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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for dlx5a

Z-value: 0.64

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Transcription factors associated with dlx5a

Gene Symbol Gene ID Gene Info
dlx5a
ENSDARG00000042296 distal-less homeobox 5a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dlx5adr11_v1_chr19_-_41472228_41472228-0.463.5e-06Click!

Activity profile of dlx5a motif

Sorted Z-values of dlx5a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29955368 7.39 ENSDART00000173686
tpma
alpha-tropomyosin
chr17_+_43867889 6.05 ENSDART00000132673
ENSDART00000167214
zgc:66313
zgc:66313
chr17_+_43863708 5.91 ENSDART00000133874
ENSDART00000140316
ENSDART00000142929
ENSDART00000148090
zgc:66313
zgc:66313
chr10_+_19596214 4.61 ENSDART00000183110
CABZ01059626.1

chr7_+_69019851 4.02 ENSDART00000162891
CABZ01057488.1

chr21_+_6751405 3.69 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr21_+_6751760 3.69 ENSDART00000135914
olfm1b
olfactomedin 1b
chr2_+_6253246 3.40 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr11_-_44801968 3.26 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr6_+_3680651 2.57 ENSDART00000013588
klhl41b
kelch-like family member 41b
chr11_+_23760470 2.52 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
nfasca
neurofascin homolog (chicken) a
chr10_-_26512742 2.28 ENSDART00000135951
si:dkey-5g14.1
si:dkey-5g14.1
chr23_+_40460333 2.24 ENSDART00000184658
soga3b
SOGA family member 3b
chr23_+_2906031 1.95 ENSDART00000109304
c23h20orf24
c23h20orf24 homolog (H. sapiens)
chr20_-_14114078 1.93 ENSDART00000168434
ENSDART00000104032
si:ch211-223m11.2
si:ch211-223m11.2
chr13_+_24829996 1.92 ENSDART00000147194
si:ch211-223p8.8
si:ch211-223p8.8
chr16_+_35661331 1.89 ENSDART00000161725
map7d1a
MAP7 domain containing 1a
chr10_-_40968095 1.86 ENSDART00000184104
npffr1l1
neuropeptide FF receptor 1 like 1
chr10_-_26512993 1.85 ENSDART00000188549
ENSDART00000193316
si:dkey-5g14.1
si:dkey-5g14.1
chr13_-_33227411 1.74 ENSDART00000057386
golga5
golgin A5
chr16_-_42056137 1.67 ENSDART00000102798
zp3d.2
zona pellucida glycoprotein 3d tandem duplicate 2
chr16_+_35661771 1.65 ENSDART00000161393
map7d1a
MAP7 domain containing 1a
chr21_+_39948300 1.63 ENSDART00000137740
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr23_+_33963619 1.51 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr17_+_41343167 1.43 ENSDART00000156405
mocs1
molybdenum cofactor synthesis 1
chr8_-_50888806 1.42 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr16_+_45425181 1.36 ENSDART00000168591
phf1
PHD finger protein 1
chr5_-_7829657 1.28 ENSDART00000158374
pdlim5a
PDZ and LIM domain 5a
chr13_-_31435137 1.23 ENSDART00000057441
rtn1a
reticulon 1a
chr19_+_5480327 1.21 ENSDART00000148794
jupb
junction plakoglobin b
chr24_+_1023839 1.20 ENSDART00000082526
zgc:111976
zgc:111976
chr24_-_39637418 1.19 ENSDART00000142522
fam234a
family with sequence similarity 234, member A
chr6_+_23026714 1.17 ENSDART00000124948
srp68
signal recognition particle 68
chr7_-_40110140 1.14 ENSDART00000173469
si:ch73-174h16.5
si:ch73-174h16.5
chr24_+_7336411 1.12 ENSDART00000191170
kmt2ca
lysine (K)-specific methyltransferase 2Ca
chr6_-_6487876 1.04 ENSDART00000137642
cep170ab
centrosomal protein 170Ab
chr15_+_15856178 0.98 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr18_+_11970987 0.94 ENSDART00000144111
si:dkeyp-2c8.3
si:dkeyp-2c8.3
chr20_-_47188966 0.91 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr17_+_25187226 0.90 ENSDART00000148431
cln8
CLN8, transmembrane ER and ERGIC protein
chr15_-_44512461 0.88 ENSDART00000155456
gria4a
glutamate receptor, ionotropic, AMPA 4a
chr20_-_2949028 0.83 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cdk19
cyclin-dependent kinase 19
chr3_-_46817499 0.82 ENSDART00000013717
elavl3
ELAV like neuron-specific RNA binding protein 3
chr2_-_21819421 0.78 ENSDART00000121586
chd7
chromodomain helicase DNA binding protein 7
chr2_-_33645411 0.76 ENSDART00000114663
b4galt2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr9_-_49964810 0.76 ENSDART00000167098
scn1a
sodium channel, voltage-gated, type I, alpha
chr2_-_2451181 0.75 ENSDART00000101033
pth1ra
parathyroid hormone 1 receptor a
chr4_-_5795309 0.75 ENSDART00000039987
pgm3
phosphoglucomutase 3
chr16_+_45424907 0.75 ENSDART00000134471
phf1
PHD finger protein 1
chr2_+_38370535 0.74 ENSDART00000179614
psmb11a
proteasome subunit beta 11a
chr20_+_39457598 0.74 ENSDART00000140931
ENSDART00000156176
pimr128
Pim proto-oncogene, serine/threonine kinase, related 128
chr7_-_12464412 0.69 ENSDART00000178723
adamtsl3
ADAMTS-like 3
chr11_+_30057762 0.68 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr23_-_31913231 0.67 ENSDART00000146852
ENSDART00000085054
mtfr2
mitochondrial fission regulator 2
chr7_-_25895189 0.65 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr15_+_5360407 0.61 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr16_+_42471455 0.56 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr5_-_30620625 0.53 ENSDART00000098273
tcnl
transcobalamin like
chr1_-_53277413 0.51 ENSDART00000150579
znf330
zinc finger protein 330
chr18_+_50461981 0.50 ENSDART00000158761
CU896640.1

chr20_+_14114258 0.47 ENSDART00000044937
kcns3b
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr11_+_31864921 0.46 ENSDART00000180252
diaph3
diaphanous-related formin 3
chr24_-_31843173 0.45 ENSDART00000185782
steap2
STEAP family member 2, metalloreductase
chr16_+_54263921 0.45 ENSDART00000002856
drd2l
dopamine receptor D2 like
chr10_+_2529037 0.44 ENSDART00000123467
zmp:0000001301
zmp:0000001301
chr23_+_34990693 0.44 ENSDART00000013449
CHST13
si:ch211-236h17.3
chr3_+_17537352 0.43 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr17_+_49500820 0.41 ENSDART00000170306
AREL1
apoptosis resistant E3 ubiquitin protein ligase 1
chr1_-_17715493 0.38 ENSDART00000133027
si:dkey-256e7.8
si:dkey-256e7.8
chr2_-_10896745 0.37 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr16_+_31804590 0.37 ENSDART00000167321
wnt4b
wingless-type MMTV integration site family, member 4b
chr14_+_11290828 0.34 ENSDART00000184078
rlim
ring finger protein, LIM domain interacting
chr4_+_306036 0.33 ENSDART00000103659
msgn1
mesogenin 1
chr23_+_31912882 0.31 ENSDART00000140505
armc1l
armadillo repeat containing 1, like
chr13_+_255067 0.29 ENSDART00000102505
foxg1d
forkhead box G1d
chr23_-_31913069 0.28 ENSDART00000135526
mtfr2
mitochondrial fission regulator 2
chr25_-_34632050 0.25 ENSDART00000170671
megf8
multiple EGF-like-domains 8
chr3_-_23512285 0.24 ENSDART00000159151
BX682558.1

chr2_-_17694504 0.23 ENSDART00000133709
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr17_-_43863700 0.21 ENSDART00000157530
ahsa1b
AHA1, activator of heat shock protein ATPase homolog 1b
chr4_-_32466676 0.20 ENSDART00000193347
ENSDART00000169396
ENSDART00000145784
si:dkey-16p6.1
si:dkey-16p6.1
chr18_+_28106139 0.17 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr6_-_40922971 0.17 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr1_+_40199074 0.16 ENSDART00000179679
ENSDART00000136849
si:ch211-113e8.5
si:ch211-113e8.5
chr19_+_4800549 0.16 ENSDART00000056235
st3gal1l
ST3 beta-galactoside alpha-2,3-sialyltransferase 1, like
chr4_-_71153608 0.14 ENSDART00000190144
ENSDART00000158406
si:dkey-193i10.4
si:dkey-193i10.4
chr25_-_7705487 0.12 ENSDART00000128099
prdm11
PR domain containing 11
chr8_-_39822917 0.11 ENSDART00000067843
zgc:162025
zgc:162025
chr19_+_19512515 0.11 ENSDART00000180065
jazf1a
JAZF zinc finger 1a
chr3_+_32832538 0.11 ENSDART00000139410
cd2bp2
CD2 (cytoplasmic tail) binding protein 2
chr25_-_26893006 0.10 ENSDART00000006709
dldh
dihydrolipoamide dehydrogenase
chr15_+_1796313 0.09 ENSDART00000126253
fam124b
family with sequence similarity 124B
chr5_+_66433287 0.06 ENSDART00000170757
kntc1
kinetochore associated 1
chr25_-_18913336 0.02 ENSDART00000171010
parietopsin
parietopsin
chr10_-_13343831 0.02 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr18_+_43891051 0.01 ENSDART00000024213
cxcr5
chemokine (C-X-C motif) receptor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of dlx5a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 5.1 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 1.2 GO:0002159 desmosome assembly(GO:0002159)
0.2 3.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.4 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 2.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.1 GO:0031060 regulation of histone methylation(GO:0031060)
0.1 0.5 GO:0015677 copper ion import(GO:0015677)
0.1 0.3 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.1 0.4 GO:0042755 eating behavior(GO:0042755)
0.1 7.4 GO:0061515 myeloid cell development(GO:0061515)
0.1 1.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.8 GO:0048796 rRNA transcription(GO:0009303) swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 0.8 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 1.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 2.5 GO:0019226 transmission of nerve impulse(GO:0019226)
0.1 1.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.4 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.9 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 2.2 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.2 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:0097065 anterior head development(GO:0097065)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.9 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.4 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.2 1.2 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 2.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 3.3 GO:0000421 autophagosome membrane(GO:0000421)
0.1 8.7 GO:0005884 actin filament(GO:0005884)
0.1 1.2 GO:0030057 desmosome(GO:0030057)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.0 GO:0016592 mediator complex(GO:0016592)
0.0 2.5 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.7 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 5.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.4 GO:0098978 glutamatergic synapse(GO:0098978)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 1.7 GO:0032190 acrosin binding(GO:0032190)
0.2 1.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 1.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 1.6 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.1 0.9 GO:0046625 sphingolipid binding(GO:0046625) ceramide binding(GO:0097001)
0.1 9.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 1.3 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.8 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 2.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 3.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.8 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 1.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.5 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.4 GO:0071855 neuropeptide hormone activity(GO:0005184) neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation