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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hlx1

Z-value: 0.36

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Transcription factors associated with hlx1

Gene Symbol Gene ID Gene Info
hlx1
ENSDARG00000009134 H2.0-like homeo box 1 (Drosophila)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hlx1dr11_v1_chr20_-_52199296_52199311-0.572.0e-09Click!

Activity profile of hlx1 motif

Sorted Z-values of hlx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_22918214 4.82 ENSDART00000163908
rnasekb
ribonuclease, RNase K b
chr3_+_29714775 4.81 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr2_+_47623202 2.91 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr5_-_66702479 2.85 ENSDART00000129197
mn1b
meningioma 1b
chr17_+_9310259 2.59 ENSDART00000186158
ENSDART00000190329
NPAS3
neuronal PAS domain protein 3
chr1_+_6172786 2.58 ENSDART00000126468
prkag3a
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr3_-_48716422 2.57 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr3_-_20040636 2.56 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr10_+_26926654 2.49 ENSDART00000078980
ENSDART00000100289
rab1bb
RAB1B, member RAS oncogene family b
chr1_-_26294995 2.33 ENSDART00000168594
cxxc4
CXXC finger 4
chr9_-_23118350 2.04 ENSDART00000020884
lypd6
LY6/PLAUR domain containing 6
chr1_-_19502322 1.59 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr2_+_2223837 1.58 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr12_-_2522487 1.56 ENSDART00000022471
ENSDART00000145213
mapk8b
mitogen-activated protein kinase 8b
chr8_-_39952727 1.15 ENSDART00000181310
cabp1a
calcium binding protein 1a
chr24_-_21404367 1.10 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr10_+_43039947 1.09 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr13_+_22964868 1.05 ENSDART00000142129
tacr2
tachykinin receptor 2
chr8_+_50953776 0.97 ENSDART00000013870
zgc:56596
zgc:56596
chr17_+_49281597 0.95 ENSDART00000155599
zgc:113176
zgc:113176
chr6_+_51773873 0.93 ENSDART00000156516
tmem74b
transmembrane protein 74B
chr22_-_20950448 0.69 ENSDART00000002029
fkbp8
FK506 binding protein 8
chr17_-_29119362 0.61 ENSDART00000104204
foxg1a
forkhead box G1a
chr16_+_7380463 0.53 ENSDART00000029727
ENSDART00000149086
atg5
ATG5 autophagy related 5 homolog (S. cerevisiae)
chr17_+_7620220 0.43 ENSDART00000081447
fbxo30a
F-box protein 30a
chr8_+_7801060 0.40 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr2_-_9818640 0.36 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr4_-_22338906 0.34 ENSDART00000131402
golgb1
golgin B1
chr8_+_12930216 0.32 ENSDART00000115405
KIF2A
zgc:103670
chr5_-_23581355 0.30 ENSDART00000191869
cwc15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr8_-_11834599 0.23 ENSDART00000190986
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr21_+_28478663 0.14 ENSDART00000077887
ENSDART00000134150
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr9_+_45227028 0.12 ENSDART00000185579
adarb1b
adenosine deaminase, RNA-specific, B1b

Network of associatons between targets according to the STRING database.

First level regulatory network of hlx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0099563 modification of synaptic structure(GO:0099563)
0.4 1.6 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.3 2.0 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.3 4.8 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 0.5 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 1.0 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.1 1.0 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 1.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.6 GO:0043584 nose development(GO:0043584)
0.1 2.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.6 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 4.8 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 2.5 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.4 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 1.1 GO:0016236 macroautophagy(GO:0016236)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.0 GO:0071818 BAT3 complex(GO:0071818)
0.1 1.0 GO:0097225 sperm midpiece(GO:0097225)
0.1 4.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 2.6 GO:0031256 leading edge membrane(GO:0031256) presynaptic active zone(GO:0048786)
0.0 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.3 2.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.2 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 1.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 2.6 GO:0016208 AMP binding(GO:0016208)
0.1 4.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 4.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors