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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for evx2

Z-value: 0.23

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Transcription factors associated with evx2

Gene Symbol Gene ID Gene Info
evx2
ENSDARG00000059255 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
evx2dr11_v1_chr9_+_2002701_2002701-0.103.2e-01Click!

Activity profile of evx2 motif

Sorted Z-values of evx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_19933356 0.54 ENSDART00000088819
ankrd13a
ankyrin repeat domain 13A
chr9_-_3934963 0.52 ENSDART00000062336
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr22_-_21897203 0.39 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr19_-_19379084 0.38 ENSDART00000165206
smarcc1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b
chr8_-_15129573 0.38 ENSDART00000142358
bcar3
BCAR3, NSP family adaptor protein
chr17_-_5426458 0.33 ENSDART00000157937
supt3h
SPT3 homolog, SAGA and STAGA complex component
chr7_+_22313533 0.32 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr13_-_36663358 0.31 ENSDART00000085319
sos2
son of sevenless homolog 2 (Drosophila)
chr25_+_19666621 0.30 ENSDART00000112746
zgc:171459
zgc:171459
chr13_-_9257728 0.29 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
HTRA2 (1 of many)
zgc:173425
chr2_-_21819421 0.29 ENSDART00000121586
chd7
chromodomain helicase DNA binding protein 7
chr21_-_13662237 0.28 ENSDART00000091647
ENSDART00000151547
pnpla7a
patatin-like phospholipase domain containing 7a
chr13_-_9213207 0.27 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11
chr25_-_6049339 0.27 ENSDART00000075184
snx1a
sorting nexin 1a
chr19_+_47476908 0.26 ENSDART00000157886
zgc:114119
zgc:114119
chr4_+_11464255 0.26 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr13_-_9159852 0.26 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
HTRA2 (1 of many)
si:dkey-112g5.16
chr21_-_13661631 0.26 ENSDART00000184408
pnpla7a
patatin-like phospholipase domain containing 7a
chr5_-_25733745 0.24 ENSDART00000051566
zgc:101016
zgc:101016
chr13_-_9236905 0.23 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-33c12.12
si:dkey-112g5.12
chr13_-_9111927 0.23 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-19p15.4
si:dkey-112g5.12
chr24_-_25004553 0.22 ENSDART00000080997
ENSDART00000136860
zdhhc20b
zinc finger, DHHC-type containing 20b
chr13_-_9184132 0.21 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
HTRA2 (1 of many)
si:dkey-33c12.10
chr13_-_9070754 0.21 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
si:dkey-112g5.12
chr13_+_9468535 0.21 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr9_+_56194410 0.20 ENSDART00000168530
LO018176.1

chr13_-_9091354 0.19 ENSDART00000140319
ENSDART00000142697
HTRA2 (1 of many)
si:dkey-112g5.13
chr5_-_67241633 0.17 ENSDART00000114783
clip1a
CAP-GLY domain containing linker protein 1a
chr13_+_9521629 0.17 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
si:dkey-19p15.4
chr14_+_21820034 0.16 ENSDART00000122739
ctbp1
C-terminal binding protein 1
chr13_-_9045879 0.16 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
si:dkey-112g5.11
chr2_-_1364678 0.15 ENSDART00000011919
ENSDART00000164674
ss18
synovial sarcoma translocation, chromosome 18 (H. sapiens)
chr9_+_1313418 0.13 ENSDART00000191361
casp8l2
caspase 8, apoptosis-related cysteine peptidase, like 2
chr21_+_4410733 0.11 ENSDART00000136831
ENSDART00000131612
HTRA2 (1 of many)
si:dkey-84o3.7
chr2_+_10007113 0.11 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr15_-_18115540 0.11 ENSDART00000131639
ENSDART00000047902
arcn1b
archain 1b
chr21_+_4328348 0.10 ENSDART00000131658
ENSDART00000143799
HTRA2 (1 of many)
si:dkey-84o3.7
chr21_+_4429001 0.10 ENSDART00000134520
HTRA2 (1 of many)
si:dkey-84o3.6
chr18_+_7639401 0.10 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr2_-_26720854 0.09 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr21_+_4348600 0.08 ENSDART00000138463
HTRA2 (1 of many)
si:dkey-84o3.2
chr11_+_5588122 0.04 ENSDART00000113281
zgc:172302
zgc:172302
chr11_+_38280454 0.03 ENSDART00000171496
CDK18
si:dkey-166c18.1
chr24_-_35282568 0.02 ENSDART00000167406
ENSDART00000088609
sntg1
syntrophin, gamma 1
chr5_-_67629263 0.01 ENSDART00000133753
zbtb20
zinc finger and BTB domain containing 20
chr3_+_23692462 0.01 ENSDART00000145934
hoxb7a
homeobox B7a
chr11_+_29790626 0.01 ENSDART00000067822
dynlt3
dynein, light chain, Tctex-type 3

Network of associatons between targets according to the STRING database.

First level regulatory network of evx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.1 GO:0051645 Golgi localization(GO:0051645)
0.0 0.3 GO:0048796 rRNA transcription(GO:0009303) swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.0 0.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.4 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac