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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for her6+her9

Z-value: 0.46

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Transcription factors associated with her6+her9

Gene Symbol Gene ID Gene Info
her6
ENSDARG00000006514 hairy-related 6
her9
ENSDARG00000056438 hairy-related 9
her6
ENSDARG00000111099 hairy-related 6
her9
ENSDARG00000115775 hairy-related 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
her6dr11_v1_chr6_-_36552844_365528440.534.1e-08Click!
her9dr11_v1_chr23_-_23401305_234013050.534.4e-08Click!

Activity profile of her6+her9 motif

Sorted Z-values of her6+her9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77551860 3.63 ENSDART00000188176
AL935186.6

chr4_-_77563411 3.41 ENSDART00000186841
AL935186.8

chr24_-_33291784 3.26 ENSDART00000124938
si:ch1073-406l10.2
si:ch1073-406l10.2
chr2_+_68789 3.24 ENSDART00000058569
cldn1
claudin 1
chr24_+_23791758 2.65 ENSDART00000066655
ENSDART00000146580
mybl1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr2_-_58257624 2.58 ENSDART00000098940
foxl2b
forkhead box L2b
chr23_+_22656477 2.51 ENSDART00000009337
ENSDART00000133322
eno1a
enolase 1a, (alpha)
chr8_-_912821 2.40 ENSDART00000082296
ptger4a
prostaglandin E receptor 4 (subtype EP4) a
chr4_+_68562464 2.17 ENSDART00000192954
BX548011.4

chr22_-_10502780 2.13 ENSDART00000136961
ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr12_+_48340133 2.01 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
ddit4
DNA-damage-inducible transcript 4
chr10_-_2942900 1.90 ENSDART00000002622
oclna
occludin a
chr20_+_39283849 1.80 ENSDART00000002481
ENSDART00000146683
scara3
scavenger receptor class A, member 3
chr19_+_19777437 1.74 ENSDART00000170662
hoxa3a
homeobox A3a
chr22_-_193234 1.65 ENSDART00000131067
fbxo42
F-box protein 42
chr18_+_5490668 1.64 ENSDART00000167035
mibp2
muscle-specific beta 1 integrin binding protein 2
chr22_+_19311411 1.34 ENSDART00000133234
ENSDART00000138284
si:dkey-21e2.16
si:dkey-21e2.16
chr5_+_35398745 1.05 ENSDART00000098010
ptger4b
prostaglandin E receptor 4 (subtype EP4) b
chr1_-_38908197 1.01 ENSDART00000101489
vegfc
vascular endothelial growth factor c
chr1_+_31942961 1.00 ENSDART00000007522
anos1a
anosmin 1a
chr3_-_8765165 0.96 ENSDART00000191131
CABZ01058333.1

chr23_-_2081554 0.92 ENSDART00000179805
ndnf
neuron-derived neurotrophic factor
chr4_+_9669717 0.91 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr19_+_19786117 0.89 ENSDART00000167757
ENSDART00000163546
hoxa1a
homeobox A1a
chr18_-_494606 0.88 ENSDART00000157564
wtip
WT1 interacting protein
chr2_+_58841181 0.80 ENSDART00000164102
cirbpa
cold inducible RNA binding protein a
chr19_-_35450661 0.78 ENSDART00000113574
ENSDART00000136895
anln
anillin, actin binding protein
chr8_+_12925385 0.75 ENSDART00000085377
KIF2A
zgc:103670
chr6_-_40195510 0.61 ENSDART00000156156
col7a1
collagen, type VII, alpha 1
chr13_-_45022527 0.59 ENSDART00000159021
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr5_-_1963498 0.59 ENSDART00000073462
rplp0
ribosomal protein, large, P0
chr18_+_16125852 0.53 ENSDART00000061106
bhlhe41
basic helix-loop-helix family, member e41
chr23_-_9919959 0.53 ENSDART00000127029
si:ch211-220i18.4
si:ch211-220i18.4
chr4_+_62576422 0.52 ENSDART00000180679
si:ch211-79g12.2
si:ch211-79g12.2
chr23_+_36616717 0.51 ENSDART00000042701
ENSDART00000192980
pip4k2ca
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a
chr3_-_58823762 0.51 ENSDART00000101253
luc7l3
LUC7-like 3 pre-mRNA splicing factor
chr9_-_43538328 0.49 ENSDART00000140526
znf385b
zinc finger protein 385B
chr8_-_39977026 0.49 ENSDART00000141707
asphd2
aspartate beta-hydroxylase domain containing 2
chr1_-_54107321 0.45 ENSDART00000148382
ENSDART00000150357
rfx1b
regulatory factor X, 1b (influences HLA class II expression)
chr23_+_44732863 0.44 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr13_-_45022301 0.42 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr9_+_9112159 0.38 ENSDART00000165932
sik1
salt-inducible kinase 1
chr24_+_26432541 0.35 ENSDART00000105784
ENSDART00000122554
cldn11b
claudin 11b
chr5_-_32890807 0.35 ENSDART00000007512
pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr5_-_36916790 0.31 ENSDART00000143827
kptn
kaptin (actin binding protein)
chr10_-_1788376 0.30 ENSDART00000123842
epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr2_+_13069168 0.29 ENSDART00000192832
prkag2b
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
chr15_-_12319065 0.26 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr13_+_7241170 0.25 ENSDART00000109434
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr5_-_23429228 0.25 ENSDART00000049291
gria3a
glutamate receptor, ionotropic, AMPA 3a
chr16_+_11029762 0.23 ENSDART00000091183
erfl3
Ets2 repressor factor like 3
chr20_-_40766387 0.22 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr9_+_30213144 0.20 ENSDART00000139920
senp7a
SUMO1/sentrin specific peptidase 7a
chr3_-_11828206 0.19 ENSDART00000018159
si:ch211-262e15.1
si:ch211-262e15.1
chr5_-_12560569 0.19 ENSDART00000133587
wsb2
WD repeat and SOCS box containing 2
chr19_-_6385594 0.16 ENSDART00000104950
atp1a3a
ATPase Na+/K+ transporting subunit alpha 3a
chr7_+_24528430 0.13 ENSDART00000133022
si:dkeyp-75h12.2
si:dkeyp-75h12.2
chr3_+_14641962 0.09 ENSDART00000091070
zgc:158403
zgc:158403
chr11_-_12800945 0.01 ENSDART00000191178
txlng
taxilin gamma
chr11_-_12801157 0.01 ENSDART00000103449
txlng
taxilin gamma
chr23_+_40452157 0.01 ENSDART00000113106
ENSDART00000140136
soga3b
SOGA family member 3b
chr20_-_5328637 0.01 ENSDART00000075974
ism2b
isthmin 2b

Network of associatons between targets according to the STRING database.

First level regulatory network of her6+her9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0048496 maintenance of organ identity(GO:0048496)
0.7 3.4 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.3 2.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.3 0.9 GO:2000637 negative regulation of hippo signaling(GO:0035331) positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.2 1.7 GO:0060017 parathyroid gland development(GO:0060017)
0.2 0.9 GO:0021543 pallium development(GO:0021543) cerebral cortex cell migration(GO:0021795) cerebral cortex tangential migration(GO:0021800) cerebral cortex tangential migration using cell-axon interactions(GO:0021824) substrate-dependent cerebral cortex tangential migration(GO:0021825) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) cerebral cortex development(GO:0021987)
0.2 0.8 GO:0008356 asymmetric cell division(GO:0008356)
0.2 3.3 GO:0050994 regulation of lipid catabolic process(GO:0050994)
0.1 1.0 GO:0060855 venous endothelial cell migration involved in lymph vessel development(GO:0060855)
0.1 5.5 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 2.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 0.3 GO:0006272 leading strand elongation(GO:0006272)
0.1 1.0 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 1.6 GO:0070831 basement membrane assembly(GO:0070831)
0.1 2.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.5 GO:0030431 sleep(GO:0030431)
0.0 0.6 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.4 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 5.5 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0070052 collagen V binding(GO:0070052)
0.5 2.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 3.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.3 1.0 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.3 2.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.6 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.3 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 1.0 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0016208 AMP binding(GO:0016208)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 3.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 2.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 2.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression