENSDART00000035188
kcnip1b
Kv channel interacting protein 1 b
chr4_-_8882572 18.66 ENSDART00000190060
mpped1
metallophosphoesterase domain containing 1
chr12_-_14922955 15.36 ENSDART00000002078
neurod2
neurogenic differentiation 2
chr2_-_27775236 15.35 ENSDART00000187983
XKR4
zgc:123035
chr14_+_25817246 14.77 ENSDART00000136733
glra1
glycine receptor, alpha 1
chr1_-_16507812 14.04 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr21_+_11468642 13.73 ENSDART00000041869
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr5_-_27994679 13.31 ENSDART00000132740
ppp3cca
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr14_-_4682114 12.78 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr6_+_54142311 10.96 ENSDART00000154115
hmga1b
high mobility group AT-hook 1b
chr19_-_7406933 10.84 ENSDART00000151137
oxr1b
oxidation resistance 1b
chr23_-_21453614 10.39 ENSDART00000079274
her4.1
hairy-related 4, tandem duplicate 1
chr4_+_15968483 9.34 ENSDART00000101575
si:dkey-117n7.5
si:dkey-117n7.5
chr13_-_24311628 9.20 ENSDART00000004420
rab4a
RAB4a, member RAS oncogene family
chr13_+_31285660 9.16 ENSDART00000148352
gdf10a
growth differentiation factor 10a
chr19_-_21766461 8.35 ENSDART00000104279
znf516
zinc finger protein 516
chr23_+_21544227 8.18 ENSDART00000140253
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr10_-_31440500 7.81 ENSDART00000024778
robo3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr14_+_31618982 7.79 ENSDART00000026195
slc9a6a
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6a
chr20_-_31252809 7.32 ENSDART00000137236
hpcal1
hippocalcin-like 1
chr14_-_4556896 6.67 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr13_+_11439486 6.52 ENSDART00000138312
zbtb18
zinc finger and BTB domain containing 18
chr24_+_2801765 6.50 ENSDART00000172385
LYRM4
si:ch211-152c8.4
chr14_+_25816874 6.41 ENSDART00000005499
glra1
glycine receptor, alpha 1
chr17_-_42218652 6.13 ENSDART00000081396
ENSDART00000190007
nkx2.2a
NK2 homeobox 2a
chr23_+_23658474 5.94 ENSDART00000162838
agrn
agrin
chr20_+_34326874 5.85 ENSDART00000061659
ivns1abpa
influenza virus NS1A binding protein a
chr21_-_25601648 5.76 ENSDART00000042578
efemp2b
EGF containing fibulin extracellular matrix protein 2b
chr12_+_24562667 5.27 ENSDART00000056256
nrxn1a
neurexin 1a
chr13_+_28821841 5.04 ENSDART00000179900
CU639469.1

chr2_-_5074812 4.96 ENSDART00000163728
dlg1l
discs, large (Drosophila) homolog 1, like
chr13_+_15581270 4.81 ENSDART00000189880
ENSDART00000190067
ENSDART00000041293
mark3a
MAP/microtubule affinity-regulating kinase 3a
chr7_-_31938938 4.79 ENSDART00000132353
bdnf
brain-derived neurotrophic factor
chr19_-_15855427 4.73 ENSDART00000133059
cited4a
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr15_+_15856178 4.65 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr8_-_39952727 4.60 ENSDART00000181310
cabp1a
calcium binding protein 1a
chr3_+_50310684 4.09 ENSDART00000112152
gas7a
growth arrest-specific 7a
chr13_-_31441042 3.61 ENSDART00000076571
rtn1a
reticulon 1a
chr22_+_11857356 3.55 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr3_+_28953274 3.37 ENSDART00000133528
ENSDART00000103602
lgals2a
lectin, galactoside-binding, soluble, 2a
chr4_+_20318127 3.09 ENSDART00000028856
ENSDART00000132909
cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr14_+_23874062 3.02 ENSDART00000172149
sh3rf2
SH3 domain containing ring finger 2
chr12_-_3753131 2.96 ENSDART00000129668
fam57bb
family with sequence similarity 57, member Bb
chr2_-_42558549 2.69 ENSDART00000025997
dip2cb
disco-interacting protein 2 homolog Cb
chr1_-_16394814 2.57 ENSDART00000013024
fgf20a
fibroblast growth factor 20a
chr19_+_1184878 2.48 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr7_-_15413019 2.34 ENSDART00000172147
si:ch211-106j24.1
si:ch211-106j24.1
chr5_+_45138934 2.34 ENSDART00000041412
ENSDART00000136002
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr24_-_9689915 2.32 ENSDART00000185972
ENSDART00000093046
uba5
ubiquitin-like modifier activating enzyme 5
chr11_-_24532988 2.27 ENSDART00000067078
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr1_+_42874410 2.13 ENSDART00000153506
ctnna2
catenin (cadherin-associated protein), alpha 2
chr22_+_3238474 2.12 ENSDART00000157954
si:ch1073-178p5.3
si:ch1073-178p5.3
chr13_+_31286076 2.00 ENSDART00000142725
gdf10a
growth differentiation factor 10a
chr19_+_31904836 1.94 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tpd52
tumor protein D52
chr4_+_12617108 1.93 ENSDART00000134362
ENSDART00000112860
lmo3
LIM domain only 3
chr17_+_28882977 1.86 ENSDART00000153937
prkd1
protein kinase D1
chr14_+_36521553 1.81 ENSDART00000136233
TENM3
si:dkey-237h12.3
chr4_+_14360372 1.80 ENSDART00000007103
nuak1a
NUAK family, SNF1-like kinase, 1a
chr11_-_34521342 1.79 ENSDART00000114004
pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr24_+_26337623 1.74 ENSDART00000145637
mynn
myoneurin
chr3_+_47322494 1.73 ENSDART00000102202
ppap2d
phosphatidic acid phosphatase type 2D
chr14_-_31854830 1.68 ENSDART00000148550
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr23_-_4019699 1.61 ENSDART00000159780
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr14_+_40852497 1.61 ENSDART00000128588
ENSDART00000166065
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr19_-_22568203 1.52 ENSDART00000182888
pleca
plectin a
chr11_+_16152316 1.48 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr5_+_36693859 1.47 ENSDART00000019259
dlb
deltaB
chr7_-_50395395 1.47 ENSDART00000065868
vps33b
vacuolar protein sorting 33B
chr12_-_35095414 1.37 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr9_+_38168012 1.37 ENSDART00000102445
clasp1a
cytoplasmic linker associated protein 1a
chr15_-_14884332 1.36 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr7_-_50395059 1.34 ENSDART00000191150
vps33b
vacuolar protein sorting 33B
chr14_-_12071679 1.31 ENSDART00000165581
tmsb1
thymosin beta 1
chr18_+_12147971 1.30 ENSDART00000162067
ENSDART00000168386
fgd4a
FYVE, RhoGEF and PH domain containing 4a
chr14_-_12071447 1.29 ENSDART00000166116
tmsb1
thymosin beta 1
chr11_+_5499661 1.27 ENSDART00000027850
slc35e1
solute carrier family 35, member E1
chr15_+_4988189 1.25 ENSDART00000142995
ENSDART00000062852
spcs2
signal peptidase complex subunit 2
chr4_+_5796761 1.24 ENSDART00000164854
si:ch73-352p4.8
si:ch73-352p4.8
chr10_+_43088270 1.21 ENSDART00000191221
xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr1_+_5275811 1.20 ENSDART00000189676
spry2
sprouty RTK signaling antagonist 2
chr4_-_27129697 1.20 ENSDART00000131240
zbed4
zinc finger, BED-type containing 4
chr6_+_7553085 1.16 ENSDART00000150939
ENSDART00000151114
myh10
myosin, heavy chain 10, non-muscle
chr24_+_17140938 1.16 ENSDART00000149134
mllt10
MLLT10, histone lysine methyltransferase DOT1L cofactor
chr10_-_23358357 1.13 ENSDART00000135475
cadm2a
cell adhesion molecule 2a
chr19_-_24125457 1.10 ENSDART00000080632
zgc:64022
zgc:64022
chr12_+_17603528 1.10 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr23_+_31979602 1.04 ENSDART00000140351
pan2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr3_-_52674089 1.02 ENSDART00000154260
ENSDART00000125455
si:dkey-210j14.4
si:dkey-210j14.4
chr1_-_17711636 0.94 ENSDART00000148322
ENSDART00000122670
ufsp2
ufm1-specific peptidase 2
chr3_+_35406998 0.91 ENSDART00000102994
rbbp6
retinoblastoma binding protein 6
chr2_+_33383227 0.90 ENSDART00000183068
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_-_30897177 0.89 ENSDART00000087918
slc7a3b
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3b
chr2_-_32551178 0.89 ENSDART00000145603
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr14_+_21159693 0.85 ENSDART00000192678
zgc:136929
zgc:136929
chr21_-_13751535 0.84 ENSDART00000111666
npdc1a
neural proliferation, differentiation and control, 1a
chr19_-_17864213 0.84 ENSDART00000151043
ints8
integrator complex subunit 8
chr22_-_18116635 0.83 ENSDART00000005724
ncanb
neurocan b
chr17_+_12658411 0.79 ENSDART00000139918
gpn1
GPN-loop GTPase 1
chr9_-_6502491 0.77 ENSDART00000102672
nck2a
NCK adaptor protein 2a
chr10_-_7347311 0.77 ENSDART00000168885
nrg1
neuregulin 1
chr5_+_37379825 0.74 ENSDART00000171826
klhl13
kelch-like family member 13
chr6_-_36182115 0.71 ENSDART00000154639
brinp3a.2
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
chr22_-_14475927 0.70 ENSDART00000135768
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr3_+_43774369 0.70 ENSDART00000157964
zc3h7a
zinc finger CCCH-type containing 7A
chr20_+_3997684 0.69 ENSDART00000113184
arv1
ARV1 homolog, fatty acid homeostasis modulator
chr18_+_39327010 0.68 ENSDART00000012164
tmod2
tropomodulin 2
chr3_+_35406395 0.65 ENSDART00000055266
ENSDART00000150918
rbbp6
retinoblastoma binding protein 6
chr8_-_51507144 0.62 ENSDART00000024882
ENSDART00000135166
fgfr1a
fibroblast growth factor receptor 1a
chr7_+_41421998 0.60 ENSDART00000083967
chpf2
chondroitin polymerizing factor 2
chr13_+_30421472 0.60 ENSDART00000143569
zmiz1a
zinc finger, MIZ-type containing 1a
chr11_-_16152105 0.58 ENSDART00000081062
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr15_+_32297441 0.55 ENSDART00000153657
trim3a
tripartite motif containing 3a
chr8_-_22660678 0.52 ENSDART00000181258
iqsec2a
IQ motif and Sec7 domain 2a
chr22_-_24248420 0.52 ENSDART00000165433
rgs2
regulator of G protein signaling 2
chr16_-_39267185 0.47 ENSDART00000058550
ENSDART00000133642
gpd1l
glycerol-3-phosphate dehydrogenase 1 like
chr9_-_34121839 0.46 ENSDART00000000004
slc35a5
solute carrier family 35, member A5
chr13_+_22295905 0.44 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr11_+_6684968 0.42 ENSDART00000139454
pde4cb
phosphodiesterase 4C, cAMP-specific b
chr17_-_51260476 0.41 ENSDART00000084348
trappc12
trafficking protein particle complex 12
chr19_+_38167468 0.37 ENSDART00000160756
phf14
PHD finger protein 14
chr4_+_9178913 0.36 ENSDART00000168558
nfyba
nuclear transcription factor Y, beta a
chr16_-_45225520 0.35 ENSDART00000158855
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr24_+_17345521 0.33 ENSDART00000024722
ENSDART00000154250
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr2_-_39036604 0.30 ENSDART00000129963
rbp1
retinol binding protein 1b, cellular
chr9_+_32860345 0.30 ENSDART00000121751
si:dkey-145p14.5
si:dkey-145p14.5
chr20_+_19423823 0.29 ENSDART00000152216
znf513a
zinc finger protein 513a
chr1_-_17711361 0.29 ENSDART00000078848
ufsp2
ufm1-specific peptidase 2
chr20_-_1265562 0.27 ENSDART00000189866
lats1
large tumor suppressor kinase 1
chr5_-_41709234 0.20 ENSDART00000083656
atxn2
ataxin 2
chr19_-_7540821 0.16 ENSDART00000143958
lix1l
limb and CNS expressed 1 like
chr3_-_24909245 0.16 ENSDART00000178321
SHISA8
shisa family member 8
chr14_-_46117345 0.16 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr11_-_16152400 0.16 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr7_+_11390462 0.15 ENSDART00000114383
tlnrd1
talin rod domain containing 1
chr2_+_1988036 0.13 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr2_-_27774783 0.12 ENSDART00000161864
XKR4
zgc:123035
chr9_+_32859967 0.11 ENSDART00000168992
si:dkey-145p14.5
si:dkey-145p14.5
chr20_+_36730049 0.10 ENSDART00000045948
ncoa1
nuclear receptor coactivator 1
chr20_+_39283849 0.08 ENSDART00000002481
ENSDART00000146683
scara3
scavenger receptor class A, member 3
chr12_+_15487834 0.04 ENSDART00000181138
arhgap23b
Rho GTPase activating protein 23b
chr21_-_40174647 0.04 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
slco2b1
solute carrier organic anion transporter family, member 2B1
chr7_-_71384391 0.02 ENSDART00000112841
ccdc149a
coiled-coil domain containing 149a
chr20_-_8365244 0.01 ENSDART00000167102
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.2 GO:0071361 cellular response to ethanol(GO:0071361)
3.8 15.4 GO:0060074 synapse maturation(GO:0060074)
2.0 6.1 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.0 5.9 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.8 13.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.6 8.2 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.6 3.1 GO:0014896 muscle hypertrophy(GO:0014896)
0.6 6.6 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.6 7.8 GO:0016199 axon midline choice point recognition(GO:0016199)
0.6 12.8 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.5 2.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.5 2.3 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.5 10.4 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.4 4.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 1.9 GO:1901490 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
0.3 9.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 5.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 1.0 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.3 2.6 GO:0042989 sequestering of actin monomers(GO:0042989)
0.3 2.6 GO:0046850 regulation of bone remodeling(GO:0046850)
0.3 0.8 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.3 14.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.2 1.2 GO:0051103 DNA ligation(GO:0006266) immunoglobulin V(D)J recombination(GO:0033152) DNA ligation involved in DNA repair(GO:0051103)
0.2 3.4 GO:0090303 positive regulation of wound healing(GO:0090303)
0.2 5.0 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 0.9 GO:0060080 inhibitory postsynaptic potential(GO:0060080) regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 11.2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.2 0.6 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.2 1.2 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 1.8 GO:0048696 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.1 0.9 GO:1902837 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.1 0.5 GO:0090299 regulation of neural crest formation(GO:0090299)
0.1 1.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 1.2 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 0.5 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.1 2.8 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 0.9 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 0.7 GO:0032366 intracellular sterol transport(GO:0032366)
0.1 0.9 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 1.9 GO:0030183 B cell differentiation(GO:0030183)
0.1 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 10.8 GO:0006979 response to oxidative stress(GO:0006979)
0.1 1.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 1.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 1.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277) intestinal epithelial structure maintenance(GO:0060729)
0.1 0.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 1.5 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 3.0 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 1.1 GO:0006298 mismatch repair(GO:0006298)
0.0 0.6 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.7 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 1.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.3 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.6 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 1.4 GO:1902850 establishment of mitotic spindle localization(GO:0040001) mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 0.8 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.5 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.4 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.3 GO:0046620 regulation of organ growth(GO:0046620)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 5.4 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 2.3 GO:0002040 sprouting angiogenesis(GO:0002040)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.3 GO:0005955 calcineurin complex(GO:0005955)
0.9 9.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.9 13.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.6 2.8 GO:0033263 CORVET complex(GO:0033263)
0.5 34.0 GO:0034707 chloride channel complex(GO:0034707)
0.5 1.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.4 1.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.3 1.0 GO:0031251 PAN complex(GO:0031251)
0.2 0.9 GO:0005787 signal peptidase complex(GO:0005787)
0.2 1.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 1.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 5.0 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 1.1 GO:0032300 mismatch repair complex(GO:0032300)
0.1 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 7.8 GO:0055037 recycling endosome(GO:0055037)
0.1 1.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.7 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.9 GO:0071564 npBAF complex(GO:0071564)
0.1 17.0 GO:0030424 axon(GO:0030424)
0.0 3.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 4.1 GO:0005884 actin filament(GO:0005884)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 5.3 GO:0030425 dendrite(GO:0030425)
0.0 0.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)
0.0 18.4 GO:0005615 extracellular space(GO:0005615)
0.0 4.0 GO:0000785 chromatin(GO:0000785)
0.0 0.7 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.6 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 21.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
2.2 13.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.9 12.8 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.7 8.2 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.7 13.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.5 14.0 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.4 4.8 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.3 7.9 GO:0043236 laminin binding(GO:0043236)
0.2 7.8 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.2 4.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.2 4.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 1.8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.2 1.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.9 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.5 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 2.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 1.5 GO:0030506 ankyrin binding(GO:0030506)
0.1 3.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 3.6 GO:0019003 GDP binding(GO:0019003)
0.1 14.5 GO:0008083 growth factor activity(GO:0008083)
0.1 9.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.6 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.1 1.7 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.7 GO:0035198 miRNA binding(GO:0035198)
0.1 1.9 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.6 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 5.0 GO:0019902 phosphatase binding(GO:0019902)
0.1 1.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.5 GO:0005112 Notch binding(GO:0005112)
0.0 2.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 23.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 6.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 11.8 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 13.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 39.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 1.2 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.5 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.2 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 8.3 GO:0003924 GTPase activity(GO:0003924)
0.0 1.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0015297 antiporter activity(GO:0015297)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 14.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 1.9 PID IGF1 PATHWAY IGF1 pathway
0.2 4.8 PID SHP2 PATHWAY SHP2 signaling
0.1 5.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 5.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 1.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.7 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 40.6 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.4 5.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.2 6.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.8 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 1.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 0.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 1.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 3.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo