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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa10b

Z-value: 0.65

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Transcription factors associated with hoxa10b

Gene Symbol Gene ID Gene Info
ENSDARG00000031337 homeobox A10b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa10bdr11_v1_chr16_+_20910186_209101860.197.2e-02Click!

Activity profile of hoxa10b motif

Sorted Z-values of hoxa10b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_70155935 5.83 ENSDART00000165570
regulator of G protein signaling 3a
chr10_-_15128771 4.54 ENSDART00000101261
secreted phosphoprotein 1
chr24_+_38306010 4.22 ENSDART00000143184
myosin binding protein C, fast type b
chr25_+_20089986 4.12 ENSDART00000143441
ENSDART00000184073
troponin I4b, tandem duplicate 2
chr16_-_44945224 4.10 ENSDART00000156921
neural cell adhesion molecule 3
chr18_+_9171778 4.01 ENSDART00000101192
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr15_-_15357178 3.87 ENSDART00000106120
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr22_+_5574952 3.52 ENSDART00000171774
zgc:171566
chr21_+_5129513 3.43 ENSDART00000102572
thrombospondin 4b
chr25_+_31276842 3.33 ENSDART00000187238
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr20_-_27733683 3.31 ENSDART00000103317
ENSDART00000138139
zgc:153157
chr6_-_30485009 3.29 ENSDART00000025698
zgc:153311
chr25_+_29161609 2.99 ENSDART00000180752
pyruvate kinase M1/2b
chr12_-_25887864 2.97 ENSDART00000152983
si:dkey-193p11.2
chr8_+_22930627 2.94 ENSDART00000187860
synaptophysin a
chr17_+_15535501 2.90 ENSDART00000002932
myristoylated alanine-rich protein kinase C substrate b
chr25_+_4750972 2.85 ENSDART00000168903
si:zfos-2372e4.1
chr7_+_66822229 2.79 ENSDART00000112109
lymphatic vessel endothelial hyaluronic receptor 1a
chr23_-_15216654 2.51 ENSDART00000131649
sulfatase 2b
chr3_-_55104310 2.47 ENSDART00000101713
hemoglobin, beta adult 1
chr9_+_45839260 2.30 ENSDART00000114814
twist2
chr14_-_36378494 2.30 ENSDART00000058503
glycoprotein M6Aa
chr24_+_2519761 2.28 ENSDART00000106619
neuritin 1a
chr20_-_34801181 2.24 ENSDART00000048375
ENSDART00000132426
stathmin-like 4
chr15_-_33933790 2.24 ENSDART00000165162
ENSDART00000182258
ENSDART00000183240
myelin associated glycoprotein
chr10_+_36650222 2.20 ENSDART00000126963
uncoupling protein 3
chr25_+_16080181 2.20 ENSDART00000061753
fatty acyl CoA reductase 1
chr9_+_44430974 2.13 ENSDART00000056846
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr25_-_19443421 2.12 ENSDART00000067362
cocaine- and amphetamine-regulated transcript 2
chr10_-_24371312 2.10 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr3_+_40576447 1.98 ENSDART00000083212
fascin actin-bundling protein 1a
chr20_-_40717900 1.95 ENSDART00000181663
connexin 43
chr14_-_16082806 1.91 ENSDART00000165656
MAX dimerization protein 3
chr8_-_36140405 1.88 ENSDART00000182806

chr25_+_34984333 1.87 ENSDART00000154760
coiled-coil domain containing 136b
chr16_+_35916371 1.87 ENSDART00000167208
SH3 domain containing 21
chr11_-_21031773 1.86 ENSDART00000065985
fibromodulin a
chr7_+_51103232 1.82 ENSDART00000073827
collagen, type IV, alpha 5 (Alport syndrome)
chr16_+_36126310 1.80 ENSDART00000166040
ENSDART00000189802
SH3-domain binding protein 5b (BTK-associated)
chr6_+_35362225 1.79 ENSDART00000133783
ENSDART00000102483
regulator of G protein signaling 4
chr12_-_5728755 1.75 ENSDART00000105887
distal-less homeobox 4b
chr12_+_23912074 1.72 ENSDART00000152864
supervillin a
chr12_+_11352630 1.69 ENSDART00000129495
si:rp71-19m20.1
chr3_+_29714775 1.68 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr15_+_43166511 1.66 ENSDART00000011737
flj13639
chr24_-_21512425 1.64 ENSDART00000184857
ATPase phospholipid transporting 8A2
chr8_-_17064243 1.63 ENSDART00000185313
RAB3C, member RAS oncogene family
chr9_-_40765868 1.63 ENSDART00000138634
ATP-binding cassette, sub-family A (ABC1), member 12
chr8_-_39952727 1.63 ENSDART00000181310
calcium binding protein 1a
chr5_-_31856681 1.63 ENSDART00000187817
protein kinase N3
chr7_+_1473929 1.62 ENSDART00000050687
lysophosphatidylcholine acyltransferase 4
chr21_-_2299002 1.60 ENSDART00000168712
si:ch73-299h12.6
chr24_-_25256230 1.56 ENSDART00000155780
HERV-H LTR-associating 2b, tandem duplicate 1
chr1_-_26131088 1.53 ENSDART00000193973
ENSDART00000054209
cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)
chr12_+_10053852 1.52 ENSDART00000078497
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr9_-_31278048 1.51 ENSDART00000022204
zic family member 5 (odd-paired homolog, Drosophila)
chr9_+_44430705 1.49 ENSDART00000190696
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_-_31661609 1.45 ENSDART00000144383
si:ch211-106h4.9
chr24_-_15159658 1.42 ENSDART00000142473
rotatin
chr1_+_46194333 1.42 ENSDART00000010894
SRY (sex determining region Y)-box 1b
chr12_+_35650321 1.42 ENSDART00000190446

chr20_-_25709247 1.42 ENSDART00000146711
si:dkeyp-117h8.2
chr22_-_881725 1.40 ENSDART00000035514
choline/ethanolamine phosphotransferase 1b
chr10_+_18877362 1.40 ENSDART00000138334
protein phosphatase 2, regulatory subunit B, alpha b
chr24_+_23791758 1.38 ENSDART00000066655
ENSDART00000146580
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr15_-_1844048 1.36 ENSDART00000102410
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr8_-_11324143 1.35 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr7_-_44672095 1.32 ENSDART00000073745
CKLF-like MARVEL transmembrane domain containing 4
chr7_+_51103416 1.31 ENSDART00000174236
collagen, type IV, alpha 5 (Alport syndrome)
chr12_+_27285994 1.30 ENSDART00000087204
dual specificity phosphatase 3a
chr20_+_37393134 1.30 ENSDART00000128321
adhesion G protein-coupled receptor G6
chr2_-_31664615 1.28 ENSDART00000190546
ENSDART00000111810
si:ch211-106h4.9
chr20_-_23219964 1.24 ENSDART00000144933
DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
chr21_-_26691959 1.21 ENSDART00000149702
ENSDART00000149840
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr9_-_32604414 1.21 ENSDART00000088876
ENSDART00000166502
SATB homeobox 2
chr1_-_22512063 1.20 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr14_+_34966598 1.20 ENSDART00000004550
ring finger protein 145a
chr19_-_20113696 1.20 ENSDART00000188813
neuropeptide Y
chr11_+_42730639 1.19 ENSDART00000165297
zgc:194981
chr9_-_16853462 1.18 ENSDART00000160273

chr5_-_31857345 1.17 ENSDART00000112546
protein kinase N3
chr9_+_34232503 1.17 ENSDART00000132836
neurexophilin and PC-esterase domain family, member 3
chr3_+_26135502 1.17 ENSDART00000146979
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr21_-_40173821 1.16 ENSDART00000180667
solute carrier organic anion transporter family, member 2B1
chr17_+_43595692 1.16 ENSDART00000156271
cilia and flagella associated protein 99
chr10_-_34889053 1.14 ENSDART00000136966
coiled-coil domain containing 169
chr15_+_16387088 1.13 ENSDART00000101789
flotillin 2b
chr20_-_29499363 1.13 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
ribonucleotide reductase M2 polypeptide
chr13_+_25455319 1.12 ENSDART00000145948
polycystic kidney disease 2-like 1
chr23_+_28092083 1.10 ENSDART00000053958
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a
chr14_+_36226243 1.09 ENSDART00000052569
paired-like homeodomain 2
chr19_-_47571797 1.09 ENSDART00000166180
ENSDART00000168134
ribonucleotide reductase M2 polypeptide
chr15_+_3825117 1.08 ENSDART00000183315

chr11_+_29856032 1.08 ENSDART00000079150
gastrin-releasing peptide receptor
chr18_+_6857071 1.08 ENSDART00000018735
ENSDART00000181969
DnaJ (Hsp40) homolog, subfamily A, member 2, like
chr25_+_3549841 1.07 ENSDART00000164030
coiled-coil domain containing 77
chr6_-_6448519 1.06 ENSDART00000180157
ENSDART00000191112
si:ch211-194e18.2
chr8_+_3820134 1.06 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr16_-_24561354 1.03 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
chr3_+_24275597 1.03 ENSDART00000183926
ENSDART00000169765
platelet-derived growth factor beta polypeptide b
chr19_-_47571456 1.03 ENSDART00000158071
ENSDART00000165841
ribonucleotide reductase M2 polypeptide
chr1_+_57371447 1.01 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
chr23_-_12014931 1.01 ENSDART00000134652
si:dkey-178k16.1
chr6_+_11989537 1.00 ENSDART00000190817
bromodomain adjacent to zinc finger domain, 2Ba
chr6_-_40697585 1.00 ENSDART00000113196
si:ch211-157b11.14
chr10_-_25816558 0.99 ENSDART00000017240
periostin, osteoblast specific factor a
chr23_-_21215520 0.98 ENSDART00000143206
multiple EGF-like-domains 6a
chr22_+_9806867 0.97 ENSDART00000137182
ENSDART00000106103
si:ch211-236g6.1
chr4_+_35594200 0.97 ENSDART00000193902
si:dkeyp-4c4.2
chr16_+_21789703 0.95 ENSDART00000153617
tripartite motif containing 108
chr19_-_31402429 0.95 ENSDART00000137292
transmembrane protein 106Bb
chr2_+_35733335 0.95 ENSDART00000113489
RAS protein activator like 2
chr1_-_55873178 0.94 ENSDART00000019936
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
chr23_-_21215311 0.94 ENSDART00000112424
multiple EGF-like-domains 6a
chr21_-_15929041 0.94 ENSDART00000080693
LIM homeobox 5
chr1_+_52392511 0.93 ENSDART00000144025
si:ch211-217k17.8
chr2_+_19163965 0.93 ENSDART00000166073
ELOVL fatty acid elongase 1a
chr25_+_3549401 0.92 ENSDART00000166312
coiled-coil domain containing 77
chr1_-_55068941 0.92 ENSDART00000152143
ENSDART00000152590
pellino E3 ubiquitin protein ligase 1a
chr21_+_6556635 0.91 ENSDART00000139598
procollagen, type V, alpha 1
chr10_-_34772211 0.89 ENSDART00000145450
ENSDART00000134307
doublecortin-like kinase 1a
chr24_-_3407507 0.88 ENSDART00000132648
NCK adaptor protein 1b
chr25_-_14433503 0.88 ENSDART00000103957
exocyst complex component 3-like 1
chr22_+_15959844 0.87 ENSDART00000182201
scl/tal1 interrupting locus
chr2_+_6126086 0.86 ENSDART00000179962
fizzy/cell division cycle 20 related 1b
chr15_-_19772372 0.85 ENSDART00000152729
phosphatidylinositol binding clathrin assembly protein b
chr7_+_34290051 0.83 ENSDART00000123498
fin bud initiation factor b
chr16_-_32649929 0.83 ENSDART00000136161
failed axon connections homolog b
chr10_-_31104983 0.82 ENSDART00000186941
pbx/knotted 1 homeobox 2
chr3_-_21037840 0.82 ENSDART00000002393
RUN domain containing 3Aa
chr25_+_7423770 0.82 ENSDART00000155458
ubiquitin associated protein 1-like a
chr15_-_1843831 0.81 ENSDART00000156718
ENSDART00000154175
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_-_36591511 0.81 ENSDART00000063347
solute carrier family 1 (glial high affinity glutamate transporter), member 3b
chr11_+_21053488 0.81 ENSDART00000189860
zgc:113307
chr23_+_45538932 0.81 ENSDART00000135602
si:ch73-290k24.6
chr2_+_7715810 0.80 ENSDART00000130781
eukaryotic translation initiation factor 4A, isoform 2
chr12_+_10599604 0.80 ENSDART00000152538
leucine rich repeat containing 3Ca
chr14_-_45604667 0.80 ENSDART00000167016
si:ch211-276i12.9
chr21_-_23475361 0.79 ENSDART00000156658
ENSDART00000157454
neural cell adhesion molecule 1a
chr16_+_31942527 0.78 ENSDART00000188334
ENSDART00000188643
ENSDART00000058496
polyhomeotic homolog 1
chr20_-_2641233 0.78 ENSDART00000145335
ENSDART00000133121
BUB1 mitotic checkpoint serine/threonine kinase
chr24_+_19578935 0.78 ENSDART00000137175
sulfatase 1
chr1_+_2321384 0.77 ENSDART00000157662
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr20_-_9273669 0.77 ENSDART00000175069
synaptotagmin XIVb
chr6_+_13933464 0.76 ENSDART00000109144
protein tyrosine phosphatase, receptor type, Nb
chr20_-_36416922 0.74 ENSDART00000019145
lamin B receptor
chr8_+_23105117 0.73 ENSDART00000025171
YTH N(6)-methyladenosine RNA binding protein 1
chr21_+_39423974 0.72 ENSDART00000031470
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
chr3_+_33761549 0.72 ENSDART00000169337
immediate early response 2a
chr10_-_11840353 0.71 ENSDART00000127581
tripartite motif containing 23
chr23_+_41799748 0.70 ENSDART00000144257
prodynorphin
chr3_-_29910547 0.70 ENSDART00000151501
si:dkey-151m15.5
chr19_+_7424347 0.70 ENSDART00000004622
splicing factor 3b, subunit 4
chr12_+_40905427 0.69 ENSDART00000170526
ENSDART00000185771
ENSDART00000193945
cadherin 18
chr18_-_39288894 0.68 ENSDART00000186216
mitogen-activated protein kinase 6
chr5_-_57723929 0.67 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr12_+_13205955 0.67 ENSDART00000092906
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr14_+_15597049 0.66 ENSDART00000159732
si:dkey-203a12.8
chr24_-_23784701 0.66 ENSDART00000090368
serum/glucocorticoid regulated kinase family, member 3
chr22_-_12337781 0.66 ENSDART00000188357
ENSDART00000123574
zinc finger, RAN-binding domain containing 3
chr23_-_24253200 0.66 ENSDART00000114840
zinc finger and BTB domain containing 17
chr16_-_32671998 0.66 ENSDART00000161395
PNN-interacting serine/arginine-rich protein
chr4_+_17336557 0.66 ENSDART00000111650
pro-melanin-concentrating hormone
chr8_-_23573084 0.65 ENSDART00000139084
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr4_-_39171837 0.64 ENSDART00000179734
si:ch211-22k7.9
chr25_-_4733221 0.63 ENSDART00000172689
dopamine receptor D4a
chr3_-_58650057 0.63 ENSDART00000057640
dehydrogenase/reductase (SDR family) member 7Ca
chr19_+_636886 0.63 ENSDART00000149192
telomerase reverse transcriptase
chr5_-_24997293 0.63 ENSDART00000177478
EMI domain containing 1
chr23_+_45200481 0.62 ENSDART00000004357
ENSDART00000111126
ENSDART00000193560
ENSDART00000190476
PC4 and SFRS1 interacting protein 1b
chr2_-_16380283 0.62 ENSDART00000149992
si:dkey-231j24.3
chr2_+_58008980 0.61 ENSDART00000171264
si:ch211-155e24.3
chr10_-_29768556 0.60 ENSDART00000052787
vacuolar protein sorting 11
chr13_-_8892514 0.59 ENSDART00000144553
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr15_+_42285643 0.59 ENSDART00000152731
SR-related CTD-associated factor 4b
chr23_-_29505645 0.59 ENSDART00000146458
kinesin family member 1B
chr2_+_2223837 0.58 ENSDART00000101038
ENSDART00000129354
transmembrane inner ear
chr25_+_15933411 0.58 ENSDART00000191581
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr17_-_22010668 0.57 ENSDART00000031998
solute carrier family 22 (organic anion transporter), member 7b, tandem duplicate 1
chr5_+_20453874 0.57 ENSDART00000124545
ENSDART00000008402
squamous cell carcinoma antigen recognized by T cells 3
chr13_-_7575216 0.56 ENSDART00000159443
paired-like homeodomain 3
chr5_+_24063046 0.56 ENSDART00000051548
ENSDART00000133355
ENSDART00000142268
G protein pathway suppressor 2
chr11_-_5953636 0.55 ENSDART00000140960
ENSDART00000123601
DET1 and DDB1 associated 1
chr2_-_30912922 0.55 ENSDART00000141669
myosin, light chain 12, genome duplicate 2
chr21_-_26071773 0.55 ENSDART00000141382
RAB34, member RAS oncogene family b
chr10_-_43771447 0.54 ENSDART00000052307
arrestin domain containing 3b
chr6_-_10728921 0.53 ENSDART00000151484
Sp3b transcription factor
chr22_-_31060579 0.50 ENSDART00000182376
cullin-associated and neddylation-dissociated 2 (putative)
chr15_-_47857687 0.50 ENSDART00000098982
ENSDART00000151594
H3 histone, family 3B.1
chr16_-_32671782 0.49 ENSDART00000123980
PNN-interacting serine/arginine-rich protein
chr21_-_38853737 0.49 ENSDART00000184100
toll-like receptor 22
chr14_+_10625112 0.49 ENSDART00000143377
ENSDART00000136480
nucleoporin 62 like
chr21_-_14878220 0.48 ENSDART00000131237
unc-51 like autophagy activating kinase 1
chr23_+_12455295 0.48 ENSDART00000143752
ENSDART00000135785
si:ch211-153a8.4
chr18_-_50614024 0.47 ENSDART00000171207
ubiquitin-conjugating enzyme E2Q family member 1
chr17_-_30652738 0.47 ENSDART00000154960
SH3 and SYLF domain containing 1
chr8_-_31416403 0.47 ENSDART00000098912
zinc finger protein 131
chr1_-_12394048 0.47 ENSDART00000146067
ENSDART00000134708
sodium channel and clathrin linker 1
chr5_+_54555567 0.46 ENSDART00000171159
anaphase promoting complex subunit 2
chr5_+_58492699 0.46 ENSDART00000181584

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa10b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:2000051 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.9 3.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.8 4.0 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508)
0.6 3.1 GO:0007412 axon target recognition(GO:0007412)
0.6 1.7 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.6 3.4 GO:0035989 tendon development(GO:0035989)
0.4 1.3 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.4 1.2 GO:2000434 regulation of protein neddylation(GO:2000434)
0.4 2.0 GO:1901166 neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.3 1.0 GO:1903392 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.3 1.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.3 1.2 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.3 3.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.2 GO:0045988 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.3 1.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 2.2 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 1.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.3 2.1 GO:0008343 adult feeding behavior(GO:0008343)
0.3 0.8 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.2 2.9 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.2 1.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 3.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 1.1 GO:0061072 iris morphogenesis(GO:0061072)
0.2 1.5 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.2 0.6 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.2 1.6 GO:0048730 epidermis morphogenesis(GO:0048730)
0.2 0.6 GO:0048917 posterior lateral line ganglion development(GO:0048917)
0.2 0.9 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.2 GO:0034389 lipid particle organization(GO:0034389)
0.2 0.5 GO:0010265 SCF complex assembly(GO:0010265)
0.2 7.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.8 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 1.9 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.9 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 1.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.8 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.1 0.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 1.4 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 2.5 GO:0015671 oxygen transport(GO:0015671)
0.1 1.4 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.8 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 0.9 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.7 GO:0048478 replication fork protection(GO:0048478)
0.1 1.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.4 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 1.2 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.1 0.6 GO:0060036 notochord cell vacuolation(GO:0060036)
0.1 3.1 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.1 1.8 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.0 GO:0014823 response to activity(GO:0014823)
0.1 0.6 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.7 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 4.0 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.1 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.1 4.5 GO:0060348 bone development(GO:0060348)
0.1 0.9 GO:0030809 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.1 1.7 GO:0051014 actin filament severing(GO:0051014)
0.1 0.9 GO:0032418 lysosome localization(GO:0032418)
0.0 3.1 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 3.0 GO:0006096 glycolytic process(GO:0006096)
0.0 2.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.8 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.9 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.7 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 1.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0042723 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.7 GO:2000404 regulation of T cell migration(GO:2000404)
0.0 0.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.3 GO:0018410 C-terminal protein amino acid modification(GO:0018410)
0.0 0.9 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.2 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.1 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 1.4 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.6 GO:0070306 adenohypophysis development(GO:0021984) lens fiber cell differentiation(GO:0070306)
0.0 0.9 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.8 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.8 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.1 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.0 3.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.6 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.0 1.2 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.0 0.9 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.9 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 2.2 GO:0007626 locomotory behavior(GO:0007626)
0.0 0.4 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.6 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.3 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 0.7 GO:0044042 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.5 GO:0002224 toll-like receptor signaling pathway(GO:0002224)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0031673 H zone(GO:0031673)
0.3 1.1 GO:0016600 flotillin complex(GO:0016600)
0.2 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.7 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.2 0.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.2 2.3 GO:0044295 axonal growth cone(GO:0044295)
0.2 0.7 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.2 2.5 GO:0005833 hemoglobin complex(GO:0005833)
0.2 7.5 GO:0005861 troponin complex(GO:0005861)
0.1 0.6 GO:0033263 CORVET complex(GO:0033263)
0.1 0.5 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.9 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 2.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.2 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 2.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 4.7 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 2.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.8 GO:0000813 ESCRT I complex(GO:0000813)
0.0 2.9 GO:0032432 actin filament bundle(GO:0032432)
0.0 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.0 GO:0030426 growth cone(GO:0030426)
0.0 4.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 3.3 GO:0005795 Golgi stack(GO:0005795)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.7 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 1.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 1.6 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 2.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.5 3.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.5 3.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 2.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.3 2.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 1.4 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.3 1.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.3 4.0 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.2 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.2 0.6 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.2 3.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 3.5 GO:0008242 omega peptidase activity(GO:0008242)
0.2 0.9 GO:0010997 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.1 3.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 2.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 2.5 GO:0019825 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.1 1.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.4 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 2.8 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.3 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.1 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 3.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 2.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.8 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.2 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.1 2.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.7 GO:0017022 myosin binding(GO:0017022)
0.1 1.3 GO:0043236 laminin binding(GO:0043236)
0.1 0.7 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.7 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.0 1.4 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.3 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 2.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.6 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.7 PID E2F PATHWAY E2F transcription factor network
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.2 3.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 4.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 4.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway