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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for ebf1b

Z-value: 1.07

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Transcription factors associated with ebf1b

Gene Symbol Gene ID Gene Info
ENSDARG00000069196 EBF transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ebf1bdr11_v1_chr21_-_33851877_338518770.697.9e-15Click!

Activity profile of ebf1b motif

Sorted Z-values of ebf1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_34933183 19.12 ENSDART00000062738
synaptosomal-associated protein, 25a
chr12_-_35787801 13.52 ENSDART00000171682
apoptosis-associated tyrosine kinase b
chr4_+_11375894 12.76 ENSDART00000190471
ENSDART00000143963
piccolo presynaptic cytomatrix protein a
chr21_-_19018455 12.30 ENSDART00000080256
neurofilament, medium polypeptide a
chr10_+_19554604 10.78 ENSDART00000063806
ATPase H+ transporting V1 subunit B2
chr25_+_21324588 10.44 ENSDART00000151842
leucine rich repeat neuronal 3a
chr14_+_25817246 10.33 ENSDART00000136733
glycine receptor, alpha 1
chr19_-_13733870 9.88 ENSDART00000177773
erythrocyte membrane protein band 4.1a
chr3_+_49397115 9.87 ENSDART00000176042
trans-2,3-enoyl-CoA reductase a
chr9_+_44430974 8.75 ENSDART00000056846
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr4_+_17336557 8.34 ENSDART00000111650
pro-melanin-concentrating hormone
chr5_-_37933983 8.31 ENSDART00000185364
sodium channel, voltage-gated, type IV, beta b
chr10_+_21650828 8.18 ENSDART00000160754
protocadherin 1 gamma 1
chr7_+_58686860 8.03 ENSDART00000052332
proenkephalin b
chr7_-_52842007 7.97 ENSDART00000182710
microtubule-associated protein 1Aa
chr21_+_26389391 7.89 ENSDART00000077197
thymosin, beta
chr1_-_44701313 6.83 ENSDART00000193926
si:dkey-28b4.8
chr10_+_33982010 6.60 ENSDART00000180431
furry homolog b (Drosophila)
chr23_+_26946744 6.58 ENSDART00000115141
calcium channel, voltage-dependent, beta 3b
chr13_-_40120252 6.27 ENSDART00000157852
cartilage acidic protein 1b
chr9_+_44431174 6.23 ENSDART00000149726
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr4_+_74255904 5.97 ENSDART00000174385
protein tyrosine phosphatase, receptor type, r
chr3_-_42086577 5.59 ENSDART00000083111
ENSDART00000187312
tweety family member 3a
chr23_-_21471022 5.55 ENSDART00000104206
hairy-related 4, tandem duplicate 2
chr9_-_22831836 5.46 ENSDART00000142585
nebulin
chr18_-_19095141 5.31 ENSDART00000090962
ENSDART00000090922
DENN/MADD domain containing 4A
chr23_+_40460333 5.21 ENSDART00000184658
SOGA family member 3b
chr1_-_46989650 5.19 ENSDART00000129072
ENSDART00000150507
si:dkey-22n8.3
chr13_+_17702853 4.91 ENSDART00000145438
si:dkey-27m7.4
chr14_+_25817628 4.88 ENSDART00000047680
glycine receptor, alpha 1
chr1_+_41666611 4.86 ENSDART00000145789
F-box protein 41
chr12_-_33359654 4.78 ENSDART00000001907
solute carrier family 16 (monocarboxylate transporter), member 3
chr14_-_2196267 4.78 ENSDART00000161674
ENSDART00000125674
protocadherin 2 alpha b 8
protocadherin 2 alpha b 9
chr12_-_26241810 4.76 ENSDART00000180335
ubiquitin specific peptidase 54b
chr18_+_50276653 4.74 ENSDART00000192120
si:dkey-105e17.1
chr4_+_13810811 4.70 ENSDART00000067168
PDZ domain containing ring finger 4
chr4_-_5019113 4.52 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr16_-_25535430 4.45 ENSDART00000077420
dystrobrevin binding protein 1a
chr23_+_20931030 4.40 ENSDART00000167014
paired box 7b
chr15_+_6114109 4.40 ENSDART00000184937
Purkinje cell protein 4
chr4_+_20318127 4.33 ENSDART00000028856
ENSDART00000132909
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr5_+_25952340 4.30 ENSDART00000147188
transient receptor potential cation channel, subfamily M, member 3
chr17_-_43558494 4.23 ENSDART00000103830
5'-nucleotidase, cytosolic IAb
chr18_+_50276337 4.01 ENSDART00000140352
si:dkey-105e17.1
chr18_+_10820430 3.95 ENSDART00000161990
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr25_-_13105310 3.83 ENSDART00000172269
sphingomyelin phosphodiesterase 3, neutral
chr14_-_32405387 3.75 ENSDART00000184647
fibroblast growth factor 13a
chr21_-_2273244 3.69 ENSDART00000171417
si:ch73-299h12.3
chr13_-_32906265 3.67 ENSDART00000113823
ENSDART00000171114
ENSDART00000180035
ENSDART00000137570
si:dkey-18j18.3
chr23_-_5032587 3.66 ENSDART00000163903
potassium voltage-gated channel, shaker-related subfamily, member 2b
chr1_+_41690402 3.61 ENSDART00000177298
F-box protein 41
chr13_+_17702522 3.56 ENSDART00000057913
si:dkey-27m7.4
chr15_-_30505607 3.54 ENSDART00000155212
musashi RNA-binding protein 2b
chr24_+_1294176 3.49 ENSDART00000106637
si:ch73-134f24.1
chr4_+_37992753 3.45 ENSDART00000193890

chr16_-_47245563 3.39 ENSDART00000190225

chr2_+_38608290 3.30 ENSDART00000159066
cadherin 24, type 2b
chr11_+_31323746 3.13 ENSDART00000180220
ENSDART00000189937
signal-induced proliferation-associated 1 like 2
chr24_-_25691020 3.11 ENSDART00000015391
cholinergic receptor, nicotinic, delta (muscle)
chr13_+_1439152 2.88 ENSDART00000159047
si:ch211-165e15.1
chr19_-_26863626 2.85 ENSDART00000145568
proline-rich transmembrane protein 1
chr11_+_31558006 2.79 ENSDART00000024296
egl-9 family hypoxia-inducible factor 1b
chr4_-_10599062 2.78 ENSDART00000048003
tetraspanin 12
chr10_-_31563049 2.77 ENSDART00000023575
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr6_+_58406014 2.71 ENSDART00000044241
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr5_+_57726425 2.64 ENSDART00000134684
ferredoxin-fold anticodon binding domain containing 1
chr10_+_26118122 2.63 ENSDART00000079207
tripartite motif containing 47
chr3_+_62317990 2.63 ENSDART00000058719
zinc finger protein 1124
chr24_-_12749116 2.62 ENSDART00000093583
COX19 cytochrome c oxidase assembly factor
chr18_+_33580391 2.61 ENSDART00000189300
si:dkey-47k20.4
chr3_+_36160979 2.51 ENSDART00000038525
si:ch211-234h8.7
chr15_+_5321612 2.50 ENSDART00000174345
odorant receptor, family A, subfamily 113, member 1
chr5_+_457729 2.47 ENSDART00000025183
intraflagellar transport 74
chr9_+_36356740 2.46 ENSDART00000139033
low density lipoprotein receptor-related protein 1Bb
chr21_-_14775724 2.44 ENSDART00000043239
glutamate-ammonia ligase (glutamine synthase) c
chr14_-_33083539 2.38 ENSDART00000160173
discs, large homolog 3 (Drosophila)
chr24_+_23730061 2.36 ENSDART00000080343
protein phosphatase 1, regulatory subunit 42
chr13_+_1928361 2.35 ENSDART00000164764
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr1_+_49878000 2.32 ENSDART00000047876
lymphoid enhancer-binding factor 1
chr11_-_33857911 2.30 ENSDART00000165370
neurexophilin 2b
chr22_+_39058269 2.30 ENSDART00000113362
inositol hexakisphosphate kinase 1
chr6_-_42036685 2.15 ENSDART00000155174
si:dkeyp-111e5.4
chr8_+_30671060 2.10 ENSDART00000193749
adenosine A2a receptor a
chr6_-_13709591 2.09 ENSDART00000151771
chondroitin polymerizing factor b
chr11_-_8782871 2.08 ENSDART00000158546
si:ch211-51h4.2
chr23_+_2825940 2.06 ENSDART00000135781
phospholipase C, gamma 1
chr7_+_25920792 2.05 ENSDART00000026295
arrestin, beta 2b
chr23_+_26946429 2.01 ENSDART00000185564
calcium channel, voltage-dependent, beta 3b
chr10_+_45059702 2.00 ENSDART00000166945
NudC domain containing 3
chr20_+_48782068 1.95 ENSDART00000159275
NK2 homeobox 2b
chr15_+_5339056 1.93 ENSDART00000174319

chr14_-_41369629 1.93 ENSDART00000173040
cleavage stimulation factor, 3' pre-RNA, subunit 2
chr9_+_21268739 1.90 ENSDART00000186514

chr22_+_2660505 1.90 ENSDART00000135555
ENSDART00000031485
zinc finger protein 1162
chr1_-_16394814 1.86 ENSDART00000013024
fibroblast growth factor 20a
chr18_-_13360106 1.86 ENSDART00000091512
c-Maf inducing protein
chr7_-_8961941 1.86 ENSDART00000111002
si:ch211-74f19.2
chr24_-_25184553 1.85 ENSDART00000166917
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr19_+_40335271 1.84 ENSDART00000135648
family with sequence similarity 133, member B
chr18_+_20871142 1.71 ENSDART00000188274
pyroglutamyl-peptidase I-like
chr2_+_5371492 1.69 ENSDART00000139762
si:ch1073-184j22.1
chr17_+_6467398 1.68 ENSDART00000149527
si:dkey-36g24.3
chr16_-_33076764 1.66 ENSDART00000192917
dopey family member 1
chr4_+_6840223 1.65 ENSDART00000161329
dedicator of cytokinesis 4b
chr1_+_13930625 1.60 ENSDART00000111026
nocturnin b
chr21_-_7687544 1.57 ENSDART00000134519
phosphodiesterase 8B
chr23_-_31506854 1.52 ENSDART00000131352
ENSDART00000138625
ENSDART00000133002
EYA transcriptional coactivator and phosphatase 4
chr20_-_46467280 1.39 ENSDART00000060702
regulator of microtubule dynamics 3
chr6_+_15145123 1.32 ENSDART00000063648
NCK adaptor protein 2b
chr9_-_45149695 1.32 ENSDART00000162033

chr5_+_32141790 1.32 ENSDART00000041504
tescalcin b
chrM_+_3803 1.31 ENSDART00000093596
NADH dehydrogenase 1, mitochondrial
chr11_+_31558207 1.22 ENSDART00000140204
egl-9 family hypoxia-inducible factor 1b
chr14_-_26094172 1.17 ENSDART00000150131
melatonin receptor type 1A like
chr16_+_12281032 1.17 ENSDART00000138638
si:dkey-26c10.5
chr20_+_30378803 1.15 ENSDART00000148242
ENSDART00000169140
ENSDART00000062441
ribonuclease H1
chr10_-_27196093 1.15 ENSDART00000185282
autism susceptibility candidate 2a
chr12_-_11306766 1.14 ENSDART00000036989
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr7_-_41693004 1.14 ENSDART00000121509
MAM and LDL receptor class A domain containing 1
chr10_+_10972795 1.14 ENSDART00000127331
cell division cycle 37-like 1
chr8_-_52557455 1.13 ENSDART00000163596
si:ch73-199g24.2
chr12_+_23812530 1.11 ENSDART00000066331
supervillin a
chr16_-_30564319 1.06 ENSDART00000145087
lamin A
chr13_-_39159810 1.03 ENSDART00000131508
collagen, type IX, alpha 1b
chr7_-_32599669 1.02 ENSDART00000173752
potassium voltage-gated channel, shaker-related subfamily, member 4
chr15_-_23420079 0.94 ENSDART00000104525
ENSDART00000148840
lysine (K)-specific methyltransferase 2A
chr18_-_4957022 0.91 ENSDART00000101686
zinc finger, B-box domain containing
chr12_-_36070473 0.85 ENSDART00000165720
G protein-coupled receptor 142
chr22_+_28446365 0.85 ENSDART00000189359
ABI family, member 3 (NESH) binding protein b
chr15_-_6976851 0.85 ENSDART00000158474
ENSDART00000168943
ENSDART00000169944
si:ch73-311h14.2
chr23_+_2760573 0.84 ENSDART00000129719
DNA topoisomerase I
chr2_-_43123949 0.84 ENSDART00000075347
ENSDART00000132346
leucine rich repeat containing 6
chr15_-_39819877 0.81 ENSDART00000142719
ENSDART00000139465
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr11_+_22134540 0.81 ENSDART00000190502
si:dkey-91m3.1
chr7_+_61876641 0.80 ENSDART00000165409

chr16_-_34212912 0.79 ENSDART00000145017
phosphatase and actin regulator 4b
chr10_-_8041948 0.77 ENSDART00000059017
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr22_+_567733 0.74 ENSDART00000171036
ubiquitin specific peptidase 49
chr22_-_30881738 0.73 ENSDART00000059965
si:dkey-49n23.1
chr22_+_26290209 0.73 ENSDART00000060898
mitochondrial ribosomal protein S28
chr8_+_22916536 0.71 ENSDART00000136403
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr11_+_25638172 0.71 ENSDART00000114226
ENSDART00000143677
glutamate receptor, metabotropic 6b
chr17_+_24597001 0.70 ENSDART00000191834
rearranged L-myc fusion
chr15_-_23936276 0.67 ENSDART00000137569
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr9_+_22080122 0.65 ENSDART00000065956
ENSDART00000136014
crystallin, gamma M2e
chr3_+_32691275 0.63 ENSDART00000191838
si:dkey-16l2.17
chr11_+_8660158 0.62 ENSDART00000169141
transducin (beta)-like 1 X-linked receptor 1a
chr25_+_35020529 0.62 ENSDART00000158016
filamin C, gamma a (actin binding protein 280)
chr17_+_24222190 0.62 ENSDART00000181698
ENSDART00000189411
EH domain binding protein 1
chr12_-_11560794 0.61 ENSDART00000149098
ENSDART00000169975
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr18_-_7112882 0.60 ENSDART00000176292
si:dkey-88e18.8
chr1_+_5275811 0.59 ENSDART00000189676
sprouty RTK signaling antagonist 2
chr6_-_30863046 0.55 ENSDART00000155330
phosphodiesterase 4B, cAMP-specific a
chr16_-_43139251 0.53 ENSDART00000021145
ENSDART00000165293
solute carrier family 25, member 40
chr3_-_51142942 0.53 ENSDART00000160789
si:ch211-148f13.1
chr23_-_6920107 0.50 ENSDART00000149230
ENSDART00000182946
si:ch211-117c9.2
chr2_-_30659222 0.48 ENSDART00000145405
catenin (cadherin-associated protein), delta 2b
chr3_-_46403778 0.48 ENSDART00000074422
cell death-inducing p53 target 1
chr12_+_13652747 0.48 ENSDART00000066359
5-oxoprolinase, ATP-hydrolysing
chr22_-_7809904 0.47 ENSDART00000182269
ENSDART00000097201
ENSDART00000138522
si:ch73-44m9.3
si:ch73-44m9.1
chr8_-_14067517 0.46 ENSDART00000140948
death effector domain containing
chr18_-_210478 0.46 ENSDART00000136693
TM2 domain containing 3
chr23_+_45027263 0.45 ENSDART00000058364
high mobility group box 2b
chr6_-_6254432 0.41 ENSDART00000081952
reticulon 4a
chr2_-_32457919 0.39 ENSDART00000132792
ENSDART00000041319
solute carrier family 4 (anion exchanger), member 2a
chr1_-_50438247 0.33 ENSDART00000114098
dickkopf WNT signaling pathway inhibitor 2
chr16_-_48914757 0.33 ENSDART00000166740

chr15_-_23482088 0.31 ENSDART00000185823
ENSDART00000185523
NLR family member X1
chr2_-_37896646 0.31 ENSDART00000075931
hexose-binding lectin 1
chr8_+_12930216 0.23 ENSDART00000115405
zgc:103670
chr15_-_3466015 0.23 ENSDART00000169559
component of oligomeric golgi complex 6
chr5_-_42083363 0.23 ENSDART00000162596
chemokine (C-X-C motif) ligand 11, duplicate 5
chr15_+_11427620 0.22 ENSDART00000168688
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr5_+_46481586 0.22 ENSDART00000144973
versican a
chr20_+_25711718 0.14 ENSDART00000033436
centrosomal protein 135
chr21_+_16144014 0.14 ENSDART00000163267
pyroglutamylated RFamide peptide receptor 4
chr10_-_32639939 0.13 ENSDART00000126952
ENSDART00000099853
uromodulin-like 1
chr8_+_8196087 0.12 ENSDART00000026965
plexin B3
chr7_-_38806186 0.09 ENSDART00000173669
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr5_-_29112956 0.08 ENSDART00000132726
whirlin b
chr8_-_34762163 0.07 ENSDART00000114080
SET domain containing 1B, b
chr6_-_43922813 0.05 ENSDART00000123341
prokineticin 2
chr11_+_3575963 0.05 ENSDART00000077305
si:dkey-33m11.8
chr22_-_28373698 0.02 ENSDART00000157592
si:ch211-213c4.5
chr16_-_14534724 0.02 ENSDART00000148126
si:dkey-237j11.3

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.2 GO:0071361 cellular response to ethanol(GO:0071361)
2.3 13.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
2.1 12.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
2.0 7.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.3 12.8 GO:1904071 presynaptic active zone assembly(GO:1904071)
1.1 4.4 GO:0033363 secretory granule organization(GO:0033363) platelet dense granule organization(GO:0060155)
0.9 5.5 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.9 4.4 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.9 4.4 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.7 4.3 GO:0016048 detection of temperature stimulus(GO:0016048) sensory perception of temperature stimulus(GO:0050951)
0.7 2.1 GO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting(GO:0035477)
0.6 19.1 GO:0016082 synaptic vesicle priming(GO:0016082)
0.6 2.4 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.5 2.1 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.4 5.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.4 2.5 GO:0035776 intraciliary transport involved in cilium morphogenesis(GO:0035735) pronephric proximal tubule development(GO:0035776)
0.3 2.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.3 4.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.3 8.0 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.3 4.5 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.3 3.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 2.6 GO:0070475 rRNA base methylation(GO:0070475)
0.3 6.0 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.3 3.6 GO:0016199 axon midline choice point recognition(GO:0016199)
0.3 3.8 GO:0061300 cerebellum vasculature development(GO:0061300)
0.3 2.8 GO:1902547 regulation of vascular endothelial growth factor signaling pathway(GO:1900746) regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902547)
0.2 3.5 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.2 7.2 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.2 1.9 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 4.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.2 5.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 10.8 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.2 1.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 1.9 GO:0046850 regulation of bone remodeling(GO:0046850)
0.2 1.1 GO:0090342 regulation of cell aging(GO:0090342)
0.2 1.5 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 4.3 GO:0055017 cardiac muscle tissue growth(GO:0055017)
0.2 0.9 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.2 16.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 2.6 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 9.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.7 GO:0043029 T cell homeostasis(GO:0043029)
0.1 2.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 2.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.8 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 3.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 2.0 GO:0021508 floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.1 7.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.2 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093) regulation of renal system process(GO:0098801)
0.1 1.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.6 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 15.4 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 2.4 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 5.1 GO:0030042 actin filament depolymerization(GO:0030042)
0.1 1.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.7 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.6 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.8 GO:0006265 DNA topological change(GO:0006265)
0.0 1.2 GO:0021884 forebrain neuron development(GO:0021884)
0.0 5.2 GO:0010506 regulation of autophagy(GO:0010506)
0.0 4.7 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.1 GO:0050821 protein stabilization(GO:0050821)
0.0 4.8 GO:0016579 protein deubiquitination(GO:0016579)
0.0 7.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.6 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 1.3 GO:0009060 aerobic respiration(GO:0009060)
0.0 3.1 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.5 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.6 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 6.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:0008272 sulfate transport(GO:0008272)
0.0 0.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 2.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 2.7 GO:0034765 regulation of ion transmembrane transport(GO:0034765)
0.0 1.3 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.0 GO:0006457 protein folding(GO:0006457)
0.0 0.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.1 GO:0000423 macromitophagy(GO:0000423)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0030431 sleep(GO:0030431)
0.0 0.6 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 19.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.5 12.3 GO:0005883 neurofilament(GO:0005883)
1.3 12.8 GO:0098982 GABA-ergic synapse(GO:0098982)
0.6 10.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 2.7 GO:0043194 axon initial segment(GO:0043194)
0.4 4.4 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.4 15.2 GO:0043204 perikaryon(GO:0043204)
0.3 5.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 3.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 6.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 3.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 8.0 GO:0043679 axon terminus(GO:0043679)
0.2 13.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.1 GO:0071818 BAT3 complex(GO:0071818)
0.1 10.4 GO:0030427 site of polarized growth(GO:0030427)
0.1 2.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 3.5 GO:0005844 polysome(GO:0005844)
0.1 1.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 8.0 GO:0043025 neuronal cell body(GO:0043025)
0.1 1.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 2.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 5.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.5 GO:0031941 filamentous actin(GO:0031941)
0.1 2.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 3.3 GO:0016342 catenin complex(GO:0016342)
0.1 4.0 GO:0030018 Z disc(GO:0030018)
0.0 0.9 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 8.0 GO:0005938 cell cortex(GO:0005938)
0.0 2.4 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.0 2.8 GO:0030424 axon(GO:0030424)
0.0 2.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.9 GO:0031514 motile cilium(GO:0031514)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 15.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.9 2.6 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.7 12.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.7 2.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.6 5.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.6 8.0 GO:0031628 opioid receptor binding(GO:0031628)
0.6 2.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.6 7.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.6 2.4 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.6 1.7 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.5 19.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 6.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 7.9 GO:0003785 actin monomer binding(GO:0003785)
0.4 15.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 2.4 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.3 2.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 3.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 2.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 8.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 4.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 4.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.2 1.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 2.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 2.4 GO:0070840 dynein complex binding(GO:0070840)
0.2 5.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 1.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 7.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 8.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.8 GO:0008301 DNA binding, bending(GO:0008301)
0.1 2.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.1 9.9 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 3.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 4.3 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 3.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.7 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.1 2.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 3.9 GO:0071949 FAD binding(GO:0071949)
0.1 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.3 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.8 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 9.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.8 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 1.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 5.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 8.4 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 3.8 GO:0045296 cadherin binding(GO:0045296)
0.0 7.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 4.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.9 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.0 9.4 GO:0008017 microtubule binding(GO:0008017)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
0.0 5.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 9.5 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 1.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 2.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 10.8 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.6 15.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 2.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 3.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.3 4.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 5.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 8.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 3.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.2 REACTOME KINESINS Genes involved in Kinesins