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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for dbpa+dbpb+hlfa

Z-value: 0.64

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Transcription factors associated with dbpa+dbpb+hlfa

Gene Symbol Gene ID Gene Info
ENSDARG00000057652 D site albumin promoter binding protein b
ENSDARG00000063014 D site albumin promoter binding protein a
ENSDARG00000074752 HLF transcription factor, PAR bZIP family member a
ENSDARG00000116703 D site albumin promoter binding protein b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hlfadr11_v1_chr3_-_11624694_116246940.741.1e-17Click!
dbpadr11_v1_chr19_-_10196370_101963700.704.2e-15Click!
dbpbdr11_v1_chr16_-_13613475_136134750.595.6e-10Click!

Activity profile of dbpa+dbpb+hlfa motif

Sorted Z-values of dbpa+dbpb+hlfa motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_34523515 9.34 ENSDART00000041007
stathmin 1b
chr3_-_46818001 9.00 ENSDART00000166505
ELAV like neuron-specific RNA binding protein 3
chr24_-_38079261 7.75 ENSDART00000105662
C-reactive protein 1
chr4_-_5302866 7.21 ENSDART00000138590
si:ch211-214j24.9
chr2_-_54387550 6.71 ENSDART00000097388
N-ethylmaleimide-sensitive factor attachment protein, gamma b
chr1_+_31112436 6.71 ENSDART00000075340
eukaryotic translation elongation factor 1 alpha 1b
chr23_-_27345425 6.24 ENSDART00000022042
ENSDART00000191870
sodium channel, voltage gated, type VIII, alpha subunit a
chr21_-_43550120 5.82 ENSDART00000151627
si:ch73-362m14.2
chr3_-_31804481 5.74 ENSDART00000028270
glial fibrillary acidic protein
chr25_+_7784582 5.59 ENSDART00000155016
diacylglycerol kinase, zeta b
chr9_-_1702648 5.43 ENSDART00000102934
heterogeneous nuclear ribonucleoprotein A3
chr19_-_9712530 5.37 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr3_-_28665291 5.36 ENSDART00000151670
F-box and leucine-rich repeat protein 16
chr23_-_33361425 5.36 ENSDART00000031638
solute carrier family 48 (heme transporter), member 1a
chr20_-_45661049 5.03 ENSDART00000124582
ENSDART00000131251
N-ethylmaleimide-sensitive factor attachment protein, beta b
chr19_+_342094 4.95 ENSDART00000151013
ENSDART00000187622
endosulfine alpha a
chr8_+_28900689 4.89 ENSDART00000141634
glutamate receptor, ionotropic, delta 2
chr4_-_5302162 4.82 ENSDART00000177099
si:ch211-214j24.9
chr19_+_46259619 4.81 ENSDART00000158032
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr16_+_46111849 4.63 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr25_+_15354095 4.47 ENSDART00000090397
KIAA1549-like a
chr17_-_43466317 4.23 ENSDART00000155313
heat shock protein 4 like
chr10_-_24371312 4.23 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr6_+_41255485 4.22 ENSDART00000042683
ENSDART00000186013
Ca2+-dependent activator protein for secretion b
chr12_+_28574863 4.19 ENSDART00000153284
TBK1 binding protein 1
chr17_-_20979077 4.15 ENSDART00000006676
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr23_+_45579497 3.83 ENSDART00000110381
early growth response 4
chr7_+_38717624 3.80 ENSDART00000132522
synaptotagmin XIII
chr12_-_26383242 3.65 ENSDART00000152941
ubiquitin specific peptidase 54b
chr23_+_37323962 3.64 ENSDART00000102881
family with sequence similarity 43, member B
chr9_-_9225980 3.52 ENSDART00000180301
cystathionine-beta-synthase b
chr20_-_40717900 3.52 ENSDART00000181663
connexin 43
chr21_-_42202792 3.50 ENSDART00000124708
gamma-aminobutyric acid (GABA) A receptor, alpha 6b
chr14_-_9199968 3.40 ENSDART00000146113
Cdc42 guanine nucleotide exchange factor (GEF) 9b
chr11_-_10770053 3.38 ENSDART00000179213
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr16_+_14029283 3.37 ENSDART00000146165
ENSDART00000132075
RUN and SH3 domain containing 1
chr5_+_3501859 3.36 ENSDART00000080486
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr25_-_11088839 3.34 ENSDART00000154748
synaptic vesicle glycoprotein 2Bb
chr22_+_27090136 3.31 ENSDART00000136770
si:dkey-246e1.3
chr20_+_1121458 3.26 ENSDART00000064472
proline-rich nuclear receptor coactivator 1
chr22_-_18491813 3.19 ENSDART00000105419
si:ch211-212d10.2
chr6_+_12326267 3.14 ENSDART00000155101
si:dkey-276j7.3
chr5_+_32162684 3.11 ENSDART00000134472
TAO kinase 3b
chr18_-_14941840 3.10 ENSDART00000091729
megalencephalic leukoencephalopathy with subcortical cysts 1
chr17_-_7371564 2.87 ENSDART00000060336
RAB32b, member RAS oncogene family
chr16_-_45069882 2.73 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr20_-_35246150 2.71 ENSDART00000090549
frizzled class receptor 3a
chr9_-_18742704 2.71 ENSDART00000145401
TSC22 domain family, member 1
chr16_+_47207691 2.71 ENSDART00000062507
islet cell autoantigen 1
chr21_-_32467799 2.69 ENSDART00000007675
ENSDART00000133099
zgc:123105
chr9_-_35069645 2.67 ENSDART00000122679
ENSDART00000077908
ENSDART00000077894
ENSDART00000125536
amyloid beta (A4) precursor protein b
chr6_+_23810529 2.56 ENSDART00000166921
glutamate-ammonia ligase (glutamine synthase) b
chr7_+_23580082 2.55 ENSDART00000183245
si:dkey-172j4.3
chr20_-_20610812 2.54 ENSDART00000181870
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr24_-_32665283 2.53 ENSDART00000038364
carbonic anhydrase II
chr20_-_20611063 2.49 ENSDART00000063492
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr3_-_36932515 2.40 ENSDART00000111981
ENSDART00000188470
contactin associated protein 1
chr6_+_22025806 2.36 ENSDART00000151240
si:dkey-156n14.3
chr11_+_16153207 2.31 ENSDART00000192356
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr6_+_23809163 2.27 ENSDART00000170402
glutamate-ammonia ligase (glutamine synthase) b
chr20_-_15132151 2.23 ENSDART00000063884
si:dkey-239i20.4
chr19_+_7549854 2.16 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr5_-_50638905 2.07 ENSDART00000180842
multiple C2 domains, transmembrane 1a
chr11_+_23933016 2.05 ENSDART00000000486
contactin 2
chr5_+_31860043 2.04 ENSDART00000036235
ENSDART00000140541
iron-sulfur cluster assembly enzyme b
chr9_-_18743012 2.03 ENSDART00000131626
TSC22 domain family, member 1
chr2_-_49860723 2.01 ENSDART00000083690
biliverdin reductase A
chr23_-_29812667 1.98 ENSDART00000006120
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr5_-_69437422 1.97 ENSDART00000073676
iron-sulfur cluster assembly 1
chr12_-_3753131 1.95 ENSDART00000129668
family with sequence similarity 57, member Bb
chr16_-_20294236 1.95 ENSDART00000059623
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
chr3_-_21348478 1.94 ENSDART00000114906
family with sequence similarity 171, member A2a
chr8_+_8712446 1.93 ENSDART00000158674
ELK1, member of ETS oncogene family
chr18_-_18850302 1.92 ENSDART00000131965
ENSDART00000167624
transglutaminase 2, like
chr3_-_31875138 1.91 ENSDART00000155298
LIM domain containing 2
chr20_+_2950005 1.84 ENSDART00000135919
adenosylmethionine decarboxylase 1
chr6_-_29612269 1.81 ENSDART00000104293
peroxisomal biogenesis factor 5-like a
chr5_-_29488245 1.75 ENSDART00000047719
ENSDART00000141154
ENSDART00000171165
calcium channel, voltage-dependent, N type, alpha 1B subunit, a
chr15_-_16121496 1.72 ENSDART00000128624
uncharacterized serine/threonine-protein kinase SgK494a
chr6_+_23809501 1.71 ENSDART00000168701
glutamate-ammonia ligase (glutamine synthase) b
chr8_-_31716302 1.58 ENSDART00000061832
si:dkey-46a10.3
chr7_+_4162994 1.58 ENSDART00000172800
si:ch211-63p21.1
chr8_-_32497815 1.57 ENSDART00000122359
si:dkey-164f24.2
chr23_+_9522781 1.57 ENSDART00000136486
oxysterol binding protein-like 2b
chr18_+_507618 1.56 ENSDART00000159464
neural precursor cell expressed, developmentally down-regulated 4a
chr12_-_20584413 1.53 ENSDART00000170923

chr8_-_32497581 1.52 ENSDART00000176298
ENSDART00000183340
si:dkey-164f24.2
chr13_+_23157053 1.46 ENSDART00000162359
sorbin and SH3 domain containing 1
chr10_-_2527342 1.46 ENSDART00000184168

chr21_-_32467099 1.43 ENSDART00000186354
zgc:123105
chr25_+_28893615 1.43 ENSDART00000156994
ENSDART00000075151
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr24_-_39772045 1.41 ENSDART00000087441
si:ch211-276f18.2
chr4_-_2727491 1.41 ENSDART00000141760
ENSDART00000039083
ENSDART00000134442
solute carrier organic anion transporter family, member 1C1
chr9_+_33788626 1.40 ENSDART00000088469
lysine (K)-specific demethylase 6A
chr8_+_12930216 1.39 ENSDART00000115405
zgc:103670
chr12_+_15002757 1.37 ENSDART00000135036
myosin light chain, phosphorylatable, fast skeletal muscle b
chr24_+_14581864 1.35 ENSDART00000134536
thiamine triphosphatase
chr8_+_26874924 1.34 ENSDART00000141794
ribosomal modification protein rimK-like family member A
chr6_-_41085692 1.33 ENSDART00000181463
serine/arginine-rich splicing factor 3a
chr7_+_38278860 1.32 ENSDART00000016265
low density lipoprotein receptor-related protein 3
chr3_-_57530323 1.31 ENSDART00000003066
cytohesin 1a
chr21_-_39058490 1.30 ENSDART00000114885
aldehyde dehydrogenase 3 family, member A2b
chr22_-_21176269 1.29 ENSDART00000112839
required for excision 1-B domain containing
chr9_-_42418470 1.28 ENSDART00000144353
calcitonin receptor-like a
chr5_+_27583117 1.28 ENSDART00000180340
zinc finger, matrin-type 4a
chr13_+_2523032 1.28 ENSDART00000172261
luteinizing hormone, beta polypeptide
chr20_-_20355577 1.28 ENSDART00000018500
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b
chr9_+_33788389 1.27 ENSDART00000144623
lysine (K)-specific demethylase 6A
chr15_-_22074315 1.25 ENSDART00000149830
dopamine receptor D2a
chr11_-_7078392 1.24 ENSDART00000112156
ENSDART00000188556
si:ch211-253b8.5
chr8_+_7975745 1.22 ENSDART00000137920
si:ch211-169p10.1
chr8_+_17884569 1.16 ENSDART00000134660
solute carrier family 44, member 5b
chr16_-_33104944 1.15 ENSDART00000151943
proline-rich nuclear receptor coactivator 2
chr5_+_69808763 1.12 ENSDART00000143482
fibronectin type III and SPRY domain containing 1-like
chr18_-_39288894 1.11 ENSDART00000186216
mitogen-activated protein kinase 6
chr7_+_67733759 1.11 ENSDART00000172015
cytochrome b5 type B
chr6_+_37754763 1.10 ENSDART00000110770
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr25_-_1235457 1.08 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr13_-_18195942 1.05 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr19_+_41080240 1.04 ENSDART00000087295
protein phosphatase 1, regulatory subunit 9A
chr3_+_33440615 1.00 ENSDART00000146005
GTP binding protein 1
chr6_-_14292307 1.00 ENSDART00000177852
ENSDART00000061745
inositol polyphosphate-4-phosphatase type I Ab
chr19_+_9032073 1.00 ENSDART00000127755
ash1 (absent, small, or homeotic)-like (Drosophila)
chr9_+_32301456 1.00 ENSDART00000078608
ENSDART00000185153
ENSDART00000144947
heat shock 10 protein 1
chr17_-_8268406 0.99 ENSDART00000149873
ENSDART00000064668
ENSDART00000148403
Abelson helper integration site 1
chr17_-_17759138 0.99 ENSDART00000157128
ENSDART00000123845
aarF domain containing kinase 1
chr17_+_43013171 0.96 ENSDART00000055541
gsk3b interacting protein
chr10_+_9595575 0.95 ENSDART00000091780
ENSDART00000184287
ring finger and CCCH-type domains 2
chr21_+_7188943 0.94 ENSDART00000172174
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr25_-_2081371 0.92 ENSDART00000104915
ENSDART00000156925
wingless-type MMTV integration site family, member 7Bb
chr10_+_10210455 0.91 ENSDART00000144214
SH2 domain containing 3Ca
chr19_-_7291733 0.90 ENSDART00000015559
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr11_+_43751263 0.88 ENSDART00000163843
zgc:153431
chr9_-_9732212 0.88 ENSDART00000092884
leucine rich repeat containing 58b
chr6_+_10333920 0.87 ENSDART00000151667
ENSDART00000151477
cordon-bleu WH2 repeat protein-like 1a
chr7_-_7823662 0.87 ENSDART00000167652
chemokine (C-X-C motif) ligand 8b, duplicate 3
chr21_-_5007109 0.86 ENSDART00000187042
ENSDART00000097796
ENSDART00000146766
ring finger protein 165a
chr2_-_32486080 0.84 ENSDART00000110821
tetratricopeptide repeat domain 19
chr9_-_13871935 0.82 ENSDART00000146597
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr22_-_881725 0.80 ENSDART00000035514
choline/ethanolamine phosphotransferase 1b
chr1_+_2128970 0.79 ENSDART00000180074
ENSDART00000022019
ENSDART00000098059
muscleblind-like splicing regulator 2
chr18_-_47662696 0.78 ENSDART00000184260

chr17_-_31308658 0.77 ENSDART00000124505
bromo adjacent homology domain containing 1
chr23_+_33963619 0.76 ENSDART00000140666
ENSDART00000084792
pyridoxal phosphate binding protein
chr7_+_56577906 0.76 ENSDART00000184023
haptoglobin
chr7_-_41420226 0.74 ENSDART00000074155
ATP-binding cassette, sub-family F (GCN20), member 2b
chr10_+_18877362 0.73 ENSDART00000138334
protein phosphatase 2, regulatory subunit B, alpha b
chr6_+_44197348 0.71 ENSDART00000075486
protein phosphatase 4, regulatory subunit 2b
chr7_+_69528850 0.70 ENSDART00000109507
Rap1 GTPase-GDP dissociation stimulator 1
chr5_-_15494164 0.70 ENSDART00000140668
ENSDART00000188076
ENSDART00000085943
TAO kinase 3a
chr5_-_36949476 0.69 ENSDART00000047269
H3 histone, family 3C
chr8_-_37249813 0.68 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
RNA binding motif protein 39b
chr17_+_15845765 0.66 ENSDART00000130881
ENSDART00000074936
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr11_+_39135050 0.63 ENSDART00000180571
ENSDART00000189685
cell division cycle 42
chr12_-_31484677 0.62 ENSDART00000066578
tectorin beta
chr5_-_43935460 0.61 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
chr16_-_35427060 0.60 ENSDART00000172294
CTP synthase 1b
chr25_-_13490744 0.58 ENSDART00000056721
lactate dehydrogenase D
chr16_-_7828838 0.58 ENSDART00000191434
ENSDART00000108653
T cell activation inhibitor, mitochondrial
chr20_+_25563105 0.57 ENSDART00000063100
cytochrome P450, family 2, subfamily P, polypeptide 6
chr23_-_37291793 0.57 ENSDART00000083281
ENSDART00000187108
mitochondrial E3 ubiquitin protein ligase 1b
chr23_-_18981595 0.57 ENSDART00000147617
bcl2-like 1
chr23_-_30960506 0.56 ENSDART00000142661
oxysterol binding protein-like 2a
chr3_+_24094581 0.54 ENSDART00000138270
ENSDART00000131509
coatomer protein complex, subunit zeta 2
chr6_-_40455109 0.54 ENSDART00000103878
von Hippel-Lindau tumor suppressor
chr7_-_41693004 0.54 ENSDART00000121509
MAM and LDL receptor class A domain containing 1
chr4_+_21867522 0.53 ENSDART00000140400
acyl-CoA synthetase short chain family member 3
chr15_-_2754056 0.52 ENSDART00000129380
protein phosphatase 5, catalytic subunit
chr15_-_21849300 0.50 ENSDART00000183603
layilin b
chr6_-_7726849 0.49 ENSDART00000151511
solute carrier family 25, member 38b
chr25_+_7435291 0.48 ENSDART00000172567
ENSDART00000163017
protein regulator of cytokinesis 1a
chr19_+_4990320 0.48 ENSDART00000147056
zgc:91968
chr4_-_14207471 0.47 ENSDART00000015134
twinfilin actin-binding protein 1b
chr8_-_29851706 0.46 ENSDART00000149297
solute carrier family 20 (phosphate transporter), member 2
chr5_-_30074332 0.44 ENSDART00000147963
beta-carotene oxygenase 2a
chr6_+_44197099 0.43 ENSDART00000124168
protein phosphatase 4, regulatory subunit 2b
chr17_-_6076084 0.43 ENSDART00000058890
epoxide hydrolase 2, cytoplasmic
chr6_+_16468776 0.42 ENSDART00000109151
ENSDART00000114667
zgc:161969
chr25_-_26833100 0.40 ENSDART00000014052
nei-like DNA glycosylase 1
chr3_+_19687217 0.39 ENSDART00000141937
tousled-like kinase 2
chr8_+_7801060 0.38 ENSDART00000161618
transcription factor binding to IGHM enhancer 3a
chr23_+_20640875 0.38 ENSDART00000147382
ubiquitin-like modifier activating enzyme 1
chr22_-_20720427 0.37 ENSDART00000105532
ornithine decarboxylase antizyme 1a
chr23_-_19486571 0.37 ENSDART00000009092
family with sequence similarity 208, member Ab
chr11_+_24900123 0.35 ENSDART00000044987
ENSDART00000148023
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr8_-_11324143 0.35 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr12_-_19862912 0.32 ENSDART00000145788
shisa family member 9a
chr10_-_25591194 0.31 ENSDART00000131640
T cell lymphoma invasion and metastasis 1a
chr22_+_17531214 0.29 ENSDART00000161174
ENSDART00000088356
heterogeneous nuclear ribonucleoprotein M
chr9_-_32300783 0.28 ENSDART00000078596
heat shock 60 protein 1
chr17_-_25831569 0.28 ENSDART00000148743
hedgehog acyltransferase
chr19_+_16016038 0.27 ENSDART00000131319
CTP synthase 1a
chr7_+_52761841 0.26 ENSDART00000111444
diphosphoinositol pentakisphosphate kinase 1a
chr12_-_9538578 0.24 ENSDART00000066445
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr25_-_12803723 0.21 ENSDART00000158787
carbonic anhydrase Va
chr21_-_39566854 0.18 ENSDART00000020174
dynein, light chain, LC8-type 2b
chr8_+_1187928 0.16 ENSDART00000127252
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr22_-_10605045 0.16 ENSDART00000184812
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr22_+_10606573 0.13 ENSDART00000192638
RAD54 like 2
chr9_-_32300611 0.11 ENSDART00000127938
heat shock 60 protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of dbpa+dbpb+hlfa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.2 GO:0007638 mechanosensory behavior(GO:0007638)
1.3 5.0 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
1.2 3.5 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.9 6.5 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.7 2.0 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.6 2.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.5 0.5 GO:0007585 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.5 5.4 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.4 8.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.3 4.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.3 3.2 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.3 2.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.3 3.1 GO:0034394 protein localization to cell surface(GO:0034394)
0.3 2.0 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 1.9 GO:0035627 ceramide transport(GO:0035627)
0.3 4.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3 2.7 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 2.0 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 2.4 GO:0032288 myelin assembly(GO:0032288)
0.2 1.3 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.2 2.5 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.2 5.0 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.2 2.7 GO:0021754 facial nucleus development(GO:0021754)
0.2 1.8 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.6 GO:0006089 lactate metabolic process(GO:0006089)
0.2 1.3 GO:0030728 ovulation(GO:0030728)
0.2 1.8 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.2 0.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.2 4.9 GO:0035308 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.2 0.5 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.2 3.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.2 7.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 3.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.8 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 2.9 GO:0032438 melanosome organization(GO:0032438)
0.1 2.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 2.0 GO:0048696 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.1 2.7 GO:0050796 regulation of insulin secretion(GO:0050796)
0.1 7.7 GO:0006414 translational elongation(GO:0006414)
0.1 0.5 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 5.0 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 4.0 GO:0046847 filopodium assembly(GO:0046847)
0.1 0.4 GO:0032755 positive regulation of interleukin-6 production(GO:0032755) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 1.0 GO:0044458 motile cilium assembly(GO:0044458)
0.1 1.9 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.3 GO:0043967 histone H4 acetylation(GO:0043967)
0.1 5.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.6 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.1 0.3 GO:0010610 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.1 0.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.9 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.3 GO:0009749 response to glucose(GO:0009749)
0.1 4.2 GO:0015914 phospholipid transport(GO:0015914)
0.1 3.1 GO:0001763 morphogenesis of a branching structure(GO:0001763)
0.1 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 1.3 GO:0048844 artery morphogenesis(GO:0048844)
0.1 8.1 GO:0006836 neurotransmitter transport(GO:0006836)
0.1 0.9 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 4.2 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.5 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.0 2.7 GO:0006096 glycolytic process(GO:0006096)
0.0 0.9 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.2 GO:0035522 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 2.7 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.9 GO:0006458 'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.9 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 8.6 GO:0050767 regulation of neurogenesis(GO:0050767)
0.0 0.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.2 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.7 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 6.8 GO:0007420 brain development(GO:0007420)
0.0 0.4 GO:0006284 base-excision repair(GO:0006284)
0.0 0.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.4 5.5 GO:0033270 paranode region of axon(GO:0033270)
0.4 1.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.3 6.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.3 2.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 0.9 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 2.7 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 5.5 GO:0098978 glutamatergic synapse(GO:0098978)
0.1 10.0 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.0 GO:0016586 RSC complex(GO:0016586)
0.1 3.9 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.5 GO:0030891 VCB complex(GO:0030891)
0.1 2.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 4.8 GO:0031201 SNARE complex(GO:0031201)
0.1 4.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 4.4 GO:0005882 intermediate filament(GO:0005882)
0.0 5.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 2.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 3.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 4.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 3.8 GO:0030424 axon(GO:0030424)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.6 GO:0030496 midbody(GO:0030496)
0.0 0.0 GO:0097268 cytoophidium(GO:0097268)
0.0 4.8 GO:0043005 neuron projection(GO:0043005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 11.7 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.9 6.5 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.7 3.5 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.7 2.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.7 5.4 GO:0015232 heme transporter activity(GO:0015232)
0.6 4.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.5 3.2 GO:0098809 nitrite reductase activity(GO:0098809)
0.4 1.3 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.4 1.3 GO:0001635 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.4 1.9 GO:1902387 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.3 8.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 1.3 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.3 4.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.3 0.9 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.3 2.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 6.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.3 8.4 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 2.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 3.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 0.9 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.2 2.0 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.2 7.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 2.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 0.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.1 1.0 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 4.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 4.1 GO:0030145 manganese ion binding(GO:0030145)
0.1 2.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 3.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.6 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.1 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.3 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 2.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 1.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.2 GO:0005461 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.0 0.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.3 GO:0051087 chaperone binding(GO:0051087)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 1.0 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.1 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 7.0 GO:0015631 tubulin binding(GO:0015631)
0.0 0.8 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 4.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.0 GO:0003883 CTP synthase activity(GO:0003883)
0.0 1.5 GO:0019904 protein domain specific binding(GO:0019904)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 3.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 1.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 1.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 5.7 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 2.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 2.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 4.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.0 5.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import