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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxb4a

Z-value: 0.44

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Transcription factors associated with hoxb4a

Gene Symbol Gene ID Gene Info
hoxb4a
ENSDARG00000013533 homeobox B4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb4adr11_v1_chr3_+_23710839_23710839-0.331.1e-03Click!

Activity profile of hoxb4a motif

Sorted Z-values of hoxb4a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_23937262 4.49 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr24_+_32472155 3.56 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr25_-_13842618 3.14 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr21_+_20901505 3.08 ENSDART00000132741
c7b
complement component 7b
chr20_-_29420713 3.03 ENSDART00000147464
ryr3
ryanodine receptor 3
chr12_+_9703172 2.88 ENSDART00000091489
ppp1r9bb
protein phosphatase 1, regulatory subunit 9Bb
chr17_+_19626479 2.85 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr21_-_24632778 2.64 ENSDART00000132533
ENSDART00000058370
arhgap32b
Rho GTPase activating protein 32b
chr18_-_42172101 2.57 ENSDART00000124211
cntn5
contactin 5
chr7_-_52842007 2.50 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr2_+_27010439 2.23 ENSDART00000030547
cdh7a
cadherin 7a
chr9_-_3653259 1.95 ENSDART00000140425
ENSDART00000025332
gad1a
glutamate decarboxylase 1a
chr7_-_41964877 1.83 ENSDART00000092351
ENSDART00000193395
ENSDART00000187947
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr5_-_18446483 1.80 ENSDART00000180027
si:dkey-215k6.1
si:dkey-215k6.1
chr25_-_4482449 1.79 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr3_-_52644737 1.70 ENSDART00000126180
si:dkey-210j14.3
si:dkey-210j14.3
chr18_-_12957451 1.57 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr13_+_36622100 1.53 ENSDART00000133198
si:ch211-67f24.7
si:ch211-67f24.7
chr11_-_13341483 1.53 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr23_-_33038423 1.49 ENSDART00000180539
plxna2
plexin A2
chr2_-_36818132 1.47 ENSDART00000110447
slitrk3b
SLIT and NTRK-like family, member 3b
chr12_+_28854963 1.46 ENSDART00000153227
nfe2l1b
nuclear factor, erythroid 2-like 1b
chr19_+_14059349 1.45 ENSDART00000166230
tpbga
trophoblast glycoprotein a
chr10_-_26744131 1.44 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fgf13b
fibroblast growth factor 13b
chr17_-_8727699 1.34 ENSDART00000049236
ENSDART00000149505
ENSDART00000148619
ENSDART00000149668
ENSDART00000148827
ctbp2a
C-terminal binding protein 2a
chr16_-_32672883 1.29 ENSDART00000124515
ENSDART00000190920
ENSDART00000188776
pnisr
PNN-interacting serine/arginine-rich protein
chr18_-_14836600 1.20 ENSDART00000045232
mtss1la
metastasis suppressor 1-like a
chr11_-_13341051 1.15 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr6_+_18367388 1.14 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr23_-_3721444 1.12 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr13_+_30912117 1.08 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr12_-_26430507 1.04 ENSDART00000153214
synpo2lb
synaptopodin 2-like b
chr2_-_54039293 1.04 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr6_-_29105727 1.01 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr18_+_6126506 0.98 ENSDART00000125725
si:ch1073-390k14.1
si:ch1073-390k14.1
chr8_+_21406769 0.95 ENSDART00000135766
si:dkey-163f12.6
si:dkey-163f12.6
chr2_+_37480669 0.92 ENSDART00000029801
sppl2
signal peptide peptidase-like 2
chr24_+_26402110 0.92 ENSDART00000133684
si:ch211-230g15.5
si:ch211-230g15.5
chr1_-_46981134 0.90 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr9_-_15789526 0.80 ENSDART00000141318
si:dkey-103d23.3
si:dkey-103d23.3
chr18_-_14836862 0.79 ENSDART00000124843
mtss1la
metastasis suppressor 1-like a
chr16_-_18960613 0.72 ENSDART00000183197
fhod3b
formin homology 2 domain containing 3b
chr11_+_40530748 0.71 ENSDART00000173239
mmel1
membrane metallo-endopeptidase-like 1
chr12_+_28854410 0.68 ENSDART00000152991
nfe2l1b
nuclear factor, erythroid 2-like 1b
chr13_+_30912385 0.64 ENSDART00000182642
drgx
dorsal root ganglia homeobox
chr14_-_30876708 0.64 ENSDART00000147597
ubl3b
ubiquitin-like 3b
chr20_-_32188897 0.61 ENSDART00000133887
si:ch211-51a19.5
si:ch211-51a19.5
chr1_+_11881559 0.58 ENSDART00000166981
snx8b
sorting nexin 8b
chr2_-_57473980 0.50 ENSDART00000149353
ENSDART00000150034
pias4b
protein inhibitor of activated STAT, 4b
chr17_-_23241393 0.50 ENSDART00000190697
AL935174.4

chr21_+_22423286 0.47 ENSDART00000133190
capslb
calcyphosine-like b
chr9_+_45605410 0.46 ENSDART00000136444
ENSDART00000007189
ENSDART00000158713
ENSDART00000182671
traf3ip1
TNF receptor-associated factor 3 interacting protein 1
chr15_+_25489406 0.43 ENSDART00000162482
zgc:152863
zgc:152863
chr12_-_20616160 0.42 ENSDART00000105362
snx11
sorting nexin 11
chr13_-_33207367 0.41 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
trip11
thyroid hormone receptor interactor 11
chr6_-_28345002 0.41 ENSDART00000158955
si:busm1-105l16.2
si:busm1-105l16.2
chr4_+_7391110 0.37 ENSDART00000160708
ENSDART00000187823
tnni4a
troponin I4a
chr6_-_57635577 0.36 ENSDART00000168708
cbfa2t2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr24_-_26460853 0.29 ENSDART00000078628
slc7a14b
solute carrier family 7, member 14b
chr2_+_44972720 0.25 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr18_-_25401002 0.21 ENSDART00000055567
gnrhr4
gonadotropin releasing hormone receptor 4
chr19_-_10425140 0.21 ENSDART00000145319
si:ch211-171h4.3
si:ch211-171h4.3
chr10_+_36026576 0.19 ENSDART00000193786
hmgb1a
high mobility group box 1a
chr15_-_26552652 0.19 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr4_-_17257435 0.19 ENSDART00000131973
lrmp
lymphoid-restricted membrane protein
chr20_+_51478939 0.19 ENSDART00000149758
tlr5a
toll-like receptor 5a
chr4_+_12340655 0.18 ENSDART00000168487
pimr214
Pim proto-oncogene, serine/threonine kinase, related 214
chr11_+_13223625 0.16 ENSDART00000161275
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr1_+_1712140 0.12 ENSDART00000081047
atp1a1a.1
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1
chr14_-_30876299 0.11 ENSDART00000180305
ubl3b
ubiquitin-like 3b
chr7_-_6268373 0.10 ENSDART00000183990
si:ch211-220f21.2
si:ch211-220f21.2
chr10_-_15910974 0.09 ENSDART00000148169
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr3_-_51109286 0.09 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr5_-_64103863 0.09 ENSDART00000135014
ENSDART00000083684
pappab
pregnancy-associated plasma protein A, pappalysin 1b
chr9_+_16449398 0.04 ENSDART00000006787
epha3
eph receptor A3
chr25_+_5604512 0.04 ENSDART00000042781
plxnb2b
plexin b2b
chr23_+_3721042 0.01 ENSDART00000143323
smim29
small integral membrane protein 29

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb4a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0003403 optic vesicle formation(GO:0003403)
0.4 1.5 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.3 1.8 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.2 1.1 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 1.3 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.2 0.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 1.8 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 3.1 GO:0019835 cytolysis(GO:0019835)
0.1 1.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 2.0 GO:0097178 ruffle assembly(GO:0097178)
0.1 2.5 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 2.2 GO:0060034 notochord cell differentiation(GO:0060034)
0.1 3.0 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 0.5 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.1 0.2 GO:0035046 pronuclear migration(GO:0035046)
0.0 1.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 3.1 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 1.0 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.2 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 1.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 2.1 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 2.9 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.9 GO:0060037 pharyngeal system development(GO:0060037)
0.0 3.6 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.0 1.6 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.0 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 2.5 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.4 2.6 GO:0001650 fibrillar center(GO:0001650)
0.2 0.9 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 3.1 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.4 GO:0030426 filopodium(GO:0030175) growth cone(GO:0030426)
0.0 2.5 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 1.1 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 1.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 2.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.2 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0 1.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 2.2 GO:0045296 cadherin binding(GO:0045296)
0.0 1.3 GO:0051287 NAD binding(GO:0051287)
0.0 1.0 GO:0071949 FAD binding(GO:0071949)
0.0 0.4 GO:0031267 small GTPase binding(GO:0031267)
0.0 2.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.6 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis