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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for egr1

Z-value: 1.01

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Transcription factors associated with egr1

Gene Symbol Gene ID Gene Info
ENSDARG00000037421 early growth response 1
ENSDARG00000115563 early growth response 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr1dr11_v1_chr14_-_21336385_21336385-0.251.4e-02Click!

Activity profile of egr1 motif

Sorted Z-values of egr1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_20422661 14.31 ENSDART00000144047
ENSDART00000104336
troponin C type 2 (fast)
chr3_-_61185746 13.15 ENSDART00000028219
parvalbumin 4
chr18_+_402048 11.53 ENSDART00000166345
glucose-6-phosphate isomerase b
chr25_-_37501371 10.44 ENSDART00000160498

chr17_+_53311618 10.22 ENSDART00000166517
ankyrin repeat and SOCS box containing 2b
chr18_+_5490668 8.95 ENSDART00000167035
muscle-specific beta 1 integrin binding protein 2
chr13_+_9432501 8.40 ENSDART00000058064
zgc:123321
chr7_+_74150839 8.17 ENSDART00000160195
protein phosphatase 1, catalytic subunit, beta isoform, like
chr11_+_77526 7.63 ENSDART00000193521

chr15_-_20939579 7.53 ENSDART00000152371
ubiquitin specific peptidase 2a
chr17_+_53311243 7.18 ENSDART00000160241
ENSDART00000160009
ENSDART00000162239
ankyrin repeat and SOCS box containing 2b
chr2_-_48753873 7.18 ENSDART00000189556

chr14_+_2243 6.95 ENSDART00000191193
cytokine like 1
chr3_-_5228137 6.77 ENSDART00000137105
myosin, heavy chain 9b, non-muscle
chr10_+_252425 6.71 ENSDART00000059478
leucine rich repeat containing 32
chr20_-_54381034 6.55 ENSDART00000136779
ectonucleoside triphosphate diphosphohydrolase 5b
chr20_+_54356272 6.54 ENSDART00000145735
zinc finger protein 410
chr18_-_50845804 6.52 ENSDART00000158517
si:cabz01113374.3
chr12_-_49149800 6.09 ENSDART00000182290
BUB3 mitotic checkpoint protein
chr9_-_105135 6.07 ENSDART00000180126

chr24_-_42072886 6.05 ENSDART00000171389

chr11_-_44347587 5.95 ENSDART00000172919
si:cabz01100188.1
chr19_+_48102560 5.76 ENSDART00000164464
UTP18 small subunit (SSU) processome component
chr6_-_13206255 5.49 ENSDART00000065373
eukaryotic translation elongation factor 1 beta 2
chr20_-_54377933 5.34 ENSDART00000182664
ectonucleoside triphosphate diphosphohydrolase 5b
chr4_+_77948517 5.07 ENSDART00000149305
protein kinase C and casein kinase substrate in neurons 2
chr19_-_6193448 4.99 ENSDART00000151405
Ets2 repressor factor
chr23_+_39606108 4.96 ENSDART00000109464
G0/G1 switch 2
chr22_-_193234 4.91 ENSDART00000131067
F-box protein 42
chr10_-_34002185 4.90 ENSDART00000046599
zygote arrest 1-like
chr18_-_49078428 4.85 ENSDART00000160702
ENSDART00000174103

chr15_+_3284684 4.79 ENSDART00000179778
forkhead box O1 a
chr12_-_49168398 4.64 ENSDART00000186608

chr15_-_47848544 4.54 ENSDART00000098711
eukaryotic translation initiation factor 3, subunit K
chr15_-_17099560 4.54 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr3_+_16722014 4.53 ENSDART00000008711
glycogen synthase 1 (muscle)
chr6_+_14301214 4.52 ENSDART00000129491
transmembrane protein 182b
chr21_-_233282 4.50 ENSDART00000157684
brix domain containing 2
chr20_+_39250673 4.24 ENSDART00000153003
RALBP1 associated Eps domain containing 1
chr21_-_308852 4.16 ENSDART00000151613
LHFPL tetraspan subfamily member 2a
chr12_+_48851381 4.03 ENSDART00000187241
ENSDART00000187796
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr24_+_42127983 3.85 ENSDART00000190157
ENSDART00000176032
ENSDART00000175790
WW domain containing E3 ubiquitin protein ligase 1
chr2_+_35880600 3.83 ENSDART00000004277
laminin, gamma 1
chr14_+_164556 3.83 ENSDART00000185606
WD repeat domain 1
chr21_+_19368720 3.83 ENSDART00000187759
ENSDART00000185829
ENSDART00000158471
ENSDART00000168728
betacellulin, epidermal growth factor family member
chr3_+_1211242 3.76 ENSDART00000171287
ENSDART00000165769
polymerase (DNA-directed), delta interacting protein 3
chr1_+_176583 3.75 ENSDART00000168760
ENSDART00000160425
lysosomal associated membrane protein 1
chr17_-_2584423 3.70 ENSDART00000013506
zona pellucida glycoprotein 3, tandem duplicate 2
chr5_+_72377851 3.68 ENSDART00000160479
lectin, mannose-binding 2-like a
chr6_+_2093367 3.65 ENSDART00000148396
transglutaminase 2b
chr21_+_26620867 3.64 ENSDART00000176008
estrogen-related receptor alpha
chr18_-_50956280 3.38 ENSDART00000058457
suppression of tumorigenicity 7
chr8_+_45294767 3.33 ENSDART00000191527
ubiquitin associated protein 2b
chr21_+_30950097 3.27 ENSDART00000187572
ras homolog family member Gb
chr19_-_7225060 3.25 ENSDART00000133179
ENSDART00000151138
ENSDART00000104799
ENSDART00000128331
collagen, type XI, alpha 2
chr11_+_45461853 3.24 ENSDART00000173409
son of sevenless homolog 1 (Drosophila)
chr16_+_23978978 3.21 ENSDART00000058964
ENSDART00000135084
apolipoprotein A-II
chr22_-_80533 3.15 ENSDART00000183124

chr5_+_337215 2.97 ENSDART00000167982
ring finger protein 170
chr23_+_44374041 2.91 ENSDART00000136056
eph receptor B4b
chr21_+_103194 2.86 ENSDART00000162755
zyg-11 related, cell cycle regulator
chr8_-_53490376 2.81 ENSDART00000158789
choline dehydrogenase
chr8_-_14144707 2.78 ENSDART00000148061
si:dkey-6n6.1
chr20_+_7398090 2.71 ENSDART00000108649
proprotein convertase subtilisin/kexin type 9
chr8_+_2642384 2.70 ENSDART00000143242
nuclear apoptosis inducing factor 1
chr13_+_25486608 2.69 ENSDART00000057689
BCL2 associated athanogene 3
chr7_-_46019756 2.68 ENSDART00000162583
zgc:162297
chr1_-_8653385 2.68 ENSDART00000193041
actin, beta 1
chr24_+_37406535 2.63 ENSDART00000138264
si:ch211-183d21.1
chr23_-_270847 2.62 ENSDART00000191867
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr25_-_32888115 2.56 ENSDART00000087586
C2 calcium dependent domain containing 4A
chr20_-_48172556 2.53 ENSDART00000097888

chr7_+_46019780 2.50 ENSDART00000163991
cyclin E1
chr25_-_16146851 2.47 ENSDART00000104043
dickkopf WNT signaling pathway inhibitor 3b
chr11_+_1565806 2.46 ENSDART00000137479
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr11_+_45436703 2.34 ENSDART00000168295
ENSDART00000173293
son of sevenless homolog 1 (Drosophila)
chr9_-_23990416 2.33 ENSDART00000113176
collagen, type VI, alpha 3
chr2_+_59046036 2.33 ENSDART00000158860
serine/threonine kinase 11
chr17_+_584369 2.32 ENSDART00000165143
chromosome 14 open reading frame 28
chr11_+_2855430 2.32 ENSDART00000172837
kinesin family member 21B
chr14_+_12316581 2.25 ENSDART00000170115
ENSDART00000149757
si:ch211-125c23.3
connexin 31.7
chr6_+_13206516 2.24 ENSDART00000036927
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr3_-_34041878 2.20 ENSDART00000185325
ENSDART00000193934
immunoglobulin heavy variable 9-4
chr18_+_16246806 2.16 ENSDART00000142584
ALX homeobox 1
chr16_+_13965923 2.15 ENSDART00000103857
zgc:162509
chr17_+_20639180 2.15 ENSDART00000063624
neuropeptide Y receptor Y4
chr5_+_37032038 2.14 ENSDART00000045036
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr2_-_54639964 2.14 ENSDART00000100103
acyl-CoA synthetase short chain family member 2 like
chr4_+_30785713 2.13 ENSDART00000165945
si:dkey-178j11.5
chr14_+_7939398 2.13 ENSDART00000189773
CXXC finger protein 5b
chr12_-_20303438 2.12 ENSDART00000153057
rhomboid 5 homolog 1b (Drosophila)
chr8_+_20398445 2.08 ENSDART00000134755
zeta chain of T cell receptor associated protein kinase 70
chr20_+_38458084 2.06 ENSDART00000020153
ENSDART00000135912
coenzyme Q8A
chr13_-_50567658 2.06 ENSDART00000132281
B cell linker
chr23_+_45822935 2.02 ENSDART00000161892
vitamin D receptor a
chr17_+_27456804 2.01 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
cathepsin L.1
chr10_+_8554929 1.94 ENSDART00000190849
TBC1 domain family, member 10Ab
chr10_-_35030673 1.93 ENSDART00000135338
SPT20 homolog, SAGA complex component
chr1_+_56972616 1.89 ENSDART00000152812
si:ch211-1f22.11
chr24_+_19542323 1.87 ENSDART00000140379
ENSDART00000142830
sulfatase 1
chr15_+_3284416 1.87 ENSDART00000187665
ENSDART00000171723
forkhead box O1 a
chr3_+_19299309 1.86 ENSDART00000046297
ENSDART00000146955
low density lipoprotein receptor a
chr16_+_19029297 1.86 ENSDART00000115263
ENSDART00000114954
Rap guanine nucleotide exchange factor (GEF) 5b
chr1_-_59422880 1.82 ENSDART00000167244
si:ch211-188p14.2
chr2_+_105748 1.78 ENSDART00000169601

chr21_+_8198652 1.76 ENSDART00000011096
nuclear receptor subfamily 6, group A, member 1b
chr12_+_19030391 1.74 ENSDART00000153927
si:ch73-139e5.2
chr14_+_15155684 1.73 ENSDART00000167966
zgc:158852
chr20_-_22778394 1.71 ENSDART00000152645
FIP1 like 1a (S. cerevisiae)
chr6_-_7776612 1.69 ENSDART00000190269
myosin, heavy chain 9a, non-muscle
chr19_+_636886 1.69 ENSDART00000149192
telomerase reverse transcriptase
chr11_+_45461419 1.67 ENSDART00000173424
son of sevenless homolog 1 (Drosophila)
chr1_-_44940830 1.67 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
transmembrane protein 176
chr20_-_26383368 1.65 ENSDART00000024518
ENSDART00000087844
estrogen receptor 1
chr23_-_27547931 1.64 ENSDART00000144419
La ribonucleoprotein domain family, member 4Aa
chr1_-_49434798 1.61 ENSDART00000150842
ENSDART00000150789
si:dkeyp-80c12.10
chr6_-_43817761 1.61 ENSDART00000183945
forkhead box P1b
chr19_-_11237125 1.60 ENSDART00000163921
signal sequence receptor, beta
chr16_-_54405976 1.58 ENSDART00000055395
odd-skipped related transciption factor 2
chr7_-_7904683 1.56 ENSDART00000192822

chr4_+_63484571 1.55 ENSDART00000169518
ENSDART00000168681
si:dkey-11d20.1
chr16_-_13965518 1.54 ENSDART00000138304
si:dkey-85k15.4
chr5_+_36513605 1.53 ENSDART00000013590
wingless-type MMTV integration site family, member 11
chr23_-_31060350 1.48 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
chr13_-_479129 1.48 ENSDART00000159803
ENSDART00000082127
HEAT repeat containing 5B
chr19_-_703898 1.48 ENSDART00000181096
ENSDART00000121462
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 2
chr14_+_29769336 1.46 ENSDART00000105898
si:dkey-34l15.1
chr16_+_50163352 1.44 ENSDART00000153890
ENSDART00000060522
si:ch211-231m23.4
chr17_+_53435279 1.43 ENSDART00000126630
connexin 52.9
chr10_-_40557210 1.42 ENSDART00000135297
trace amine associated receptor 18b
chr20_-_51697437 1.40 ENSDART00000145391
si:ch211-14a11.2
chr11_-_26666501 1.38 ENSDART00000188067
ENSDART00000111539
EF-hand and coiled-coil domain containing 1
chr12_-_44016898 1.36 ENSDART00000175304
si:dkey-201i2.4
chr7_-_10560964 1.36 ENSDART00000172761
ENSDART00000170476
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr25_+_36315127 1.35 ENSDART00000191984
zgc:165555
chr20_-_52631998 1.35 ENSDART00000145283
ENSDART00000139072
si:ch211-221n20.1
chr25_-_36370292 1.35 ENSDART00000152766
Histone H2B 1/2
chr15_-_14038227 1.33 ENSDART00000139068
zgc:114130
chr19_+_2619444 1.27 ENSDART00000169483
family with sequence similarity 126, member A
chr20_-_46808870 1.27 ENSDART00000190911
estrogen-related receptor gamma b
chr10_-_40402904 1.27 ENSDART00000145101
trace amine associated receptor 20t
chr15_+_47838836 1.25 ENSDART00000182918

chr5_+_66170479 1.25 ENSDART00000172117
glycine dehydrogenase (decarboxylating)
chr9_+_45227028 1.19 ENSDART00000185579
adenosine deaminase, RNA-specific, B1b
chr20_-_10288156 1.19 ENSDART00000064110
si:dkey-63b1.1
chr15_-_14486534 1.18 ENSDART00000179368
numb homolog (Drosophila)-like
chr19_+_935565 1.15 ENSDART00000113368
ring finger protein 5
chr16_-_26132122 1.15 ENSDART00000157787
lipase, hormone-sensitive b
chr1_-_48922273 1.11 ENSDART00000150254
si:ch211-112b1.2
chr11_+_37251825 1.11 ENSDART00000169804
interleukin 17 receptor C
chr8_+_28724692 1.11 ENSDART00000140115
coiled-coil serine-rich protein 1
chr25_+_37348730 1.10 ENSDART00000156639
peptidase domain containing associated with muscle regeneration 1
chr1_+_58977262 1.08 ENSDART00000168832
ERI1 exoribonuclease family member 2
chr10_+_40548616 1.08 ENSDART00000147894
si:ch211-238p8.10
chr7_-_24995631 1.08 ENSDART00000173955
ENSDART00000173791
REST corepressor 2
chr9_+_51784922 1.08 ENSDART00000125850
CD302 molecule
chr24_+_26379441 1.06 ENSDART00000137786
si:ch211-230g15.5
chr21_-_24865454 1.06 ENSDART00000142907
immunoglobulin superfamily, member 9Bb
chr5_+_43870389 1.05 ENSDART00000141002
zgc:112966
chr7_-_12596727 1.04 ENSDART00000186413
ADAMTS-like 3
chr2_+_38271392 1.03 ENSDART00000042100
homeobox and leucine zipper encoding a
chr6_+_59808677 1.02 ENSDART00000164469
calcium/calmodulin-dependent serine protein kinase b
chr10_+_40774215 1.01 ENSDART00000131493
trace amine associated receptor 19b
chr7_-_58776400 0.98 ENSDART00000167433
SRY (sex determining region Y)-box 17
chr21_-_280769 0.97 ENSDART00000157753
plasminogen receptor, C-terminal lysine transmembrane protein
chr14_+_17397534 0.96 ENSDART00000180162
ENSDART00000129838
ring finger protein 212
chr10_-_40448736 0.91 ENSDART00000137644
ENSDART00000168190
trace amine associated receptor 20p
chr25_+_1304173 0.91 ENSDART00000155229
relaxin/insulin-like family peptide receptor 3.3b
chr9_-_41401564 0.91 ENSDART00000059628
NGFI-A binding protein 1b (EGR1 binding protein 1)
chr17_+_34206167 0.89 ENSDART00000136167
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr7_-_66126628 0.87 ENSDART00000184492
BTB (POZ) domain containing 10b
chr10_+_2742499 0.87 ENSDART00000122847
G protein-coupled receptor kinase 5
chr16_+_52105227 0.86 ENSDART00000150025
ENSDART00000097863
si:ch73-373m9.1
chr23_-_22072460 0.85 ENSDART00000132343
polyhomeotic homolog 2a (Drosophila)
chr22_-_20289948 0.84 ENSDART00000132951
si:dkey-110c1.10
chr19_+_43504480 0.83 ENSDART00000159421

chr2_+_50062165 0.83 ENSDART00000097939
ENSDART00000138214
zinc finger, CCHC domain containing 2
chr24_-_30275735 0.82 ENSDART00000168723
sorting nexin 7
chr5_-_1999417 0.80 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
chr22_+_24770744 0.79 ENSDART00000142882
si:rp71-23d18.4
chr19_-_24163845 0.77 ENSDART00000133277
perforin 1.2
chr20_+_28803642 0.77 ENSDART00000188526
farnesyltransferase, CAAX box, beta
chr21_-_43398122 0.75 ENSDART00000050533
cyclin I family, member 2
chr19_-_2115040 0.74 ENSDART00000020497
sorting nexin 13
chr23_+_14269311 0.74 ENSDART00000170414

chr21_-_24865217 0.72 ENSDART00000101136
immunoglobulin superfamily, member 9Bb
chr23_+_35426404 0.71 ENSDART00000164658
si:ch211-225h24.2
chr16_-_6821927 0.71 ENSDART00000149070
ENSDART00000149570
myelin basic protein b
chr14_+_909769 0.69 ENSDART00000021346
ENSDART00000172777
ADP-ribosylation factor-like 3, like 2
chr1_-_411331 0.67 ENSDART00000092524
RAS p21 protein activator 3
chr7_+_5968225 0.64 ENSDART00000083397
zgc:165555
chr19_-_3287393 0.63 ENSDART00000135698
si:ch211-133n4.10
chr25_-_28587896 0.63 ENSDART00000111908
si:dkeyp-67e1.6
chr6_-_13498745 0.63 ENSDART00000027684
ENSDART00000189438
myosin light chain kinase b
chr9_-_33121535 0.63 ENSDART00000166371
ENSDART00000138052
zgc:172014
chr12_-_990149 0.63 ENSDART00000054367
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr4_+_70556298 0.62 ENSDART00000170985
si:dkey-11d20.1
chr8_-_1973220 0.60 ENSDART00000184435
si:dkey-178e17.1
chr16_-_12512568 0.58 ENSDART00000055161
ENSDART00000160906
cytochrome c oxidase subunit VIb polypeptide 2
chr20_+_32523576 0.58 ENSDART00000147319
Scm polycomb group protein like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of egr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:1902103 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
1.1 3.4 GO:0010662 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
1.1 6.8 GO:0070650 actin filament bundle distribution(GO:0070650)
1.0 6.7 GO:0048745 smooth muscle tissue development(GO:0048745)
0.9 2.8 GO:0019695 choline metabolic process(GO:0019695)
0.9 2.6 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.7 14.3 GO:0014823 response to activity(GO:0014823)
0.7 11.9 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.6 17.4 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.6 1.7 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.5 11.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.5 5.1 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.5 4.2 GO:0046546 development of primary male sexual characteristics(GO:0046546)
0.5 5.9 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.4 2.2 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.4 3.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.4 1.7 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.4 2.1 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.3 3.8 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 1.2 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 1.9 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.3 6.1 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174) negative regulation of metaphase/anaphase transition of cell cycle(GO:1902100)
0.3 9.0 GO:0007044 cell-substrate junction assembly(GO:0007044)
0.3 6.7 GO:0030168 platelet activation(GO:0030168)
0.2 1.0 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.2 1.9 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.2 2.3 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 0.9 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 3.7 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 1.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 1.4 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.2 1.7 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 4.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 0.7 GO:0018343 protein farnesylation(GO:0018343)
0.2 8.2 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.2 1.3 GO:0032475 otolith formation(GO:0032475)
0.2 4.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.2 3.7 GO:0018149 peptide cross-linking(GO:0018149)
0.2 1.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 2.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 0.6 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.1 0.6 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.1 3.2 GO:0030199 collagen fibril organization(GO:0030199)
0.1 2.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.5 GO:0035522 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 2.8 GO:1990798 pancreas regeneration(GO:1990798)
0.1 2.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 3.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 1.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 3.6 GO:0061035 regulation of cartilage development(GO:0061035)
0.1 0.7 GO:0043363 nucleate erythrocyte differentiation(GO:0043363)
0.1 4.5 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 2.1 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058) regulation of ERBB signaling pathway(GO:1901184)
0.1 0.6 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.7 GO:0071632 optomotor response(GO:0071632)
0.1 5.5 GO:0006414 translational elongation(GO:0006414)
0.1 3.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 3.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 1.1 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 1.7 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.1 0.4 GO:0010269 response to selenium ion(GO:0010269)
0.1 7.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.3 GO:0010885 cholesterol storage(GO:0010878) regulation of cholesterol storage(GO:0010885)
0.0 3.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 2.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 2.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.7 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.5 GO:0060037 pharyngeal system development(GO:0060037)
0.0 1.2 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 2.6 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 2.3 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 1.0 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 2.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 1.0 GO:0007129 synapsis(GO:0007129) protein sumoylation(GO:0016925)
0.0 1.2 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.2 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 5.3 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 2.2 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.0 2.1 GO:1902652 cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652)
0.0 2.9 GO:0001756 somitogenesis(GO:0001756)
0.0 1.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.6 GO:0016575 histone deacetylation(GO:0016575)
0.0 2.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 5.5 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 0.5 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.2 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 1.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.8 5.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 2.5 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.6 1.7 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.5 2.7 GO:0097433 dense body(GO:0097433)
0.4 1.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.3 14.3 GO:0005861 troponin complex(GO:0005861)
0.2 4.5 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.2 2.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.2 0.7 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 6.2 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 1.9 GO:0000124 SAGA complex(GO:0000124)
0.1 1.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 9.2 GO:0000786 nucleosome(GO:0000786)
0.1 0.5 GO:0035517 PR-DUB complex(GO:0035517)
0.1 5.9 GO:0005581 collagen trimer(GO:0005581)
0.1 3.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 6.1 GO:0000776 kinetochore(GO:0000776)
0.0 0.6 GO:0030137 COPI-coated vesicle(GO:0030137) COPI-coated vesicle membrane(GO:0030663)
0.0 14.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 2.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.6 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 1.0 GO:0000795 synaptonemal complex(GO:0000795)
0.0 4.8 GO:0016459 myosin complex(GO:0016459)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.7 GO:0030018 Z disc(GO:0030018)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 4.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 25.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 4.5 GO:0005730 nucleolus(GO:0005730)
0.0 0.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.0 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
1.1 4.5 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.8 11.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.7 11.9 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.7 2.8 GO:0070052 collagen V binding(GO:0070052)
0.7 2.0 GO:0005499 vitamin D binding(GO:0005499)
0.6 1.7 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.5 2.7 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.5 2.6 GO:0039706 co-receptor binding(GO:0039706)
0.5 14.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 1.9 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.4 3.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.4 2.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 5.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.3 3.7 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 3.7 GO:0005537 mannose binding(GO:0005537)
0.3 2.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.7 GO:1903924 estradiol binding(GO:1903924)
0.2 0.6 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 3.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 0.7 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.2 3.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 2.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 4.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 2.9 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 2.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 5.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.2 GO:0016594 glycine binding(GO:0016594)
0.1 1.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 2.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 5.7 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 16.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 8.1 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.1 6.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 3.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.9 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 1.1 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 4.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 2.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 4.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 7.1 GO:0003774 motor activity(GO:0003774)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.0 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 2.8 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 2.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 4.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 6.8 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0004180 carboxypeptidase activity(GO:0004180)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.3 3.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 3.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 4.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 5.9 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 2.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.8 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 4.0 PID LKB1 PATHWAY LKB1 signaling events
0.1 6.1 PID P73PATHWAY p73 transcription factor network
0.1 2.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 1.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 0.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 2.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 4.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.7 11.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.5 6.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.5 14.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 3.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 6.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 2.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 5.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 5.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 4.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 4.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.8 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.1 7.1 REACTOME TRANSLATION Genes involved in Translation
0.0 2.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres