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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for glis3

Z-value: 0.44

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Transcription factors associated with glis3

Gene Symbol Gene ID Gene Info
glis3
ENSDARG00000069726 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glis3dr11_v1_chr10_-_690072_6901700.214.4e-02Click!

Activity profile of glis3 motif

Sorted Z-values of glis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_7461624 13.10 ENSDART00000170569
syt12
synaptotagmin XII
chr8_-_33114202 6.54 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr14_-_34044369 5.28 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr20_-_9963713 3.97 ENSDART00000104234
gjd2b
gap junction protein delta 2b
chr13_-_638485 3.58 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr24_+_26134029 3.16 ENSDART00000185134
tmtopsb
teleost multiple tissue opsin b
chr5_+_67662430 2.82 ENSDART00000137700
ENSDART00000142586
si:dkey-70b23.2
si:dkey-70b23.2
chr20_-_18915376 2.74 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr14_-_30704075 2.49 ENSDART00000134098
efemp2a
EGF containing fibulin extracellular matrix protein 2a
chr3_+_30190419 2.38 ENSDART00000157320
akt1s1
AKT1 substrate 1 (proline-rich)
chr2_+_49246099 2.31 ENSDART00000179089
sema6ba
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr20_-_26588736 1.92 ENSDART00000134337
exoc2
exocyst complex component 2
chr3_-_25106878 1.88 ENSDART00000142503
rbx1
ring-box 1, E3 ubiquitin protein ligase
chr18_-_41375120 1.82 ENSDART00000098673
ptx3a
pentraxin 3, long a
chr21_+_20949976 1.72 ENSDART00000135342
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr21_+_20950161 1.21 ENSDART00000079698
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr22_-_3261879 1.19 ENSDART00000159643
gpr35.1
G protein-coupled receptor 35, tandem duplicate 1
chr17_+_8925232 0.96 ENSDART00000036668
psmc1a
proteasome 26S subunit, ATPase 1a
chr24_-_38574631 0.69 ENSDART00000154539
slc17a7b
solute carrier family 17 (vesicular glutamate transporter), member 7b
chr13_+_22421151 0.24 ENSDART00000122687
opn4a
opsin 4a (melanopsin)
chr18_+_7309150 0.18 ENSDART00000052792
cers3b
ceramide synthase 3b
chr17_+_49500820 0.13 ENSDART00000170306
AREL1
apoptosis resistant E3 ubiquitin protein ligase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of glis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.1 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.4 2.4 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.4 5.3 GO:0001964 startle response(GO:0001964)
0.2 2.7 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.2 3.6 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.9 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 2.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 1.9 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.1 2.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 2.3 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 1.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 5.2 GO:0007264 small GTPase mediated signal transduction(GO:0007264)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 GO:0031209 SCAR complex(GO:0031209)
0.3 4.0 GO:0005922 connexon complex(GO:0005922)
0.1 1.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 1.9 GO:0000145 exocyst(GO:0000145)
0.1 2.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 12.3 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.9 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.3 5.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 11.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.0 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 2.9 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.9 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 2.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 2.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 5.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.4 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing