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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for e2f3

Z-value: 0.40

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Transcription factors associated with e2f3

Gene Symbol Gene ID Gene Info
e2f3
ENSDARG00000070463 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f3dr11_v1_chr19_-_29294457_29294457-0.303.4e-03Click!

Activity profile of e2f3 motif

Sorted Z-values of e2f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_186583 3.35 ENSDART00000161504
pclaf
PCNA clamp associated factor
chr24_+_39108243 3.15 ENSDART00000156353
mss51
MSS51 mitochondrial translational activator
chr6_+_60112200 2.18 ENSDART00000008243
prelid3b
PRELI domain containing 3
chr18_+_54354 2.17 ENSDART00000097163
zgc:158482
zgc:158482
chr9_-_2892045 1.88 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr3_-_53486169 1.80 ENSDART00000115243
soul5
heme-binding protein soul5
chr9_-_2892250 1.79 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr15_+_33991928 1.68 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr17_-_29224908 1.65 ENSDART00000156288
si:dkey-28g23.6
si:dkey-28g23.6
chr14_+_22076596 1.53 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr24_+_21684189 1.50 ENSDART00000014696
pdx1
pancreatic and duodenal homeobox 1
chr15_-_34056733 1.39 ENSDART00000170130
ENSDART00000188272
VWDE
si:dkey-30e9.7
chr19_+_636886 1.39 ENSDART00000149192
tert
telomerase reverse transcriptase
chr19_+_43604643 1.38 ENSDART00000151168
si:ch211-199g17.9
si:ch211-199g17.9
chr16_-_25085327 1.12 ENSDART00000077661
prss1
protease, serine 1
chr23_+_43950674 1.07 ENSDART00000167813
corin
corin, serine peptidase
chr14_+_904850 1.03 ENSDART00000161847
si:ch73-208h1.1
si:ch73-208h1.1
chr16_-_21140097 1.02 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
si:dkey-271j15.3
chr18_+_34861568 1.01 ENSDART00000192825
LO018333.1

chr20_-_44090624 1.00 ENSDART00000048978
ENSDART00000082283
ENSDART00000082276
runx2b
runt-related transcription factor 2b
chr19_+_43604256 0.99 ENSDART00000151080
ENSDART00000110305
si:ch211-199g17.9
si:ch211-199g17.9
chr11_-_11792766 0.95 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr17_-_6535941 0.91 ENSDART00000109249
cenpo
centromere protein O
chr19_+_2546775 0.90 ENSDART00000148527
ENSDART00000097528
sp4
sp4 transcription factor
chr7_+_26534131 0.88 ENSDART00000173980
si:dkey-62k3.5
si:dkey-62k3.5
chr19_-_6988837 0.85 ENSDART00000145741
ENSDART00000167640
znf384l
zinc finger protein 384 like
chr21_-_26490186 0.80 ENSDART00000009889
zgc:110540
zgc:110540
chr23_-_18913032 0.71 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr22_-_20259309 0.66 ENSDART00000139160
si:dkey-110c1.10
si:dkey-110c1.10
chr7_+_67434677 0.65 ENSDART00000165971
ENSDART00000166702
kars
lysyl-tRNA synthetase
chr25_+_36339867 0.64 ENSDART00000152195
si:ch211-113a14.18
si:ch211-113a14.18
chr1_-_42289704 0.64 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr15_-_37425468 0.61 ENSDART00000059630
si:ch211-113j13.2
si:ch211-113j13.2
chr15_-_14884332 0.52 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr11_-_44945636 0.50 ENSDART00000157658
orc2
origin recognition complex, subunit 2
chr4_-_72100774 0.49 ENSDART00000170099
slco1f1
solute carrier organic anion transporter family, member 1F1
chr16_+_28728347 0.48 ENSDART00000149240
si:dkey-24i24.3
si:dkey-24i24.3
chr6_-_1865323 0.47 ENSDART00000155775
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr14_-_30918662 0.44 ENSDART00000176631
si:ch211-126c2.4
si:ch211-126c2.4
chr21_-_21514176 0.42 ENSDART00000031205
nectin3b
nectin cell adhesion molecule 3b
chr15_-_2954443 0.38 ENSDART00000161053
zgc:153184
zgc:153184
chr23_-_44219902 0.32 ENSDART00000185874
zgc:158659
zgc:158659
chr4_-_9909371 0.31 ENSDART00000102656
si:dkey-22l11.6
si:dkey-22l11.6
chr3_-_5664123 0.28 ENSDART00000145866
si:ch211-106h11.1
si:ch211-106h11.1
chr7_-_1101071 0.20 ENSDART00000176053
dctn1a
dynactin 1a
chr5_+_66433287 0.15 ENSDART00000170757
kntc1
kinetochore associated 1
chr25_+_6451038 0.14 ENSDART00000009971
snx33
sorting nexin 33
chr6_+_7533601 0.14 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr14_+_14841685 0.11 ENSDART00000158291
ENSDART00000162039
slbp
stem-loop binding protein
chr17_-_465285 0.10 ENSDART00000168718
chrm5a
cholinergic receptor, muscarinic 5a
chr8_-_11988065 0.09 ENSDART00000005140
med27
mediator complex subunit 27
chr3_-_32275975 0.09 ENSDART00000178448
cpt1cb
carnitine palmitoyltransferase 1Cb
chr3_-_61592417 0.09 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr16_+_40575742 0.08 ENSDART00000161503
ccne2
cyclin E2
chr17_+_6536152 0.06 ENSDART00000062952
ENSDART00000121789
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr13_+_13033837 0.01 ENSDART00000079558
letm1
leucine zipper-EF-hand containing transmembrane protein 1
chr14_-_31814149 0.00 ENSDART00000173393
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr3_+_38540411 0.00 ENSDART00000154943
si:dkey-7f16.3
si:dkey-7f16.3

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.2 3.4 GO:0019985 translesion synthesis(GO:0019985)
0.1 2.4 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1 1.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 3.7 GO:0048538 thymus development(GO:0048538)
0.1 1.5 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.0 1.5 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.0 2.2 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.5 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.2 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 1.0 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.4 GO:0007286 spermatid development(GO:0007286)
0.0 1.7 GO:0021782 glial cell development(GO:0021782)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.2 0.9 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.1 2.4 GO:0000795 synaptonemal complex(GO:0000795)
0.1 2.2 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.5 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 3.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.5 GO:0098978 glutamatergic synapse(GO:0098978)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.3 2.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.2 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 2.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.8 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 1.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.9 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.5 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation