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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for cebpd

Z-value: 1.16

Motif logo

Transcription factors associated with cebpd

Gene Symbol Gene ID Gene Info
ENSDARG00000087303 CCAAT enhancer binding protein delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cebpddr11_v1_chr24_+_35564668_355646680.056.1e-01Click!

Activity profile of cebpd motif

Sorted Z-values of cebpd motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_63509581 24.84 ENSDART00000097325
complement component 5
chr1_-_10071422 22.85 ENSDART00000135522
ENSDART00000033118
fibrinogen alpha chain
chr20_+_23440632 22.11 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr8_-_39739627 20.95 ENSDART00000135422
ENSDART00000067844
si:ch211-170d8.5
chr16_+_23984755 16.88 ENSDART00000145328
apolipoprotein C-II
chr14_+_16345003 16.83 ENSDART00000003040
ENSDART00000165193
intelectin 3
chr4_-_17409533 13.96 ENSDART00000011943
phenylalanine hydroxylase
chr16_-_27749172 13.23 ENSDART00000145198
STEAP family member 4
chr20_-_40755614 12.01 ENSDART00000061247
connexin 32.3
chr20_-_40750953 11.42 ENSDART00000061256
connexin 28.9
chr16_+_44298902 11.17 ENSDART00000114795
dihydropyrimidinase
chr21_+_17051478 11.01 ENSDART00000047201
ENSDART00000161650
ENSDART00000167298
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
chr22_-_26175237 10.41 ENSDART00000108737
complement component c3b, tandem duplicate 2
chr14_+_21106444 9.17 ENSDART00000075744
ENSDART00000132363
aldolase b, fructose-bisphosphate
chr14_+_21107032 9.02 ENSDART00000138319
ENSDART00000139103
ENSDART00000184735
aldolase b, fructose-bisphosphate
chr5_-_69948099 8.79 ENSDART00000034639
ENSDART00000191111
UDP glucuronosyltransferase 2 family, polypeptide A4
chr16_+_50289916 8.72 ENSDART00000168861
ENSDART00000167332
hepcidin antimicrobial peptide
chr22_-_17595310 8.70 ENSDART00000099056
glutathione peroxidase 4a
chr16_+_23984179 8.66 ENSDART00000175879
apolipoprotein C-II
chr6_+_10333920 7.87 ENSDART00000151667
ENSDART00000151477
cordon-bleu WH2 repeat protein-like 1a
chr24_-_32665283 7.73 ENSDART00000038364
carbonic anhydrase II
chr9_-_9225980 7.56 ENSDART00000180301
cystathionine-beta-synthase b
chr4_-_17391091 7.19 ENSDART00000056002
tyrosine hydroxylase 2
chr7_+_67733759 6.94 ENSDART00000172015
cytochrome b5 type B
chr15_-_29348212 6.25 ENSDART00000133117
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr8_+_17884569 5.93 ENSDART00000134660
solute carrier family 44, member 5b
chr21_-_39058490 5.55 ENSDART00000114885
aldehyde dehydrogenase 3 family, member A2b
chr17_-_6076084 5.51 ENSDART00000058890
epoxide hydrolase 2, cytoplasmic
chr8_+_30699429 5.51 ENSDART00000005345
ureidopropionase, beta
chr2_-_51772438 5.34 ENSDART00000170241
Danio rerio three-finger protein 5 (LOC100003647), mRNA.
chr17_-_6076266 5.24 ENSDART00000171084
epoxide hydrolase 2, cytoplasmic
chr9_+_38292947 5.04 ENSDART00000146663
transcription factor CP2-like 1
chr22_+_15336752 4.89 ENSDART00000139070
sulfotransferase family 3, cytosolic sulfotransferase 2
chr12_+_4920451 4.86 ENSDART00000171525
ENSDART00000159986
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr2_-_37277626 4.80 ENSDART00000135340
NAD kinase b
chr6_+_9130989 4.67 ENSDART00000162588
regucalcin
chr8_+_42917515 4.63 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr9_-_53062083 4.38 ENSDART00000122155
zmp:0000000936
chr20_+_25563105 4.29 ENSDART00000063100
cytochrome P450, family 2, subfamily P, polypeptide 6
chr5_+_8196264 4.25 ENSDART00000174564
ENSDART00000161261
LMBR1 domain containing 2a
chr25_-_12805295 4.21 ENSDART00000157629
carbonic anhydrase Va
chr5_+_25585869 3.84 ENSDART00000138060
si:dkey-229d2.7
chr7_-_7823662 3.75 ENSDART00000167652
chemokine (C-X-C motif) ligand 8b, duplicate 3
chr12_+_46960579 3.72 ENSDART00000149032
ornithine aminotransferase
chr20_-_19511700 3.71 ENSDART00000040191
sorting nexin 17
chr17_+_10318071 3.66 ENSDART00000161844
forkhead box A1
chr12_+_25775734 3.56 ENSDART00000024415
ENSDART00000149198
endothelial PAS domain protein 1a
chr5_-_43935460 3.38 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
chr5_+_51111343 3.18 ENSDART00000092002
protein-O-mannosyltransferase 1
chr15_-_17869115 3.14 ENSDART00000112838
activating transcription factor 5b
chr3_+_36972298 3.02 ENSDART00000150917
si:ch211-18i17.2
chr15_-_17868870 2.99 ENSDART00000170950
activating transcription factor 5b
chr12_-_22238004 2.90 ENSDART00000038310
ORMDL sphingolipid biosynthesis regulator 3
chr15_-_17960228 2.90 ENSDART00000155898
pleckstrin homology-like domain, family B, member 1b
chr16_-_17072440 2.89 ENSDART00000002493
ENSDART00000178443
tumor necrosis factor receptor superfamily, member 1a
chr10_+_38526496 2.87 ENSDART00000144329
alkaline ceramidase 3
chr5_+_51111766 2.78 ENSDART00000188552
protein-O-mannosyltransferase 1
chr7_-_39751540 2.74 ENSDART00000016803
GrpE-like 1, mitochondrial
chr12_-_17592215 2.74 ENSDART00000134597
ubiquitin specific peptidase 42
chr9_+_2574122 2.63 ENSDART00000166326
ENSDART00000191822
si:ch73-167c12.2
chr3_+_19216567 2.63 ENSDART00000134433
interleukin 12 receptor, beta 2a, like
chr24_-_36727922 2.60 ENSDART00000135142
si:ch73-334d15.1
chr11_+_43419809 2.58 ENSDART00000172982
solute carrier family 29 (equilibrative nucleoside transporter), member 1b
chr5_-_54395488 2.50 ENSDART00000160781
zinc finger, MYND-type containing 19
chr9_+_9502610 2.41 ENSDART00000061525
ENSDART00000125174
nuclear receptor subfamily 1, group I, member 2
chr19_+_1370504 2.37 ENSDART00000158946
diacylglycerol O-acyltransferase 1a
chr7_-_46019756 2.28 ENSDART00000162583
zgc:162297
chr6_+_44197348 2.24 ENSDART00000075486
protein phosphatase 4, regulatory subunit 2b
chr17_+_18031899 2.20 ENSDART00000022758
SET domain containing 3
chr14_-_38929885 2.20 ENSDART00000148737
Bruton agammaglobulinemia tyrosine kinase
chr5_-_43935119 2.17 ENSDART00000142271
si:ch211-204c21.1
chr7_-_52963493 2.07 ENSDART00000052029
cocaine- and amphetamine-regulated transcript 3
chr21_-_14762944 2.05 ENSDART00000114096
arrestin domain containing 1b
chr19_+_46259619 2.04 ENSDART00000158032
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr17_-_10838434 2.03 ENSDART00000064597
lectin, galactoside binding soluble 3b
chr9_-_7238839 2.01 ENSDART00000142726
cellular repressor of E1A-stimulated genes 2
chr13_-_30996072 1.97 ENSDART00000181661
WDFY family member 4
chr7_+_15736230 1.94 ENSDART00000109942
multiple C2 domains, transmembrane 2b
chr8_+_23703464 1.94 ENSDART00000132584
peroxisome proliferator-activated receptor delta b
chr12_-_1085227 1.93 ENSDART00000169936
SRY (sex determining region Y)-box 8a
chr7_+_65240227 1.91 ENSDART00000168287
beta-carotene oxygenase 1, like
chr6_-_39649504 1.90 ENSDART00000179960
ENSDART00000190951
La ribonucleoprotein domain family, member 4Ab
chr1_+_14253118 1.87 ENSDART00000161996
chemokine (C-X-C motif) ligand 8a
chr14_-_38809561 1.83 ENSDART00000159159
SIL1 nucleotide exchange factor
chr3_+_36972586 1.81 ENSDART00000102784
si:ch211-18i17.2
chr20_+_37820992 1.79 ENSDART00000064692
TatD DNase domain containing 3
chr20_-_33675676 1.78 ENSDART00000147168
rho-associated, coiled-coil containing protein kinase 2b
chr6_+_44197099 1.76 ENSDART00000124168
protein phosphatase 4, regulatory subunit 2b
chr11_-_6265574 1.63 ENSDART00000181974
ENSDART00000104405
chemokine (C-C motif) ligand 25b
chr19_+_8606883 1.60 ENSDART00000054469
ENSDART00000185264
S100 calcium binding protein A10a
chr13_-_25548733 1.60 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
minichromosome maintenance complex binding protein
chr22_-_16377960 1.59 ENSDART00000168170
tetratricopeptide repeat domain 39C
chr20_-_45661049 1.56 ENSDART00000124582
ENSDART00000131251
N-ethylmaleimide-sensitive factor attachment protein, beta b
chr6_+_11397269 1.54 ENSDART00000114260
SUMO1/sentrin/SMT3 specific peptidase 2
chr19_-_20446756 1.54 ENSDART00000140711
TBC1 domain family, member 5
chr11_+_13176568 1.54 ENSDART00000125371
ENSDART00000123257
MAP kinase interacting serine/threonine kinase 1
chr2_-_10098191 1.53 ENSDART00000138081
B-cell CLL/lymphoma 6a, genome duplicate b
chr7_+_38089650 1.50 ENSDART00000052365
CCAAT/enhancer binding protein (C/EBP), gamma
chr7_-_37895771 1.48 ENSDART00000084282
PAP associated domain containing 5
chr24_-_39772045 1.48 ENSDART00000087441
si:ch211-276f18.2
chr14_+_7902374 1.48 ENSDART00000113299
zgc:110843
chr14_-_8890437 1.47 ENSDART00000167242
si:ch73-45o6.2
chr3_-_30152836 1.45 ENSDART00000165920
nucleobindin 1
chr5_-_23574234 1.44 ENSDART00000002453
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr2_-_7246848 1.42 ENSDART00000146434
zgc:153115
chr23_+_44732863 1.36 ENSDART00000160044
ENSDART00000172268
ATPase Na+/K+ transporting subunit beta 2a
chr25_+_3294150 1.34 ENSDART00000030683
thymopoietin b
chr19_-_15192638 1.29 ENSDART00000048151
phosphatase and actin regulator 4a
chr8_+_4368534 1.26 ENSDART00000015214
PTC7 protein phosphatase homolog a
chr3_-_30153242 1.24 ENSDART00000077089
nucleobindin 1
chr24_-_31123365 1.23 ENSDART00000182947
transmembrane protein 56a
chr22_+_10158502 1.23 ENSDART00000005869
ribonuclease P/MRP 14 subunit
chr12_+_13205955 1.23 ENSDART00000092906
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr18_-_16922905 1.22 ENSDART00000187165
WEE1 G2 checkpoint kinase
chr15_+_20543770 1.21 ENSDART00000092357
small G protein signaling modulator 2
chr12_+_17154655 1.18 ENSDART00000028003
ankyrin repeat domain 22
chr5_-_45894802 1.17 ENSDART00000097648
cytokine receptor family member b6
chr5_-_26893310 1.15 ENSDART00000126669
lectin, mannose-binding 2-like b
chr1_+_26071869 1.15 ENSDART00000059264
MAX dimerization protein 4
chr20_-_27381691 1.13 ENSDART00000010293
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a
chr7_-_22790630 1.13 ENSDART00000173496
si:ch211-15b10.6
chr7_+_23580082 1.13 ENSDART00000183245
si:dkey-172j4.3
chr22_+_15973122 1.10 ENSDART00000144545
ring finger and CCCH-type domains 1a
chr13_-_32898962 1.06 ENSDART00000163757
rho-associated, coiled-coil containing protein kinase 2a
chr16_-_7793457 1.03 ENSDART00000113483
tripartite motif containing 71, E3 ubiquitin protein ligase
chr11_+_39135050 1.02 ENSDART00000180571
ENSDART00000189685
cell division cycle 42
chr5_-_48680580 0.99 ENSDART00000031194
LysM, putative peptidoglycan-binding, domain containing 3
chr7_-_7845540 0.93 ENSDART00000166280
chemokine (C-X-C motif) ligand 8b, duplicate 1
chr16_+_14029283 0.92 ENSDART00000146165
ENSDART00000132075
RUN and SH3 domain containing 1
chr20_-_25533739 0.89 ENSDART00000063064
cytochrome P450, family 2, subfamily AD, polypeptide 6
chr9_-_12034444 0.83 ENSDART00000038651
zinc finger protein 804A
chr14_-_5642371 0.83 ENSDART00000183859
ENSDART00000054876
nucleophosmin 1b
chr13_-_18195942 0.79 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr4_-_14207471 0.77 ENSDART00000015134
twinfilin actin-binding protein 1b
chr17_-_20236228 0.77 ENSDART00000136490
ENSDART00000029380
BCL2 interacting protein 4
chr18_+_507835 0.77 ENSDART00000189701
neural precursor cell expressed, developmentally down-regulated 4a
chr8_-_23702295 0.76 ENSDART00000162296
complement factor properdin
chr2_-_36819624 0.74 ENSDART00000140844
SLIT and NTRK-like family, member 3b
chr17_-_42799104 0.74 ENSDART00000154755
protein kinase D3
chr12_-_13205572 0.74 ENSDART00000152670
pelota mRNA surveillance and ribosome rescue factor
chr3_+_41731527 0.72 ENSDART00000049007
ENSDART00000187866
carbohydrate (chondroitin 4) sulfotransferase 12a
chr19_+_16064439 0.66 ENSDART00000151169
glucocorticoid modulatory element binding protein 1
chr8_+_12930216 0.65 ENSDART00000115405
zgc:103670
chr22_-_10158038 0.65 ENSDART00000047444
RanBP-type and C3HC4-type zinc finger containing 1
chr10_-_29733194 0.64 ENSDART00000149252
si:ch73-261i21.2
chr3_-_43821191 0.63 ENSDART00000186816
stannin
chr20_-_33961697 0.61 ENSDART00000061765
selectin P
chr12_-_13205854 0.61 ENSDART00000077829
pelota mRNA surveillance and ribosome rescue factor
chr16_+_46111849 0.60 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr17_+_23975762 0.60 ENSDART00000155941
exportin 1 (CRM1 homolog, yeast) b
chr2_-_24348948 0.60 ENSDART00000136559
anoctamin 8a
chr21_-_43550120 0.59 ENSDART00000151627
si:ch73-362m14.2
chr17_+_43013171 0.59 ENSDART00000055541
gsk3b interacting protein
chr13_-_25842074 0.58 ENSDART00000015154
poly(A) polymerase gamma
chr3_-_31079186 0.52 ENSDART00000145636
ENSDART00000140569
elongin B
elongin B
chr17_+_28670132 0.46 ENSDART00000076344
ENSDART00000164981
ENSDART00000182851
HECT domain containing 1
chr9_-_32300611 0.46 ENSDART00000127938
heat shock 60 protein 1
chr4_-_5302866 0.39 ENSDART00000138590
si:ch211-214j24.9
chr8_-_23701880 0.38 ENSDART00000139897
si:ch73-237c6.1
chr2_+_11029138 0.37 ENSDART00000138737
ENSDART00000081058
ENSDART00000153662
acyl-CoA thioesterase 11a
chr5_-_29488245 0.37 ENSDART00000047719
ENSDART00000141154
ENSDART00000171165
calcium channel, voltage-dependent, N type, alpha 1B subunit, a
chr2_-_50298337 0.35 ENSDART00000155125
contactin associated protein like 2b
chr11_+_23933016 0.35 ENSDART00000000486
contactin 2
chr6_+_8314451 0.35 ENSDART00000147793
ENSDART00000183688
glutaryl-CoA dehydrogenase a
chr2_-_4032732 0.34 ENSDART00000158335
RAB18B, member RAS oncogene family
chr16_-_27138478 0.34 ENSDART00000147438
transmembrane protein 245
chr22_+_24645325 0.34 ENSDART00000159531
lysophosphatidic acid receptor 3
chr5_+_32162684 0.33 ENSDART00000134472
TAO kinase 3b
chr7_+_12950507 0.29 ENSDART00000067629
ENSDART00000158004
serum amyloid A
chr10_-_20523405 0.29 ENSDART00000114824
DDHD domain containing 2
chr18_-_46369516 0.29 ENSDART00000018163
interferon regulatory factor 2 binding protein 1
chr5_-_43682930 0.28 ENSDART00000075017
si:dkey-40c11.1
chr4_-_5302162 0.23 ENSDART00000177099
si:ch211-214j24.9
chr24_-_15648636 0.22 ENSDART00000136200
cerebellin 2b precursor
chr4_+_21867522 0.21 ENSDART00000140400
acyl-CoA synthetase short chain family member 3
chr24_+_11083146 0.17 ENSDART00000009473
zinc finger, AN1-type domain 1
chr19_-_9829965 0.17 ENSDART00000136842
ENSDART00000142766
calcium channel, voltage-dependent, gamma subunit 8a
chr5_-_69437422 0.16 ENSDART00000073676
iron-sulfur cluster assembly 1
chr18_+_16330025 0.15 ENSDART00000142353
neurotensin
chr9_-_35069645 0.13 ENSDART00000122679
ENSDART00000077908
ENSDART00000077894
ENSDART00000125536
amyloid beta (A4) precursor protein b
chr6_-_11780070 0.12 ENSDART00000151195
membrane-associated ring finger (C3HC4) 7
chr20_+_2950005 0.12 ENSDART00000135919
adenosylmethionine decarboxylase 1
chr24_+_119680 0.12 ENSDART00000061973
transforming growth factor, beta receptor 1 b
chr3_-_46818001 0.12 ENSDART00000166505
ELAV like neuron-specific RNA binding protein 3
chr24_+_38671054 0.10 ENSDART00000154214
si:ch73-70c5.1
chr23_-_36003282 0.08 ENSDART00000103150
calcium binding and coiled-coil domain 1a
chr9_-_32300783 0.06 ENSDART00000078596
heat shock 60 protein 1
chr13_+_40437550 0.02 ENSDART00000057090
ENSDART00000167859
glutamic-oxaloacetic transaminase 1, soluble
chr2_-_30460293 0.02 ENSDART00000113193
cerebellin 2a precursor
chr8_-_31716302 0.02 ENSDART00000061832
si:dkey-46a10.3
chr4_+_71989418 0.00 ENSDART00000170996
poly(ADP-ribose) polymerase family member 11

Network of associatons between targets according to the STRING database.

First level regulatory network of cebpd

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.2 GO:0015677 copper ion import(GO:0015677)
3.1 9.3 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
2.5 7.6 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
2.4 7.2 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
1.9 7.7 GO:0015670 carbon dioxide transport(GO:0015670)
1.6 4.8 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
1.6 6.3 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
1.5 22.8 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
1.3 25.5 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
1.2 8.7 GO:0032570 response to progesterone(GO:0032570)
1.2 14.0 GO:0006570 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) tyrosine metabolic process(GO:0006570) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
1.1 5.5 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.8 18.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.7 11.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.7 2.9 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.7 4.8 GO:0006741 NADP biosynthetic process(GO:0006741)
0.5 1.6 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
0.4 2.6 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.4 3.7 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.4 2.0 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.4 10.7 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) venous blood vessel development(GO:0060841)
0.4 1.6 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.4 6.0 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.4 3.7 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.4 1.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) mediolateral intercalation(GO:0060031)
0.3 1.4 GO:0032790 ribosome disassembly(GO:0032790)
0.3 4.7 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.3 5.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.3 2.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 2.8 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.2 2.9 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.2 1.9 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.2 1.9 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.2 1.0 GO:0010586 miRNA metabolic process(GO:0010586)
0.2 1.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 4.9 GO:0051923 sulfation(GO:0051923)
0.2 1.4 GO:0008343 adult feeding behavior(GO:0008343) negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.2 1.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.8 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.2 2.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 3.5 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 3.6 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 0.5 GO:0032755 positive regulation of interleukin-6 production(GO:0032755) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.7 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.3 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 1.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 4.2 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.1 1.8 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.1 0.6 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.1 5.2 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 5.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.3 GO:0006953 acute-phase response(GO:0006953)
0.1 1.5 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 7.5 GO:0008016 regulation of heart contraction(GO:0008016)
0.1 1.4 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 2.4 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.4 GO:0099612 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 2.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 3.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 1.6 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.9 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.3 GO:0031106 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.0 0.8 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.0 1.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 2.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 1.8 GO:0048741 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.6 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 2.9 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 2.2 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 1.2 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 1.2 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 1.1 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 4.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.7 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 0.7 GO:0016051 carbohydrate biosynthetic process(GO:0016051)
0.0 0.5 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 2.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.8 GO:0005577 fibrinogen complex(GO:0005577)
2.6 25.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
1.3 4.0 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.7 2.9 GO:0035339 SPOTS complex(GO:0035339)
0.7 2.7 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.4 9.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 1.6 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.3 2.0 GO:0001772 immunological synapse(GO:0001772)
0.2 7.2 GO:0043204 perikaryon(GO:0043204)
0.1 1.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 2.9 GO:0045180 basal cortex(GO:0045180)
0.1 1.4 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.1 1.6 GO:0042555 MCM complex(GO:0042555)
0.1 10.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.6 GO:0071797 LUBAC complex(GO:0071797)
0.1 3.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 13.2 GO:0010008 endosome membrane(GO:0010008)
0.1 0.5 GO:0070449 elongin complex(GO:0070449)
0.1 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 3.7 GO:0005769 early endosome(GO:0005769)
0.0 1.0 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 2.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 13.0 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 36.0 GO:0005615 extracellular space(GO:0005615)
0.0 2.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.7 GO:0005764 lysosome(GO:0005764)
0.0 2.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 8.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0004301 epoxide hydrolase activity(GO:0004301)
3.3 13.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
2.3 21.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
2.3 18.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
2.2 8.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
1.7 8.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.6 6.6 GO:0005153 interleukin-8 receptor binding(GO:0005153)
1.5 7.6 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.9 11.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.9 4.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.7 16.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.6 11.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.6 2.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.6 5.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.5 2.9 GO:0017040 ceramidase activity(GO:0017040)
0.4 11.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 6.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.4 2.0 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.4 2.0 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.4 2.8 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.3 2.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 2.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.2 1.9 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.2 11.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 33.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.2 5.9 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 0.6 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 2.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 3.7 GO:0008483 transaminase activity(GO:0008483)
0.1 1.2 GO:0005537 mannose binding(GO:0005537)
0.1 6.9 GO:0009055 electron carrier activity(GO:0009055)
0.1 1.0 GO:0035198 miRNA binding(GO:0035198)
0.1 1.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.5 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 5.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 1.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.3 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 5.6 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 26.1 GO:0008047 enzyme activator activity(GO:0008047)
0.1 2.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 3.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
0.0 4.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 7.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 3.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.0 1.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.6 GO:0019955 cytokine binding(GO:0019955)
0.0 2.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 2.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 3.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.6 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 3.1 GO:0004518 nuclease activity(GO:0004518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 22.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 21.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 2.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 0.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 25.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
2.1 16.7 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
1.9 22.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.0 11.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.9 23.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 18.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 3.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 2.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 5.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 14.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall