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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hic1

Z-value: 0.91

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Transcription factors associated with hic1

Gene Symbol Gene ID Gene Info
hic1
ENSDARG00000055493 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hic1dr11_v1_chr15_+_25683069_25683069-0.251.6e-02Click!

Activity profile of hic1 motif

Sorted Z-values of hic1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_55728559 13.15 ENSDART00000186201
CT583728.14

chr4_+_55778679 12.42 ENSDART00000183009
CT583728.19

chr4_+_55794876 12.42 ENSDART00000189043
CT583728.17

chr4_+_55810436 12.42 ENSDART00000182875
CT583728.16

chr4_-_68568233 12.42 ENSDART00000184284
BX548011.1

chr4_-_77561679 11.62 ENSDART00000180809
AL935186.9

chr14_-_21064199 10.64 ENSDART00000172099
si:dkey-74k8.3
si:dkey-74k8.3
chr14_-_21063977 9.83 ENSDART00000164373
si:dkey-74k8.3
si:dkey-74k8.3
chr6_+_28203 9.76 ENSDART00000191561
CZQB01141835.1

chr4_-_77557279 8.63 ENSDART00000180113
AL935186.10

chr14_+_52369262 7.04 ENSDART00000169352
ENSDART00000157833
igfbp7
insulin-like growth factor binding protein 7
chr21_-_45878872 6.48 ENSDART00000029763
sap30l
sap30-like
chr17_+_132555 6.34 ENSDART00000158159
zgc:77287
zgc:77287
chr1_+_135903 5.73 ENSDART00000124837
f10
coagulation factor X
chr8_+_54137350 4.56 ENSDART00000164153
brpf1
bromodomain and PHD finger containing, 1
chr10_+_23088 4.27 ENSDART00000022840
riox2
ribosomal oxygenase 2
chr4_+_90048 3.75 ENSDART00000166440
lrp6
low density lipoprotein receptor-related protein 6
chr23_+_14590767 3.61 ENSDART00000143675
si:rp71-79p20.2
si:rp71-79p20.2
chr12_-_54375 3.47 ENSDART00000152304
si:ch1073-357b18.4
si:ch1073-357b18.4
chr10_-_2682198 3.21 ENSDART00000183727
pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr9_-_1990323 2.66 ENSDART00000082332
hoxd13a
homeobox D13a
chr10_-_9192450 2.36 ENSDART00000139783
si:dkeyp-41f9.4
si:dkeyp-41f9.4
chr7_-_61845282 2.17 ENSDART00000182586
HTRA3
HtrA serine peptidase 3
chr23_-_31060350 2.17 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr17_-_8976307 2.16 ENSDART00000092113
zranb1b
zinc finger, RAN-binding domain containing 1b
chr23_+_45611980 2.15 ENSDART00000181582
dclk2b
doublecortin-like kinase 2b
chr5_-_52784152 2.12 ENSDART00000169307
fam189a2
family with sequence similarity 189, member A2
chr15_-_20916251 2.00 ENSDART00000134053
usp2a
ubiquitin specific peptidase 2a
chr14_-_48588422 1.97 ENSDART00000161147
si:ch211-154c21.1
si:ch211-154c21.1
chr4_-_797831 1.92 ENSDART00000158970
ENSDART00000170012
mapre3b
microtubule-associated protein, RP/EB family, member 3b
chr9_-_849069 1.71 ENSDART00000136091
c1ql2
complement component 1, q subcomponent-like 2
chr12_-_979789 1.35 ENSDART00000128188
daglb
diacylglycerol lipase, beta
chr19_-_38830582 1.35 ENSDART00000189966
ENSDART00000183055
adgrb2
adhesion G protein-coupled receptor B2
chr5_+_62723233 1.33 ENSDART00000183718
nanos2
nanos homolog 2
chr11_-_6420917 1.33 ENSDART00000193717
FO681393.2

chr3_-_61592417 1.15 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr19_+_17642356 1.01 ENSDART00000176431
CR382334.1

chr9_-_14992730 0.97 ENSDART00000137117
pard3bb
par-3 family cell polarity regulator beta b
chr17_-_49412313 0.92 ENSDART00000152100
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr9_+_7358749 0.89 ENSDART00000081660
ihha
Indian hedgehog homolog a
chr14_+_49602 0.83 ENSDART00000035581
OTOP1
otopetrin 1
chr2_-_49370042 0.83 ENSDART00000180515
CT583662.1

chr7_-_24995631 0.82 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr19_-_22488952 0.78 ENSDART00000179856
ENSDART00000141503
pleca
plectin a
chr23_+_45611649 0.77 ENSDART00000169521
dclk2b
doublecortin-like kinase 2b
chr8_-_13678415 0.67 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
si:dkey-258f14.3
chr16_+_41067586 0.61 ENSDART00000181876
scap
SREBF chaperone
chr3_-_56896702 0.58 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr15_-_18138607 0.40 ENSDART00000176690
CR385077.1

chr8_+_35172594 0.36 ENSDART00000177146
BX897670.1

chr1_-_59571758 0.35 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr22_-_18116635 0.16 ENSDART00000005724
ncanb
neurocan b

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 20.5 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.9 4.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.8 3.2 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.4 2.2 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 1.3 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.3 4.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.2 1.0 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 7.0 GO:0001569 patterning of blood vessels(GO:0001569)
0.2 1.9 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 0.9 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.1 3.8 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.1 5.7 GO:0007596 blood coagulation(GO:0007596)
0.1 0.6 GO:0050957 equilibrioception(GO:0050957)
0.1 2.4 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 0.9 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.6 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 6.5 GO:0001947 heart looping(GO:0001947)
0.0 1.3 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.2 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 1.3 GO:0048477 oogenesis(GO:0048477)
0.0 2.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.8 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 7.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 4.3 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.3 4.6 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.3 4.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 7.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 3.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.9 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.9 GO:0005113 patched binding(GO:0005113)
0.1 0.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.0 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 3.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 7.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis