Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for glis2a+glis2b

Z-value: 0.48

Motif logo

logo of

Transcription factors associated with glis2a+glis2b

Gene Symbol Gene ID Gene Info
glis2a
ENSDARG00000078388 GLIS family zinc finger 2a
glis2b
ENSDARG00000100232 GLIS family zinc finger 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glis2bdr11_v1_chr3_+_12334509_12334509-0.204.9e-02Click!
glis2adr11_v1_chr22_-_26558166_265581660.113.1e-01Click!

Activity profile of glis2a+glis2b motif

Sorted Z-values of glis2a+glis2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_4070058 5.75 ENSDART00000042200
aldoab
aldolase a, fructose-bisphosphate, b
chr24_+_25471196 5.20 ENSDART00000066625
smpx
small muscle protein, X-linked
chr23_-_17470146 2.84 ENSDART00000002398
trim101
tripartite motif containing 101
chr23_-_45705525 2.75 ENSDART00000148959
ednrab
endothelin receptor type Ab
chr23_+_42810055 2.05 ENSDART00000186647
myl9a
myosin, light chain 9a, regulatory
chr7_+_18364176 2.02 ENSDART00000171606
ENSDART00000186368
cd248a
CD248 molecule, endosialin a
chr2_-_30987538 1.99 ENSDART00000148157
emilin2a
elastin microfibril interfacer 2a
chr9_+_20781047 1.86 ENSDART00000139174
fam46c
family with sequence similarity 46, member C
chr17_-_20717845 1.85 ENSDART00000150037
ank3b
ankyrin 3b
chr25_+_13191615 1.61 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr19_-_15281996 1.61 ENSDART00000103784
edn2
endothelin 2
chr20_+_25340814 1.60 ENSDART00000063028
ctgfa
connective tissue growth factor a
chr5_-_42272517 1.60 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr23_-_29004753 1.47 ENSDART00000002812
casz1
castor zinc finger 1
chr25_+_13191391 1.44 ENSDART00000109937
si:ch211-147m6.2
si:ch211-147m6.2
chr5_+_51079504 1.40 ENSDART00000097466
fam169aa
family with sequence similarity 169, member Aa
chr8_+_7033049 1.36 ENSDART00000064172
ENSDART00000134440
gpd1a
glycerol-3-phosphate dehydrogenase 1a
chr10_+_33982010 1.32 ENSDART00000180431
fryb
furry homolog b (Drosophila)
chr10_-_34976812 1.23 ENSDART00000170625
smad9
SMAD family member 9
chr7_+_38509333 1.12 ENSDART00000153482
slc7a9
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr10_-_13116337 0.98 ENSDART00000164568
musk
muscle, skeletal, receptor tyrosine kinase
chr10_-_1961576 0.98 ENSDART00000042441
tdgf1
teratocarcinoma-derived growth factor 1
chr23_-_29003864 0.95 ENSDART00000148257
casz1
castor zinc finger 1
chr5_-_71995108 0.79 ENSDART00000124587
fam78ab
family with sequence similarity 78, member Ab
chr19_-_42928979 0.78 ENSDART00000086659
cyhr1
cysteine/histidine-rich 1
chr12_+_22672323 0.78 ENSDART00000123808
ENSDART00000159864
cdca9
cell division cycle associated 9
chr23_+_43668756 0.73 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr17_-_4245902 0.65 ENSDART00000151851
gdf3
growth differentiation factor 3
chr6_+_37625787 0.61 ENSDART00000065122
tubgcp5
tubulin, gamma complex associated protein 5
chr3_-_31804481 0.60 ENSDART00000028270
gfap
glial fibrillary acidic protein
chr16_+_3004422 0.51 ENSDART00000189969
CABZ01043952.1

chr18_+_33100606 0.49 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr19_+_15443540 0.48 ENSDART00000193355
lin28a
lin-28 homolog A (C. elegans)
chr23_-_31060350 0.48 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr16_-_41059329 0.45 ENSDART00000145556
si:dkey-201i6.8
si:dkey-201i6.8
chr24_-_38574631 0.43 ENSDART00000154539
slc17a7b
solute carrier family 17 (vesicular glutamate transporter), member 7b
chr7_-_24838857 0.41 ENSDART00000179766
ENSDART00000180892
fam113
family with sequence similarity 113
chr6_+_38845848 0.41 ENSDART00000184907
stk35l
serine/threonine kinase 35, like
chr19_+_20540843 0.41 ENSDART00000192500
kcnh8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr17_-_4245311 0.40 ENSDART00000055379
gdf3
growth differentiation factor 3
chr2_-_9744081 0.40 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr6_+_38845697 0.39 ENSDART00000053187
stk35l
serine/threonine kinase 35, like
chr20_+_7799615 0.37 ENSDART00000152792
si:dkey-19f4.2
si:dkey-19f4.2
chr17_-_49275690 0.37 ENSDART00000150172
tfb1m
transcription factor B1, mitochondrial
chr13_-_24880525 0.36 ENSDART00000136624
kat6b
K(lysine) acetyltransferase 6B
chr19_-_36640677 0.36 ENSDART00000189743
csmd2
CUB and Sushi multiple domains 2
chr18_+_17827149 0.35 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr24_-_9960290 0.33 ENSDART00000143390
ENSDART00000092975
ENSDART00000184953
vps41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr5_-_1047504 0.32 ENSDART00000159346
mbd2
methyl-CpG binding domain protein 2
chr5_+_38886499 0.32 ENSDART00000076845
fras1
Fraser extracellular matrix complex subunit 1
chr12_-_145076 0.31 ENSDART00000160926
dnah9
dynein, axonemal, heavy chain 9
chr12_+_2676878 0.30 ENSDART00000185909
antxr1c
anthrax toxin receptor 1c
chr22_-_18116635 0.29 ENSDART00000005724
ncanb
neurocan b
chr3_+_8826905 0.28 ENSDART00000167474
ENSDART00000168088
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr13_-_638485 0.24 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr20_-_1239596 0.22 ENSDART00000049063
ENSDART00000140650
ankrd6b
ankyrin repeat domain 6b
chr4_-_4756349 0.21 ENSDART00000057507
ssbp1
single-stranded DNA binding protein 1
chr8_-_53926228 0.21 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr23_-_26536055 0.21 ENSDART00000182719
si:dkey-205h13.2
si:dkey-205h13.2
chr7_+_11390462 0.20 ENSDART00000114383
tlnrd1
talin rod domain containing 1
chr8_-_20914829 0.20 ENSDART00000025356
haus5
HAUS augmin-like complex, subunit 5
chr13_+_1928361 0.19 ENSDART00000164764
hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr12_-_41619257 0.18 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr25_+_30196039 0.18 ENSDART00000005299
hsd17b12a
hydroxysteroid (17-beta) dehydrogenase 12a
chr5_-_22001003 0.15 ENSDART00000134393
ENSDART00000143878
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr22_+_26853254 0.15 ENSDART00000182487
tmem186
transmembrane protein 186
chr7_-_21928826 0.14 ENSDART00000088043
si:dkey-85k7.11
si:dkey-85k7.11
chr15_-_97205 0.14 ENSDART00000158734
BACE1
beta-secretase 1
chr25_-_997894 0.13 ENSDART00000169011
znf609a
zinc finger protein 609a
chr18_+_17151916 0.10 ENSDART00000175488
trhr2
thyrotropin releasing hormone receptor 2
chr2_+_51783120 0.09 ENSDART00000177559
crygn1
crystallin, gamma N1
chr10_+_2742499 0.05 ENSDART00000122847
grk5
G protein-coupled receptor kinase 5
chr16_-_45854882 0.03 ENSDART00000027013
ENSDART00000128068
ntrk1
neurotrophic tyrosine kinase, receptor, type 1
chr4_-_1776352 0.02 ENSDART00000123089
dnajc2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr15_+_518092 0.00 ENSDART00000154594
pcsk7
proprotein convertase subtilisin/kexin type 7

Network of associatons between targets according to the STRING database.

First level regulatory network of glis2a+glis2b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.4 2.8 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.3 1.4 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 1.0 GO:0090008 hypoblast development(GO:0090008)
0.2 5.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 1.1 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.2 0.7 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 1.0 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 0.4 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.2 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.1 0.2 GO:0042373 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.1 0.4 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.3 GO:1901998 toxin transport(GO:1901998)
0.0 0.6 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 1.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 1.2 GO:0071560 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.0 0.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.2 GO:0048264 determination of ventral identity(GO:0048264)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0043034 costamere(GO:0043034)
0.2 1.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 0.6 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 1.3 GO:0030427 site of polarized growth(GO:0030427)
0.0 3.0 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 2.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 1.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.4 2.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 1.4 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 0.4 GO:0034246 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
0.1 1.0 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 1.0 GO:0070697 activin receptor binding(GO:0070697)
0.0 0.2 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.1 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 1.1 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.6 PID ENDOTHELIN PATHWAY Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 0.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels