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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Z-value: 0.68

Motif logo

Transcription factors associated with dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Gene Symbol Gene ID Gene Info
ENSDARG00000017174 distal-less homeobox 2b
ENSDARG00000079964 distal-less homeobox 2a
ENSDARG00000116017 distal-less homeobox 2b
ENSDARG00000011956 distal-less homeobox 4a
ENSDARG00000042291 distal-less homeobox 6a
ENSDARG00000071560 distal-less homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dlx4bdr11_v1_chr12_-_5728755_5728755-0.354.9e-04Click!
dlx4adr11_v1_chr3_+_34670076_34670076-0.355.5e-04Click!
dlx6adr11_v1_chr19_+_41419519_41419519-0.286.7e-03Click!
dlx2adr11_v1_chr9_-_3400727_3400729-0.122.4e-01Click!
dlx2bdr11_v1_chr1_-_30979707_30979707-0.122.6e-01Click!

Activity profile of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Sorted Z-values of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_9462433 8.07 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr6_-_54826061 7.68 ENSDART00000149982
troponin I type 1b (skeletal, slow)
chr23_+_28731379 6.69 ENSDART00000047378
cortistatin
chr20_-_29420713 6.63 ENSDART00000147464
ryanodine receptor 3
chr25_+_29160102 5.84 ENSDART00000162854
pyruvate kinase M1/2b
chr4_+_7391110 5.49 ENSDART00000160708
ENSDART00000187823
troponin I4a
chr24_-_24849091 5.15 ENSDART00000133649
ENSDART00000038290
corticotropin releasing hormone b
chr13_-_31435137 5.01 ENSDART00000057441
reticulon 1a
chr17_-_20717845 4.91 ENSDART00000150037
ankyrin 3b
chr20_-_28800999 4.72 ENSDART00000049462
RAB15, member RAS oncogene family
chr19_-_32804535 4.40 ENSDART00000175613
ENSDART00000052098
5'-nucleotidase, cytosolic IAa
chr12_+_24342303 4.08 ENSDART00000111239
neurexin 1a
chr4_+_12615836 3.91 ENSDART00000003583
LIM domain only 3
chr16_+_5774977 3.64 ENSDART00000134202
cholecystokinin a
chr7_+_30787903 3.42 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr1_+_16397063 3.42 ENSDART00000159794
mitochondrial calcium uptake family, member 3a
chr9_-_21918963 3.39 ENSDART00000090782
LIM domain 7a
chr13_+_38430466 3.34 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr1_+_16396870 3.23 ENSDART00000189245
ENSDART00000113266
mitochondrial calcium uptake family, member 3a
chr25_+_29662411 3.16 ENSDART00000077445
Pim-3 proto-oncogene, serine/threonine kinase
chr6_-_14292307 3.12 ENSDART00000177852
ENSDART00000061745
inositol polyphosphate-4-phosphatase type I Ab
chr24_+_38306010 3.11 ENSDART00000143184
myosin binding protein C, fast type b
chr10_-_34871737 3.06 ENSDART00000138755
doublecortin-like kinase 1a
chr11_-_6974022 3.04 ENSDART00000172851
si:ch211-43f4.1
chr6_+_52804267 2.95 ENSDART00000065681
matrilin 4
chr16_+_20161805 2.94 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr8_+_21353878 2.91 ENSDART00000056420
aminolevulinate, delta-, synthase 2
chr22_+_16535575 2.90 ENSDART00000083063
T-cell acute lymphocytic leukemia 1
chr2_-_16380283 2.90 ENSDART00000149992
si:dkey-231j24.3
chr21_+_34088110 2.75 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr20_+_34933183 2.73 ENSDART00000062738
synaptosomal-associated protein, 25a
chr15_-_6247775 2.70 ENSDART00000148350
Down syndrome cell adhesion molecule b
chr2_-_33645411 2.65 ENSDART00000114663
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr4_+_11384891 2.63 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chrM_+_9052 2.57 ENSDART00000093612
ATP synthase 6, mitochondrial
chr19_+_46158078 2.56 ENSDART00000183933
ENSDART00000164055
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr18_+_9637744 2.53 ENSDART00000190171
piccolo presynaptic cytomatrix protein b
chr4_+_26629368 2.50 ENSDART00000183575
IQ motif and Sec7 domain 3a
chr19_-_7358184 2.49 ENSDART00000092379
oxidation resistance 1b
chr6_-_41229787 2.41 ENSDART00000065013
synaptoporin
chr6_+_39232245 2.39 ENSDART00000187351
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr21_+_34088377 2.24 ENSDART00000170070
myotubularin related protein 1b
chr13_-_36911118 2.22 ENSDART00000048739
tripartite motif containing 9
chr17_+_23298928 2.20 ENSDART00000153652
zgc:165461
chr16_-_17197546 2.13 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
glyceraldehyde-3-phosphate dehydrogenase
chr16_-_12953739 2.11 ENSDART00000103894
calcium channel, voltage-dependent, gamma subunit 8b
chr14_+_23184517 2.07 ENSDART00000181410
ecto-NOX disulfide-thiol exchanger 2
chr11_+_30244356 2.06 ENSDART00000036050
ENSDART00000150080
retinoschisin 1a
chr15_-_22074315 2.04 ENSDART00000149830
dopamine receptor D2a
chr12_+_34953038 1.98 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
QKI, KH domain containing, RNA binding 2
chr16_+_17389116 1.97 ENSDART00000103750
ENSDART00000173448
family with sequence similarity 131, member Bb
chr20_-_45060241 1.93 ENSDART00000185227
kelch-like family member 29
chr20_-_32270866 1.92 ENSDART00000153140
armadillo repeat containing 2
chr8_-_46894362 1.89 ENSDART00000111124
acyl-CoA thioesterase 7
chr7_-_25895189 1.87 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
CD99 molecule-like 2
chr16_+_13818500 1.87 ENSDART00000135245
folliculin
chr20_+_19238382 1.84 ENSDART00000136757
fibronectin type III domain containing 4a
chr11_-_37509001 1.83 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr18_-_1185772 1.80 ENSDART00000143245
neuroplastin b
chr1_-_50859053 1.76 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr2_+_50608099 1.73 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr19_-_5103141 1.73 ENSDART00000150952
triosephosphate isomerase 1a
chr11_+_30057762 1.71 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr17_-_12389259 1.71 ENSDART00000185724
synaptosomal-associated protein, 25b
chr10_+_29698467 1.70 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr22_+_16308450 1.68 ENSDART00000105678
leucine rich repeat containing 39
chr25_+_11456696 1.66 ENSDART00000171408
si:ch73-141f14.1
chr22_+_16308806 1.64 ENSDART00000162685
leucine rich repeat containing 39
chr21_+_28478663 1.63 ENSDART00000077887
ENSDART00000134150
solute carrier family 22 (organic anion transporter), member 6, like
chr17_-_16965809 1.59 ENSDART00000153697
neurexin 3a
chr14_-_30587814 1.57 ENSDART00000144912
ENSDART00000149714
transmembrane protein 265
chr5_+_19314574 1.52 ENSDART00000133247
RUN and SH3 domain containing 2
chrM_+_9735 1.49 ENSDART00000093613
cytochrome c oxidase III, mitochondrial
chr3_+_34919810 1.48 ENSDART00000055264
carbonic anhydrase Xb
chr20_+_30445971 1.48 ENSDART00000153150
myelin transcription factor 1-like, a
chr12_-_33579873 1.47 ENSDART00000184661
tudor and KH domain containing
chr16_+_13818743 1.46 ENSDART00000090191
folliculin
chr15_+_15856178 1.44 ENSDART00000080338
dual specificity phosphatase 14
chr23_+_20563779 1.42 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr20_-_46362606 1.41 ENSDART00000153087
BCL2 modifying factor 2
chr22_+_5176255 1.40 ENSDART00000092647
ceramide synthase 1
chr6_-_6487876 1.40 ENSDART00000137642
centrosomal protein 170Ab
chr13_-_44630111 1.39 ENSDART00000110092
MAM domain containing glycosylphosphatidylinositol anchor 1
chr17_+_21295132 1.35 ENSDART00000103845
enolase family member 4
chr21_-_42100471 1.34 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr16_-_47483142 1.32 ENSDART00000147072
collagen triple helix repeat containing 1b
chr1_+_45323400 1.32 ENSDART00000148906
ENSDART00000132366
epithelial membrane protein 1
chr3_-_34296361 1.28 ENSDART00000181485
ENSDART00000113726
trinucleotide repeat containing 6C1
chr21_+_29077509 1.26 ENSDART00000128561
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr1_+_11977426 1.26 ENSDART00000103399
tetraspanin 5b
chr20_-_10120442 1.26 ENSDART00000144970
Meis homeobox 2b
chr15_+_42397125 1.25 ENSDART00000169751
T cell lymphoma invasion and metastasis 1b
chr15_-_20024205 1.24 ENSDART00000161379
autism susceptibility candidate 2b
chr1_-_44701313 1.21 ENSDART00000193926
si:dkey-28b4.8
chr8_-_19051906 1.21 ENSDART00000089024
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr22_-_7129631 1.21 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr11_-_8126223 1.19 ENSDART00000091617
ENSDART00000192391
ENSDART00000101561
tubulin tyrosine ligase-like family, member 7
chr15_+_36309070 1.19 ENSDART00000157034
geminin coiled-coil domain containing
chr15_+_31344472 1.18 ENSDART00000146695
ENSDART00000159182
ENSDART00000060125
odorant receptor, family D, subfamily 107, member 1
chr5_-_23117078 1.14 ENSDART00000051529
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr6_+_23887314 1.14 ENSDART00000163188
zinc finger protein 648
chr18_+_19006063 1.11 ENSDART00000135729
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr10_+_3049636 1.07 ENSDART00000081794
ENSDART00000183167
ENSDART00000191634
ENSDART00000183514
Ras protein-specific guanine nucleotide-releasing factor 2a
chr3_+_33341640 1.05 ENSDART00000186352
peptide YYa
chr21_+_28958471 1.03 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_-_28148310 1.03 ENSDART00000044208
LIM domain only 1
chr24_+_9412450 1.03 ENSDART00000132724
si:ch211-285f17.1
chr22_+_5176693 1.02 ENSDART00000160927
ceramide synthase 1
chr14_+_34971554 1.00 ENSDART00000184271
ring finger protein 145a
chr3_-_46817499 0.98 ENSDART00000013717
ELAV like neuron-specific RNA binding protein 3
chr14_+_36220479 0.94 ENSDART00000148319
paired-like homeodomain 2
chr17_-_44247707 0.93 ENSDART00000126097
orthodenticle homeobox 2b
chr18_+_9362455 0.93 ENSDART00000187025
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr17_+_24687338 0.91 ENSDART00000135794
selenoprotein N
chr9_+_17983463 0.91 ENSDART00000182150
A kinase (PRKA) anchor protein 11
chr13_+_25449681 0.88 ENSDART00000101328
atonal bHLH transcription factor 7
chr21_-_10488379 0.86 ENSDART00000163878
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr20_-_27711970 0.85 ENSDART00000139637
zinc finger and BTB domain containing 25
chr5_+_20147830 0.84 ENSDART00000098727
SV2 related protein a
chr19_-_19556778 0.84 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr13_+_38990939 0.84 ENSDART00000145979
collagen, type XIX, alpha 1
chr16_-_30434279 0.83 ENSDART00000018504
zgc:77086
chr10_+_42690374 0.81 ENSDART00000123496
Rho-related BTB domain containing 2b
chr5_-_50781623 0.79 ENSDART00000114950
zgc:194908
chr23_+_38957472 0.79 ENSDART00000193836
ATPase phospholipid transporting 9A (putative)
chr16_+_20910186 0.78 ENSDART00000046766
homeobox A10b
chr21_-_11654422 0.78 ENSDART00000081614
ENSDART00000132699
calpastatin
chr11_+_38280454 0.77 ENSDART00000171496
si:dkey-166c18.1
chr21_-_17296789 0.77 ENSDART00000192180
growth factor independent 1B transcription repressor
chr13_+_21768447 0.74 ENSDART00000100941
coiled-coil-helix-coiled-coil-helix domain containing 1
chr10_-_35236949 0.74 ENSDART00000145804
yippee-like 2a
chr19_-_205104 0.73 ENSDART00000011890
zinc finger and BTB domain containing 22a
chr6_-_44044385 0.73 ENSDART00000075497
RING1 and YY1 binding protein b
chr4_+_12612723 0.73 ENSDART00000133767
LIM domain only 3
chr14_-_17622080 0.72 ENSDART00000112149
si:ch211-159i8.4
chr10_+_41765944 0.71 ENSDART00000171484
ring finger protein 34b
chr6_-_46782176 0.69 ENSDART00000185559
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 4
chr7_+_42460302 0.69 ENSDART00000004120
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr12_-_8504278 0.69 ENSDART00000135865
early growth response 2b
chr6_+_52880292 0.68 ENSDART00000077848
odorant receptor, family H, subfamily 137, member 4
chr17_-_19963718 0.67 ENSDART00000154251
cholinergic receptor, muscarinic 3a
chr18_+_34478959 0.67 ENSDART00000059394
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr2_-_15324837 0.66 ENSDART00000015655
trans-2,3-enoyl-CoA reductase-like 2b
chr10_+_43039947 0.66 ENSDART00000193434
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr21_-_3853204 0.66 ENSDART00000188829
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr25_+_26798673 0.64 ENSDART00000157235
carbonic anhydrase XII
chr1_-_22512063 0.63 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr22_-_20166660 0.62 ENSDART00000085913
ENSDART00000188241
BTB (POZ) domain containing 2a
chr11_+_35050253 0.62 ENSDART00000124800
family with sequence similarity 212, member Aa
chr21_-_5856050 0.61 ENSDART00000115367

chr5_-_28109416 0.60 ENSDART00000042002
si:ch211-48m9.1
chr3_+_33440615 0.60 ENSDART00000146005
GTP binding protein 1
chr16_+_54263921 0.59 ENSDART00000002856
dopamine receptor D2 like
chr23_-_31974060 0.54 ENSDART00000168087

chr8_-_19467011 0.54 ENSDART00000162010
zgc:92140
chr5_-_30481263 0.53 ENSDART00000086734
pleckstrin homology-like domain, family B, member 1a
chr4_-_15420452 0.53 ENSDART00000016230
plexin A4
chr9_-_20372977 0.52 ENSDART00000113418
immunoglobulin superfamily, member 3
chr14_-_41075262 0.51 ENSDART00000180518
dystrophin related protein 2
chr2_+_4146299 0.51 ENSDART00000173418
mindbomb E3 ubiquitin protein ligase 1
chr10_+_41765616 0.51 ENSDART00000170682
ring finger protein 34b
chr1_+_34696503 0.49 ENSDART00000186106

chr10_+_36178713 0.48 ENSDART00000140816
odorant receptor, family D, subfamily 108, member 3
chr1_+_52929185 0.47 ENSDART00000147683
inositol polyphosphate-4-phosphatase type II B
chr20_-_38617766 0.47 ENSDART00000050474
solute carrier family 30 (zinc transporter), member 2
chr15_+_40792667 0.47 ENSDART00000193186
ENSDART00000184559
FAT atypical cadherin 3a
chr7_-_12464412 0.45 ENSDART00000178723
ADAMTS-like 3
chr7_-_48263516 0.44 ENSDART00000006619
ENSDART00000142370
ENSDART00000148273
ENSDART00000147968
RNA binding protein with multiple splicing 2b
chr13_+_38817871 0.44 ENSDART00000187708
collagen, type XIX, alpha 1
chr4_+_12612145 0.44 ENSDART00000181201
LIM domain only 3
chr17_-_31659670 0.43 ENSDART00000030448
visual system homeobox 2
chr23_+_5499307 0.42 ENSDART00000170361
TEA domain family member 3 a
chr1_+_513986 0.42 ENSDART00000109083
ENSDART00000081945
thioredoxin-like 4B
chr6_-_29515709 0.42 ENSDART00000180205
peroxisomal biogenesis factor 5-like a
chr2_+_21229909 0.41 ENSDART00000046127
vasoactive intestinal peptide receptor 1a
chr21_-_15046065 0.41 ENSDART00000178507
matrix metallopeptidase 17a
chr17_-_29119362 0.40 ENSDART00000104204
forkhead box G1a
chr19_+_2631565 0.40 ENSDART00000171487
family with sequence similarity 126, member A
chr16_-_13623928 0.39 ENSDART00000164344
si:dkeyp-69b9.6
chr20_+_4060839 0.39 ENSDART00000178565
tripartite motif containing 67
chr14_+_30568961 0.38 ENSDART00000184303
mitochondrial ribosomal protein L11
chr4_+_22343093 0.37 ENSDART00000023588
guanylate cyclase activator 1A
chr13_+_2625150 0.37 ENSDART00000164177
phospholipid phosphatase 4
chr18_-_2433011 0.36 ENSDART00000181922
ENSDART00000193276

chr21_-_40676224 0.35 ENSDART00000162623
aristaless related homeobox b
chr7_-_44957503 0.34 ENSDART00000165077
cadherin 16, KSP-cadherin
chr24_-_39518599 0.34 ENSDART00000145606
ENSDART00000031486
LYR motif containing 1
chr15_-_2184638 0.34 ENSDART00000135460
short stature homeobox 2
chr8_+_50953776 0.34 ENSDART00000013870
zgc:56596
chr9_+_20557793 0.33 ENSDART00000178434
mannosidase, alpha, class 1A, member 2
chr5_+_38837429 0.33 ENSDART00000160236
Fraser extracellular matrix complex subunit 1
chr19_-_38830582 0.32 ENSDART00000189966
ENSDART00000183055
adhesion G protein-coupled receptor B2
chr1_-_54765262 0.32 ENSDART00000150362
si:ch211-197k17.3
chr21_-_11655010 0.31 ENSDART00000144370
ENSDART00000139814
ENSDART00000139289
calpastatin
chr19_+_22062202 0.31 ENSDART00000100181
spalt-like transcription factor 3b
chr10_+_16584382 0.30 ENSDART00000112039

chr16_+_35661771 0.30 ENSDART00000161393
MAP7 domain containing 1a
chr13_+_22295905 0.30 ENSDART00000180133
ENSDART00000181125
ubiquitin specific peptidase 54a
chr6_+_36807861 0.29 ENSDART00000161708
si:ch73-29l19.1
chr23_-_17484555 0.29 ENSDART00000187181
DnaJ (Hsp40) homolog, subfamily C, member 5ab

Network of associatons between targets according to the STRING database.

First level regulatory network of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0035902 response to immobilization stress(GO:0035902)
1.0 2.9 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.7 7.0 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.7 3.3 GO:0016322 neuron remodeling(GO:0016322)
0.5 3.3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.4 1.7 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.4 2.1 GO:0007624 ultradian rhythm(GO:0007624)
0.4 1.1 GO:0060292 long term synaptic depression(GO:0060292)
0.4 6.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.3 4.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.3 1.9 GO:0007288 sperm axoneme assembly(GO:0007288)
0.3 7.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.3 1.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.3 13.2 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 1.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.2 3.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 0.7 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.2 1.3 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.2 0.6 GO:0021519 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.2 0.9 GO:0061072 iris morphogenesis(GO:0061072)
0.2 2.6 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 2.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 0.5 GO:0007414 axonal defasciculation(GO:0007414)
0.2 1.2 GO:1900118 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 1.2 GO:0070207 protein homotrimerization(GO:0070207)
0.2 1.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.2 0.7 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.2 1.1 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.2 4.5 GO:0070593 dendrite self-avoidance(GO:0070593)
0.2 0.9 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.2 8.0 GO:0006096 glycolytic process(GO:0006096)
0.1 4.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 4.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 2.6 GO:0030817 regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of adenylate cyclase activity(GO:0045761)
0.1 1.3 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.1 2.1 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 1.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 3.3 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 2.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.5 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 3.6 GO:0007586 digestion(GO:0007586)
0.1 5.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 0.4 GO:0051145 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.1 1.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 1.3 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.9 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.0 GO:0048016 calcineurin-NFAT signaling cascade(GO:0033173) inositol phosphate-mediated signaling(GO:0048016)
0.1 1.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.9 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 1.2 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 2.0 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 2.5 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0043584 nose development(GO:0043584)
0.0 1.1 GO:0007631 feeding behavior(GO:0007631)
0.0 2.4 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.7 GO:0048931 myelination of lateral line nerve axons(GO:0048897) posterior lateral line nerve glial cell differentiation(GO:0048931) myelination of posterior lateral line nerve axons(GO:0048932) lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048938) posterior lateral line nerve glial cell development(GO:0048941) posterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048942)
0.0 0.4 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 1.8 GO:0036269 swimming behavior(GO:0036269)
0.0 0.8 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 2.5 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 6.6 GO:0030334 regulation of cell migration(GO:0030334)
0.0 1.1 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 4.1 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.7 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.3 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 0.7 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 2.6 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.4 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 1.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.3 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.5 GO:0060536 cartilage morphogenesis(GO:0060536)
0.0 0.1 GO:0021794 thalamus development(GO:0021794)
0.0 0.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 2.4 GO:0001525 angiogenesis(GO:0001525)
0.0 2.6 GO:0060537 muscle tissue development(GO:0060537)
0.0 1.6 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 1.5 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.6 GO:0060216 definitive hemopoiesis(GO:0060216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.7 4.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.7 7.0 GO:0098982 GABA-ergic synapse(GO:0098982)
0.6 3.3 GO:0043083 synaptic cleft(GO:0043083)
0.5 6.6 GO:1990246 uniplex complex(GO:1990246)
0.5 4.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 13.2 GO:0005861 troponin complex(GO:0005861)
0.2 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 3.3 GO:0031430 M band(GO:0031430)
0.1 2.6 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 2.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.1 1.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 3.8 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 2.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.3 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 2.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 8.1 GO:0030424 axon(GO:0030424)
0.0 2.1 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 3.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 3.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
1.0 5.8 GO:0004743 pyruvate kinase activity(GO:0004743)
1.0 2.9 GO:0016748 succinyltransferase activity(GO:0016748)
0.9 2.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 2.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5 3.6 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.5 5.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.4 1.7 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.4 7.0 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.3 1.9 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.2 0.7 GO:0019777 Atg12 transferase activity(GO:0019777)
0.2 1.1 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.2 4.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 2.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2 1.0 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 6.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 2.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 3.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 4.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 3.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 1.3 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.2 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.7 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 8.2 GO:0005179 hormone activity(GO:0005179)
0.1 1.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 0.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 2.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 1.5 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.9 GO:0030552 cAMP binding(GO:0030552)
0.0 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 3.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.6 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 1.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 5.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 6.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.9 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 2.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.9 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 2.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation