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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gata1b+gata2a

Z-value: 2.65

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Transcription factors associated with gata1b+gata2a

Gene Symbol Gene ID Gene Info
ENSDARG00000059130 GATA binding protein 1b
ENSDARG00000059327 GATA binding protein 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gata1bdr11_v1_chr8_-_7474997_7474997-0.511.8e-07Click!
gata2adr11_v1_chr11_-_3865472_3865472-0.363.0e-04Click!

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_7379728 68.30 ENSDART00000012194
GATA binding protein 5
chr5_-_64168415 50.35 ENSDART00000048395
cardiac myosin light chain-1
chr2_-_51794472 43.86 ENSDART00000186652

chr2_-_24289641 42.06 ENSDART00000128784
ENSDART00000123565
ENSDART00000141922
ENSDART00000184550
ENSDART00000191469
myosin heavy chain 7-like
chr16_-_36834505 37.15 ENSDART00000141275
ENSDART00000139588
ENSDART00000041993
purine nucleoside phosphorylase 4b
chr13_+_10945337 36.80 ENSDART00000091845
ATP-binding cassette, sub-family G (WHITE), member 5
chr8_-_40464935 36.39 ENSDART00000040013
myosin, light chain 7, regulatory
chr25_-_28674739 36.27 ENSDART00000067073
leucine rich repeat containing 10
chr2_+_4207209 35.39 ENSDART00000157903
ENSDART00000166476
GATA binding protein 6
chr18_-_42830563 30.70 ENSDART00000191488
tetratricopeptide repeat domain 36
chr13_-_20381485 30.68 ENSDART00000131351
si:ch211-270n8.1
chr10_+_10801564 29.22 ENSDART00000027026
alpha-1-microglobulin/bikunin precursor
chr13_-_10945288 28.73 ENSDART00000114315
ENSDART00000164667
ENSDART00000159482
ATP-binding cassette, sub-family G (WHITE), member 8
chr14_+_36738069 27.49 ENSDART00000105590
tryptophan 2,3-dioxygenase a
chr4_+_1530287 27.40 ENSDART00000067446
solute carrier family 38, member 4
chr15_-_21877726 26.22 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr22_-_36856405 24.63 ENSDART00000029588
kininogen 1
chr10_+_10801719 24.39 ENSDART00000193648
alpha-1-microglobulin/bikunin precursor
chr19_+_8606883 24.21 ENSDART00000054469
ENSDART00000185264
S100 calcium binding protein A10a
chr23_-_5685023 22.90 ENSDART00000148680
ENSDART00000149365
troponin T type 2a (cardiac)
chr24_-_39858710 22.46 ENSDART00000134251
solute carrier family 12 (potassium/chloride transporter), member 7b
chr7_-_41858513 21.85 ENSDART00000109918
myosin light chain kinase 3
chr21_-_25756119 21.75 ENSDART00000002341
claudin c
chr6_-_49078263 21.44 ENSDART00000032982
solute carrier family 5 (iodide transporter), member 8-like
chr11_-_7380674 20.67 ENSDART00000014979
ENSDART00000103418
vitellogenin 3, phosvitinless
chr24_-_2843107 20.47 ENSDART00000165290
cytochrome b5 type A (microsomal)
chr7_-_41851605 20.35 ENSDART00000142981
myosin light chain kinase 3
chr5_+_21211135 18.98 ENSDART00000088492
bone morphogenetic protein 10
chr7_+_35075847 17.91 ENSDART00000193469
ENSDART00000037346
chymotrypsinogen B1
chr6_-_609880 17.61 ENSDART00000149248
ENSDART00000148867
ENSDART00000149414
ENSDART00000148552
ENSDART00000148391
lectin, galactoside-binding, soluble, 2b
chr23_+_25856541 17.51 ENSDART00000145426
ENSDART00000028236
hepatocyte nuclear factor 4, alpha
chr20_+_40150612 14.71 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
triadin
chr25_-_7974494 14.69 ENSDART00000171446
histidine ammonia-lyase
chr3_-_33395233 14.12 ENSDART00000167349
si:dkey-283b1.6
chr12_-_32421046 13.79 ENSDART00000075567
ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1
chr18_-_16795262 13.34 ENSDART00000048722
adenosine monophosphate deaminase 3b
chr11_-_1400507 13.33 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
ribosomal protein L29
chr13_-_23031803 13.23 ENSDART00000056523
hexokinase domain containing 1
chr13_+_2908764 12.54 ENSDART00000162362
wu:fj16a03
chr20_+_15552657 12.27 ENSDART00000063912
Jun proto-oncogene, AP-1 transcription factor subunit
chr20_+_33981946 12.02 ENSDART00000131775
si:dkey-51e6.1
chr7_+_12835048 11.92 ENSDART00000016465
connexin 36.7
chr16_+_12611362 11.91 ENSDART00000055160
interleukin 11a
chr13_+_22480496 11.64 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
LIM domain binding 3a
chr20_+_23625387 11.61 ENSDART00000147945
ENSDART00000150497
palladin, cytoskeletal associated protein
chr8_-_40555340 11.48 ENSDART00000163348
NPC1 like intracellular cholesterol transporter 1
chr21_-_40880317 11.41 ENSDART00000100054
ENSDART00000137696
elastin b
chr25_+_18564266 11.27 ENSDART00000172338
caveolin 1
chr5_+_23151169 11.15 ENSDART00000125638
T-box 5b
chr16_-_24668620 11.09 ENSDART00000012807
paraoxonase 3, tandem duplicate 2
chr14_+_2487672 10.97 ENSDART00000170629
ENSDART00000123063
fibroblast growth factor 18a
chr15_-_43164591 10.78 ENSDART00000171305
adaptor-related protein complex 1, sigma 3 subunit, a
chr5_-_30620625 10.74 ENSDART00000098273
transcobalamin like
chr16_-_24815091 10.69 ENSDART00000154269
ENSDART00000131025
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr20_+_33875256 10.68 ENSDART00000002554
retinoid X receptor, gamma b
chr21_+_19547806 10.46 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
retinoic acid induced 14
chr23_-_23401305 10.45 ENSDART00000078936
hairy-related 9
chr1_-_9109699 10.23 ENSDART00000147833
vascular associated protein
chr25_-_13728111 10.07 ENSDART00000169865
lecithin-cholesterol acyltransferase
chr13_-_25774183 10.05 ENSDART00000046981
PDZ and LIM domain 1 (elfin)
chr15_+_26600611 10.02 ENSDART00000155352
solute carrier family 47 (multidrug and toxin extrusion), member 3
chr7_-_73752955 9.91 ENSDART00000171254
ENSDART00000009888
calsequestrin 1b
chr22_+_15336752 9.84 ENSDART00000139070
sulfotransferase family 3, cytosolic sulfotransferase 2
chr8_-_18537866 9.66 ENSDART00000148802
ENSDART00000148962
ENSDART00000149506
nexilin (F actin binding protein)
chr16_+_25126935 9.42 ENSDART00000058945
zgc:92590
chr18_-_6803424 9.41 ENSDART00000142647
si:dkey-266m15.5
chr8_-_50287949 9.33 ENSDART00000023639
NK2 transcription factor related 7
chr13_-_40282770 9.28 ENSDART00000140875
zgc:123010
chr17_+_39242437 9.23 ENSDART00000156138
ENSDART00000128863
zgc:174356
chr21_+_12010505 9.14 ENSDART00000123522
aquaporin 7
chr3_+_55105066 9.12 ENSDART00000110848
si:ch211-5k11.8
chr7_+_54642005 9.11 ENSDART00000171864
fibroblast growth factor 19
chr23_-_33750135 9.03 ENSDART00000187641
bridging integrator 2a
chr23_-_33750307 9.02 ENSDART00000162772
bridging integrator 2a
chr20_-_33705044 9.00 ENSDART00000166573
rho-associated, coiled-coil containing protein kinase 2b
chr7_+_69019851 8.99 ENSDART00000162891

chr10_+_26612321 8.86 ENSDART00000134322
four and a half LIM domains 1b
chr19_+_20778011 8.83 ENSDART00000024208
nuclear transport factor 2, like
chr5_-_51166025 8.80 ENSDART00000097471
caspase recruitment domain family, member 9
chr13_+_22479988 8.66 ENSDART00000188182
ENSDART00000192972
ENSDART00000178372
LIM domain binding 3a
chr13_+_844150 8.39 ENSDART00000058260
glutathione S-transferase, alpha tandem duplicate 1
chr16_-_24945337 8.38 ENSDART00000154004
hyaluronan synthase 1
chr11_+_31285127 8.24 ENSDART00000160154
si:dkey-238i5.2
chr8_+_6576940 8.15 ENSDART00000138135
V-set and immunoglobulin domain containing 8b
chr13_+_835390 7.95 ENSDART00000171329
glutathione S-transferase, alpha tandem duplicate 1
chr5_+_15203421 7.85 ENSDART00000040826
T-box 1
chr1_+_9954489 7.66 ENSDART00000005895
ENSDART00000183003
protein disulfide isomerase family A, member 2
chr7_+_44445595 7.60 ENSDART00000108766
cadherin 5
chr16_+_54829574 7.52 ENSDART00000148392
poly(A) binding protein, cytoplasmic 1a
chr12_+_6391243 7.42 ENSDART00000152765
protein kinase, cGMP-dependent, type Ib
chr24_-_12958668 7.34 ENSDART00000178982
Danio rerio fat storage inducing transmembrane protein 1 (LOC792443), mRNA.
chr2_-_38261272 7.33 ENSDART00000143743
si:ch211-14a17.10
chr8_+_31872992 7.32 ENSDART00000146933
complement component 7a
chr18_+_48428126 7.26 ENSDART00000137978
Fli-1 proto-oncogene, ETS transcription factor a
chr7_-_15252540 7.20 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
chr14_+_32839535 7.13 ENSDART00000168975
arrestin 3b, retinal (X-arrestin)
chr20_+_18992679 6.99 ENSDART00000147105
ENSDART00000152811
L-threonine dehydrogenase
chr3_+_16762483 6.91 ENSDART00000132732
transmembrane protein 86B
chr2_+_21486529 6.84 ENSDART00000047468
inhibin, beta Ab
chr17_+_23554932 6.81 ENSDART00000135814
pantothenate kinase 1a
chr17_+_30894431 6.73 ENSDART00000127996
delta(4)-desaturase, sphingolipid 2
chr3_+_55100045 6.66 ENSDART00000113098
hemoglobin, alpha adult 1
chr17_+_34206167 6.61 ENSDART00000136167
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr20_-_33704753 6.57 ENSDART00000157427
rho-associated, coiled-coil containing protein kinase 2b
chr17_+_45654724 6.55 ENSDART00000098952
zgc:162184
chr14_-_28052474 6.50 ENSDART00000172948
ENSDART00000135337
si:ch211-220e11.3
zgc:64189
chr11_-_25418856 6.49 ENSDART00000013714
GATA binding protein 1a
chr20_-_25533739 6.49 ENSDART00000063064
cytochrome P450, family 2, subfamily AD, polypeptide 6
chr24_+_2843268 6.46 ENSDART00000170529
si:ch211-152c8.2
chr22_-_11626014 6.33 ENSDART00000063133
ENSDART00000160085
glucagon a
chr14_+_17382803 6.21 ENSDART00000040383
si:ch211-255i20.3
chr9_+_343062 6.16 ENSDART00000164012
ENSDART00000164365
BPI fold containing family C, like
chr22_+_5120033 6.16 ENSDART00000169200
muscle-specific beta 1 integrin binding protein
chr1_+_36674584 6.12 ENSDART00000186772
ENSDART00000192274
endothelin receptor type Aa
chr17_-_29736019 6.10 ENSDART00000183483
Usher syndrome 2A (autosomal recessive, mild)
chr5_-_26247973 6.09 ENSDART00000098527
endoplasmic reticulum aminopeptidase 1b
chr21_+_39941875 6.04 ENSDART00000190414
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr12_-_20665164 5.90 ENSDART00000105352
gastric inhibitory polypeptide
chr6_-_33129045 5.90 ENSDART00000073757
tetraspanin 1
chr18_+_33550667 5.77 ENSDART00000141246
ENSDART00000136070
si:dkey-47k20.1
chr12_-_23658888 5.76 ENSDART00000088319
mitogen-activated protein kinase kinase kinase 8
chr6_-_33129312 5.74 ENSDART00000156987
tetraspanin 1
chr2_-_37312927 5.68 ENSDART00000141214
SKI-like proto-oncogene a
chr5_+_26248380 5.67 ENSDART00000079049
si:ch211-214j8.1
chr6_+_51932563 5.67 ENSDART00000181778
angiopoietin 4
chr20_-_26066020 5.61 ENSDART00000078559
myc target 1a
chr4_+_18824959 5.60 ENSDART00000146141
ENSDART00000040424
solute carrier family 26 (anion exchanger), member 3
chr23_+_26079467 5.58 ENSDART00000129617
ATPase H+ transporting accessory protein 1b
chr2_+_38261748 5.49 ENSDART00000076478
dehydrogenase/reductase (SDR family) member 1
chr20_+_46897504 5.39 ENSDART00000158124
si:ch73-21k16.1
chr9_-_42871756 5.39 ENSDART00000191396
titin, tandem duplicate 1
chr24_+_14801844 5.33 ENSDART00000141620
peptidase inhibitor 15a
chr24_+_19518570 5.29 ENSDART00000056081
sulfatase 1
chr12_+_47945664 5.27 ENSDART00000189824
ENSDART00000055743
ENSDART00000188936

chr17_-_26867725 5.18 ENSDART00000153590
si:dkey-221l4.10
chr16_+_54829293 5.05 ENSDART00000024729
poly(A) binding protein, cytoplasmic 1a
chr3_+_17251542 5.02 ENSDART00000024832
signal transducer and activator of transcription 5a
chr12_+_23850661 4.99 ENSDART00000152921
supervillin a
chr11_-_28614608 4.99 ENSDART00000065853
dehydrogenase/reductase (SDR family) member 3b
chr2_+_39021282 4.90 ENSDART00000056577
si:ch211-119o8.7
chr24_+_10202718 4.82 ENSDART00000126668
POU class 6 homeobox 2
chr12_-_20350629 4.82 ENSDART00000066384
hemoglobin beta embryonic-2
chr5_-_66301142 4.81 ENSDART00000067541
prolactin receptor b
chr10_-_17484762 4.73 ENSDART00000137905
ENSDART00000007961
5'-nucleotidase, cytosolic II, like 1
chr14_+_46268248 4.63 ENSDART00000172979
calcium binding protein 2b
chr14_+_26546175 4.56 ENSDART00000105932
si:dkeyp-110e4.11
chr5_-_8817841 4.55 ENSDART00000170921
fibroblast growth factor 10b
chr16_+_13424534 4.52 ENSDART00000114944
zgc:101640
chr16_-_17300030 4.48 ENSDART00000149267
Kell blood group, metallo-endopeptidase
chr25_-_35102781 4.46 ENSDART00000180881
ENSDART00000153747
si:dkey-108k21.24
chr12_-_29301022 4.43 ENSDART00000187826
SH2 domain containing 4Bb
chr20_+_25879826 4.36 ENSDART00000018519
zgc:153896
chr17_+_8175998 4.35 ENSDART00000131200
myc target 1b
chr11_-_34577034 4.31 ENSDART00000133302
ENSDART00000184367
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr7_+_34290051 4.30 ENSDART00000123498
fin bud initiation factor b
chr3_-_34547000 4.29 ENSDART00000166623
septin 9a
chr4_+_16725960 4.25 ENSDART00000034441
t-complex 11, testis-specific-like 2
chr19_+_7124337 4.24 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr8_-_1219815 4.21 ENSDART00000016800
ENSDART00000149969
zinc finger protein 367
chr21_+_19648814 4.15 ENSDART00000048581
fibroblast growth factor 10a
chr14_-_25949951 4.13 ENSDART00000141304
secreted protein, acidic, cysteine-rich (osteonectin)
chr2_-_17393216 4.09 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr2_+_47927026 4.08 ENSDART00000143023
finTRIM family, member 25
chr24_+_19518303 4.03 ENSDART00000027022
ENSDART00000056080
sulfatase 1
chr17_+_51746830 4.03 ENSDART00000184230
ornithine decarboxylase 1
chr3_-_26204867 4.02 ENSDART00000103748
glycerophosphodiester phosphodiesterase domain containing 3a
chr13_+_45476181 3.98 ENSDART00000045329
microsomal glutathione S-transferase 3b
chr5_-_16425781 3.97 ENSDART00000185624
ENSDART00000180617
solute carrier family 39 (zinc transporter), member 14
chr19_+_43523690 3.94 ENSDART00000113031
WAS protein family, member 2
chr16_+_26449615 3.94 ENSDART00000039746
erythrocyte membrane protein band 4.1b
chr18_+_48428713 3.76 ENSDART00000076861
Fli-1 proto-oncogene, ETS transcription factor a
chr5_-_68795063 3.69 ENSDART00000016307
hairy-related 1
chr7_+_5976613 3.65 ENSDART00000173105
si:dkey-23a13.21
chr14_-_41556720 3.57 ENSDART00000149244
integrin, alpha 6, like
chr21_+_39941184 3.56 ENSDART00000133604
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr8_+_26059677 3.56 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr23_-_45501177 3.56 ENSDART00000150103
collagen type XXIV alpha 1
chr23_+_25172682 3.43 ENSDART00000191197
ENSDART00000183497
si:dkey-151g10.3
chr18_+_17155896 3.43 ENSDART00000140654
thyrotropin releasing hormone receptor 2
chr6_+_51932267 3.35 ENSDART00000156256
angiopoietin 4
chr14_+_29780113 3.30 ENSDART00000173195
zgc:153146
chr6_-_9695294 3.29 ENSDART00000162728
NOP58 ribonucleoprotein homolog (yeast)
chr7_+_17120811 3.23 ENSDART00000147140
protein arginine methyltransferase 3
chr18_+_18000695 3.21 ENSDART00000146898
si:ch211-212o1.2
chr13_+_24263049 3.20 ENSDART00000135992
ENSDART00000088005
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr19_+_37509638 3.20 ENSDART00000139999
si:ch211-250g4.3
chr1_-_17570013 3.18 ENSDART00000146946
acyl-CoA synthetase long chain family member 1a
chr8_+_23709280 3.17 ENSDART00000185842
peroxisome proliferator-activated receptor delta b
chr17_-_26868169 3.16 ENSDART00000157204
si:dkey-221l4.10
chr12_-_36070473 3.12 ENSDART00000165720
G protein-coupled receptor 142
chr22_+_5118361 3.12 ENSDART00000168371
ENSDART00000170222
ENSDART00000158846
muscle-specific beta 1 integrin binding protein
chr14_+_30568961 3.11 ENSDART00000184303
mitochondrial ribosomal protein L11
chr23_-_35483163 3.10 ENSDART00000138660
ENSDART00000113643
ENSDART00000189269
F-box protein 25
chr10_+_19525839 3.09 ENSDART00000162912
ENSDART00000158512
V-set and immunoglobulin domain containing 8a
chr2_+_9757453 3.07 ENSDART00000168972
phosphate cytidylyltransferase 1, choline, alpha a
chr19_+_40250682 3.07 ENSDART00000102888
cyclin-dependent kinase 6
chr2_-_6482240 3.04 ENSDART00000132623
regulator of G protein signaling 13
chr12_+_15078124 3.01 ENSDART00000187571

chr20_-_27390258 2.93 ENSDART00000010584
peripherin 2, like
chr6_-_39275793 2.93 ENSDART00000180477
ENSDART00000148531
Rho guanine nucleotide exchange factor (GEF) 25b

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
21.5 128.9 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
20.7 103.7 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
5.7 22.9 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
5.2 26.2 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
4.9 14.7 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
4.0 12.0 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
3.7 11.2 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214) cardiac left ventricle formation(GO:0003218)
3.7 47.5 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
3.5 24.6 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of wound healing(GO:0061045) negative regulation of hemostasis(GO:1900047)
3.4 27.5 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
3.3 9.9 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
3.0 18.1 GO:0071800 podosome assembly(GO:0071800)
2.8 8.4 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
2.6 7.8 GO:0003156 regulation of organ formation(GO:0003156)
2.4 65.5 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
2.2 8.7 GO:0061033 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
1.7 6.6 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
1.6 6.5 GO:0030224 monocyte differentiation(GO:0030224)
1.4 9.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
1.4 13.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.3 4.0 GO:0033212 iron assimilation(GO:0033212)
1.3 7.6 GO:2000114 blood vessel maturation(GO:0001955) regulation of establishment of cell polarity(GO:2000114)
1.2 4.8 GO:0038161 prolactin signaling pathway(GO:0038161)
1.2 26.4 GO:1990798 pancreas regeneration(GO:1990798)
1.2 9.3 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
1.1 5.6 GO:1901207 regulation of heart looping(GO:1901207)
1.1 13.2 GO:0001678 cellular glucose homeostasis(GO:0001678)
1.0 51.4 GO:0018298 protein-chromophore linkage(GO:0018298)
1.0 29.2 GO:0032474 otolith morphogenesis(GO:0032474)
1.0 6.2 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
1.0 6.1 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
1.0 5.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
1.0 20.6 GO:0015671 oxygen transport(GO:0015671)
1.0 13.3 GO:0032264 IMP salvage(GO:0032264)
0.9 9.3 GO:0003207 cardiac chamber formation(GO:0003207)
0.9 16.5 GO:0046686 response to cadmium ion(GO:0046686)
0.9 7.0 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.8 22.5 GO:0006884 cell volume homeostasis(GO:0006884)
0.7 15.6 GO:1901888 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) regulation of cell junction assembly(GO:1901888)
0.7 2.7 GO:0061015 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.6 20.7 GO:0032355 response to estradiol(GO:0032355)
0.6 7.1 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.6 5.9 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.6 2.8 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.6 8.3 GO:0031641 regulation of myelination(GO:0031641)
0.6 6.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.5 1.6 GO:0046048 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.5 25.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.5 7.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.5 10.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.5 3.6 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.5 16.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.5 2.0 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.5 27.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.5 6.7 GO:0034311 diol metabolic process(GO:0034311)
0.5 6.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.4 5.4 GO:0048769 sarcomerogenesis(GO:0048769)
0.4 4.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.4 6.3 GO:0003323 type B pancreatic cell development(GO:0003323)
0.4 5.0 GO:0042572 retinol metabolic process(GO:0042572)
0.4 3.2 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.4 9.8 GO:0051923 sulfation(GO:0051923)
0.3 10.7 GO:0032526 response to retinoic acid(GO:0032526)
0.3 3.1 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.3 31.7 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.3 2.3 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.3 4.7 GO:0009651 response to salt stress(GO:0009651)
0.3 18.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.3 4.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of potassium ion transport(GO:0043268) positive regulation of potassium ion transmembrane transport(GO:1901381) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.3 9.1 GO:0048665 neuron fate specification(GO:0048665)
0.3 4.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 3.9 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3 1.3 GO:0007624 ultradian rhythm(GO:0007624)
0.3 7.3 GO:0019835 cytolysis(GO:0019835)
0.2 4.3 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.2 5.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 3.2 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.2 5.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.2 25.4 GO:0001756 somitogenesis(GO:0001756)
0.2 7.7 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 2.9 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 1.8 GO:0021707 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 0.9 GO:0090342 regulation of cell aging(GO:0090342)
0.2 2.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 11.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 13.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.6 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.1 1.4 GO:0090050 positive regulation of blood vessel endothelial cell migration(GO:0043536) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 8.8 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 2.1 GO:0008272 sulfate transport(GO:0008272)
0.1 2.0 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 2.5 GO:0042476 odontogenesis(GO:0042476)
0.1 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 9.0 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.1 23.1 GO:0009116 nucleoside metabolic process(GO:0009116)
0.1 12.6 GO:0006417 regulation of translation(GO:0006417)
0.1 3.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 5.2 GO:0007030 Golgi organization(GO:0007030)
0.1 7.7 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.1 0.6 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 5.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 8.7 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 4.7 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 4.5 GO:0016485 protein processing(GO:0016485)
0.0 4.8 GO:0031099 regeneration(GO:0031099)
0.0 1.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 29.0 GO:0006508 proteolysis(GO:0006508)
0.0 0.9 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 3.1 GO:0043043 translation(GO:0006412) peptide biosynthetic process(GO:0043043)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 3.3 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 3.8 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.3 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 0.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
2.6 18.1 GO:0001891 phagocytic cup(GO:0001891)
2.0 26.2 GO:0042627 chylomicron(GO:0042627)
1.7 20.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
1.4 9.9 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.2 3.6 GO:0005592 collagen type XI trimer(GO:0005592)
1.0 8.8 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.9 5.6 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.7 2.6 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.6 30.3 GO:0031941 filamentous actin(GO:0031941)
0.6 14.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.5 3.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.5 7.3 GO:0005579 membrane attack complex(GO:0005579)
0.4 12.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 55.1 GO:0030017 sarcomere(GO:0030017)
0.3 40.4 GO:0016459 myosin complex(GO:0016459)
0.3 6.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.3 2.9 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.3 11.3 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 3.9 GO:0031209 SCAR complex(GO:0031209)
0.2 13.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 2.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 0.8 GO:0097433 dense body(GO:0097433)
0.2 7.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 66.8 GO:0009986 cell surface(GO:0009986)
0.1 7.6 GO:0016342 catenin complex(GO:0016342)
0.1 6.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 5.0 GO:0005811 lipid particle(GO:0005811)
0.1 33.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 8.1 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 3.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.1 GO:0016592 mediator complex(GO:0016592)
0.1 18.9 GO:0005813 centrosome(GO:0005813)
0.1 74.5 GO:0005615 extracellular space(GO:0005615)
0.1 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 5.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.5 GO:0000786 nucleosome(GO:0000786)
0.0 2.0 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 6.7 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.0 GO:0008305 integrin complex(GO:0008305)
0.0 3.8 GO:0016607 nuclear speck(GO:0016607)
0.0 2.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 44.6 GO:0005829 cytosol(GO:0005829)
0.0 2.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.0 GO:0005930 axoneme(GO:0005930)
0.0 7.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 27.5 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
5.2 26.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
5.1 20.5 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
4.1 37.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
3.7 14.7 GO:0016841 ammonia-lyase activity(GO:0016841)
3.2 42.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
3.0 12.0 GO:0101006 protein histidine phosphatase activity(GO:0101006)
3.0 20.7 GO:0045735 nutrient reservoir activity(GO:0045735)
2.8 8.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
2.8 11.1 GO:0004064 arylesterase activity(GO:0004064)
2.4 12.2 GO:0031769 glucagon receptor binding(GO:0031769)
2.2 13.2 GO:0005536 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.9 15.6 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
1.8 17.6 GO:0016936 galactoside binding(GO:0016936)
1.7 20.6 GO:0031720 haptoglobin binding(GO:0031720)
1.6 19.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.5 30.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
1.5 16.4 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
1.4 7.0 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
1.3 9.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
1.3 4.0 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
1.3 21.1 GO:0042910 xenobiotic transporter activity(GO:0042910)
1.2 7.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
1.2 13.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.2 4.8 GO:0004925 prolactin receptor activity(GO:0004925)
1.2 7.2 GO:0004594 pantothenate kinase activity(GO:0004594)
1.2 10.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.2 10.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.1 9.1 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
1.0 14.5 GO:0008266 poly(U) RNA binding(GO:0008266)
1.0 13.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.9 5.6 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.9 22.5 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.9 8.8 GO:0050700 CARD domain binding(GO:0050700)
0.9 6.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.9 6.9 GO:0016803 ether hydrolase activity(GO:0016803)
0.8 7.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.7 2.8 GO:0051380 norepinephrine binding(GO:0051380)
0.7 19.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 5.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.6 24.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.6 3.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.6 20.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 3.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.6 7.7 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.6 9.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.6 4.1 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.6 8.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.5 9.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 1.6 GO:0009041 uridylate kinase activity(GO:0009041)
0.5 3.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.5 53.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 71.1 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.5 23.5 GO:0008013 beta-catenin binding(GO:0008013)
0.4 4.0 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.4 3.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.4 5.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 10.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 20.5 GO:0009055 electron carrier activity(GO:0009055)
0.3 4.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 4.7 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.3 9.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 5.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 27.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 4.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 3.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 6.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 5.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.2 3.2 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 37.8 GO:0005125 cytokine activity(GO:0005125)
0.2 20.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.2 5.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 2.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 3.3 GO:0030515 snoRNA binding(GO:0030515)
0.2 5.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 8.9 GO:0044325 ion channel binding(GO:0044325)
0.2 0.8 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.2 2.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 40.4 GO:0003774 motor activity(GO:0003774)
0.1 0.6 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.1 17.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 5.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 1.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 128.5 GO:0008270 zinc ion binding(GO:0008270)
0.1 2.2 GO:0002039 p53 binding(GO:0002039)
0.1 30.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 9.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 5.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 6.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 1.3 GO:0008026 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 3.0 GO:0005518 collagen binding(GO:0005518)
0.1 5.7 GO:0046332 SMAD binding(GO:0046332)
0.1 7.6 GO:0045296 cadherin binding(GO:0045296)
0.1 40.0 GO:0003779 actin binding(GO:0003779)
0.1 2.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 13.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 2.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 43.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 19.3 GO:0005543 phospholipid binding(GO:0005543)
0.1 3.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 8.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 6.7 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 5.0 GO:0008092 cytoskeletal protein binding(GO:0008092)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 18.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.4 24.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.7 30.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.7 11.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.5 7.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.4 17.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 14.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.4 62.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 2.6 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 3.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 2.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 3.6 NABA COLLAGENS Genes encoding collagen proteins
0.2 9.1 PID FGF PATHWAY FGF signaling pathway
0.2 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 6.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 8.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 7.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 15.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 4.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 65.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
3.0 9.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
2.6 17.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
1.6 24.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
1.3 11.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.2 12.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.1 27.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.1 103.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.0 9.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.9 17.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.9 10.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.7 11.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 8.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.6 5.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.5 5.9 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.5 5.8 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.5 1.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4 20.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 9.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 7.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 0.8 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 10.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.3 3.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 3.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 6.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 2.7 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 10.7 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 6.2 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 13.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 4.0 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 3.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 6.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+