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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for creb3l1

Z-value: 0.90

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Transcription factors associated with creb3l1

Gene Symbol Gene ID Gene Info
creb3l1
ENSDARG00000015793 cAMP responsive element binding protein 3-like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
creb3l1dr11_v1_chr7_+_38897836_38897836-0.151.5e-01Click!

Activity profile of creb3l1 motif

Sorted Z-values of creb3l1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_2886937 17.27 ENSDART00000063533
aqp12
aquaporin 12
chr1_-_7930679 8.10 ENSDART00000146090
si:dkey-79f11.10
si:dkey-79f11.10
chr18_-_34549721 8.09 ENSDART00000137101
ENSDART00000021880
ssr3
signal sequence receptor, gamma
chr21_+_10702031 8.05 ENSDART00000102304
lman1
lectin, mannose-binding, 1
chr21_+_10701834 7.66 ENSDART00000192473
lman1
lectin, mannose-binding, 1
chr16_+_19637384 7.28 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr18_-_7031409 5.81 ENSDART00000148485
ENSDART00000005405
calub
calumenin b
chr23_-_31266586 5.49 ENSDART00000139746
si:dkey-261l7.2
si:dkey-261l7.2
chr6_+_13506841 5.44 ENSDART00000032331
gmppab
GDP-mannose pyrophosphorylase Ab
chr14_-_45464112 5.43 ENSDART00000173209
ehd1a
EH-domain containing 1a
chr4_+_25651720 5.19 ENSDART00000100693
ENSDART00000100717
acot16
acyl-CoA thioesterase 16
chr4_-_26095755 4.86 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
si:ch211-244b2.3
chr6_-_50685862 4.82 ENSDART00000134146
mtss1
metastasis suppressor 1
chr12_-_17479078 4.65 ENSDART00000079115
papss2b
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr21_-_43636595 4.48 ENSDART00000151115
ENSDART00000151486
ENSDART00000151778
si:ch1073-263o8.2
si:ch1073-263o8.2
chr1_+_54124209 4.43 ENSDART00000187730
LO017722.1

chr9_-_29497916 4.23 ENSDART00000060246
dnajc3a
DnaJ (Hsp40) homolog, subfamily C, member 3a
chr25_+_37443194 3.96 ENSDART00000163178
ENSDART00000190262
slc10a3
solute carrier family 10, member 3
chr25_-_3034668 3.90 ENSDART00000053405
scamp2
secretory carrier membrane protein 2
chr18_-_7481036 3.88 ENSDART00000101292
si:dkey-238c7.16
si:dkey-238c7.16
chr5_-_48680580 3.86 ENSDART00000031194
lysmd3
LysM, putative peptidoglycan-binding, domain containing 3
chr4_+_13568469 3.75 ENSDART00000171235
ENSDART00000136152
calua
calumenin a
chr4_-_17812131 3.66 ENSDART00000025731
spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr5_+_32924669 3.66 ENSDART00000085219
lmo4a
LIM domain only 4a
chr4_+_11464255 3.58 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr3_+_32862730 3.25 ENSDART00000144939
ENSDART00000125126
ENSDART00000144531
ENSDART00000141717
ENSDART00000137599
zgc:162613
zgc:162613
chr3_-_26183699 3.14 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
si:ch211-11k18.4
chr1_+_277731 3.11 ENSDART00000133431
cenpe
centromere protein E
chr4_+_68562464 3.10 ENSDART00000192954
BX548011.4

chr23_-_25798099 2.95 ENSDART00000041833
fitm2
fat storage-inducing transmembrane protein 2
chr1_-_18592068 2.70 ENSDART00000082063
fam114a1
family with sequence similarity 114, member A1
chr20_-_22464250 2.70 ENSDART00000165904
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr18_+_2153530 2.70 ENSDART00000158255
pygo1
pygopus family PHD finger 1
chr7_-_30177691 2.68 ENSDART00000046689
tmed3
transmembrane p24 trafficking protein 3
chr22_+_30446987 2.67 ENSDART00000146471
si:dkey-169i5.4
si:dkey-169i5.4
chr5_-_39474235 2.67 ENSDART00000171557
antxr2a
anthrax toxin receptor 2a
chr15_-_18115540 2.63 ENSDART00000131639
ENSDART00000047902
arcn1b
archain 1b
chr10_-_3427589 2.57 ENSDART00000133452
ENSDART00000037183
tmed2
transmembrane p24 trafficking protein 2
chr22_+_31059919 2.54 ENSDART00000077063
sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr7_+_18100996 2.42 ENSDART00000055810
rab1ba
zRAB1B, member RAS oncogene family a
chr10_+_31646020 2.34 ENSDART00000115251
esama
endothelial cell adhesion molecule a
chr23_-_306796 2.30 ENSDART00000143125
anks1aa
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr19_+_33139164 2.30 ENSDART00000043039
fam84b
family with sequence similarity 84, member B
chr7_-_45990681 2.25 ENSDART00000165441
si:ch211-260e23.7
si:ch211-260e23.7
chr17_-_28797395 2.25 ENSDART00000134735
scfd1
sec1 family domain containing 1
chr13_-_9875538 2.20 ENSDART00000041609
tm9sf3
transmembrane 9 superfamily member 3
chr5_-_30516646 2.18 ENSDART00000014666
arcn1a
archain 1a
chr8_+_47219107 2.15 ENSDART00000146018
ENSDART00000075068
mthfr
methylenetetrahydrofolate reductase (NAD(P)H)
chr22_-_21897203 2.10 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr3_-_180860 1.99 ENSDART00000059956
ENSDART00000192506
kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr5_-_28968964 1.93 ENSDART00000184936
ENSDART00000016628
fam129bb
family with sequence similarity 129, member Bb
chr17_+_10090638 1.85 ENSDART00000169522
ENSDART00000160156
sec23a
Sec23 homolog A, COPII coat complex component
chr3_-_26184018 1.84 ENSDART00000191604
si:ch211-11k18.4
si:ch211-11k18.4
chr11_-_2456656 1.84 ENSDART00000171219
ENSDART00000167938
slc2a10
solute carrier family 2 (facilitated glucose transporter), member 10
chr17_-_11417551 1.82 ENSDART00000128291
arid4a
AT rich interactive domain 4A (RBP1-like)
chr5_+_58996765 1.80 ENSDART00000062175
derl2
derlin 2
chr12_-_35582683 1.72 ENSDART00000167933
sec24c
SEC24 homolog C, COPII coat complex component
chr3_+_26123736 1.70 ENSDART00000010477
hsp70.3
heat shock cognate 70-kd protein, tandem duplicate 3
chr12_+_30789611 1.68 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr18_-_18587745 1.51 ENSDART00000191973
sf3b3
splicing factor 3b, subunit 3
chr12_-_35582521 1.51 ENSDART00000162175
ENSDART00000168958
sec24c
SEC24 homolog C, COPII coat complex component
chr20_+_22799857 1.50 ENSDART00000058527
scfd2
sec1 family domain containing 2
chr4_+_58576146 1.42 ENSDART00000164911
si:ch211-212k5.4
si:ch211-212k5.4
chr24_+_854877 1.37 ENSDART00000188408
piezo2a.2
piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2
chr25_-_37331513 1.34 ENSDART00000111862
ldlrad3
low density lipoprotein receptor class A domain containing 3
chr7_-_45990386 1.32 ENSDART00000186008
si:ch211-260e23.7
si:ch211-260e23.7
chr22_-_10482253 1.24 ENSDART00000143164
aspn
asporin (LRR class 1)
chr15_-_41245962 1.17 ENSDART00000155359
smco4
single-pass membrane protein with coiled-coil domains 4
chr22_-_1168291 1.11 ENSDART00000167724
si:ch1073-181h11.4
si:ch1073-181h11.4
chr14_-_26411918 1.11 ENSDART00000020582
tmed9
transmembrane p24 trafficking protein 9
chr4_-_5795309 1.08 ENSDART00000039987
pgm3
phosphoglucomutase 3
chr20_+_43083745 1.00 ENSDART00000139014
ENSDART00000153438
moxd1l
monooxygenase, DBH-like 1, like
chr14_+_8594367 0.87 ENSDART00000037749
stx5a
syntaxin 5A
chr21_+_11105007 0.86 ENSDART00000128859
ENSDART00000193105
prlra
prolactin receptor a
chr18_+_7553950 0.80 ENSDART00000193420
ENSDART00000062143
zgc:77650
zgc:77650
chr6_+_3864040 0.60 ENSDART00000013743
gorasp2
golgi reassembly stacking protein 2
chr20_+_22799641 0.53 ENSDART00000131132
scfd2
sec1 family domain containing 2
chr4_-_2637689 0.43 ENSDART00000192550
ENSDART00000021953
ENSDART00000150344
cog5
component of oligomeric golgi complex 5
chr14_-_45595711 0.42 ENSDART00000074038
scyl1
SCY1-like, kinase-like 1
chr4_+_2637947 0.41 ENSDART00000130623
dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr21_+_5932140 0.41 ENSDART00000193767
rexo4
REX4 homolog, 3'-5' exonuclease
chr18_-_21097663 0.38 ENSDART00000060196
anpepa
alanyl (membrane) aminopeptidase a
chr15_+_23784842 0.30 ENSDART00000192889
ENSDART00000138375
ift20
intraflagellar transport 20 homolog (Chlamydomonas)
chr20_+_34511678 0.27 ENSDART00000061588
prrx1b
paired related homeobox 1b
chr18_-_3542435 0.17 ENSDART00000184017
dcun1d5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr1_-_49649122 0.16 ENSDART00000134399
slkb
STE20-like kinase b
chr17_+_30448452 0.12 ENSDART00000153939
lpin1
lipin 1
chr9_+_8898835 0.10 ENSDART00000147820
naxd
NAD(P)HX dehydratase
chr22_-_14346575 0.07 ENSDART00000136326
si:dkeyp-122a9.1
si:dkeyp-122a9.1
chr16_+_24684107 0.02 ENSDART00000183920
ywhabl
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like

Network of associatons between targets according to the STRING database.

First level regulatory network of creb3l1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0050428 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
1.2 4.8 GO:0051645 Golgi localization(GO:0051645)
0.9 5.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.8 2.5 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.8 2.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.7 4.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.6 33.0 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.5 2.7 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.5 8.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.4 3.0 GO:0034389 lipid particle organization(GO:0034389)
0.4 1.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.4 5.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.0 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.3 2.7 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.3 2.7 GO:1901998 toxin transport(GO:1901998)
0.3 2.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 4.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 0.9 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 1.7 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 1.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 2.3 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.2 GO:0035999 methionine biosynthetic process(GO:0009086) tetrahydrofolate interconversion(GO:0035999)
0.1 5.4 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.7 GO:0042026 protein refolding(GO:0042026)
0.1 9.7 GO:0007030 Golgi organization(GO:0007030)
0.1 4.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.3 GO:0035790 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.0 5.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 2.7 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 1.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 3.7 GO:0031076 embryonic camera-type eye development(GO:0031076)
0.0 1.8 GO:0008643 carbohydrate transport(GO:0008643)
0.0 7.3 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 2.4 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.9 GO:0048278 vesicle docking(GO:0048278)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 4.8 GO:0007009 plasma membrane organization(GO:0007009)
0.0 4.5 GO:0016197 endosomal transport(GO:0016197)
0.0 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.0 8.1 GO:0006955 immune response(GO:0006955)
0.0 3.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0051443 protein neddylation(GO:0045116) positive regulation of ubiquitin-protein transferase activity(GO:0051443)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.6 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.6 9.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.4 27.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.4 1.8 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 2.7 GO:0070938 contractile ring(GO:0070938)
0.2 9.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.5 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.2 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 7.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 5.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
1.4 5.4 GO:0008905 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
1.2 15.7 GO:0005537 mannose binding(GO:0005537)
1.2 3.6 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.7 2.7 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.7 2.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.7 4.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.6 1.8 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.4 3.0 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 1.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3 1.0 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.3 1.5 GO:0030620 U2 snRNA binding(GO:0030620)
0.2 2.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 5.2 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.2 0.9 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 1.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.7 GO:0031267 small GTPase binding(GO:0031267)
0.1 2.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.2 GO:0051087 chaperone binding(GO:0051087)
0.1 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 2.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.4 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 8.4 GO:0000149 SNARE binding(GO:0000149)
0.0 1.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 13.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 15.7 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 2.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 3.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.3 1.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 1.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 8.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 2.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.7 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 3.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases