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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gata1a+gata2b

Z-value: 0.25

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Transcription factors associated with gata1a+gata2b

Gene Symbol Gene ID Gene Info
gata2b
ENSDARG00000009094 GATA binding protein 2b
gata1a
ENSDARG00000013477 GATA binding protein 1a
gata1a
ENSDARG00000117116 GATA binding protein 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gata1adr11_v1_chr11_-_25418856_254188560.541.5e-08Click!
gata2bdr11_v1_chr6_+_40794015_407940150.526.4e-08Click!

Activity profile of gata1a+gata2b motif

Sorted Z-values of gata1a+gata2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_15507218 2.13 ENSDART00000125450
gpc1a
glypican 1a
chr6_-_49159207 2.03 ENSDART00000041942
tspan2a
tetraspanin 2a
chr21_+_24287403 1.80 ENSDART00000111169
cadm1a
cell adhesion molecule 1a
chr19_-_32710922 1.75 ENSDART00000004034
hpca
hippocalcin
chr12_-_5505205 1.68 ENSDART00000092319
abi3b
ABI family, member 3b
chr22_+_21398508 1.48 ENSDART00000089408
ENSDART00000186091
shdb
Src homology 2 domain containing transforming protein D, b
chr19_+_12444943 1.29 ENSDART00000135706
ldlrad4a
low density lipoprotein receptor class A domain containing 4a
chr4_-_1360495 1.28 ENSDART00000164623
ptn
pleiotrophin
chr16_-_35532937 0.84 ENSDART00000193209
ctps1b
CTP synthase 1b
chr10_-_31175744 0.73 ENSDART00000191728
pknox2
pbx/knotted 1 homeobox 2
chr22_-_16270462 0.43 ENSDART00000105681
cdc14ab
cell division cycle 14Ab
chr10_+_42589391 0.43 ENSDART00000067689
ENSDART00000075259
fgfr1b
fibroblast growth factor receptor 1b
chr7_-_72067475 0.34 ENSDART00000017763
LO018380.1

chr15_-_16704417 0.27 ENSDART00000155163
caln1
calneuron 1
chr5_+_18047111 0.22 ENSDART00000132164
hira
histone cell cycle regulator a

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1a+gata2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 1.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 2.1 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 1.3 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.2 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 1.8 GO:0021782 glial cell development(GO:0021782)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0097268 cytoophidium(GO:0097268)
0.1 2.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.0 1.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.8 GO:0003883 CTP synthase activity(GO:0003883)
0.1 2.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events