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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hmx1+hmx3b

Z-value: 0.31

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Transcription factors associated with hmx1+hmx3b

Gene Symbol Gene ID Gene Info
hmx1
ENSDARG00000095651 H6 family homeobox 1
hmx3b
ENSDARG00000096716 H6 family homeobox 3b
hmx1
ENSDARG00000109725 H6 family homeobox 1
hmx1
ENSDARG00000111765 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx3bdr11_v1_chr12_-_49154934_49154934-0.251.7e-02Click!
hmx1dr11_v1_chr1_-_40914752_40914752-0.084.3e-01Click!

Activity profile of hmx1+hmx3b motif

Sorted Z-values of hmx1+hmx3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_9295244 1.79 ENSDART00000132255
ENSDART00000144299
si:ch73-15n24.1
si:ch73-15n24.1
chr20_-_23426339 0.96 ENSDART00000004625
zar1
zygote arrest 1
chr11_+_18183220 0.95 ENSDART00000113468
LO018315.10

chr13_-_50108337 0.91 ENSDART00000133308
nid1a
nidogen 1a
chr5_-_69620722 0.90 ENSDART00000097248
aldh2.2
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr25_+_3326885 0.82 ENSDART00000104866
ldhbb
lactate dehydrogenase Bb
chr11_+_18157260 0.82 ENSDART00000144659
zgc:173545
zgc:173545
chr18_-_5595546 0.81 ENSDART00000191825
cyp1a
cytochrome P450, family 1, subfamily A
chr10_-_44560165 0.81 ENSDART00000181217
ENSDART00000076084
npm2b
nucleophosmin/nucleoplasmin, 2b
chr11_+_18130300 0.79 ENSDART00000169146
zgc:175135
zgc:175135
chr11_-_37691449 0.75 ENSDART00000185340
zgc:158258
zgc:158258
chr25_+_3327071 0.69 ENSDART00000136131
ENSDART00000133243
ldhbb
lactate dehydrogenase Bb
chr3_+_22327738 0.69 ENSDART00000055675
gh1
growth hormone 1
chr22_-_20695237 0.67 ENSDART00000112722
org
oogenesis-related gene
chr22_+_16293071 0.64 ENSDART00000170960
dbt
dihydrolipoamide branched chain transacylase E2
chr5_+_37032038 0.56 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr2_-_17115256 0.52 ENSDART00000190488
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr22_+_1911269 0.47 ENSDART00000164158
ENSDART00000168205
znf1156
zinc finger protein 1156
chrM_+_8130 0.46 ENSDART00000093609
mt-co2
cytochrome c oxidase II, mitochondrial
chr2_+_16652238 0.46 ENSDART00000091351
gk5
glycerol kinase 5 (putative)
chr1_-_56032619 0.45 ENSDART00000143793
c3a.4
complement component c3a, duplicate 4
chr5_+_32835219 0.40 ENSDART00000140832
ENSDART00000186055
si:ch211-208h16.4
si:ch211-208h16.4
chr6_+_11681011 0.39 ENSDART00000151447
ENSDART00000151618
calcrlb
calcitonin receptor-like b
chr5_+_24287927 0.39 ENSDART00000143563
zdhhc23a
zinc finger, DHHC-type containing 23a
chr7_+_17443567 0.39 ENSDART00000060383
nitr2b
novel immune-type receptor 2b
chr10_+_16069987 0.37 ENSDART00000043936
megf10
multiple EGF-like-domains 10
chr6_-_37422841 0.36 ENSDART00000138351
cth
cystathionase (cystathionine gamma-lyase)
chr5_-_25645593 0.36 ENSDART00000044471
tmc2b
transmembrane channel-like 2b
chr10_+_40660772 0.35 ENSDART00000148007
taar19l
trace amine associated receptor 19l
chr6_-_40352215 0.35 ENSDART00000103992
ttll3
tubulin tyrosine ligase-like family, member 3
chr13_+_30169681 0.35 ENSDART00000138326
pald1b
phosphatase domain containing, paladin 1b
chr23_+_9353552 0.34 ENSDART00000163298
BX511246.1

chrM_+_4993 0.33 ENSDART00000093600
mt-nd2
NADH dehydrogenase 2, mitochondrial
chr20_+_37295006 0.32 ENSDART00000153137
cx23
connexin 23
chr14_-_9128919 0.31 ENSDART00000108641
sh2d1ab
SH2 domain containing 1A duplicate b
chr19_+_43604256 0.31 ENSDART00000151080
ENSDART00000110305
si:ch211-199g17.9
si:ch211-199g17.9
chr18_-_25568994 0.31 ENSDART00000133029
si:ch211-13k12.2
si:ch211-13k12.2
chr2_+_24781026 0.30 ENSDART00000145692
pde4ca
phosphodiesterase 4C, cAMP-specific a
chr21_+_21702623 0.30 ENSDART00000136840
or125-2
odorant receptor, family E, subfamily 125, member 2
chr17_+_7510220 0.28 ENSDART00000192648
klhl10b.1
kelch-like family member 10b, tandem duplicate 1
chr18_+_44080948 0.28 ENSDART00000191036
BX908388.2

chr2_-_25159309 0.28 ENSDART00000137290
si:dkey-223d7.6
si:dkey-223d7.6
chr25_-_10503043 0.27 ENSDART00000155404
cox8b
cytochrome c oxidase subunit 8b
chr4_-_72609735 0.26 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
si:cabz01054394.6
chr11_+_30244356 0.26 ENSDART00000036050
ENSDART00000150080
rs1a
retinoschisin 1a
chr15_+_33696559 0.26 ENSDART00000188248
ENSDART00000161951
hdac12
histone deacetylase 12
chr7_+_71683853 0.25 ENSDART00000163002
emilin2b
elastin microfibril interfacer 2b
chr22_-_4649238 0.25 ENSDART00000125302
fbn2b
fibrillin 2b
chr10_-_39154594 0.24 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr1_-_10577945 0.23 ENSDART00000179237
ENSDART00000040502
ENSDART00000186876
trpc5a
transient receptor potential cation channel, subfamily C, member 5a
chr15_+_1134870 0.23 ENSDART00000155392
p2ry13
purinergic receptor P2Y13
chr10_+_40690411 0.23 ENSDART00000146865
taar19m
trace amine associated receptor 19m
chr21_-_37973819 0.22 ENSDART00000133405
ripply1
ripply transcriptional repressor 1
chr24_+_26134209 0.22 ENSDART00000038824
tmtopsb
teleost multiple tissue opsin b
chr8_+_22472584 0.22 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr19_-_6239248 0.21 ENSDART00000014127
pou2f2a
POU class 2 homeobox 2a
chr5_+_43782267 0.19 ENSDART00000130355
nos2a
nitric oxide synthase 2a, inducible
chr18_-_33080454 0.19 ENSDART00000191907
v2ra18
vomeronasal 2 receptor, a18
chr8_-_19649617 0.18 ENSDART00000189033
fam78bb
family with sequence similarity 78, member B b
chr4_+_20576857 0.17 ENSDART00000125340
BX248410.2

chr21_-_14966718 0.16 ENSDART00000151200
mmp17a
matrix metallopeptidase 17a
chr23_-_36857964 0.16 ENSDART00000188822
ENSDART00000134061
ENSDART00000093061
hipk1a
homeodomain interacting protein kinase 1a
chr20_+_28861629 0.16 ENSDART00000187274
ENSDART00000047826
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr23_-_18913032 0.16 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr22_-_6988102 0.15 ENSDART00000185618
fgfr1bl
fibroblast growth factor receptor 1b, like
chr10_-_39153959 0.15 ENSDART00000150193
ENSDART00000111362
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr6_-_40697585 0.15 ENSDART00000113196
si:ch211-157b11.14
si:ch211-157b11.14
chr20_+_28861435 0.14 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr21_-_14803366 0.14 ENSDART00000190872
si:dkey-11o18.5
si:dkey-11o18.5
chr4_-_4751981 0.13 ENSDART00000147436
ENSDART00000092984
ENSDART00000158466
creb3l2
cAMP responsive element binding protein 3-like 2
chr5_+_32009542 0.13 ENSDART00000182025
ENSDART00000179879
scai
suppressor of cancer cell invasion
chr15_-_14884332 0.12 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr8_+_7097740 0.12 ENSDART00000159670
abtb1
ankyrin repeat and BTB (POZ) domain containing 1
chr18_-_20458412 0.12 ENSDART00000012241
kif23
kinesin family member 23
chr6_+_4528631 0.11 ENSDART00000122042
RNF219
ring finger protein 219
chr23_+_38953545 0.11 ENSDART00000184621
ATP9A
ATPase phospholipid transporting 9A (putative)
chr4_-_837768 0.09 ENSDART00000185280
ENSDART00000135618
sobpb
sine oculis binding protein homolog (Drosophila) b
chr1_-_23596391 0.09 ENSDART00000155184
lcorl
ligand dependent nuclear receptor corepressor-like
chr2_-_42827336 0.09 ENSDART00000140913
adcy8
adenylate cyclase 8 (brain)
chr22_+_1313046 0.08 ENSDART00000170421
si:ch73-138e16.6
si:ch73-138e16.6
chr16_-_42965192 0.07 ENSDART00000113714
mtx1a
metaxin 1a
chr8_-_23194408 0.06 ENSDART00000141090
si:ch211-196c10.15
si:ch211-196c10.15
chr5_-_42272517 0.04 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr16_-_6391275 0.04 ENSDART00000060550
ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr18_+_11970987 0.04 ENSDART00000144111
si:dkeyp-2c8.3
si:dkeyp-2c8.3
chr9_-_36924388 0.03 ENSDART00000059756
ralba
v-ral simian leukemia viral oncogene homolog Ba (ras related)
chr4_+_13931733 0.02 ENSDART00000141742
ENSDART00000067175
pphln1
periphilin 1
chr8_+_23194212 0.02 ENSDART00000028946
ENSDART00000186842
ENSDART00000137815
ENSDART00000136914
ENSDART00000144855
ENSDART00000182689
tpd52l2a
tumor protein D52-like 2a
chr13_+_23176330 0.02 ENSDART00000168351
sorbs1
sorbin and SH3 domain containing 1
chr15_-_1822548 0.01 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr22_-_7129631 0.00 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx1+hmx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0050996 positive regulation of lipid catabolic process(GO:0050996)
0.1 0.2 GO:0060958 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793)
0.1 0.5 GO:0019563 glycerol catabolic process(GO:0019563)
0.1 0.8 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 0.4 GO:0019344 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.0 0.5 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.0 0.4 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.0 0.2 GO:0030823 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.6 GO:0009081 branched-chain amino acid metabolic process(GO:0009081)
0.0 0.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.9 GO:0042493 response to drug(GO:0042493)
0.0 0.6 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005131 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.2 1.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.8 GO:0070330 aromatase activity(GO:0070330)
0.1 0.4 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.1 0.4 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1 0.5 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 0.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.7 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism