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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxa11a

Z-value: 0.30

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Transcription factors associated with hoxa11a

Gene Symbol Gene ID Gene Info
hoxa11a
ENSDARG00000104162 homeobox A11a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa11adr11_v1_chr19_+_19737214_197373000.141.9e-01Click!

Activity profile of hoxa11a motif

Sorted Z-values of hoxa11a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_27868183 2.34 ENSDART00000185812
abat
4-aminobutyrate aminotransferase
chr10_+_2587234 1.60 ENSDART00000126937
wu:fb59d01
wu:fb59d01
chr7_+_20524064 1.40 ENSDART00000052917
slc3a2a
solute carrier family 3 (amino acid transporter heavy chain), member 2a
chr2_-_13254821 1.39 ENSDART00000022621
kdsr
3-ketodihydrosphingosine reductase
chr17_-_23727978 1.38 ENSDART00000079600
minpp1a
multiple inositol-polyphosphate phosphatase 1a
chr7_-_41014773 1.31 ENSDART00000013785
insig1
insulin induced gene 1
chr14_-_48348973 1.26 ENSDART00000185822
CABZ01080056.1

chr6_+_42338309 1.21 ENSDART00000015277
gpx1b
glutathione peroxidase 1b
chr2_-_10338759 1.16 ENSDART00000150166
ENSDART00000149584
gng12a
guanine nucleotide binding protein (G protein), gamma 12a
chr15_+_9297340 1.13 ENSDART00000055554
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr3_+_24190207 1.08 ENSDART00000034762
prr15la
proline rich 15-like a
chr7_+_25036188 1.07 ENSDART00000163957
ENSDART00000169749
sb:cb1058
sb:cb1058
chr24_-_40009446 1.04 ENSDART00000087422
aoc1
amine oxidase, copper containing 1
chr8_-_14049404 1.02 ENSDART00000093117
atp2b3a
ATPase plasma membrane Ca2+ transporting 3a
chr2_-_13254594 0.99 ENSDART00000155671
kdsr
3-ketodihydrosphingosine reductase
chr15_+_8767650 0.98 ENSDART00000033871
ap2s1
adaptor-related protein complex 2, sigma 1 subunit
chr9_-_3671911 0.89 ENSDART00000102900
sp5a
Sp5 transcription factor a
chr7_+_9308625 0.87 ENSDART00000084598
selenos
selenoprotein S
chr13_-_25196758 0.83 ENSDART00000184722
adka
adenosine kinase a
chr6_+_49551614 0.80 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr15_+_36115955 0.79 ENSDART00000032702
sst1.2
somatostatin 1, tandem duplicate 2
chr18_-_2433011 0.79 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr20_-_44576949 0.78 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr1_+_36722122 0.73 ENSDART00000111566
tmem184c
transmembrane protein 184C
chr13_-_9875538 0.59 ENSDART00000041609
tm9sf3
transmembrane 9 superfamily member 3
chr6_-_53334259 0.59 ENSDART00000172465
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr5_-_35301800 0.54 ENSDART00000085142
map1b
microtubule-associated protein 1B
chr17_+_44463230 0.51 ENSDART00000130311
naa30
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr6_-_40744720 0.51 ENSDART00000154916
ENSDART00000186922
p4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr11_-_36051004 0.47 ENSDART00000025033
gpx1a
glutathione peroxidase 1a
chr12_-_26851726 0.44 ENSDART00000047724
zeb1b
zinc finger E-box binding homeobox 1b
chr16_-_6205790 0.44 ENSDART00000038495
ctnnb1
catenin (cadherin-associated protein), beta 1
chr20_+_37820992 0.42 ENSDART00000064692
tatdn3
TatD DNase domain containing 3
chr15_+_44093286 0.41 ENSDART00000114352
zgc:112998
zgc:112998
chr3_+_36284986 0.40 ENSDART00000059533
wipi1
WD repeat domain, phosphoinositide interacting 1
chr23_-_33750135 0.39 ENSDART00000187641
bin2a
bridging integrator 2a
chr23_-_33750307 0.38 ENSDART00000162772
bin2a
bridging integrator 2a
chr17_-_31695217 0.36 ENSDART00000104332
ENSDART00000143090
lin52
lin-52 DREAM MuvB core complex component
chr9_-_29039506 0.35 ENSDART00000100744
tmem177
transmembrane protein 177
chr4_+_39368978 0.33 ENSDART00000160640
si:dkey-261o4.1
si:dkey-261o4.1
chr2_-_37874647 0.33 ENSDART00000039386
zgc:66427
zgc:66427
chr4_-_20108833 0.31 ENSDART00000100867
fam3c
family with sequence similarity 3, member C
chr5_-_32489796 0.30 ENSDART00000168870
gpr107
G protein-coupled receptor 107
chr22_-_33916620 0.29 ENSDART00000191276
CR974456.1

chr4_-_9586713 0.29 ENSDART00000145613
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr14_-_31060082 0.29 ENSDART00000111601
ENSDART00000161113
mbnl3
muscleblind-like splicing regulator 3
chr25_-_18002498 0.28 ENSDART00000158688
cep290
centrosomal protein 290
chr24_-_31223232 0.28 ENSDART00000164155
alg14
ALG14, UDP-N-acetylglucosaminyltransferase subunit
chr6_+_33885828 0.26 ENSDART00000179994
gpbp1l1
GC-rich promoter binding protein 1-like 1
chr2_-_43851915 0.26 ENSDART00000146493
zeb1a
zinc finger E-box binding homeobox 1a
chr11_+_41135055 0.26 ENSDART00000173252
camta1
calmodulin binding transcription activator 1
chr2_+_43851983 0.25 ENSDART00000126413
nlrb5
NOD-like receptor family B, member 5
chr25_-_19395156 0.24 ENSDART00000155335
map1ab
microtubule-associated protein 1Ab
chr5_+_36611128 0.24 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr5_+_59397739 0.24 ENSDART00000148659
clip2
CAP-GLY domain containing linker protein 2
chr2_-_9259283 0.24 ENSDART00000133092
st6galnac5a
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5a
chr25_-_18002937 0.23 ENSDART00000149696
cep290
centrosomal protein 290
chr22_+_2239974 0.23 ENSDART00000141993
znf1144
zinc finger protein 1144
chr9_+_20483846 0.21 ENSDART00000192067
ENSDART00000145111
parp4
poly (ADP-ribose) polymerase family, member 4
chr20_-_46541834 0.20 ENSDART00000060685
ENSDART00000181720
tmed10
transmembrane p24 trafficking protein 10
chr24_+_20658760 0.20 ENSDART00000188362
sec22c
SEC22 homolog C, vesicle trafficking protein
chr2_-_43852207 0.20 ENSDART00000192627
zeb1a
zinc finger E-box binding homeobox 1a
chr25_+_3788443 0.19 ENSDART00000189747
chid1
chitinase domain containing 1
chr15_-_734203 0.19 ENSDART00000177867
ENSDART00000154918
si:dkey-7i4.21
BX004964.1
si:dkey-7i4.21

chr24_+_20658942 0.18 ENSDART00000142848
sec22c
SEC22 homolog C, vesicle trafficking protein
chr20_+_34671386 0.17 ENSDART00000152836
ENSDART00000138226
elp3
elongator acetyltransferase complex subunit 3
chr1_-_56213723 0.16 ENSDART00000142505
ENSDART00000137237
si:dkey-76b14.2
si:dkey-76b14.2
chr11_+_25560632 0.15 ENSDART00000033914
mbd1b
methyl-CpG binding domain protein 1b
chr11_+_25560072 0.14 ENSDART00000124131
ENSDART00000147179
mbd1b
methyl-CpG binding domain protein 1b
chr16_-_24561354 0.13 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
si:ch211-79k12.2
chr12_-_11560794 0.10 ENSDART00000149098
ENSDART00000169975
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr7_-_30624435 0.09 ENSDART00000173828
rnf111
ring finger protein 111
chr2_+_54696042 0.08 ENSDART00000074270
ankrd12
ankyrin repeat domain 12
chr10_-_25561751 0.08 ENSDART00000147089
grik1a
glutamate receptor, ionotropic, kainate 1a
chr21_+_13127742 0.07 ENSDART00000179221
odf2a
outer dense fiber of sperm tails 2a
chr15_-_14552101 0.07 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr21_-_25618175 0.06 ENSDART00000133512
fosl1b
FOS-like antigen 1b
chr20_+_43379029 0.06 ENSDART00000142486
ENSDART00000186486
unc93a
unc-93 homolog A
chr2_-_6065416 0.06 ENSDART00000037698
uck2b
uridine-cytidine kinase 2b
chr11_-_21303946 0.03 ENSDART00000185786
RASSF5
si:dkey-85p17.3
chr21_+_11865972 0.03 ENSDART00000081676
ubap1
ubiquitin associated protein 1
chr16_-_47426482 0.02 ENSDART00000148631
ENSDART00000149723
sept7b
septin 7b
chr3_-_18737126 0.01 ENSDART00000055767
e4f1
E4F transcription factor 1
chr19_-_22507715 0.01 ENSDART00000160153
pleca
plectin a
chr12_-_34713690 0.01 ENSDART00000180807
bahcc1b
BAH domain and coiled-coil containing 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa11a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.5 2.3 GO:0009450 gamma-aminobutyric acid catabolic process(GO:0009450)
0.4 1.3 GO:2000639 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.3 1.7 GO:0010269 response to selenium ion(GO:0010269)
0.2 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.9 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.2 0.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.4 GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000055)
0.1 0.8 GO:0044209 AMP salvage(GO:0044209)
0.1 0.8 GO:0071800 podosome assembly(GO:0071800)
0.1 1.4 GO:0060142 regulation of syncytium formation by plasma membrane fusion(GO:0060142)
0.1 1.0 GO:0046958 nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1 0.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.6 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.1 0.5 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.2 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.3 GO:0098815 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.5 GO:0001840 neural plate development(GO:0001840)
0.0 0.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.9 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 0.2 GO:0031114 regulation of microtubule depolymerization(GO:0031114)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 0.5 GO:0031417 NatC complex(GO:0031417)
0.1 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.4 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 1.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.2 1.3 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.8 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 2.3 GO:0008483 transaminase activity(GO:0008483)
0.1 1.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.0 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.6 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 1.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 2.4 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.2 GO:0008061 chitin binding(GO:0008061)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes