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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for creb3l2

Z-value: 0.69

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Transcription factors associated with creb3l2

Gene Symbol Gene ID Gene Info
creb3l2
ENSDARG00000063563 cAMP responsive element binding protein 3-like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
creb3l2dr11_v1_chr4_-_4751981_47519830.214.6e-02Click!

Activity profile of creb3l2 motif

Sorted Z-values of creb3l2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_17200120 10.55 ENSDART00000147739
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr2_+_50999675 9.79 ENSDART00000158064
ENSDART00000165746
ENSDART00000163917
ENSDART00000172038
ENSDART00000169048
ENSDART00000164775
eef1da
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr8_+_44783424 8.72 ENSDART00000025875
si:ch1073-459j12.1
si:ch1073-459j12.1
chr16_-_45178430 8.15 ENSDART00000165186
si:dkey-33i11.9
si:dkey-33i11.9
chr2_+_50999477 7.63 ENSDART00000190111
eef1da
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr5_-_1962500 6.84 ENSDART00000150163
rplp0
ribosomal protein, large, P0
chr14_+_22076596 5.91 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr15_-_29387446 5.88 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr22_-_31059670 5.60 ENSDART00000022445
cand2
cullin-associated and neddylation-dissociated 2 (putative)
chr3_-_55092051 5.51 ENSDART00000053077
hbba2
hemoglobin, beta adult 2
chr23_-_10175898 5.50 ENSDART00000146185
krt5
keratin 5
chr4_-_17409533 5.27 ENSDART00000011943
pah
phenylalanine hydroxylase
chr6_+_269204 5.01 ENSDART00000191678
atf4a
activating transcription factor 4a
chr22_-_817479 4.67 ENSDART00000123487
zgc:153675
zgc:153675
chr9_+_6587364 4.43 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr25_+_37443194 4.26 ENSDART00000163178
ENSDART00000190262
slc10a3
solute carrier family 10, member 3
chr21_-_5881344 4.20 ENSDART00000009241
rpl35
ribosomal protein L35
chr19_+_47405867 3.95 ENSDART00000041114
psmb2
proteasome subunit beta 2
chr2_+_39618951 3.93 ENSDART00000077108
zgc:136870
zgc:136870
chr15_-_29388012 3.55 ENSDART00000115032
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr19_-_42607451 3.52 ENSDART00000004392
fkbp9
FK506 binding protein 9
chr3_+_53773256 3.43 ENSDART00000170461
col5a3a
collagen, type V, alpha 3a
chr6_-_40899618 3.34 ENSDART00000153949
ENSDART00000021969
zgc:172271
zgc:172271
chr6_+_12968101 3.33 ENSDART00000013781
mcm6
minichromosome maintenance complex component 6
chr5_-_54714789 3.28 ENSDART00000063357
ccnb1
cyclin B1
chr5_-_54714525 3.25 ENSDART00000150138
ENSDART00000150070
ccnb1
cyclin B1
chr22_+_25841786 3.23 ENSDART00000180863
vasna
vasorin a
chr12_-_9132682 3.16 ENSDART00000066471
adam8b
ADAM metallopeptidase domain 8b
chr5_-_28968964 3.09 ENSDART00000184936
ENSDART00000016628
fam129bb
family with sequence similarity 129, member Bb
chr18_-_37252036 3.06 ENSDART00000132230
six5
SIX homeobox 5
chr16_+_49249669 3.03 ENSDART00000181899
LO018128.1

chr25_+_5035343 3.01 ENSDART00000011751
parvb
parvin, beta
chr19_+_7173613 2.98 ENSDART00000001331
hsd17b8
hydroxysteroid (17-beta) dehydrogenase 8
chr9_-_7683799 2.92 ENSDART00000102713
si:ch73-199e17.1
si:ch73-199e17.1
chr3_+_42923275 2.79 ENSDART00000168228
tmem184a
transmembrane protein 184a
chr7_-_45990681 2.68 ENSDART00000165441
si:ch211-260e23.7
si:ch211-260e23.7
chr2_-_10386738 2.68 ENSDART00000016369
wls
wntless Wnt ligand secretion mediator
chr21_+_45685757 2.60 ENSDART00000160530
sec24a
SEC24 homolog A, COPII coat complex component
chr7_-_45990386 2.36 ENSDART00000186008
si:ch211-260e23.7
si:ch211-260e23.7
chr12_-_44010532 2.36 ENSDART00000183875
si:ch211-182p11.1
si:ch211-182p11.1
chr3_+_22335030 2.30 ENSDART00000055676
zgc:103564
zgc:103564
chr5_-_32338866 2.29 ENSDART00000017956
ENSDART00000047670
dab2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr8_+_7316568 2.21 ENSDART00000140874
selenoh
selenoprotein H
chr8_-_15292197 2.11 ENSDART00000140867
spata6
spermatogenesis associated 6
chr6_-_23931442 2.02 ENSDART00000160547
sec16b
SEC16 homolog B, endoplasmic reticulum export factor
chr22_-_14128716 1.99 ENSDART00000140323
si:ch211-246m6.4
si:ch211-246m6.4
chr22_+_31059919 1.98 ENSDART00000077063
sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr5_-_67757188 1.92 ENSDART00000167168
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr3_+_39568290 1.92 ENSDART00000020741
aldoaa
aldolase a, fructose-bisphosphate, a
chr8_+_49065348 1.84 ENSDART00000032277
ddx51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr8_-_51579286 1.82 ENSDART00000147878
ankrd39
ankyrin repeat domain 39
chr18_+_7553950 1.81 ENSDART00000193420
ENSDART00000062143
zgc:77650
zgc:77650
chr8_-_51578926 1.77 ENSDART00000190625
ankrd39
ankyrin repeat domain 39
chr21_+_40589770 1.69 ENSDART00000164650
ENSDART00000161584
ENSDART00000161108
pdk3b
pyruvate dehydrogenase kinase, isozyme 3b
chr4_-_22749553 1.69 ENSDART00000040033
nup107
nucleoporin 107
chr24_+_12913329 1.68 ENSDART00000141829
si:dkeyp-28d2.4
si:dkeyp-28d2.4
chr8_-_46386024 1.59 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr3_-_1190132 1.55 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr22_-_94352 1.52 ENSDART00000184883
ndufaf3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr18_-_43857089 1.39 ENSDART00000150170
treh
trehalase (brush-border membrane glycoprotein)
chr16_+_20294976 1.35 ENSDART00000059619
fkbp14
FK506 binding protein 14
chr17_-_11417904 1.35 ENSDART00000103228
arid4a
AT rich interactive domain 4A (RBP1-like)
chr25_-_1323623 1.29 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calml4b
calmodulin-like 4b
chr25_+_34862225 1.20 ENSDART00000149782
CHST6
zgc:194879
chr19_-_3303995 1.13 ENSDART00000105150
si:ch211-133n4.9
si:ch211-133n4.9
chr25_-_7670616 1.12 ENSDART00000131583
ENSDART00000142794
bet1l
Bet1 golgi vesicular membrane trafficking protein-like
chr14_-_3071564 1.11 ENSDART00000166136
ENSDART00000167138
slc35a4
solute carrier family 35, member A4
chr20_+_15565926 1.10 ENSDART00000063917
si:dkey-86e18.1
si:dkey-86e18.1
chr12_+_13282797 1.07 ENSDART00000137757
ENSDART00000152397
irf9
interferon regulatory factor 9
chr6_+_42693114 1.07 ENSDART00000154353
si:ch211-207d10.2
si:ch211-207d10.2
chr1_+_2301961 1.05 ENSDART00000108919
ENSDART00000143361
ENSDART00000142944
farp1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr9_+_31222026 1.01 ENSDART00000145573
clybl
citrate lyase beta like
chr11_-_43104475 0.95 ENSDART00000125368
acyp2
acylphosphatase 2, muscle type
chr1_-_26444075 0.91 ENSDART00000125690
ints12
integrator complex subunit 12
chr11_-_7156620 0.88 ENSDART00000172823
ENSDART00000172879
ENSDART00000078916
smim7
small integral membrane protein 7
chr16_+_26824691 0.83 ENSDART00000135053
zmp:0000001316
zmp:0000001316
chr21_+_21357309 0.82 ENSDART00000079634
ENSDART00000146102
kcnk12l
potassium channel, subfamily K, member 12 like
chr6_+_42693288 0.81 ENSDART00000155010
si:ch211-207d10.2
si:ch211-207d10.2
chr2_+_3452590 0.79 ENSDART00000153935
cyp8b2
cytochrome P450, family 8, subfamily B, polypeptide 2
chr17_-_28811747 0.77 ENSDART00000001444
g2e3
G2/M-phase specific E3 ubiquitin protein ligase
chr2_-_11504347 0.73 ENSDART00000019392
sdr16c5a
short chain dehydrogenase/reductase family 16C, member 5a
chr11_+_45323455 0.69 ENSDART00000189249
mafgb
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr16_-_32727199 0.68 ENSDART00000137232
usp45
ubiquitin specific peptidase 45
chr7_-_1108935 0.67 ENSDART00000102795
dctn1a
dynactin 1a
chr9_+_38737924 0.67 ENSDART00000147652
kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr17_-_11417551 0.66 ENSDART00000128291
arid4a
AT rich interactive domain 4A (RBP1-like)
chr20_+_32406011 0.60 ENSDART00000018640
ENSDART00000137910
snx3
sorting nexin 3
chr13_-_4992395 0.59 ENSDART00000102651
nolc1
nucleolar and coiled-body phosphoprotein 1
chr13_+_1015749 0.58 ENSDART00000190982
prokr1b
prokineticin receptor 1b
chr17_+_1514711 0.55 ENSDART00000165641
akt1
v-akt murine thymoma viral oncogene homolog 1
chr8_-_25980694 0.54 ENSDART00000135456
si:dkey-72l14.3
si:dkey-72l14.3
chr4_+_357810 0.52 ENSDART00000163436
ENSDART00000103645
tmem181
transmembrane protein 181
chr14_+_46028003 0.48 ENSDART00000113469
nocta
nocturnin a
chr4_-_12718103 0.46 ENSDART00000144388
mgst1.1
microsomal glutathione S-transferase 1.1
chr2_-_48497175 0.44 ENSDART00000158839
CR391991.5

chr19_-_7540821 0.43 ENSDART00000143958
lix1l
limb and CNS expressed 1 like
chr5_+_57328535 0.43 ENSDART00000149646
slc31a1
solute carrier family 31 (copper transporter), member 1
chr4_+_77957611 0.42 ENSDART00000156692
arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr6_-_40195510 0.39 ENSDART00000156156
col7a1
collagen, type VII, alpha 1
chr14_+_16287968 0.38 ENSDART00000106593
prpf19
pre-mRNA processing factor 19
chr21_-_27413294 0.38 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr1_+_17593392 0.37 ENSDART00000078889
helt
helt bHLH transcription factor
chr4_-_48578324 0.35 ENSDART00000122707
znf980
zinc finger protein 980
chr22_-_5099824 0.28 ENSDART00000122341
ENSDART00000161345
zfr2
zinc finger RNA binding protein 2
chr16_-_31622777 0.28 ENSDART00000137311
ENSDART00000002930
phf20l1
PHD finger protein 20 like 1
chr17_+_28706946 0.25 ENSDART00000126967
strn3
striatin, calmodulin binding protein 3
chr13_+_36958086 0.21 ENSDART00000024386
frmd6
FERM domain containing 6
chr20_+_29209926 0.20 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr17_+_44441042 0.14 ENSDART00000142123
ap5m1
adaptor-related protein complex 5, mu 1 subunit
chr3_+_44062576 0.11 ENSDART00000161277
ENSDART00000168784
nsmce1
NSE1 homolog, SMC5-SMC6 complex component
chr15_+_32419303 0.11 ENSDART00000162663
si:dkey-285b23.3
si:dkey-285b23.3
chr4_-_16883051 0.10 ENSDART00000124627
strap
serine/threonine kinase receptor associated protein
chr22_-_25043103 0.08 ENSDART00000015512
polr3f
polymerase (RNA) III (DNA directed) polypeptide F
chr20_+_29209767 0.05 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr7_+_15308042 0.02 ENSDART00000185170
mespaa
mesoderm posterior aa

Network of associatons between targets according to the STRING database.

First level regulatory network of creb3l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0010265 SCF complex assembly(GO:0010265)
1.1 3.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.9 3.6 GO:0032206 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.9 2.7 GO:0061355 Wnt protein secretion(GO:0061355)
0.7 6.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.7 2.0 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.6 1.7 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.5 1.4 GO:0005991 trehalose metabolic process(GO:0005991)
0.4 5.3 GO:0006558 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.4 5.0 GO:0070309 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.4 2.0 GO:0070973 positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 1.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.3 12.9 GO:0030199 collagen fibril organization(GO:0030199)
0.3 10.6 GO:0050821 protein stabilization(GO:0050821)
0.3 4.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 3.3 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 2.3 GO:1905207 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.3 6.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 17.4 GO:0006414 translational elongation(GO:0006414)
0.3 5.5 GO:0015671 oxygen transport(GO:0015671)
0.2 4.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.2 2.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 5.9 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 0.4 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.4 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.1 3.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 4.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 3.3 GO:0006826 iron ion transport(GO:0006826)
0.1 0.7 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 1.9 GO:0001966 thigmotaxis(GO:0001966)
0.1 2.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.5 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.4 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 0.7 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 1.0 GO:0003094 glomerular filtration(GO:0003094)
0.0 5.5 GO:0031101 fin regeneration(GO:0031101)
0.0 0.6 GO:0030431 sleep(GO:0030431)
0.0 3.2 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.7 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 3.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 2.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 2.1 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.5 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.5 GO:0045765 regulation of angiogenesis(GO:0045765)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.2 6.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
1.1 3.2 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.5 5.5 GO:0045095 keratin filament(GO:0045095)
0.5 5.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 2.1 GO:0097224 sperm connecting piece(GO:0097224)
0.4 5.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.3 3.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 4.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 11.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 4.0 GO:0005839 proteasome core complex(GO:0005839)
0.1 1.5 GO:1990246 uniplex complex(GO:1990246)
0.1 1.4 GO:0042555 MCM complex(GO:0042555)
0.1 7.4 GO:0030018 Z disc(GO:0030018)
0.1 0.4 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.9 GO:0044545 NSL complex(GO:0044545)
0.1 0.6 GO:0030904 retromer complex(GO:0030904)
0.0 2.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.8 GO:0005581 collagen trimer(GO:0005581)
0.0 3.3 GO:0055037 recycling endosome(GO:0055037)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.7 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 6.3 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 10.6 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 3.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.7 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.6 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.1 6.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.7 5.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.7 4.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.7 2.1 GO:0032027 myosin light chain binding(GO:0032027)
0.7 3.3 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.5 4.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.5 1.4 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 5.5 GO:0031720 haptoglobin binding(GO:0031720)
0.4 17.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.0 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.3 0.8 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
0.2 9.4 GO:0005518 collagen binding(GO:0005518)
0.2 1.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 3.2 GO:0048495 Roundabout binding(GO:0048495)
0.1 5.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 6.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 4.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 2.0 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 2.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.9 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 3.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.8 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 3.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0003724 RNA helicase activity(GO:0003724)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.0 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 1.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 5.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.5 10.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 2.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 3.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 1.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 3.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.1 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 2.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 11.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 4.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 5.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules