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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for eomesa

Z-value: 1.00

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Transcription factors associated with eomesa

Gene Symbol Gene ID Gene Info
ENSDARG00000006640 eomesodermin homolog a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
eomesadr11_v1_chr19_-_868187_8681870.354.7e-04Click!

Activity profile of eomesa motif

Sorted Z-values of eomesa motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_19596214 15.04 ENSDART00000183110

chr19_-_27564458 13.54 ENSDART00000123155
si:dkeyp-46h3.6
chr2_-_32637592 11.36 ENSDART00000136353
si:dkeyp-73d8.8
chr10_+_19595009 10.25 ENSDART00000112276
zgc:173837
chr10_-_25217347 9.72 ENSDART00000036906
karyopherin alpha 7 (importin alpha 8)
chr22_+_25693295 9.35 ENSDART00000123888
ENSDART00000150783
si:dkeyp-98a7.4
si:dkeyp-98a7.3
chr22_+_25681911 8.62 ENSDART00000113381
si:dkeyp-98a7.3
chr22_+_25687525 8.62 ENSDART00000135717
si:dkeyp-98a7.3
chr22_+_25704430 8.44 ENSDART00000143776
si:dkeyp-98a7.3
chr22_+_25352530 8.21 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
chr22_+_25715925 7.66 ENSDART00000150650
si:dkeyp-98a7.7
chr22_+_25274712 7.60 ENSDART00000137341

chr22_+_25753972 7.58 ENSDART00000188417

chr16_+_44314097 6.97 ENSDART00000148684
dihydropyrimidinase
chr13_-_7031033 6.92 ENSDART00000193211

chr20_-_40755614 6.63 ENSDART00000061247
connexin 32.3
chr22_+_25774750 6.36 ENSDART00000174421

chr16_+_23947196 6.29 ENSDART00000103190
ENSDART00000132961
ENSDART00000147690
ENSDART00000142168
apolipoprotein A-IV b, tandem duplicate 2
chr15_-_35112937 5.87 ENSDART00000154565
ENSDART00000099642
zgc:77118
chr11_-_1550709 5.24 ENSDART00000110097
si:ch73-303b9.1
chr3_+_16449490 4.79 ENSDART00000141467
potassium inwardly-rectifying channel, subfamily J, member 12b
chr13_-_9318891 4.47 ENSDART00000137364
si:dkey-33c12.3
chr2_-_57469115 4.03 ENSDART00000192201
protein inhibitor of activated STAT, 4b
chr18_-_20444296 3.98 ENSDART00000132993
kinesin family member 23
chr7_+_27691647 3.65 ENSDART00000079091
cytochrome P450, family 2, subfamily R, polypeptide 1
chr17_+_23554932 3.32 ENSDART00000135814
pantothenate kinase 1a
chr15_-_45538773 2.66 ENSDART00000113494
Mab-21 domain containing 2
chr1_+_45323142 2.60 ENSDART00000132210
epithelial membrane protein 1
chr7_+_17716601 2.46 ENSDART00000173792
ENSDART00000080825
reticulon 3
chr8_-_43158486 2.07 ENSDART00000134801
coiled-coil domain containing 92
chr19_-_867071 2.07 ENSDART00000122257
eomesodermin homolog a
chr16_+_5196226 2.06 ENSDART00000189704
SOGA family member 3a
chr12_+_1385192 2.06 ENSDART00000160788
phosphatidylethanolamine N-methyltransferase
chr21_-_1742159 2.04 ENSDART00000151049
one cut homeobox 2
chr20_-_14665002 1.88 ENSDART00000152816
secernin 2
chr14_-_2361692 1.84 ENSDART00000167696
si:ch73-233f7.4
chr2_-_13216269 1.83 ENSDART00000149947
BCL2, apoptosis regulator b
chr15_-_21877726 1.70 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr1_+_45323400 1.70 ENSDART00000148906
ENSDART00000132366
epithelial membrane protein 1
chr10_-_5847904 1.64 ENSDART00000161096
ankyrin repeat domain 55
chr25_-_23583101 1.51 ENSDART00000149107
ENSDART00000103704
ENSDART00000184903
nucleosome assembly protein 1-like 4a
chr19_+_2275019 1.43 ENSDART00000136138
integrin, beta 8
chr9_-_12885201 1.30 ENSDART00000124957
ankyrin repeat and zinc finger domain containing 1
chr11_-_40504170 1.28 ENSDART00000165394
si:dkeyp-61b2.1
chr7_-_67842997 1.26 ENSDART00000169763
polyamine modulated factor 1 binding protein 1
chr10_-_5847655 1.25 ENSDART00000192773
ankyrin repeat domain 55
chr2_-_34555945 1.24 ENSDART00000056671
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr5_-_45877387 1.21 ENSDART00000183714
ENSDART00000041503
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr1_-_45042210 1.19 ENSDART00000073694
SMU1, DNA replication regulator and spliceosomal factor b
chr5_+_32007627 1.18 ENSDART00000183061
suppressor of cancer cell invasion
chr16_+_14812585 1.15 ENSDART00000134087
collagen, type XIV, alpha 1a
chr23_-_31648026 1.15 ENSDART00000133569
serum/glucocorticoid regulated kinase 1
chr7_+_73332486 1.14 ENSDART00000174119
ENSDART00000092051
ENSDART00000192388

chr6_+_54538948 1.13 ENSDART00000149270
tubby like protein 1b
chr7_-_1101694 1.13 ENSDART00000183017
ENSDART00000182681
dynactin 1a
chr20_-_32007209 1.13 ENSDART00000021575
androglobin
chr20_-_46773258 1.10 ENSDART00000060653
si:ch211-57i17.5
chr25_+_24250247 1.10 ENSDART00000064646
transmembrane protein 86A
chr16_+_25107344 1.09 ENSDART00000033211
zgc:66448
chr7_-_69983462 1.09 ENSDART00000123380
potassium voltage-gated channel interacting protein 4
chr10_+_35953068 1.08 ENSDART00000015279
reticulon 4 receptor-like 1a
chr7_+_30493684 1.08 ENSDART00000027466
MINDY lysine 48 deubiquitinase 2
chr1_-_57129179 1.05 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
chr11_-_40728380 1.05 ENSDART00000023745
coiled-coil domain containing 114
chr22_-_36690742 1.04 ENSDART00000017188
ENSDART00000124698
nucleolin
chr23_-_31647793 0.98 ENSDART00000145621
serum/glucocorticoid regulated kinase 1
chr25_-_17367578 0.96 ENSDART00000064591
ENSDART00000110692
cytochrome P450, family 2, subfamily X, polypeptide 6
chr21_-_14815952 0.95 ENSDART00000134278
ENSDART00000067004
phosphohistidine phosphatase 1
chr1_+_29741843 0.90 ENSDART00000136066
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr10_+_16092671 0.88 ENSDART00000182761
ENSDART00000154835
multiple EGF-like-domains 10
chr4_-_77624155 0.87 ENSDART00000099761
si:ch211-250m6.7
chr11_+_14312260 0.86 ENSDART00000102518
si:ch211-262i1.5
chr13_-_280827 0.86 ENSDART00000144819
solute carrier family 30 (zinc transporter), member 6
chr16_+_4654333 0.85 ENSDART00000167665
si:ch1073-284b18.2
chr23_+_37579107 0.80 ENSDART00000169376
pleckstrin homology domain containing, family G (with RhoGef domain) member 5b
chr2_-_42393590 0.74 ENSDART00000135529
solute carrier organic anion transporter family member 5A1b
chr8_+_25267903 0.73 ENSDART00000093090
adenosine monophosphate deaminase 2b
chr17_+_36588281 0.65 ENSDART00000076115
5-hydroxytryptamine (serotonin) receptor 1B
chr7_+_23907692 0.64 ENSDART00000045479
synaptotagmin IV
chr20_-_35052464 0.61 ENSDART00000037195
kinesin family member 26Bb
chr7_+_9981757 0.60 ENSDART00000113429
ENSDART00000173233
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr17_-_29312506 0.59 ENSDART00000133668
tectonin beta-propeller repeat containing 2
chr7_-_5396154 0.58 ENSDART00000172980
Rho guanine nucleotide exchange factor (GEF) 11
chr18_+_6641542 0.58 ENSDART00000160379
C2 calcium-dependent domain containing 5
chr5_-_41645058 0.56 ENSDART00000051092
RIO kinase 2 (yeast)
chr22_-_6066867 0.56 ENSDART00000142383
si:dkey-19a16.1
chr1_-_40016058 0.55 ENSDART00000165373
cyclin-dependent kinase 2 associated protein 2
chr5_+_62319217 0.53 ENSDART00000050879
phoenix
chr1_-_56951369 0.52 ENSDART00000152294
si:ch211-1f22.2
chr22_+_26263290 0.48 ENSDART00000184840

chr24_-_24060460 0.48 ENSDART00000142813
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr23_+_4362463 0.48 ENSDART00000039829
zgc:112175
chr2_+_35240485 0.45 ENSDART00000179804
tenascin R (restrictin, janusin)
chr5_+_37379825 0.42 ENSDART00000171826
kelch-like family member 13
chr4_+_77948970 0.41 ENSDART00000149636
protein kinase C and casein kinase substrate in neurons 2
chr4_-_11603149 0.41 ENSDART00000150468
neuroepithelial cell transforming 1
chr18_+_33779440 0.40 ENSDART00000133349
si:dkey-145c18.3
chr2_+_42177113 0.38 ENSDART00000056441
transmembrane protein with EGF-like and two follistatin-like domains 1a
chr22_-_5252005 0.37 ENSDART00000132942
ENSDART00000081801
nicalin
chr10_-_8956973 0.35 ENSDART00000189564
molybdenum cofactor synthesis 2
chr15_+_28940352 0.35 ENSDART00000154085
gastric inhibitory polypeptide receptor
chr22_-_3564563 0.35 ENSDART00000145114
protein tyrosine phosphatase, receptor type, s, a
chr1_-_55750208 0.32 ENSDART00000142244
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr25_-_13703826 0.31 ENSDART00000163398
phospholipase A2, group XV
chr11_+_14622379 0.28 ENSDART00000112589
ephrin-A2b
chr5_-_16475374 0.26 ENSDART00000134274
ENSDART00000136004
piwi-like RNA-mediated gene silencing 2
chr18_+_5618368 0.24 ENSDART00000159945
unc-51 like kinase 3
chr12_-_48960308 0.24 ENSDART00000176247

chr12_+_5129245 0.21 ENSDART00000169073
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr11_-_13341051 0.19 ENSDART00000121872
microtubule associated serine/threonine kinase 3b
chr25_-_16076257 0.19 ENSDART00000140780
ovochymase 2
chr1_-_40015782 0.17 ENSDART00000157425
ENSDART00000159238
cyclin-dependent kinase 2 associated protein 2
chr2_+_9536021 0.16 ENSDART00000187357

chr12_-_10421955 0.16 ENSDART00000052004
zgc:153595
chr2_-_10896745 0.15 ENSDART00000114609
CUB domain containing protein 2
chr15_-_35126632 0.14 ENSDART00000187324
ENSDART00000037389
zgc:77118
zgc:55413
chr5_+_37749503 0.14 ENSDART00000148586
D4, zinc and double PHD fingers family 2
chr3_+_59051503 0.12 ENSDART00000160767
rasd family member 4
chr23_+_24957008 0.10 ENSDART00000181069
nucleolar protein 9
chr4_-_72555545 0.09 ENSDART00000172315
si:ch211-161m3.4
chr7_+_26100024 0.06 ENSDART00000173726
si:ch211-196f2.3
chr14_+_49231776 0.03 ENSDART00000169096
required for meiotic nuclear division 5 homolog B
chr1_+_5576151 0.01 ENSDART00000109756
carboxypeptidase O

Network of associatons between targets according to the STRING database.

First level regulatory network of eomesa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.7 2.1 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.6 3.7 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.6 4.0 GO:0040016 embryonic cleavage(GO:0040016)
0.4 7.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.3 1.7 GO:0010872 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.3 0.9 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.3 2.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 3.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 4.0 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.6 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.1 2.9 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 1.1 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.1 1.0 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.4 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 1.8 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.1 1.2 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.7 GO:0032264 IMP salvage(GO:0032264)
0.0 1.4 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 1.1 GO:0070831 basement membrane assembly(GO:0070831)
0.0 2.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 0.6 GO:0046849 bone remodeling(GO:0046849)
0.0 0.5 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.1 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.0 0.3 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 1.1 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.3 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 1.0 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.9 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 2.1 GO:0010506 regulation of autophagy(GO:0010506)
0.0 2.7 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.8 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 1.3 GO:0007283 spermatogenesis(GO:0007283)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0097224 sperm connecting piece(GO:0097224)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:0042627 chylomicron(GO:0042627)
0.1 4.6 GO:0005871 kinesin complex(GO:0005871)
0.1 0.3 GO:1990923 PET complex(GO:1990923)
0.1 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 4.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.2 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 1.4 GO:0008305 integrin complex(GO:0008305)
0.0 1.8 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.6 7.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.6 9.7 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.6 3.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 1.7 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 4.0 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 0.9 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.2 64.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.1 GO:0016803 ether hydrolase activity(GO:0016803)
0.1 4.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 4.6 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 0.3 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.1 0.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 2.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.6 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0034584 piRNA binding(GO:0034584)
0.0 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 2.1 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.1 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0 1.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID AURORA B PATHWAY Aurora B signaling
0.1 1.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.1 PID FOXO PATHWAY FoxO family signaling
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 4.0 REACTOME KINESINS Genes involved in Kinesins
0.2 3.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK