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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for e2f8

Z-value: 0.79

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Transcription factors associated with e2f8

Gene Symbol Gene ID Gene Info
ENSDARG00000057323 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f8dr11_v1_chr7_-_16598212_165982120.214.1e-02Click!

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_33220342 7.90 ENSDART00000100893
ENSDART00000113451
si:ch211-125e6.13
chr7_+_24814866 7.83 ENSDART00000173581
si:ch211-226l4.6
chr1_-_18811517 5.16 ENSDART00000142026
si:dkey-167i21.2
chr7_-_55648336 4.84 ENSDART00000147792
ENSDART00000135304
ENSDART00000131923
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr6_-_33916756 4.62 ENSDART00000137447
ENSDART00000138488
nuclear autoantigenic sperm protein (histone-binding)
chr19_-_2582858 4.24 ENSDART00000113829
cell division cycle associated 7b
chr6_+_21005725 3.93 ENSDART00000041370
connexin 44.2
chr3_+_25999477 3.89 ENSDART00000024316
minichromosome maintenance complex component 5
chr5_-_64168415 3.81 ENSDART00000048395
cardiac myosin light chain-1
chr13_+_46941930 3.56 ENSDART00000056962
F-box protein 5
chr20_+_13141408 3.46 ENSDART00000034098
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr7_+_41812190 3.40 ENSDART00000113732
ENSDART00000174137
origin recognition complex, subunit 6
chr7_+_41812817 3.24 ENSDART00000174165
origin recognition complex, subunit 6
chr7_+_41812636 3.20 ENSDART00000174333
origin recognition complex, subunit 6
chr7_+_71535045 3.12 ENSDART00000047069
thymidylate synthetase
chr8_-_44238526 3.09 ENSDART00000061115
ENSDART00000132473
ENSDART00000138019
ENSDART00000133021
piwi-like RNA-mediated gene silencing 1
chr3_+_43086548 2.99 ENSDART00000163579
si:dkey-43p13.5
chr16_-_12723738 2.91 ENSDART00000080414
SH3 domain binding kinase family, member 3
chr24_-_35561672 2.64 ENSDART00000058564
minichromosome maintenance complex component 4
chr4_-_7869731 2.47 ENSDART00000067339
minichromosome maintenance 10 replication initiation factor
chr13_+_8255106 2.39 ENSDART00000080465
helicase, lymphoid specific
chr10_+_6884123 2.32 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr3_-_49514874 2.32 ENSDART00000167179
anti-silencing function 1Ba histone chaperone
chr8_+_52415603 2.29 ENSDART00000021604
ENSDART00000191424
GINS complex subunit 4 (Sld5 homolog)
chr13_-_14929236 2.09 ENSDART00000020576
cell division cycle 25B
chr9_-_2892250 2.09 ENSDART00000140695
cell division cycle associated 7a
chr13_+_31402067 2.05 ENSDART00000019202
tudor domain containing 9
chr9_-_2892045 2.00 ENSDART00000137201
cell division cycle associated 7a
chr11_-_11792766 1.95 ENSDART00000011657
cell division cycle 6 homolog (S. cerevisiae)
chr16_-_12723324 1.93 ENSDART00000131915
SH3 domain binding kinase family, member 3
chr7_+_22823889 1.89 ENSDART00000127467
ENSDART00000148576
ENSDART00000149993
phosphorylase, glycogen, muscle b
chr15_+_5923851 1.83 ENSDART00000152520
ENSDART00000145827
ENSDART00000121529
SH3 domain binding glutamate-rich protein
chr11_-_26576754 1.80 ENSDART00000191733
ENSDART00000002846
ST3 beta-galactoside alpha-2,3-sialyltransferase 8
chr22_-_22301672 1.43 ENSDART00000111711
chromatin assembly factor 1, subunit A (p150)
chr14_-_25956804 1.39 ENSDART00000135627
ENSDART00000146022
ENSDART00000039660
secreted protein, acidic, cysteine-rich (osteonectin)
chr13_+_48359573 1.36 ENSDART00000161959
ENSDART00000165311
mutS homolog 6 (E. coli)
chr22_-_4439311 1.36 ENSDART00000169317
ubiquitin-like with PHD and ring finger domains 1
chr13_+_2894536 1.36 ENSDART00000183678

chr2_+_37424261 1.35 ENSDART00000132427
polyhomeotic homolog 3 (Drosophila)
chr23_-_30045661 1.33 ENSDART00000122239
ENSDART00000103480
coiled-coil domain containing 187
chr12_+_27462225 1.27 ENSDART00000105661
mesenchyme homeobox 1
chr23_-_21515182 1.26 ENSDART00000142000
ring finger protein 207b
chr1_-_34450622 1.23 ENSDART00000083736
LIM domain 7b
chr8_+_41038141 1.20 ENSDART00000075620
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr22_-_38274188 1.17 ENSDART00000139420
ENSDART00000015117
ELAV like neuron-specific RNA binding protein 2
chr14_-_28566238 1.16 ENSDART00000172547
preproinsulin b
chr11_+_24804556 1.13 ENSDART00000082761
ENSDART00000186283
adiponectin receptor 1a
chr12_+_21299338 1.11 ENSDART00000074540
ENSDART00000133188
carbonic anhydrase Xa
chr9_+_30294096 1.07 ENSDART00000026551
sushi-repeat containing protein, X-linked
chr16_-_15988320 1.05 ENSDART00000160883

chr24_-_13349464 1.05 ENSDART00000134482
ENSDART00000139212
telomeric repeat binding factor (NIMA-interacting) 1
chr1_-_38170997 0.97 ENSDART00000142811
high mobility group box 2a
chr5_-_30535327 0.96 ENSDART00000040328
H2A histone family, member X
chr19_-_44064842 0.91 ENSDART00000151541
mitochondrial transcription termination factor 3
chr19_+_40069524 0.88 ENSDART00000151365
ENSDART00000140926
zinc finger, MYM-type 4
chr14_+_33458294 0.86 ENSDART00000075278
ATPase Na+/K+ transporting subunit beta 4
chr25_+_35020529 0.83 ENSDART00000158016
filamin C, gamma a (actin binding protein 280)
chr2_+_17055069 0.82 ENSDART00000115078
thrombopoietin
chr3_-_14571514 0.82 ENSDART00000137197
SWIM-type zinc finger 7 associated protein 1
chr8_-_2543327 0.81 ENSDART00000134115
si:ch211-51h9.6
chr25_-_35524166 0.79 ENSDART00000156782
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr9_-_49964810 0.77 ENSDART00000167098
sodium channel, voltage-gated, type I, alpha
chr13_+_48358467 0.75 ENSDART00000171080
ENSDART00000162531
mutS homolog 6 (E. coli)
chr13_-_18069421 0.72 ENSDART00000146772
ENSDART00000134477
zinc finger, AN1-type domain 4
chr7_+_39166460 0.71 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
midkine a
chr25_-_17579701 0.68 ENSDART00000073684
matrix metallopeptidase 15a
chr5_-_30382925 0.67 ENSDART00000125381
grass carp reovirus (GCRV)-induced gene 2o
chr14_+_5861435 0.66 ENSDART00000041279
ENSDART00000147341
tubulin, beta 4B class IVb
chr3_-_35865040 0.66 ENSDART00000102952
SUZ12 polycomb repressive complex 2a subunit
chr18_-_35842554 0.64 ENSDART00000088488
optic atrophy 3
chr24_-_13349802 0.64 ENSDART00000164729
telomeric repeat binding factor (NIMA-interacting) 1
chr13_+_26703922 0.63 ENSDART00000020946
Fanconi anemia, complementation group L
chr20_+_38525567 0.62 ENSDART00000147787
zinc finger protein 512
chr17_+_11372531 0.62 ENSDART00000130975
ENSDART00000149366
translocase of inner mitochondrial membrane 9 homolog
chr25_-_26753196 0.59 ENSDART00000155698
ubiquitin specific peptidase 3
chr7_+_36898850 0.59 ENSDART00000113342
TOX high mobility group box family member 3
chr25_+_5035343 0.59 ENSDART00000011751
parvin, beta
chr23_-_16981899 0.58 ENSDART00000125472
ENSDART00000142297
ENSDART00000143180
DNA (cytosine-5-)-methyltransferase beta, duplicate b.3
chr21_-_41818359 0.58 ENSDART00000046076

chr7_+_28724919 0.55 ENSDART00000011324
coiled-coil domain containing 102A
chr5_-_20678300 0.52 ENSDART00000088639
WSC domain containing 2
chr3_+_52545400 0.52 ENSDART00000184183
solute carrier family 27 (fatty acid transporter), member 1a
chr15_-_17618800 0.51 ENSDART00000157185
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr7_+_5956937 0.50 ENSDART00000170763
histone cluster 1 H2A family member 4
chr11_+_24290130 0.48 ENSDART00000029695
purine nucleoside phosphorylase 4a
chr4_-_74069252 0.47 ENSDART00000112802
si:cabz01069012.2
chr11_-_29685853 0.47 ENSDART00000128468
nuclear receptor subfamily 0, group B, member 1
chr25_-_17579242 0.46 ENSDART00000184934
matrix metallopeptidase 15a
chr16_+_32184485 0.45 ENSDART00000084009
zinc finger with UFM1-specific peptidase domain
chr16_+_31942527 0.44 ENSDART00000188334
ENSDART00000188643
ENSDART00000058496
polyhomeotic homolog 1
chr7_+_27253063 0.43 ENSDART00000191138
SRY (sex determining region Y)-box 6
chr4_-_74062634 0.43 ENSDART00000105992
si:cabz01069012.2
chr11_-_6206520 0.43 ENSDART00000150199
ENSDART00000148246
ENSDART00000019440
polymerase (DNA-directed), epsilon 4, accessory subunit
chr16_+_24681177 0.43 ENSDART00000058956
ENSDART00000189335
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr16_+_53278406 0.42 ENSDART00000010792
phosphatidylserine synthase 1a
chr24_-_2829049 0.42 ENSDART00000164913
si:ch211-152c8.5
chr16_+_33953644 0.41 ENSDART00000164447
ENSDART00000159969
AT rich interactive domain 1Aa (SWI-like)
chr3_+_8826905 0.41 ENSDART00000167474
ENSDART00000168088
si:dkeyp-30d6.2
chr24_-_26945390 0.40 ENSDART00000123354
male-specific lethal 2 homolog b (Drosophila)
chr24_-_22756508 0.40 ENSDART00000035409
ENSDART00000146247
zinc finger, C2HC-type containing 1A
chr1_-_24558838 0.39 ENSDART00000102522
glutamyl-tRNA(Gln) amidotransferase, subunit B
chr18_-_34170918 0.39 ENSDART00000015079
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_18107447 0.38 ENSDART00000187376
glutamine-rich 1
chr6_+_38896158 0.37 ENSDART00000029930
ENSDART00000131347
solute carrier family 48 (heme transporter), member 1b
chr7_+_23495986 0.36 ENSDART00000190739
ENSDART00000115299
ENSDART00000101423
ENSDART00000142401
zgc:109889
chr7_+_41421998 0.36 ENSDART00000083967
chondroitin polymerizing factor 2
chr6_-_18531760 0.35 ENSDART00000167167
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr12_-_1557286 0.35 ENSDART00000082110
somatostatin receptor 2a
chr2_+_9755422 0.34 ENSDART00000018524
phosphate cytidylyltransferase 1, choline, alpha a
chr1_-_45614318 0.34 ENSDART00000149725
activating transcription factor 7 interacting protein
chr12_+_17933775 0.33 ENSDART00000186047
ENSDART00000160586
transformation/transcription domain-associated protein
chr12_+_31616412 0.33 ENSDART00000124439
carboxypeptidase N, polypeptide 1
chr15_-_4596623 0.33 ENSDART00000132227
eukaryotic translation initiation factor 4h
chr3_+_17744339 0.33 ENSDART00000132622
zinc finger protein 385C
chr5_-_64454459 0.31 ENSDART00000172321
ENSDART00000168030
bromodomain containing 3b
chr23_+_45025909 0.31 ENSDART00000188105
high mobility group box 2b
chr17_+_9310259 0.31 ENSDART00000186158
ENSDART00000190329
neuronal PAS domain protein 3
chr1_+_44814322 0.31 ENSDART00000059227
NADH dehydrogenase (ubiquinone) Fe-S protein 8a
chr17_+_9009098 0.29 ENSDART00000180856
A kinase (PRKA) anchor protein 6
chr22_+_8753092 0.29 ENSDART00000140720
si:dkey-182g1.2
chr24_-_11821505 0.29 ENSDART00000058992
GLI family zinc finger 3
chr1_-_28890028 0.29 ENSDART00000075500
protein O-glucosyltransferase 1
chr25_-_35110695 0.27 ENSDART00000099859
histone cluster 1 H2A family member 10
chr10_+_3875716 0.27 ENSDART00000189268
ENSDART00000180624
tetratricopeptide repeat domain 28
chr22_+_8753365 0.27 ENSDART00000106086
si:dkey-182g1.2
chr3_+_52545014 0.26 ENSDART00000018908
solute carrier family 27 (fatty acid transporter), member 1a
chr21_-_27413294 0.26 ENSDART00000131646
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr23_+_10805188 0.26 ENSDART00000035693
protein phosphatase 4, regulatory subunit 2a
chr16_-_9453591 0.26 ENSDART00000126154
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr23_-_33738945 0.25 ENSDART00000136386
si:ch211-210c8.7
chr23_-_10137322 0.24 ENSDART00000142442
plexin b1a
chr11_-_18017287 0.23 ENSDART00000155443
glutamine-rich 1
chr11_-_18017918 0.22 ENSDART00000040171
glutamine-rich 1
chr7_-_38634845 0.22 ENSDART00000173861
C1q and TNF related 4
chr5_+_13308139 0.21 ENSDART00000182189
YdjC chitooligosaccharide deacetylase homolog
chr14_+_49220026 0.20 ENSDART00000063643
ENSDART00000128744
required for meiotic nuclear division 5 homolog B
chr20_+_2732992 0.19 ENSDART00000152697
synaptotagmin binding, cytoplasmic RNA interacting protein
chr7_+_29509255 0.19 ENSDART00000076172
si:dkey-182o15.5
chr10_+_10386435 0.19 ENSDART00000179214
ENSDART00000189799
ENSDART00000193875
sarcosine dehydrogenase
chr9_+_34380299 0.19 ENSDART00000131705
lysosomal-associated membrane protein 1
chr9_+_34232503 0.19 ENSDART00000132836
neurexophilin and PC-esterase domain family, member 3
chr19_-_30359059 0.18 ENSDART00000103471
KH domain containing, RNA binding, signal transduction associated 1b
chr19_-_3255725 0.18 ENSDART00000105165
immune-related, lectin-like receptor 1
chr4_-_7231480 0.18 ENSDART00000159436
si:ch211-170p16.1
chr23_-_29357764 0.18 ENSDART00000156512
si:ch211-129o18.4
chr8_-_45430817 0.18 ENSDART00000150067
ENSDART00000112394
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b
chr18_-_34171280 0.18 ENSDART00000122321
solute carrier family 33 (acetyl-CoA transporter), member 1
chr16_-_22775480 0.17 ENSDART00000141778
ENSDART00000145585
ENSDART00000125963
ENSDART00000127570
pre-B-cell leukemia homeobox interacting protein 1b
chr12_+_18234557 0.16 ENSDART00000130741
family with sequence similarity 20, member Cb
chr7_+_22616212 0.16 ENSDART00000052844
claudin 7a
chr3_-_53092509 0.16 ENSDART00000062081
lysophosphatidic acid receptor 2a
chr18_+_35842933 0.16 ENSDART00000151587
ENSDART00000131121
protein phosphatase 1, regulatory subunit 13 like
chr23_-_44848961 0.15 ENSDART00000136839
wu:fb72h05
chr23_+_21482571 0.15 ENSDART00000187368
si:dkey-1c11.1
chr5_-_19394440 0.14 ENSDART00000163771
forkhead box N4
chr18_+_27571448 0.14 ENSDART00000147886
CD82 molecule b
chr6_+_21062416 0.14 ENSDART00000141643
si:dkey-91f15.1
chr17_-_45009782 0.13 ENSDART00000123971
family with sequence similarity 161, member B
chr20_+_18703454 0.13 ENSDART00000152342
eukaryotic translation initiation factor 5
chr22_-_6959769 0.13 ENSDART00000105866
si:ch73-213k20.5
chr4_+_20318127 0.12 ENSDART00000028856
ENSDART00000132909
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr22_+_11535131 0.12 ENSDART00000113930
neuropeptide B
chr1_+_9144958 0.12 ENSDART00000046507
RASD family member 3
chr17_+_2727807 0.11 ENSDART00000178759
potassium channel, subfamily K, member 10b
chr10_+_35952532 0.10 ENSDART00000184730
reticulon 4 receptor-like 1a
chr15_+_5628363 0.08 ENSDART00000148193
melanocortin 2 receptor accessory protein
chr11_+_3006124 0.08 ENSDART00000126071
copine Vb
chr10_+_36650222 0.08 ENSDART00000126963
uncoupling protein 3
chr19_+_32603627 0.07 ENSDART00000052086
transmembrane protein 54b
chr12_-_30345444 0.07 ENSDART00000152985
von Willebrand factor A domain containing 2
chr6_-_40899618 0.06 ENSDART00000153949
ENSDART00000021969
zgc:172271
chr2_+_7818368 0.06 ENSDART00000007068
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr17_+_45009868 0.05 ENSDART00000085009
coenzyme Q6 monooxygenase
chr25_+_7532627 0.05 ENSDART00000187660
phosphatidylserine synthase 2
chr19_+_41080240 0.05 ENSDART00000087295
protein phosphatase 1, regulatory subunit 9A
chr16_+_7154266 0.04 ENSDART00000168830
BMP binding endothelial regulator
chr22_-_26274177 0.03 ENSDART00000060978
WD repeat domain containing 83
chr2_-_45027754 0.03 ENSDART00000168469
von Willebrand factor A domain containing 5B2
chr18_+_33762090 0.02 ENSDART00000147605
si:dkey-145c18.4
chr6_-_8466717 0.02 ENSDART00000151577
ENSDART00000151800
ENSDART00000151227
si:dkey-217d24.6
chr2_-_25120197 0.02 ENSDART00000132549
propionyl CoA carboxylase, beta polypeptide
chr14_+_46223458 0.01 ENSDART00000173428
calcium binding protein 2b
chr17_-_36529016 0.01 ENSDART00000025019
collectin sub-family member 11
chr9_-_10460087 0.01 ENSDART00000186001
thrombospondin, type I, domain containing 7Ba
chr1_+_18811679 0.00 ENSDART00000078610
solute carrier family 25, member 51a

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.9 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 3.1 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.9 3.6 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.7 2.1 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.6 3.8 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.6 1.9 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.6 20.7 GO:0006270 DNA replication initiation(GO:0006270)
0.6 5.1 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.5 2.1 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.4 3.5 GO:0072425 mitotic G2 DNA damage checkpoint(GO:0007095) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.4 1.3 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.4 2.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.4 3.7 GO:0044030 regulation of DNA methylation(GO:0044030)
0.3 1.2 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.2 0.9 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.2 1.9 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 2.3 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 1.3 GO:0061056 sclerotome development(GO:0061056)
0.1 8.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 4.1 GO:0048538 thymus development(GO:0048538)
0.1 0.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.8 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 4.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 0.5 GO:0008584 male gonad development(GO:0008584)
0.1 1.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 0.2 GO:1901052 sarcosine metabolic process(GO:1901052)
0.1 1.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 3.0 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.3 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.3 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.4 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.7 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.2 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.8 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.4 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.0 1.1 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.4 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0014896 muscle hypertrophy(GO:0014896)
0.0 0.2 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 1.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.6 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.6 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 0.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.3 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 1.2 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.6 GO:0050879 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)
0.0 0.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.8 9.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.7 2.1 GO:0032301 MutSalpha complex(GO:0032301)
0.5 2.5 GO:0031298 replication fork protection complex(GO:0031298)
0.5 2.3 GO:0000811 GINS complex(GO:0000811)
0.4 6.5 GO:0042555 MCM complex(GO:0042555)
0.4 1.4 GO:0033186 CAF-1 complex(GO:0033186)
0.2 7.5 GO:0043186 P granule(GO:0043186)
0.1 0.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.4 GO:0000792 heterochromatin(GO:0000792)
0.1 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 0.3 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 1.7 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.4 GO:0035060 brahma complex(GO:0035060)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.1 0.4 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 9.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 3.5 GO:0005819 spindle(GO:0005819)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0032404 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.6 1.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.4 10.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 3.1 GO:0034584 piRNA binding(GO:0034584)
0.4 1.9 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.3 7.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 1.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 0.8 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1 1.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.6 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 1.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.3 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 4.4 GO:0003724 RNA helicase activity(GO:0003724)
0.1 0.5 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.2 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.3 GO:0034057 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.0 0.4 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.3 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 1.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 2.0 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 8.3 GO:0042393 histone binding(GO:0042393)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.9 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0031779 melanocortin receptor binding(GO:0031779)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.6 PID PLK1 PATHWAY PLK1 signaling events
0.1 4.7 PID E2F PATHWAY E2F transcription factor network
0.0 2.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID ATM PATHWAY ATM pathway
0.0 0.6 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.7 11.8 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 6.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 2.5 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 2.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.8 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 1.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway