Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for egr3

Z-value: 0.64

Motif logo

logo of

Transcription factors associated with egr3

Gene Symbol Gene ID Gene Info
egr3
ENSDARG00000089156 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr3dr11_v1_chr8_+_50727220_50727220-0.046.8e-01Click!

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_56422311 5.52 ENSDART00000171958
gpr39
G protein-coupled receptor 39
chr19_-_617246 4.78 ENSDART00000062551
cyp51
cytochrome P450, family 51
chr23_-_29556844 4.36 ENSDART00000138021
rbp7a
retinol binding protein 7a, cellular
chr23_-_31645760 4.31 ENSDART00000035031
sgk1
serum/glucocorticoid regulated kinase 1
chr15_+_9294620 3.98 ENSDART00000133588
ENSDART00000140009
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr3_-_49504023 3.96 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr5_+_29831235 3.75 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr1_+_12295142 3.04 ENSDART00000158595
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr14_+_29769336 2.96 ENSDART00000105898
si:dkey-34l15.1
si:dkey-34l15.1
chr20_+_13894123 2.91 ENSDART00000007744
slc30a1a
solute carrier family 30 (zinc transporter), member 1a
chr22_-_16180849 2.88 ENSDART00000090390
vcam1b
vascular cell adhesion molecule 1b
chr10_-_26512742 2.65 ENSDART00000135951
si:dkey-5g14.1
si:dkey-5g14.1
chr8_+_8927870 2.58 ENSDART00000081985
pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr7_-_46019756 2.48 ENSDART00000162583
zgc:162297
zgc:162297
chr8_+_6576940 2.45 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr10_-_26512993 2.42 ENSDART00000188549
ENSDART00000193316
si:dkey-5g14.1
si:dkey-5g14.1
chr21_-_41369370 2.37 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr9_-_33725972 2.31 ENSDART00000028225
mao
monoamine oxidase
chr16_+_4138331 2.22 ENSDART00000192403
ENSDART00000193036
mtf1
metal-regulatory transcription factor 1
chr12_-_990149 1.92 ENSDART00000054367
kdelr2b
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr3_+_22984098 1.78 ENSDART00000043190
lsm12a
LSM12 homolog a
chr3_-_7106678 1.74 ENSDART00000175293
ENSDART00000187732
ENSDART00000158652
zgc:113102
BX005085.2
zgc:113102

chr18_+_3169579 1.55 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr24_+_3328354 1.53 ENSDART00000147468
bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr22_-_6651382 1.45 ENSDART00000124308
si:ch211-209l18.4
si:ch211-209l18.4
chr12_-_37449396 1.45 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr20_+_27712714 1.41 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr22_+_9806867 1.39 ENSDART00000137182
ENSDART00000106103
si:ch211-236g6.1
si:ch211-236g6.1
chr22_-_16275236 1.33 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr15_+_36105581 1.33 ENSDART00000184099
col4a3
collagen, type IV, alpha 3
chr11_+_14049131 1.25 ENSDART00000172471
grin3bb
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr22_-_10591876 1.09 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr3_-_11624694 0.97 ENSDART00000127157
hlfa
hepatic leukemia factor a
chr12_+_5215795 0.96 ENSDART00000170270
SLC35G1
si:ch211-197g18.2
chr4_+_30785713 0.91 ENSDART00000165945
si:dkey-178j11.5
si:dkey-178j11.5
chr12_-_26537145 0.87 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acsf2
acyl-CoA synthetase family member 2
chr25_-_18125769 0.84 ENSDART00000140484
kitlga
kit ligand a
chr21_-_22325124 0.83 ENSDART00000142100
gdpd4b
glycerophosphodiester phosphodiesterase domain containing 4b
chr15_-_14038227 0.81 ENSDART00000139068
zgc:114130
zgc:114130
chr22_+_1806235 0.79 ENSDART00000158966
znf1168
zinc finger protein 1168
chr6_-_53391727 0.78 ENSDART00000155483
si:ch211-161c3.6
si:ch211-161c3.6
chr18_+_3004572 0.73 ENSDART00000190328
CABZ01002690.1

chr21_-_41369539 0.69 ENSDART00000187546
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr4_+_30775376 0.69 ENSDART00000158528
si:dkey-11d20.1
si:dkey-11d20.1
chr7_+_41340520 0.66 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr6_-_23117348 0.60 ENSDART00000154941
ENSDART00000154252
ten1
TEN1 CST complex subunit
chr13_+_35925490 0.51 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr3_+_24537023 0.50 ENSDART00000077702
sp100.1
SP110 nuclear body protein, tandem duplicate 1
chr9_-_30363770 0.49 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr7_+_55518519 0.49 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr3_+_23737795 0.40 ENSDART00000182247
hoxb3a
homeobox B3a
chr3_-_38918697 0.40 ENSDART00000145630
si:dkey-106c17.2
si:dkey-106c17.2
chr9_+_56422517 0.39 ENSDART00000168620
gpr39
G protein-coupled receptor 39
chr13_-_36141486 0.35 ENSDART00000044115
med6
mediator complex subunit 6
chr17_+_46387086 0.35 ENSDART00000157079
si:dkey-206p8.1
si:dkey-206p8.1
chr23_+_16910071 0.35 ENSDART00000104793
si:dkey-147f3.8
si:dkey-147f3.8
chr12_-_44016898 0.34 ENSDART00000175304
si:dkey-201i2.4
si:dkey-201i2.4
chr13_-_31166544 0.29 ENSDART00000146250
ENSDART00000132129
ENSDART00000139591
mapk8a
mitogen-activated protein kinase 8a
chr1_-_48922273 0.26 ENSDART00000150254
si:ch211-112b1.2
si:ch211-112b1.2
chr22_+_34784075 0.22 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr16_+_10918252 0.21 ENSDART00000172949
pou2f2a
POU class 2 homeobox 2a
chr19_-_48039400 0.20 ENSDART00000166748
ENSDART00000165921
csf3b
colony stimulating factor 3 (granulocyte) b
chr23_+_804119 0.17 ENSDART00000148163
frmd4bb
FERM domain containing 4Bb
chr13_-_49666615 0.14 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr7_+_67325933 0.13 ENSDART00000170575
ENSDART00000183342
nfat5b
nuclear factor of activated T cells 5b
chr6_+_42818963 0.13 ENSDART00000184833
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr11_+_1565806 0.13 ENSDART00000137479
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr5_+_6617401 0.12 ENSDART00000060532
zgc:110796
zgc:110796
chr4_-_73587205 0.09 ENSDART00000150837
znf1015
zinc finger protein 1015
chr18_+_19974289 0.05 ENSDART00000090334
ENSDART00000192982
skor1b
SKI family transcriptional corepressor 1b
chr7_+_46019780 0.04 ENSDART00000163991
ccne1
cyclin E1

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:1990359 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.6 2.2 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.4 4.0 GO:0071331 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.3 1.9 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 3.7 GO:0050892 intestinal absorption(GO:0050892)
0.3 1.5 GO:0003232 bulbus arteriosus development(GO:0003232)
0.3 2.3 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.2 3.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 4.8 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.2 3.0 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1 0.6 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.1 1.4 GO:0031272 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.3 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.3 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 1.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 3.2 GO:0060972 left/right pattern formation(GO:0060972)
0.0 2.9 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.5 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.0 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 4.0 GO:0048545 response to steroid hormone(GO:0048545)
0.0 4.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.7 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.8 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.2 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.3 GO:1902636 kinociliary basal body(GO:1902636)
0.2 3.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.6 GO:1990879 CST complex(GO:1990879)
0.1 1.9 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.1 0.4 GO:0070847 core mediator complex(GO:0070847)
0.0 3.9 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.8 GO:0030175 filopodium(GO:0030175)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.0 12.5 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.8 4.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.6 1.9 GO:0046923 ER retention sequence binding(GO:0046923)
0.5 2.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 0.9 GO:0031956 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.2 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 4.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 3.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 2.9 GO:0008200 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.1 0.3 GO:0071253 connexin binding(GO:0071253)
0.1 4.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 3.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0005548 phospholipid transporter activity(GO:0005548)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID FOXO PATHWAY FoxO family signaling
0.1 1.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 5.9 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 1.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 1.9 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism