ISMARA results: esr1+esr2a+esr2b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for esr1+esr2a+esr2b

Z-value: 1.08

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Transcription factors associated with esr1+esr2a+esr2b

Gene Symbol	Gene ID	Gene Info
esr1 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000004111	estrogen receptor 1
esr2a NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000016454	estrogen receptor 2a
esr2b NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000034181	estrogen receptor 2b
esr1 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000112357	estrogen receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
esr2b	dr11_v1_chr13_+_37022601_37022632	-0.41	4.7e-05	Click!
esr2a	dr11_v1_chr20_+_21595244_21595244	-0.25	1.7e-02	Click!
esr1	dr11_v1_chr20_-_26382284_26382284	-0.15	1.5e-01	Click!

Activity profile of esr1+esr2a+esr2b motif

Sorted Z-values of esr1+esr2a+esr2b motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_55032439 Show fit	8.16	ENSDART00000164232 ENSDART00000158845 ENSDART00000157584 ENSDART00000026359 ENSDART00000122794 ENSDART00000183742	mybphb NCBI UniProt ZFIN ENSEMBL Google Show fit	myosin binding protein Hb
chr5_-_71722257 Show fit	7.71	ENSDART00000013404	ak1 NCBI UniProt ZFIN ENSEMBL Google Show fit	adenylate kinase 1
chr20_+_54738210 Show fit	7.50	ENSDART00000151399	pak7 NCBI UniProt ZFIN ENSEMBL Google Show fit	p21 protein (Cdc42/Rac)-activated kinase 7
chr1_-_59176949 Show fit	6.67	ENSDART00000128742	CABZ01118678.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr25_-_19374710 Show fit	6.08	ENSDART00000184483 ENSDART00000188706	map1ab NCBI UniProt ZFIN ENSEMBL Google Show fit	microtubule-associated protein 1Ab
chr9_+_54644626 Show fit	5.80	ENSDART00000190609	egfl6 NCBI UniProt ZFIN ENSEMBL Google Show fit	EGF-like-domain, multiple 6
chr6_-_40722200 Show fit	5.71	ENSDART00000035101	kbtbd12 NCBI UniProt ZFIN ENSEMBL Google Show fit	kelch repeat and BTB (POZ) domain containing 12
chr5_-_55395964 Show fit	5.57	ENSDART00000145791	prune2 NCBI UniProt ZFIN ENSEMBL Google Show fit	prune homolog 2 (Drosophila)
chr12_-_4683325 Show fit	5.23	ENSDART00000152771	si:ch211-255p10.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-255p10.3
chr20_+_5564042 Show fit	5.05	ENSDART00000090934 ENSDART00000127050	nrxn3b NCBI UniProt ZFIN ENSEMBL Google Show fit	neurexin 3b
chr12_+_7491690 Show fit	4.99	ENSDART00000152564	phyhiplb NCBI UniProt ZFIN ENSEMBL Google Show fit	phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr6_+_48618512 Show fit	4.87	ENSDART00000111190	FAM19A3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-238f9.1
chr23_-_45705525 Show fit	4.84	ENSDART00000148959	ednrab NCBI UniProt ZFIN ENSEMBL Google Show fit	endothelin receptor type Ab
chr16_+_29650698 Show fit	4.84	ENSDART00000137153	tmod4 NCBI UniProt ZFIN ENSEMBL Google Show fit	tropomodulin 4 (muscle)
chr13_+_22480496 Show fit	4.71	ENSDART00000136863 ENSDART00000131870 ENSDART00000078720 ENSDART00000078740 ENSDART00000139218	ldb3a NCBI UniProt ZFIN ENSEMBL Google Show fit	LIM domain binding 3a
chr11_+_7158723 Show fit	4.70	ENSDART00000035560	tmem38a NCBI UniProt ZFIN ENSEMBL Google Show fit	transmembrane protein 38A
chr17_-_6738538 Show fit	4.67	ENSDART00000157125	vsnl1b NCBI UniProt ZFIN ENSEMBL Google Show fit	visinin-like 1b
chr23_+_43954809 Show fit	4.61	ENSDART00000164080	corin NCBI UniProt ZFIN ENSEMBL Google Show fit	corin, serine peptidase
chr24_+_2495197 Show fit	4.59	ENSDART00000146887	f13a1a.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	coagulation factor XIII, A1 polypeptide a, tandem duplicate 1
chr13_-_31435137 Show fit	4.55	ENSDART00000057441	rtn1a NCBI UniProt ZFIN ENSEMBL Google Show fit	reticulon 1a
chr6_-_11768198 Show fit	4.37	ENSDART00000183463	march7 NCBI UniProt ZFIN ENSEMBL Google Show fit	membrane-associated ring finger (C3HC4) 7
chr2_-_24289641 Show fit	4.36	ENSDART00000128784 ENSDART00000123565 ENSDART00000141922 ENSDART00000184550 ENSDART00000191469	myh7l NCBI UniProt ZFIN ENSEMBL Google Show fit	myosin heavy chain 7-like
chr2_-_30460293 Show fit	4.27	ENSDART00000113193	cbln2a NCBI UniProt ZFIN ENSEMBL Google Show fit	cerebellin 2a precursor
chr3_+_39566999 Show fit	4.19	ENSDART00000146867	aldoaa NCBI UniProt ZFIN ENSEMBL Google Show fit	aldolase a, fructose-bisphosphate, a
chr23_+_44741500 Show fit	4.18	ENSDART00000166421	atp1b2a NCBI UniProt ZFIN ENSEMBL Google Show fit	ATPase Na+/K+ transporting subunit beta 2a
chr19_-_32783373 Show fit	4.14	ENSDART00000145790	nt5c1aa NCBI UniProt ZFIN ENSEMBL Google Show fit	5'-nucleotidase, cytosolic IAa
chr18_-_226800 Show fit	4.12	ENSDART00000165180	tarsl2 NCBI UniProt ZFIN ENSEMBL Google Show fit	threonyl-tRNA synthetase-like 2
chr24_-_38374744 Show fit	4.10	ENSDART00000007208	lrrc4bb NCBI UniProt ZFIN ENSEMBL Google Show fit	leucine rich repeat containing 4Bb
chr24_+_25467465 Show fit	4.06	ENSDART00000189933	smpx NCBI UniProt ZFIN ENSEMBL Google Show fit	small muscle protein, X-linked
chr5_-_31901468 Show fit	4.01	ENSDART00000147814 ENSDART00000141446	coro1cb NCBI UniProt ZFIN ENSEMBL Google Show fit	coronin, actin binding protein, 1Cb
chr15_+_19544052 Show fit	3.87	ENSDART00000062560	zgc:77784 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:77784
chr16_+_52771199 Show fit	3.75	ENSDART00000111383	baalca NCBI UniProt ZFIN ENSEMBL Google Show fit	brain and acute leukemia, cytoplasmic a
chr6_-_9792004 Show fit	3.73	ENSDART00000081129	cdk15 NCBI UniProt ZFIN ENSEMBL Google Show fit	cyclin-dependent kinase 15
chr22_-_13857729 Show fit	3.72	ENSDART00000177971	s100b NCBI UniProt ZFIN ENSEMBL Google Show fit	S100 calcium binding protein, beta (neural)
chr25_-_19420949 Show fit	3.71	ENSDART00000181338	map1ab NCBI UniProt ZFIN ENSEMBL Google Show fit	microtubule-associated protein 1Ab
chr8_+_48613040 Show fit	3.69	ENSDART00000121432	nppa NCBI UniProt ZFIN ENSEMBL Google Show fit	natriuretic peptide A
chr11_+_11201096 Show fit	3.69	ENSDART00000171916 ENSDART00000171521 ENSDART00000087105 ENSDART00000159603	myom2a NCBI UniProt ZFIN ENSEMBL Google Show fit	myomesin 2a
chr4_+_38344 Show fit	3.68	ENSDART00000170197 ENSDART00000175348	phtf2 NCBI UniProt ZFIN ENSEMBL Google Show fit	putative homeodomain transcription factor 2
chr9_-_7539297 Show fit	3.68	ENSDART00000081550 ENSDART00000081553	desma NCBI UniProt ZFIN ENSEMBL Google Show fit	desmin a
chr20_+_40150612 Show fit	3.66	ENSDART00000143680 ENSDART00000109681 ENSDART00000101041 ENSDART00000121818	trdn NCBI UniProt ZFIN ENSEMBL Google Show fit	triadin
chr17_-_12385308 Show fit	3.64	ENSDART00000080927	snap25b NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptosomal-associated protein, 25b
chr13_+_22480857 Show fit	3.62	ENSDART00000078721 ENSDART00000044719 ENSDART00000130957 ENSDART00000078757 ENSDART00000130424 ENSDART00000078747	ldb3a NCBI UniProt ZFIN ENSEMBL Google Show fit	LIM domain binding 3a
chr5_+_23624684 Show fit	3.59	ENSDART00000051539	cx27.5 NCBI UniProt ZFIN ENSEMBL Google Show fit	connexin 27.5
chr5_+_64319590 Show fit	3.58	ENSDART00000192652	FQ377918.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr16_-_560574 Show fit	3.56	ENSDART00000148452	irx2a NCBI UniProt ZFIN ENSEMBL Google Show fit	iroquois homeobox 2a
chr3_-_6767440 Show fit	3.54	ENSDART00000156174	mast1b NCBI UniProt ZFIN ENSEMBL Google Show fit	microtubule associated serine/threonine kinase 1b
chr7_+_40228422 Show fit	3.53	ENSDART00000052222	ptprn2 NCBI UniProt ZFIN ENSEMBL Google Show fit	protein tyrosine phosphatase, receptor type, N polypeptide 2
chr6_+_36942966 Show fit	3.52	ENSDART00000028895	negr1 NCBI UniProt ZFIN ENSEMBL Google Show fit	neuronal growth regulator 1
chr1_-_38813679 Show fit	3.52	ENSDART00000148917	asb5b NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin repeat and SOCS box containing 5b
chr9_+_4306122 Show fit	3.52	ENSDART00000193722 ENSDART00000190521	kalrna NCBI UniProt ZFIN ENSEMBL Google Show fit	kalirin RhoGEF kinase a
chr10_+_22782522 Show fit	3.50	ENSDART00000079498 ENSDART00000145558	si:ch211-237l4.6 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-237l4.6
chr5_+_70155935 Show fit	3.50	ENSDART00000165570	rgs3a NCBI UniProt ZFIN ENSEMBL Google Show fit	regulator of G protein signaling 3a
chr21_-_131236 Show fit	3.49	ENSDART00000160005	si:ch1073-398f15.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch1073-398f15.1
chr2_-_31302615 Show fit	3.49	ENSDART00000034784 ENSDART00000060812	adcyap1b NCBI UniProt ZFIN ENSEMBL Google Show fit	adenylate cyclase activating polypeptide 1b
chr12_+_35119762 Show fit	3.43	ENSDART00000085774	si:ch73-127m5.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-127m5.1
chr2_+_34767171 Show fit	3.41	ENSDART00000145451	astn1 NCBI UniProt ZFIN ENSEMBL Google Show fit	astrotactin 1
chr3_-_1317290 Show fit	3.39	ENSDART00000047094	LO018552.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr10_-_17103651 Show fit	3.36	ENSDART00000108959	RNF208 NCBI UniProt ZFIN ENSEMBL Google Show fit	ring finger protein 208
chr5_+_1278092 Show fit	3.28	ENSDART00000147972 ENSDART00000159783	dnm1a NCBI UniProt ZFIN ENSEMBL Google Show fit	dynamin 1a
chr1_-_12278522 Show fit	3.25	ENSDART00000142122 ENSDART00000003825	cplx2l NCBI UniProt ZFIN ENSEMBL Google Show fit	complexin 2, like
chr11_+_5842632 Show fit	3.24	ENSDART00000111374 ENSDART00000158599	ndufs7 NCBI UniProt ZFIN ENSEMBL Google Show fit	NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)
chr2_+_5446087 Show fit	3.23	ENSDART00000155165	dusp28 NCBI UniProt ZFIN ENSEMBL Google Show fit	dual specificity phosphatase 28
chr5_-_23280098 Show fit	3.22	ENSDART00000126540 ENSDART00000051533	plp1b NCBI UniProt ZFIN ENSEMBL Google Show fit	proteolipid protein 1b
chr19_+_712127 Show fit	3.22	ENSDART00000093281 ENSDART00000180002 ENSDART00000146050	fhod3a NCBI UniProt ZFIN ENSEMBL Google Show fit	formin homology 2 domain containing 3a
chr5_-_46980651 Show fit	3.20	ENSDART00000181022 ENSDART00000168038	edil3a NCBI UniProt ZFIN ENSEMBL Google Show fit	EGF-like repeats and discoidin I-like domains 3a
chr2_-_38000276 Show fit	3.13	ENSDART00000034790	pcp4l1 NCBI UniProt ZFIN ENSEMBL Google Show fit	Purkinje cell protein 4 like 1
chr3_-_13147310 Show fit	3.12	ENSDART00000160840	prkar1b NCBI UniProt ZFIN ENSEMBL Google Show fit	protein kinase, cAMP-dependent, regulatory, type I, beta
chr25_-_29134654 Show fit	3.09	ENSDART00000067066	parp6b NCBI UniProt ZFIN ENSEMBL Google Show fit	poly (ADP-ribose) polymerase family, member 6b
chr1_-_55810730 Show fit	3.09	ENSDART00000100551	zgc:136908 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:136908
chr4_-_191736 Show fit	3.07	ENSDART00000169187 ENSDART00000192054	ptpro NCBI UniProt ZFIN ENSEMBL Google Show fit	protein tyrosine phosphatase, receptor type, O
chr6_+_10450000 Show fit	3.06	ENSDART00000151288 ENSDART00000187431 ENSDART00000192474 ENSDART00000188214 ENSDART00000184766 ENSDART00000190082	kcnh7 NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium channel, voltage gated eag related subfamily H, member 7
chr23_+_6232895 Show fit	3.05	ENSDART00000139795	syt2a NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptotagmin IIa
chr8_+_23213320 Show fit	3.04	ENSDART00000032996 ENSDART00000137536	ppdpfa NCBI UniProt ZFIN ENSEMBL Google Show fit	pancreatic progenitor cell differentiation and proliferation factor a
chr9_-_31747106 Show fit	3.00	ENSDART00000048469 ENSDART00000145204 ENSDART00000186889	nalcn NCBI UniProt ZFIN ENSEMBL Google Show fit	sodium leak channel, non-selective
chr18_-_14937211 Show fit	2.98	ENSDART00000141893	mlc1 NCBI UniProt ZFIN ENSEMBL Google Show fit	megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_-_26415499 Show fit	2.98	ENSDART00000185779	synpo2lb NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptopodin 2-like b
chr6_-_32025225 Show fit	2.97	ENSDART00000006417	pgm1 NCBI UniProt ZFIN ENSEMBL Google Show fit	phosphoglucomutase 1
chr7_-_51793333 Show fit	2.95	ENSDART00000180654	BX957362.5 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr19_-_9712530 Show fit	2.94	ENSDART00000134816	slc2a3a NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 2 (facilitated glucose transporter), member 3a
chr24_+_2470061 Show fit	2.94	ENSDART00000140383 ENSDART00000191261	F13A1 (1 of many) NCBI UniProt ZFIN ENSEMBL Google Show fit	coagulation factor XIII A chain
chr6_-_40722480 Show fit	2.93	ENSDART00000188187	kbtbd12 NCBI UniProt ZFIN ENSEMBL Google Show fit	kelch repeat and BTB (POZ) domain containing 12
chr12_+_18556929 Show fit	2.92	ENSDART00000191277	CT009714.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr1_+_17676745 Show fit	2.92	ENSDART00000030665	slc25a4 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr4_+_17280868 Show fit	2.91	ENSDART00000145349	bcat1 NCBI UniProt ZFIN ENSEMBL Google Show fit	branched chain amino-acid transaminase 1, cytosolic
chr16_-_55028740 Show fit	2.88	ENSDART00000156368 ENSDART00000161704	zgc:114181 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:114181
chr15_-_12500938 Show fit	2.85	ENSDART00000159627	scn4ba NCBI UniProt ZFIN ENSEMBL Google Show fit	sodium channel, voltage-gated, type IV, beta a
chr18_-_16179129 Show fit	2.83	ENSDART00000125353	slc6a15 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 6 (neutral amino acid transporter), member 15
chr9_-_22821901 Show fit	2.82	ENSDART00000101711	neb NCBI UniProt ZFIN ENSEMBL Google Show fit	nebulin
chr23_-_11870962 Show fit	2.82	ENSDART00000143481	si:dkey-178k16.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-178k16.1
chr8_+_31821396 Show fit	2.81	ENSDART00000077053	plcxd3 NCBI UniProt ZFIN ENSEMBL Google Show fit	phosphatidylinositol-specific phospholipase C, X domain containing 3
chr18_+_16330025 Show fit	2.80	ENSDART00000142353	nts NCBI UniProt ZFIN ENSEMBL Google Show fit	neurotensin
chr6_+_28124393 Show fit	2.80	ENSDART00000089195	gpr17 NCBI UniProt ZFIN ENSEMBL Google Show fit	G protein-coupled receptor 17
chr25_+_16945348 Show fit	2.79	ENSDART00000016591	fgf6a NCBI UniProt ZFIN ENSEMBL Google Show fit	fibroblast growth factor 6a
chr6_+_3828560 Show fit	2.78	ENSDART00000185273 ENSDART00000179091	gad1b NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamate decarboxylase 1b
chr14_-_7128980 Show fit	2.76	ENSDART00000171311	si:ch73-43g23.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-43g23.1
chr13_-_31452516 Show fit	2.76	ENSDART00000193268	rtn1a NCBI UniProt ZFIN ENSEMBL Google Show fit	reticulon 1a
chr8_-_49431939 Show fit	2.75	ENSDART00000011453 ENSDART00000088240 ENSDART00000114173	sypb NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptophysin b
chr15_+_5923851 Show fit	2.74	ENSDART00000152520 ENSDART00000145827 ENSDART00000121529	sh3bgr NCBI UniProt ZFIN ENSEMBL Google Show fit	SH3 domain binding glutamate-rich protein
chr9_+_4429593 Show fit	2.72	ENSDART00000184855	FP015810.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr7_-_51476276 Show fit	2.72	ENSDART00000082464	nhsl2 NCBI UniProt ZFIN ENSEMBL Google Show fit	NHS-like 2
chr3_+_27770110 Show fit	2.69	ENSDART00000017962	eci1 NCBI UniProt ZFIN ENSEMBL Google Show fit	enoyl-CoA delta isomerase 1
chr9_-_22834860 Show fit	2.68	ENSDART00000146486	neb NCBI UniProt ZFIN ENSEMBL Google Show fit	nebulin
chr19_+_30990815 Show fit	2.67	ENSDART00000134645	sync NCBI UniProt ZFIN ENSEMBL Google Show fit	syncoilin, intermediate filament protein
chr9_-_710896 Show fit	2.67	ENSDART00000180478	ndufb3 NCBI UniProt ZFIN ENSEMBL Google Show fit	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3
chr7_+_26132665 Show fit	2.67	ENSDART00000129834	nat16 NCBI UniProt ZFIN ENSEMBL Google Show fit	N-acetyltransferase 16
chr3_+_29980603 Show fit	2.64	ENSDART00000151509	kcna7 NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium voltage-gated channel, shaker-related subfamily, member 7
chr8_+_24861264 Show fit	2.64	ENSDART00000099607	slc6a17 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 6 (neutral amino acid transporter), member 17
chr8_+_14792830 Show fit	2.63	ENSDART00000139972	cacna1ea NCBI UniProt ZFIN ENSEMBL Google Show fit	calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr10_+_22775253 Show fit	2.63	ENSDART00000190141	tmem88a NCBI UniProt ZFIN ENSEMBL Google Show fit	transmembrane protein 88 a
chr14_-_9277152 Show fit	2.62	ENSDART00000189048	asb12b NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin repeat and SOCS box-containing 12b
chr4_+_4849789 Show fit	2.62	ENSDART00000130818 ENSDART00000127751	ptprz1b NCBI UniProt ZFIN ENSEMBL Google Show fit	protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr20_-_39273987 Show fit	2.61	ENSDART00000127173	clu NCBI UniProt ZFIN ENSEMBL Google Show fit	clusterin
chr23_-_21471022 Show fit	2.60	ENSDART00000104206	her4.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	hairy-related 4, tandem duplicate 2
chr8_+_49778486 Show fit	2.59	ENSDART00000131732	ntrk2a NCBI UniProt ZFIN ENSEMBL Google Show fit	neurotrophic tyrosine kinase, receptor, type 2a
chr17_-_44968177 Show fit	2.58	ENSDART00000075510	ngb NCBI UniProt ZFIN ENSEMBL Google Show fit	neuroglobin
chr9_-_49493305 Show fit	2.58	ENSDART00000148707 ENSDART00000148561	xirp2b NCBI UniProt ZFIN ENSEMBL Google Show fit	xin actin binding repeat containing 2b
chr6_-_31348999 Show fit	2.58	ENSDART00000153734	dnajc6 NCBI UniProt ZFIN ENSEMBL Google Show fit	DnaJ (Hsp40) homolog, subfamily C, member 6
chr20_+_30490682 Show fit	2.58	ENSDART00000184871	myt1la NCBI UniProt ZFIN ENSEMBL Google Show fit	myelin transcription factor 1-like, a
chr19_+_30662529 Show fit	2.55	ENSDART00000175662	fam49al NCBI UniProt ZFIN ENSEMBL Google Show fit	family with sequence similarity 49, member A-like
chr3_+_40170216 Show fit	2.53	ENSDART00000011568	syngr3a NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptogyrin 3a
chr7_-_30174882 Show fit	2.53	ENSDART00000110409	frmd5 NCBI UniProt ZFIN ENSEMBL Google Show fit	FERM domain containing 5
chr2_-_10062575 Show fit	2.52	ENSDART00000091726	fam78ba NCBI UniProt ZFIN ENSEMBL Google Show fit	family with sequence similarity 78, member B a
chr21_+_15704556 Show fit	2.52	ENSDART00000024858 ENSDART00000146909	chchd10 NCBI UniProt ZFIN ENSEMBL Google Show fit	coiled-coil-helix-coiled-coil-helix domain containing 10
chr2_-_44720551 Show fit	2.52	ENSDART00000146380	map6d1 NCBI UniProt ZFIN ENSEMBL Google Show fit	MAP6 domain containing 1
chr16_+_5774977 Show fit	2.51	ENSDART00000134202	ccka NCBI UniProt ZFIN ENSEMBL Google Show fit	cholecystokinin a
chr10_+_37145007 Show fit	2.51	ENSDART00000131777	cuedc1a NCBI UniProt ZFIN ENSEMBL Google Show fit	CUE domain containing 1a
chr6_+_41463786 Show fit	2.51	ENSDART00000065006	twf2a NCBI UniProt ZFIN ENSEMBL Google Show fit	twinfilin actin-binding protein 2a
chr11_+_42587900 Show fit	2.50	ENSDART00000167529	asb14a NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin repeat and SOCS box containing 14a
chr20_+_3108597 Show fit	2.50	ENSDART00000133435	CEP170B (1 of many) NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-212j7.1
chr9_+_42095220 Show fit	2.48	ENSDART00000148317 ENSDART00000134431	pcbp3 NCBI UniProt ZFIN ENSEMBL Google Show fit	poly(rC) binding protein 3
chr18_-_16123222 Show fit	2.48	ENSDART00000061189	sspn NCBI UniProt ZFIN ENSEMBL Google Show fit	sarcospan (Kras oncogene-associated gene)
chr5_-_68916455 Show fit	2.48	ENSDART00000171465	ank1a NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin 1, erythrocytic a
chr1_-_25911292 Show fit	2.44	ENSDART00000145012	usp53b NCBI UniProt ZFIN ENSEMBL Google Show fit	ubiquitin specific peptidase 53b
chr6_+_12853655 Show fit	2.44	ENSDART00000156341	fam117ba NCBI UniProt ZFIN ENSEMBL Google Show fit	family with sequence similarity 117, member Ba
chr10_+_10636237 Show fit	2.43	ENSDART00000136853	fam163b NCBI UniProt ZFIN ENSEMBL Google Show fit	family with sequence similarity 163, member B
chr18_+_23249519 Show fit	2.42	ENSDART00000005740 ENSDART00000147446 ENSDART00000124818	mef2aa NCBI UniProt ZFIN ENSEMBL Google Show fit	myocyte enhancer factor 2aa
chr3_+_33367954 Show fit	2.41	ENSDART00000103161	mpp2a NCBI UniProt ZFIN ENSEMBL Google Show fit	membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr1_-_14332283 Show fit	2.41	ENSDART00000090025	wfs1a NCBI UniProt ZFIN ENSEMBL Google Show fit	Wolfram syndrome 1a (wolframin)
chr19_+_41080240 Show fit	2.41	ENSDART00000087295	ppp1r9a NCBI UniProt ZFIN ENSEMBL Google Show fit	protein phosphatase 1, regulatory subunit 9A
chr1_-_22757145 Show fit	2.39	ENSDART00000134719	prom1b NCBI UniProt ZFIN ENSEMBL Google Show fit	prominin 1 b
chr12_-_16084835 Show fit	2.37	ENSDART00000090881	kcnj19b NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium voltage-gated channel, subfamily J, member 19b
chr20_-_25709247 Show fit	2.36	ENSDART00000146711	si:dkeyp-117h8.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkeyp-117h8.2
chr25_+_13406069 Show fit	2.36	ENSDART00000010495	znrf1 NCBI UniProt ZFIN ENSEMBL Google Show fit	zinc and ring finger 1
chr18_-_42313798 Show fit	2.36	ENSDART00000098639	cntn5 NCBI UniProt ZFIN ENSEMBL Google Show fit	contactin 5
chr3_+_39568290 Show fit	2.35	ENSDART00000020741	aldoaa NCBI UniProt ZFIN ENSEMBL Google Show fit	aldolase a, fructose-bisphosphate, a
chr23_-_21515182 Show fit	2.34	ENSDART00000142000	rnf207b NCBI UniProt ZFIN ENSEMBL Google Show fit	ring finger protein 207b
chr15_-_47838391 Show fit	2.34	ENSDART00000180337	kbtbd3 NCBI UniProt ZFIN ENSEMBL Google Show fit	kelch repeat and BTB (POZ) domain containing 3
chr6_-_42112191 Show fit	2.33	ENSDART00000085472	grm2a NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamate receptor, metabotropic 2a
chr17_-_40397752 Show fit	2.33	ENSDART00000178483	BX548062.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr4_+_5796761 Show fit	2.32	ENSDART00000164854	si:ch73-352p4.8 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-352p4.8
chr11_-_6970107 Show fit	2.32	ENSDART00000171255	COMP NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-43f4.1
chr17_+_29276544 Show fit	2.32	ENSDART00000049399	ankrd9 NCBI UniProt ZFIN ENSEMBL Google Show fit	ankyrin repeat domain 9
chr11_+_30729745 Show fit	2.30	ENSDART00000103270	slc22a7a NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 22 (organic anion transporter), member 7a
chr3_+_59117136 Show fit	2.29	ENSDART00000182745	MGAT5B NCBI UniProt ZFIN ENSEMBL Google Show fit	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr10_-_31782616 Show fit	2.29	ENSDART00000128839	fez1 NCBI UniProt ZFIN ENSEMBL Google Show fit	fasciculation and elongation protein zeta 1 (zygin I)
chr16_+_12236339 Show fit	2.29	ENSDART00000132468	tpi1b NCBI UniProt ZFIN ENSEMBL Google Show fit	triosephosphate isomerase 1b
chr24_-_23974559 Show fit	2.29	ENSDART00000080510 ENSDART00000135242	ndufb4 NCBI UniProt ZFIN ENSEMBL Google Show fit	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4
chr6_-_60031693 Show fit	2.28	ENSDART00000160275	CABZ01079262.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr10_-_39153959 Show fit	2.27	ENSDART00000150193 ENSDART00000111362	slc37a4b NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr1_-_22726233 Show fit	2.23	ENSDART00000140920	prom1b NCBI UniProt ZFIN ENSEMBL Google Show fit	prominin 1 b
chr23_-_35082494 Show fit	2.23	ENSDART00000189809	BX294434.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr4_+_15981096 Show fit	2.23	ENSDART00000122493	ucn3l NCBI UniProt ZFIN ENSEMBL Google Show fit	urocortin 3, like
chr18_-_15373620 Show fit	2.23	ENSDART00000031752	rfx4 NCBI UniProt ZFIN ENSEMBL Google Show fit	regulatory factor X, 4
chr4_+_10366532 Show fit	2.21	ENSDART00000189901	kcnd2 NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium voltage-gated channel, Shal-related subfamily, member 2
chr6_+_42587637 Show fit	2.20	ENSDART00000179964	camkva NCBI UniProt ZFIN ENSEMBL Google Show fit	CaM kinase-like vesicle-associated a
chr8_+_14158021 Show fit	2.20	ENSDART00000080832	si:dkey-6n6.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-6n6.2
chr4_-_72080351 Show fit	2.20	ENSDART00000174925	LO017820.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr14_-_31465905 Show fit	2.20	ENSDART00000173108	gpc3 NCBI UniProt ZFIN ENSEMBL Google Show fit	glypican 3
chr3_-_36260102 Show fit	2.18	ENSDART00000126588	rac3a NCBI UniProt ZFIN ENSEMBL Google Show fit	Rac family small GTPase 3a
chr22_+_18816662 Show fit	2.16	ENSDART00000132476	cbarpb NCBI UniProt ZFIN ENSEMBL Google Show fit	calcium channel, voltage-dependent, beta subunit associated regulatory protein b
chr3_-_18710009 Show fit	2.16	ENSDART00000142478	grid2ipa NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, a
chr6_-_957830 Show fit	2.16	ENSDART00000090019 ENSDART00000184286	zeb2b NCBI UniProt ZFIN ENSEMBL Google Show fit	zinc finger E-box binding homeobox 2b
chr5_-_29643381 Show fit	2.15	ENSDART00000034849	grin1b NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr5_+_29784172 Show fit	2.15	ENSDART00000139035	si:ch211-215c18.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-215c18.3
chr24_+_39186940 Show fit	2.15	ENSDART00000155817	spsb3b NCBI UniProt ZFIN ENSEMBL Google Show fit	splA/ryanodine receptor domain and SOCS box containing 3b
chr12_+_49125510 Show fit	2.14	ENSDART00000185804	FO704607.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr20_-_28638871 Show fit	2.14	ENSDART00000184779	rgs6 NCBI UniProt ZFIN ENSEMBL Google Show fit	regulator of G protein signaling 6
chr24_+_29449690 Show fit	2.13	ENSDART00000105743 ENSDART00000193556 ENSDART00000145816	ntng1a NCBI UniProt ZFIN ENSEMBL Google Show fit	netrin g1a
chr3_-_8510201 Show fit	2.13	ENSDART00000009151	CABZ01064671.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr13_+_2523032 Show fit	2.12	ENSDART00000172261	lhb NCBI UniProt ZFIN ENSEMBL Google Show fit	luteinizing hormone, beta polypeptide
chr17_-_38778826 Show fit	2.12	ENSDART00000168182 ENSDART00000124041 ENSDART00000136921	dglucy NCBI UniProt ZFIN ENSEMBL Google Show fit	D-glutamate cyclase
chr3_+_34821327 Show fit	2.12	ENSDART00000055262	cdk5r1a NCBI UniProt ZFIN ENSEMBL Google Show fit	cyclin-dependent kinase 5, regulatory subunit 1a (p35)
chr1_-_30039331 Show fit	2.10	ENSDART00000086935 ENSDART00000143800	MARCH4 (1 of many) NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:153256
chr12_-_10220036 Show fit	2.09	ENSDART00000134619	mpp2b NCBI UniProt ZFIN ENSEMBL Google Show fit	membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr18_+_48608366 Show fit	2.08	ENSDART00000151229	kcnj5 NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium inwardly-rectifying channel, subfamily J, member 5
chr7_-_69983948 Show fit	2.07	ENSDART00000185827	KCNIP4 NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium voltage-gated channel interacting protein 4
chr2_-_42827336 Show fit	2.07	ENSDART00000140913	adcy8 NCBI UniProt ZFIN ENSEMBL Google Show fit	adenylate cyclase 8 (brain)
chr21_-_14773692 Show fit	2.06	ENSDART00000142145	glulc NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamate-ammonia ligase (glutamine synthase) c
chr5_+_65491390 Show fit	2.06	ENSDART00000159921	si:dkey-21e5.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-21e5.1
chr7_-_22132265 Show fit	2.05	ENSDART00000125284 ENSDART00000112978	nlgn2a NCBI UniProt ZFIN ENSEMBL Google Show fit	neuroligin 2a
chr2_-_44038698 Show fit	2.05	ENSDART00000079582 ENSDART00000146804	kirrel1b NCBI UniProt ZFIN ENSEMBL Google Show fit	kirre like nephrin family adhesion molecule 1b
chr15_+_24691088 Show fit	2.04	ENSDART00000110618	LRRC75A NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-151p21.7
chr6_+_49412754 Show fit	2.03	ENSDART00000027398	kcna2a NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium voltage-gated channel, shaker-related subfamily, member 2a
chr4_-_49607096 Show fit	2.03	ENSDART00000154381	si:dkey-159n16.4 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-159n16.4
chr11_+_30162407 Show fit	2.02	ENSDART00000190333 ENSDART00000127502	cdkl5 NCBI UniProt ZFIN ENSEMBL Google Show fit	cyclin-dependent kinase-like 5
chr17_+_9040165 Show fit	2.02	ENSDART00000181221 ENSDART00000181846	akap6 NCBI UniProt ZFIN ENSEMBL Google Show fit	A kinase (PRKA) anchor protein 6
chr10_-_44027391 Show fit	2.02	ENSDART00000145404	crybb1 NCBI UniProt ZFIN ENSEMBL Google Show fit	crystallin, beta B1
chr7_-_72427616 Show fit	2.02	ENSDART00000181878	rph3ab NCBI UniProt ZFIN ENSEMBL Google Show fit	rabphilin 3A homolog (mouse), b
chr19_-_30565122 Show fit	2.01	ENSDART00000185650	hpcal4 NCBI UniProt ZFIN ENSEMBL Google Show fit	hippocalcin like 4
chr4_-_20243021 Show fit	2.01	ENSDART00000048023	cacna2d4a NCBI UniProt ZFIN ENSEMBL Google Show fit	calcium channel, voltage-dependent, alpha 2/delta subunit 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of esr1+esr2a+esr2b

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.8	7.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
1.2	3.7	GO:1905072	cardiac jelly development(GO:1905072)
1.1	7.7	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
1.0	3.1	GO:0051228	mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.9	2.8	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.9	3.7	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.9	5.5	GO:0071691	cardiac muscle thin filament assembly(GO:0071691)
0.9	3.5	GO:0009098	leucine biosynthetic process(GO:0009098)
0.9	2.6	GO:0055026	negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.9	2.6	GO:0099540	synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.8	4.2	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.8	3.2	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.8	2.3	GO:1903779	regulation of cardiac conduction(GO:1903779)
0.7	2.9	GO:0015868	intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.7	4.9	GO:0003319	cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.7	3.5	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.7	2.6	GO:0060405	copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.6	7.0	GO:0006797	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.6	1.7	GO:0072020	proximal straight tubule development(GO:0072020)
0.6	2.3	GO:0019242	methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6	1.7	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.5	4.8	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.5	1.6	GO:0090131	mesenchyme migration(GO:0090131)
0.5	1.5	GO:0018872	arsonoacetate metabolic process(GO:0018872)
0.5	1.5	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.5	1.5	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.4	0.8	GO:0055070	copper ion homeostasis(GO:0055070)
0.4	3.7	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.4	2.9	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.4	1.6	GO:0061549	sympathetic ganglion development(GO:0061549)
0.4	4.6	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4	3.0	GO:0060976	coronary vasculature development(GO:0060976)
0.4	9.4	GO:0031114	regulation of microtubule depolymerization(GO:0031114)
0.4	0.4	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.4	3.7	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4	8.7	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4	4.6	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.4	3.9	GO:0034394	protein localization to cell surface(GO:0034394)
0.3	2.4	GO:0030728	ovulation(GO:0030728)
0.3	4.4	GO:0010996	response to auditory stimulus(GO:0010996)
0.3	1.7	GO:0097510	base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.3	6.3	GO:0098884	postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.3	4.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.3	0.9	GO:0009191	ribonucleoside diphosphate catabolic process(GO:0009191)
0.3	2.2	GO:0045955	negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.3	5.5	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.3	2.0	GO:0014846	esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.3	2.2	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.3	1.6	GO:0071305	vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.3	0.3	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.3	4.7	GO:0035778	pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.3	3.6	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.3	1.5	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2	1.2	GO:0006121	mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.2	6.1	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2	2.1	GO:0006561	proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2	1.4	GO:0060251	regulation of glial cell proliferation(GO:0060251)
0.2	3.5	GO:0046549	retinal cone cell development(GO:0046549)
0.2	4.2	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2	1.7	GO:2000650	negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.2	1.9	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2	1.9	GO:1903578	regulation of oxidative phosphorylation(GO:0002082) regulation of nucleoside metabolic process(GO:0009118) regulation of ATP metabolic process(GO:1903578)
0.2	1.3	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.2	4.7	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2	1.3	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.2	4.3	GO:0022010	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.2	2.2	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.2	1.8	GO:0019233	sensory perception of pain(GO:0019233)
0.2	1.6	GO:0021627	olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.2	4.3	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.2	0.6	GO:1901232	regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.2	3.3	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2	1.9	GO:0006868	glutamine transport(GO:0006868)
0.2	1.7	GO:0043981	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.2	3.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2	2.7	GO:0042551	neuron maturation(GO:0042551)
0.2	4.9	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.2	1.1	GO:0006574	valine catabolic process(GO:0006574)
0.2	0.7	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2	3.0	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.2	1.7	GO:0021794	thalamus development(GO:0021794)
0.2	4.2	GO:0051639	actin filament network formation(GO:0051639)
0.2	0.9	GO:1902369	negative regulation of RNA catabolic process(GO:1902369)
0.2	0.5	GO:0097240	telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.2	5.9	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2	0.3	GO:0001919	regulation of receptor recycling(GO:0001919)
0.2	3.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	2.0	GO:0030431	sleep(GO:0030431)
0.2	0.5	GO:0000103	sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2	0.7	GO:0072314	visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.2	1.3	GO:0001964	startle response(GO:0001964)
0.2	3.4	GO:0006825	copper ion transport(GO:0006825)
0.2	0.8	GO:1901842	regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2	1.4	GO:0016119	carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.2	4.4	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.2	0.8	GO:0051031	tRNA transport(GO:0051031)
0.2	1.1	GO:0043589	skin morphogenesis(GO:0043589) mesenchymal cell migration(GO:0090497)
0.2	1.2	GO:0021588	cerebellum formation(GO:0021588)
0.1	0.9	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.1	2.4	GO:0010766	positive regulation of sodium ion transport(GO:0010765) negative regulation of sodium ion transport(GO:0010766) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1	2.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.1	0.6	GO:0044210	'de novo' CTP biosynthetic process(GO:0044210)
0.1	0.3	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.1	0.7	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.1	2.0	GO:0032836	glomerular basement membrane development(GO:0032836)
0.1	0.4	GO:0046184	aldehyde biosynthetic process(GO:0046184)
0.1	1.0	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1	1.7	GO:0099565	excitatory postsynaptic potential(GO:0060079) chemical synaptic transmission, postsynaptic(GO:0099565)
0.1	0.8	GO:0016572	histone phosphorylation(GO:0016572)
0.1	0.4	GO:0003408	optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519) tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195)
0.1	0.7	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1	6.5	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	1.2	GO:0035677	posterior lateral line neuromast hair cell development(GO:0035677)
0.1	2.3	GO:0045773	positive regulation of axon extension(GO:0045773)
0.1	0.7	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.1	0.4	GO:0007414	axonal defasciculation(GO:0007414)
0.1	0.4	GO:0055109	invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.1	0.5	GO:0060956	cardiac endothelial cell differentiation(GO:0003348) endocardial cell differentiation(GO:0060956)
0.1	0.9	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.1	1.1	GO:0001682	tRNA 5'-leader removal(GO:0001682)
0.1	2.7	GO:0048168	regulation of neuronal synaptic plasticity(GO:0048168)
0.1	3.1	GO:0007007	inner mitochondrial membrane organization(GO:0007007)
0.1	2.6	GO:0015671	oxygen transport(GO:0015671)
0.1	0.5	GO:0060092	regulation of synaptic transmission, glycinergic(GO:0060092)
0.1	0.4	GO:0090141	positive regulation of mitochondrial fission(GO:0090141)
0.1	1.2	GO:0007418	ventral midline development(GO:0007418) floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.1	4.8	GO:0006635	fatty acid beta-oxidation(GO:0006635)
0.1	2.6	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1	3.3	GO:0060997	dendritic spine morphogenesis(GO:0060997)
0.1	0.6	GO:0045124	regulation of bone resorption(GO:0045124)
0.1	0.9	GO:0006543	glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.1	0.8	GO:0000706	meiotic DNA double-strand break processing(GO:0000706)
0.1	1.1	GO:0022615	protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1	0.3	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.1	4.2	GO:0060840	artery development(GO:0060840)
0.1	0.7	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	1.1	GO:0044458	motile cilium assembly(GO:0044458)
0.1	1.0	GO:0060004	reflex(GO:0060004) vestibular reflex(GO:0060005)
0.1	0.3	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.1	0.7	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	1.4	GO:0000272	polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1	0.5	GO:0043029	T cell homeostasis(GO:0043029)
0.1	4.2	GO:0007586	digestion(GO:0007586)
0.1	0.8	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.1	1.5	GO:0030323	respiratory tube development(GO:0030323) lung development(GO:0030324)
0.1	1.2	GO:0035094	response to nicotine(GO:0035094)
0.1	0.6	GO:0021877	forebrain neuron fate commitment(GO:0021877)
0.1	0.6	GO:0001990	regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1	0.9	GO:0060061	Spemann organizer formation(GO:0060061)
0.1	0.9	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1	11.7	GO:0002088	lens development in camera-type eye(GO:0002088)
0.1	2.6	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.1	1.3	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.1	1.8	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1	0.8	GO:0008343	adult feeding behavior(GO:0008343) negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1	0.3	GO:0072679	negative T cell selection(GO:0043383) thymocyte migration(GO:0072679)
0.1	0.6	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1	0.7	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	2.4	GO:0070593	dendrite self-avoidance(GO:0070593)
0.1	5.2	GO:0030903	notochord development(GO:0030903)
0.1	4.3	GO:0018298	protein-chromophore linkage(GO:0018298)
0.1	2.6	GO:0021587	cerebellum morphogenesis(GO:0021587)
0.1	0.6	GO:0008207	C21-steroid hormone metabolic process(GO:0008207)
0.1	1.9	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	0.7	GO:2000479	regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.1	2.6	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1	0.8	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.1	1.0	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.1	9.8	GO:0001756	somitogenesis(GO:0001756)
0.1	1.2	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.1	0.8	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1	2.1	GO:0070831	basement membrane assembly(GO:0070831)
0.1	2.5	GO:0014866	skeletal myofibril assembly(GO:0014866)
0.1	0.5	GO:0003422	growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1	1.0	GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.1	0.7	GO:0042694	muscle cell fate specification(GO:0042694)
0.1	1.6	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.1	1.3	GO:0015693	magnesium ion transport(GO:0015693)
0.1	0.2	GO:0051660	establishment of centrosome localization(GO:0051660)
0.1	0.4	GO:0043114	regulation of vascular permeability(GO:0043114)
0.1	0.3	GO:0035777	pronephric distal tubule development(GO:0035777)
0.1	3.4	GO:0006171	cAMP biosynthetic process(GO:0006171)
0.1	1.0	GO:0050936	xanthophore differentiation(GO:0050936)
0.1	1.1	GO:0061300	cerebellum vasculature development(GO:0061300)
0.1	0.4	GO:0007060	male meiosis chromosome segregation(GO:0007060)
0.1	0.6	GO:0090148	membrane fission(GO:0090148)
0.1	0.3	GO:0016116	tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.1	9.0	GO:0051260	protein homooligomerization(GO:0051260)
0.1	0.8	GO:0014074	response to purine-containing compound(GO:0014074) response to ATP(GO:0033198) response to organophosphorus(GO:0046683)
0.1	0.3	GO:0032655	interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1	0.4	GO:0070378	ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.1	1.3	GO:0033555	multicellular organismal response to stress(GO:0033555)
0.1	1.8	GO:0043409	negative regulation of MAPK cascade(GO:0043409)
0.1	1.1	GO:0046473	phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1	1.2	GO:0072114	pronephros morphogenesis(GO:0072114)
0.1	5.9	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.1	3.3	GO:0045214	sarcomere organization(GO:0045214)
0.1	2.8	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.1	0.4	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.1	1.0	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.1	0.3	GO:0038107	nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of epiboly involved in gastrulation with mouth forming second(GO:1904086)
0.1	1.6	GO:0030239	myofibril assembly(GO:0030239)
0.1	1.5	GO:0030322	stabilization of membrane potential(GO:0030322)
0.1	0.2	GO:0044068	modification by symbiont of host morphology or physiology(GO:0044003) modulation by symbiont of host cellular process(GO:0044068)
0.1	0.7	GO:0002028	regulation of sodium ion transport(GO:0002028)
0.1	0.9	GO:0007634	optokinetic behavior(GO:0007634)
0.1	0.2	GO:0060541	respiratory system development(GO:0060541)
0.1	1.4	GO:0006284	base-excision repair(GO:0006284)
0.1	1.0	GO:0018095	protein polyglutamylation(GO:0018095)
0.1	0.7	GO:0007602	phototransduction(GO:0007602)
0.1	1.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.1	0.4	GO:0046294	formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.1	0.6	GO:0060325	face morphogenesis(GO:0060325)
0.1	7.0	GO:0042391	regulation of membrane potential(GO:0042391)
0.1	0.7	GO:0021772	olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1	1.4	GO:0006828	manganese ion transport(GO:0006828)
0.1	0.5	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.2	GO:0030329	prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.0	1.6	GO:0006096	glycolytic process(GO:0006096)
0.0	0.1	GO:1905048	regulation of metallopeptidase activity(GO:1905048)
0.0	0.1	GO:0002155	regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0	1.4	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.7	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.0	2.0	GO:0006289	nucleotide-excision repair(GO:0006289)
0.0	2.7	GO:0048015	phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017)
0.0	0.1	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.0	10.9	GO:0006470	protein dephosphorylation(GO:0006470)
0.0	3.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	3.4	GO:0070507	regulation of microtubule cytoskeleton organization(GO:0070507)
0.0	0.3	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.9	GO:0007019	microtubule depolymerization(GO:0007019)
0.0	0.4	GO:0030317	sperm motility(GO:0030317)
0.0	0.1	GO:0099563	modification of synaptic structure(GO:0099563)
0.0	2.5	GO:0016079	synaptic vesicle exocytosis(GO:0016079)
0.0	0.5	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.8	GO:0032958	inositol phosphate biosynthetic process(GO:0032958)
0.0	2.7	GO:0007098	centrosome cycle(GO:0007098)
0.0	0.8	GO:0003094	glomerular filtration(GO:0003094)
0.0	0.7	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.9	GO:0006306	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	1.6	GO:0003009	skeletal muscle contraction(GO:0003009)
0.0	2.7	GO:0006936	muscle contraction(GO:0006936)
0.0	0.7	GO:0021884	forebrain neuron development(GO:0021884)
0.0	1.5	GO:0061512	protein localization to cilium(GO:0061512)
0.0	0.5	GO:0071156	regulation of cell cycle arrest(GO:0071156)
0.0	0.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.6	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	1.6	GO:0010842	retina layer formation(GO:0010842)
0.0	0.5	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.5	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	1.2	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.0	2.1	GO:0045732	positive regulation of protein catabolic process(GO:0045732)
0.0	1.4	GO:0031032	actomyosin structure organization(GO:0031032)
0.0	1.0	GO:0003407	neural retina development(GO:0003407)
0.0	0.2	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	1.5	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
0.0	0.6	GO:0046058	cAMP metabolic process(GO:0046058)
0.0	0.4	GO:0006265	DNA topological change(GO:0006265)
0.0	1.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	1.2	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968)
0.0	1.4	GO:0031638	zymogen activation(GO:0031638)
0.0	1.5	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	2.4	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.0	0.7	GO:0070286	axonemal dynein complex assembly(GO:0070286)
0.0	0.8	GO:0055064	chloride ion homeostasis(GO:0055064)
0.0	1.2	GO:1901214	regulation of neuron death(GO:1901214)
0.0	0.3	GO:0018200	peptidyl-glutamic acid modification(GO:0018200)
0.0	0.5	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.0	0.7	GO:0019835	cytolysis(GO:0019835)
0.0	0.1	GO:0038203	TORC2 signaling(GO:0038203)
0.0	0.1	GO:0051341	regulation of oxidoreductase activity(GO:0051341)
0.0	0.3	GO:0043248	proteasome assembly(GO:0043248)
0.0	1.9	GO:0019722	calcium-mediated signaling(GO:0019722)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.9	GO:0016126	sterol biosynthetic process(GO:0016126)
0.0	0.4	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.5	GO:0022904	respiratory electron transport chain(GO:0022904)
0.0	6.2	GO:0046777	protein autophosphorylation(GO:0046777)
0.0	0.5	GO:0007129	synapsis(GO:0007129)
0.0	0.5	GO:0051781	positive regulation of cell division(GO:0051781)
0.0	1.0	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.1	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.6	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.2	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.4	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.0	1.1	GO:0007605	sensory perception of sound(GO:0007605)
0.0	0.5	GO:0008214	protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0	0.4	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.7	GO:0048247	lymphocyte chemotaxis(GO:0048247)
0.0	3.0	GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.0	0.6	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.7	GO:0048741	myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0	1.1	GO:0007601	visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953)
0.0	0.8	GO:0035725	sodium ion transmembrane transport(GO:0035725)
0.0	0.1	GO:0035092	spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.2	GO:0042073	intraciliary transport(GO:0042073)
0.0	0.2	GO:0010507	negative regulation of autophagy(GO:0010507)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.8	4.1	GO:0043034	costamere(GO:0043034)
0.8	6.4	GO:0071914	prominosome(GO:0071914)
0.8	3.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7	2.1	GO:0060077	inhibitory synapse(GO:0060077)
0.6	3.1	GO:0042584	chromaffin granule membrane(GO:0042584)
0.6	3.6	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5	2.6	GO:0042583	chromaffin granule(GO:0042583)
0.5	1.4	GO:0005592	collagen type XI trimer(GO:0005592)
0.4	2.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.4	3.0	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4	4.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.4	0.8	GO:0035253	ciliary rootlet(GO:0035253)
0.4	7.2	GO:0031430	M band(GO:0031430)
0.4	3.7	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4	9.2	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.3	3.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.3	6.3	GO:0098844	postsynaptic endocytic zone membrane(GO:0098844)
0.3	2.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.3	2.2	GO:0001401	mitochondrial sorting and assembly machinery complex(GO:0001401)
0.3	1.5	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3	1.3	GO:1990071	TRAPPII protein complex(GO:1990071)
0.3	3.8	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.3	10.9	GO:0043204	perikaryon(GO:0043204)
0.2	1.2	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2	3.2	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.2	21.0	GO:0030018	Z disc(GO:0030018)
0.2	0.9	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.2	3.2	GO:0043209	myelin sheath(GO:0043209)
0.2	3.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2	11.1	GO:0070469	respiratory chain(GO:0070469)
0.2	1.0	GO:0097224	sperm connecting piece(GO:0097224)
0.2	11.2	GO:0005865	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.2	2.0	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.2	0.5	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2	3.8	GO:0043195	terminal bouton(GO:0043195)
0.1	0.6	GO:0097268	cytoophidium(GO:0097268)
0.1	2.5	GO:0031594	neuromuscular junction(GO:0031594)
0.1	0.8	GO:1902636	kinociliary basal body(GO:1902636)
0.1	2.5	GO:0005801	cis-Golgi network(GO:0005801)
0.1	11.8	GO:0044297	cell body(GO:0044297)
0.1	3.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.8	GO:0000801	central element(GO:0000801)
0.1	0.4	GO:0098533	ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.1	5.2	GO:0031970	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1	1.4	GO:0061617	MICOS complex(GO:0061617)
0.1	2.0	GO:0030017	sarcomere(GO:0030017)
0.1	5.8	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1	0.8	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1	11.5	GO:0014069	postsynaptic density(GO:0014069)
0.1	1.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	0.9	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	0.7	GO:0031045	dense core granule(GO:0031045)
0.1	2.1	GO:0005605	basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1	1.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	2.2	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	3.6	GO:0031225	anchored component of membrane(GO:0031225)
0.1	1.5	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.1	4.1	GO:0001750	photoreceptor outer segment(GO:0001750)
0.1	6.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	0.9	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	1.5	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	0.5	GO:0005955	calcineurin complex(GO:0005955)
0.1	1.3	GO:0031209	SCAR complex(GO:0031209)
0.1	0.7	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1	1.0	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	5.4	GO:0030141	secretory granule(GO:0030141)
0.1	1.6	GO:0034707	chloride channel complex(GO:0034707)
0.1	0.4	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.1	2.7	GO:0032432	actin filament bundle(GO:0032432)
0.1	0.7	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	1.8	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	0.3	GO:0071986	Ragulator complex(GO:0071986)
0.1	10.6	GO:0030424	axon(GO:0030424)
0.1	0.4	GO:0097225	sperm midpiece(GO:0097225)
0.1	6.3	GO:0016459	myosin complex(GO:0016459)
0.1	0.5	GO:0005943	phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0	0.5	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.7	GO:0005579	membrane attack complex(GO:0005579)
0.0	8.4	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	0.8	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.7	GO:0097546	ciliary base(GO:0097546)
0.0	0.9	GO:0032421	stereocilium bundle(GO:0032421)
0.0	1.6	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	1.1	GO:0031941	filamentous actin(GO:0031941)
0.0	1.0	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	2.5	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.3	GO:0045171	intercellular bridge(GO:0045171)
0.0	1.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.9	GO:0000145	exocyst(GO:0000145)
0.0	0.3	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.6	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.8	GO:0005844	polysome(GO:0005844)
0.0	36.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	0.5	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.5	GO:0000795	synaptonemal complex(GO:0000795)
0.0	0.5	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	1.9	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.2	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0098837	postsynaptic recycling endosome(GO:0098837) postsynaptic endosome(GO:0098845)
0.0	2.0	GO:0005795	Golgi stack(GO:0005795)
0.0	1.0	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.5	GO:0045180	basal cortex(GO:0045180)
0.0	9.3	GO:0030054	cell junction(GO:0030054)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.8	GO:0005930	axoneme(GO:0005930)
0.0	0.4	GO:0031514	motile cilium(GO:0031514)
0.0	0.2	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	5.2	GO:0016531	copper chaperone activity(GO:0016531)
0.9	7.5	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.9	3.7	GO:0044548	S100 protein binding(GO:0044548)
0.9	2.8	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.9	3.5	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.9	3.5	GO:0016521	pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.9	2.6	GO:0060175	brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.7	2.9	GO:0005471	ATP:ADP antiporter activity(GO:0005471)
0.7	4.8	GO:0004962	endothelin receptor activity(GO:0004962)
0.7	6.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6	7.0	GO:0004309	exopolyphosphatase activity(GO:0004309)
0.6	3.6	GO:0051429	corticotropin-releasing hormone receptor binding(GO:0051429)
0.6	7.7	GO:0004017	adenylate kinase activity(GO:0004017)
0.6	2.3	GO:0008929	triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.6	4.0	GO:0001641	group II metabotropic glutamate receptor activity(GO:0001641)
0.6	2.8	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.5	2.7	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5	1.5	GO:0030792	arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.5	1.4	GO:0072591	N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.5	3.8	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.4	3.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4	8.3	GO:0051393	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.4	1.2	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.4	2.9	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4	1.6	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.4	1.9	GO:2001070	starch binding(GO:2001070)
0.4	1.9	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.4	3.7	GO:0030332	cyclin binding(GO:0030332)
0.4	2.6	GO:0098809	nitrite reductase activity(GO:0098809)
0.4	2.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.3	1.4	GO:0004135	glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.3	7.5	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3	1.7	GO:0008281	sulfonylurea receptor activity(GO:0008281)
0.3	1.0	GO:0008517	folic acid transporter activity(GO:0008517)
0.3	2.3	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.3	1.5	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.3	0.9	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.3	2.9	GO:0016805	dipeptidase activity(GO:0016805)
0.3	1.1	GO:0008442	3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.3	1.1	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3	1.6	GO:0004743	pyruvate kinase activity(GO:0004743)
0.3	3.2	GO:0016868	intramolecular transferase activity, phosphotransferases(GO:0016868)
0.3	0.8	GO:0016530	metallochaperone activity(GO:0016530)
0.3	5.8	GO:0005523	tropomyosin binding(GO:0005523)
0.3	1.3	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3	5.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.3	1.0	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2	9.0	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.2	9.6	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	0.7	GO:0031704	apelin receptor binding(GO:0031704)
0.2	4.7	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.2	4.1	GO:0097472	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2	4.7	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.2	0.9	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.2	3.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.2	1.3	GO:0043914	NADPH:sulfur oxidoreductase activity(GO:0043914)
0.2	1.3	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.2	4.2	GO:0001671	ATPase activator activity(GO:0001671)
0.2	2.5	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.2	5.5	GO:0004016	adenylate cyclase activity(GO:0004016)
0.2	0.6	GO:0048030	disaccharide binding(GO:0048030)
0.2	2.2	GO:0005000	vasopressin receptor activity(GO:0005000)
0.2	1.8	GO:0004985	opioid receptor activity(GO:0004985)
0.2	1.0	GO:0042809	vitamin D receptor binding(GO:0042809)
0.2	1.3	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.2	1.5	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.2	2.6	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.2	2.4	GO:0070628	proteasome binding(GO:0070628)
0.2	0.5	GO:0004779	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2	1.7	GO:0005522	profilin binding(GO:0005522)
0.2	4.6	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2	1.1	GO:0004630	phospholipase D activity(GO:0004630)
0.2	3.3	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2	0.5	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.2	2.1	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2	12.0	GO:0005212	structural constituent of eye lens(GO:0005212)
0.2	3.6	GO:0009975	cyclase activity(GO:0009975)
0.2	1.9	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
0.2	1.4	GO:0010436	beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.2	1.2	GO:0001972	retinoic acid binding(GO:0001972)
0.2	0.8	GO:0001223	transcription coactivator binding(GO:0001223)
0.2	8.9	GO:0005178	integrin binding(GO:0005178)
0.1	0.7	GO:0070412	R-SMAD binding(GO:0070412)
0.1	0.9	GO:0004960	thromboxane receptor activity(GO:0004960)
0.1	2.4	GO:0019869	chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1	0.6	GO:0003883	CTP synthase activity(GO:0003883)
0.1	0.7	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.1	1.2	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	0.9	GO:0004997	thyrotropin-releasing hormone receptor activity(GO:0004997)
0.1	1.7	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1	2.4	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.1	1.1	GO:0005052	peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1	0.4	GO:0070738	protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1	4.5	GO:0098632	protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.1	2.0	GO:0030544	Hsp70 protein binding(GO:0030544)
0.1	1.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1	2.1	GO:0048495	Roundabout binding(GO:0048495)
0.1	1.9	GO:0098988	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.1	1.7	GO:0048018	receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.1	0.9	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	0.7	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1	6.5	GO:0015485	cholesterol binding(GO:0015485)
0.1	0.8	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1	0.9	GO:0034452	dynactin binding(GO:0034452)
0.1	1.9	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1	1.6	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	0.7	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1	1.8	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1	2.8	GO:0005246	calcium channel regulator activity(GO:0005246)
0.1	1.5	GO:0008061	chitin binding(GO:0008061)
0.1	3.0	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.1	0.3	GO:0003875	ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1	0.7	GO:0005549	olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.1	1.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.1	3.0	GO:0030165	PDZ domain binding(GO:0030165)
0.1	1.3	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.1	10.4	GO:0030276	clathrin binding(GO:0030276)
0.1	5.7	GO:0051427	hormone receptor binding(GO:0051427)
0.1	5.0	GO:0009881	photoreceptor activity(GO:0009881)
0.1	1.0	GO:0047676	arachidonate-CoA ligase activity(GO:0047676)
0.1	0.3	GO:0004968	gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1	0.7	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.5	GO:0033192	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	0.5	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1	1.3	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.1	1.6	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1	2.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.1	1.5	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.1	0.6	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1	0.6	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1	1.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.1	3.4	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	3.4	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.1	0.3	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1	0.9	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1	1.7	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.1	0.3	GO:0050251	retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.1	1.0	GO:0070739	protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1	5.7	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.1	0.8	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	0.5	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1	0.6	GO:0015250	water channel activity(GO:0015250)
0.1	0.4	GO:0030298	receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.1	0.3	GO:0050254	rhodopsin kinase activity(GO:0050254)
0.1	44.0	GO:0003779	actin binding(GO:0003779)
0.1	0.5	GO:0048039	ubiquinone binding(GO:0048039)
0.1	0.4	GO:0004995	tachykinin receptor activity(GO:0004995)
0.1	0.8	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1	0.2	GO:0016206	catechol O-methyltransferase activity(GO:0016206)
0.1	1.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	0.7	GO:0005223	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1	0.8	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.1	0.5	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.1	0.5	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1	2.4	GO:0031593	polyubiquitin binding(GO:0031593)
0.1	3.6	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	2.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	1.2	GO:0005272	sodium channel activity(GO:0005272)
0.0	0.2	GO:0001735	prenylcysteine oxidase activity(GO:0001735)
0.0	1.0	GO:0050811	GABA receptor binding(GO:0050811)
0.0	1.5	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	1.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.8	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828)
0.0	0.5	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0	8.2	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	1.0	GO:0004620	phospholipase activity(GO:0004620)
0.0	2.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.7	GO:0016208	AMP binding(GO:0016208)
0.0	2.2	GO:0044325	ion channel binding(GO:0044325)
0.0	2.4	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	6.8	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.0	1.3	GO:0051020	GTPase binding(GO:0051020)
0.0	0.8	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.7	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.6	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	1.1	GO:0017022	myosin binding(GO:0017022)
0.0	0.9	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.6	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	1.1	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	3.2	GO:0005179	hormone activity(GO:0005179)
0.0	1.0	GO:0051087	chaperone binding(GO:0051087)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.5	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.6	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0035575	histone demethylase activity (H4-K20 specific)(GO:0035575)
0.0	0.6	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.7	GO:0004623	phospholipase A2 activity(GO:0004623)
0.0	0.7	GO:0051018	protein kinase A binding(GO:0051018)
0.0	2.8	GO:0005516	calmodulin binding(GO:0005516)
0.0	0.4	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0060182	apelin receptor activity(GO:0060182)
0.0	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	1.0	GO:0019905	syntaxin binding(GO:0019905)
0.0	1.3	GO:0015179	L-amino acid transmembrane transporter activity(GO:0015179)
0.0	0.1	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.0	0.5	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.6	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.9	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.2	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	2.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	1.1	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993)
0.0	0.2	GO:0052795	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	1.0	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	3.5	GO:0015293	symporter activity(GO:0015293)
0.0	0.8	GO:0005507	copper ion binding(GO:0005507)
0.0	0.4	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.3	GO:0009055	electron carrier activity(GO:0009055)
0.0	0.4	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.7	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	1.6	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.4	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.8	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.9	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.0	0.0	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.9	GO:0016209	antioxidant activity(GO:0016209)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.2	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.3	GO:0045182	translation regulator activity(GO:0045182)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	3.7	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	2.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	3.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	3.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	3.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	4.0	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	1.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	2.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	3.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.4	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.4	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	1.3	PID CDC42 PATHWAY	CDC42 signaling events
0.0	1.3	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.8	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.8	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.7	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	1.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.1	PID SHP2 PATHWAY	SHP2 signaling
0.0	0.5	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	1.0	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.7	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.8	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	2.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	0.2	PID CONE PATHWAY	Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	7.9	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.4	5.6	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.4	3.7	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.3	4.6	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3	2.4	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.3	8.2	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.3	5.5	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.3	16.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.3	1.9	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.3	2.6	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.3	7.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	8.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	2.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	3.0	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.2	3.3	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2	1.5	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2	1.6	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.2	3.7	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	0.8	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.2	1.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.2	1.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	2.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	2.3	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.1	1.5	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	1.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	0.5	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	1.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	1.9	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	1.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	1.6	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	0.8	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	0.9	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	4.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	0.7	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	2.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	0.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	0.8	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.8	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	1.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	2.1	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.8	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.6	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	1.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.4	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.4	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.7	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Results for esr1+esr2a+esr2b

Z-value: 1.08

Motif logo

Transcription factors associated with esr1+esr2a+esr2b

Activity-expression correlation:

Activity profile of esr1+esr2a+esr2b motif

Sorted Z-values of esr1+esr2a+esr2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of esr1+esr2a+esr2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: