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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxb5a+hoxb5b

Z-value: 0.62

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Transcription factors associated with hoxb5a+hoxb5b

Gene Symbol Gene ID Gene Info
hoxb5a
ENSDARG00000013057 homeobox B5a
hoxb5b
ENSDARG00000054030 homeobox B5b
hoxb5b
ENSDARG00000113174 homeobox B5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb5bdr11_v1_chr12_+_27129659_271296590.431.9e-05Click!
hoxb5adr11_v1_chr3_+_23707691_237076910.187.7e-02Click!

Activity profile of hoxb5a+hoxb5b motif

Sorted Z-values of hoxb5a+hoxb5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_22656477 5.98 ENSDART00000009337
ENSDART00000133322
eno1a
enolase 1a, (alpha)
chr1_+_12766351 5.69 ENSDART00000165785
pcdh10a
protocadherin 10a
chr16_-_27640995 5.58 ENSDART00000019658
nacad
NAC alpha domain containing
chr9_-_12034444 5.37 ENSDART00000038651
znf804a
zinc finger protein 804A
chr15_-_12500938 5.11 ENSDART00000159627
scn4ba
sodium channel, voltage-gated, type IV, beta a
chr15_-_12319065 4.90 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr6_-_52156427 4.73 ENSDART00000082821
rims4
regulating synaptic membrane exocytosis 4
chr2_+_44426609 4.52 ENSDART00000112711
ENSDART00000154188
kcnab1b
potassium voltage-gated channel, shaker-related subfamily, beta member 1 b
chr7_+_30867008 4.44 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr22_+_11857356 4.42 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr19_+_46259619 4.10 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr20_-_29418620 4.09 ENSDART00000172634
ryr3
ryanodine receptor 3
chr11_-_44030962 4.03 ENSDART00000171910
FP016005.1

chr7_+_33314925 4.03 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr14_-_25078569 3.99 ENSDART00000172802
ENSDART00000173345
ENSDART00000135004
matr3l1.1
matrin 3-like 1.1
chr12_+_7865470 3.90 ENSDART00000161683
BX548028.1

chr4_+_3482312 3.77 ENSDART00000109044
grm8a
glutamate receptor, metabotropic 8a
chr3_+_28831450 3.74 ENSDART00000055422
flr
fleer
chr8_-_15398760 3.69 ENSDART00000162011
agbl4
ATP/GTP binding protein-like 4
chr22_-_15385442 3.66 ENSDART00000090975
tmem264
transmembrane protein 264
chr16_-_9980402 3.54 ENSDART00000066372
id4
inhibitor of DNA binding 4
chr19_-_8600383 3.46 ENSDART00000081546
trim46b
tripartite motif containing 46b
chr6_+_54888493 3.44 ENSDART00000113331
nav1b
neuron navigator 1b
chr1_-_8192418 3.02 ENSDART00000136654
grapb
GRB2-related adaptor protein b
chr9_+_6082793 2.92 ENSDART00000192045
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr5_-_26284276 2.71 ENSDART00000148608
arvcfb
ARVCF, delta catenin family member b
chr23_-_637347 2.69 ENSDART00000132175
l1camb
L1 cell adhesion molecule, paralog b
chr1_-_46981134 2.54 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr2_+_24317465 2.48 ENSDART00000139339
ENSDART00000136284
mrpl34
mitochondrial ribosomal protein L34
chr6_-_15603675 2.33 ENSDART00000143502
lrrfip1b
leucine rich repeat (in FLII) interacting protein 1b
chr14_-_31893996 2.22 ENSDART00000173222
gpr101
G protein-coupled receptor 101
chr2_-_42065069 2.19 ENSDART00000140188
cspp1b
centrosome and spindle pole associated protein 1b
chr5_-_41142467 2.09 ENSDART00000129415
zfr
zinc finger RNA binding protein
chr23_+_39331216 2.08 ENSDART00000160957
kcng1
potassium voltage-gated channel, subfamily G, member 1
chr18_+_33580391 2.04 ENSDART00000189300
si:dkey-47k20.4
si:dkey-47k20.4
chr10_+_2684958 1.82 ENSDART00000112019
setd9
SET domain containing 9
chr3_-_5413018 1.76 ENSDART00000063138
vmo1a
vitelline membrane outer layer 1 homolog a
chr7_+_36035432 1.72 ENSDART00000179004
irx3a
iroquois homeobox 3a
chr6_-_18992896 1.71 ENSDART00000170228
sept9b
septin 9b
chr24_-_29822913 1.68 ENSDART00000160929
aglb
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr1_-_49498116 1.63 ENSDART00000137357
zgc:175214
zgc:175214
chr15_-_25099679 1.62 ENSDART00000154628
rflnb
refilin B
chr7_-_72426484 1.60 ENSDART00000190063
rph3ab
rabphilin 3A homolog (mouse), b
chr22_+_696931 1.42 ENSDART00000149712
ENSDART00000009756
gpr37l1a
G protein-coupled receptor 37 like 1a
chr11_-_2297832 1.41 ENSDART00000158266
znf740a
zinc finger protein 740a
chr4_-_59094319 1.39 ENSDART00000162560
si:dkey-28i19.1
si:dkey-28i19.1
chr8_+_25962833 1.38 ENSDART00000086583
si:dkey-72l14.4
si:dkey-72l14.4
chr17_+_49081828 1.34 ENSDART00000156492
tiam2a
T cell lymphoma invasion and metastasis 2a
chr17_-_39772999 1.28 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr22_-_7461603 1.26 ENSDART00000170630
BX511034.6

chr6_-_19340889 1.24 ENSDART00000181407
mif4gda
MIF4G domain containing a
chr10_+_35439952 1.14 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr11_+_24957858 0.95 ENSDART00000145647
sulf2a
sulfatase 2a
chr5_+_59392183 0.94 ENSDART00000082983
ENSDART00000180882
clip2
CAP-GLY domain containing linker protein 2
chr14_+_33723309 0.89 ENSDART00000132488
apln
apelin
chr22_+_1680628 0.81 ENSDART00000166672
si:dkey-1b17.6
si:dkey-1b17.6
chr7_+_56889879 0.80 ENSDART00000039810
myo9aa
myosin IXAa
chr22_+_12477996 0.75 ENSDART00000177704
CR847870.3

chr22_+_17536989 0.75 ENSDART00000149531
hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr18_-_14337065 0.73 ENSDART00000135703
hsbp1b
heat shock factor binding protein 1b
chr9_+_30475563 0.72 ENSDART00000133118
gja5a
gap junction protein, alpha 5a
chr19_-_27827744 0.67 ENSDART00000181620
papd7
PAP associated domain containing 7
chr19_-_30904590 0.66 ENSDART00000137633
si:ch211-194e15.5
si:ch211-194e15.5
chr23_+_3513201 0.63 ENSDART00000092258
spata2
spermatogenesis associated 2
chr2_-_3038904 0.60 ENSDART00000186795
guk1a
guanylate kinase 1a
chr15_-_35031523 0.59 ENSDART00000154848
si:ch211-272b8.6
si:ch211-272b8.6
chr20_+_33708318 0.54 ENSDART00000135845
ak9
adenylate kinase 9
chr14_+_8476769 0.52 ENSDART00000131773
dnajc4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr13_-_11986754 0.50 ENSDART00000164214
npm3
nucleophosmin/nucleoplasmin, 3
chr12_+_17436904 0.50 ENSDART00000079130
atad1b
ATPase family, AAA domain containing 1b
chr9_+_16854121 0.43 ENSDART00000110866
cln5
CLN5, intracellular trafficking protein
chr20_+_51730658 0.31 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr9_+_48755638 0.29 ENSDART00000047401
abcb11a
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr8_+_247163 0.27 ENSDART00000122378
cep120
centrosomal protein 120
chr5_-_16791223 0.25 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr2_+_22823952 0.22 ENSDART00000147935
aire
autoimmune regulator
chr20_+_48543492 0.20 ENSDART00000175480
LO018254.1

chr1_+_42224769 0.19 ENSDART00000177496
ENSDART00000184778
ENSDART00000110860
ctnna2
catenin (cadherin-associated protein), alpha 2
chr15_-_41408148 0.18 ENSDART00000133459
CR854897.1

chr15_-_684911 0.18 ENSDART00000161685
zgc:171901
zgc:171901
chr16_+_16826504 0.17 ENSDART00000108691
kcnj14
potassium inwardly-rectifying channel, subfamily J, member 14
chr4_-_76154252 0.13 ENSDART00000161269
BX957252.1

chr4_+_41789497 0.11 ENSDART00000126634
si:dkey-237m9.2
si:dkey-237m9.2
chr3_+_39579393 0.10 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr20_+_53181017 0.10 ENSDART00000189692
ENSDART00000177109
FIG4
FIG4 phosphoinositide 5-phosphatase
chr11_-_6070192 0.07 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr3_+_54776475 0.06 ENSDART00000142710
si:ch211-74m13.1
si:ch211-74m13.1
chr4_+_77966055 0.06 ENSDART00000174203
ENSDART00000130100
ENSDART00000080665
ENSDART00000174317
ENSDART00000190123
zgc:113921
zgc:113921
chr9_+_51147380 0.05 ENSDART00000003913
ifih1
interferon induced with helicase C domain 1
chr4_+_42295479 0.02 ENSDART00000162279
znf1118
zinc finger protein 1118
chr23_+_22293682 0.00 ENSDART00000187304
CR354612.1

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb5a+hoxb5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.7 6.0 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.7 2.1 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.5 1.6 GO:1900157 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.5 3.7 GO:0036372 opsin transport(GO:0036372)
0.4 4.1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.3 5.7 GO:0097324 melanocyte migration(GO:0097324)
0.3 3.5 GO:0003307 regulation of Wnt signaling pathway involved in heart development(GO:0003307)
0.2 4.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 0.7 GO:0010610 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.2 0.8 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.1 0.9 GO:0090134 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.1 0.5 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202) dGDP metabolic process(GO:0046066)
0.1 0.6 GO:0010939 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544)
0.1 2.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 1.7 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 2.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 4.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 3.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.2 GO:0002513 tolerance induction(GO:0002507) tolerance induction to self antigen(GO:0002513)
0.1 1.1 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 4.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 1.4 GO:0032418 lysosome localization(GO:0032418)
0.1 2.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.1 0.9 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 5.6 GO:0006612 protein targeting to membrane(GO:0006612)
0.1 0.3 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 2.5 GO:0060037 pharyngeal system development(GO:0060037)
0.1 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 2.2 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.1 3.4 GO:0001764 neuron migration(GO:0001764)
0.0 0.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 1.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 1.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 1.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.7 GO:0014029 neural crest formation(GO:0014029)
0.0 1.7 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 1.7 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.5 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.9 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 3.9 GO:0007265 Ras protein signal transduction(GO:0007265)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.7 6.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 3.7 GO:0005879 axonemal microtubule(GO:0005879)
0.6 4.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.5 3.4 GO:0043194 axon initial segment(GO:0043194)
0.3 4.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.7 GO:0044295 axonal growth cone(GO:0044295)
0.2 4.7 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.1 2.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 2.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.7 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 4.4 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.6 GO:0032432 actin filament bundle(GO:0032432)
0.0 2.2 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0005795 Golgi stack(GO:0005795)
0.0 0.8 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.8 4.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.7 6.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 3.8 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.4 1.7 GO:0004134 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.4 1.6 GO:0031005 filamin binding(GO:0031005)
0.4 2.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.3 0.9 GO:0031704 apelin receptor binding(GO:0031704)
0.2 4.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 4.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 4.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.2 GO:0008494 translation activator activity(GO:0008494)
0.1 0.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 4.4 GO:0019003 GDP binding(GO:0019003)
0.1 4.7 GO:0044325 ion channel binding(GO:0044325)
0.1 0.3 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.7 GO:0005243 gap junction channel activity(GO:0005243)
0.0 4.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 2.9 GO:0045296 cadherin binding(GO:0045296)
0.0 1.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels