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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hoxb7a

Z-value: 0.37

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Transcription factors associated with hoxb7a

Gene Symbol Gene ID Gene Info
hoxb7a
ENSDARG00000056030 homeobox B7a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb7adr11_v1_chr3_+_23691847_236918470.405.3e-05Click!

Activity profile of hoxb7a motif

Sorted Z-values of hoxb7a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_7048245 3.59 ENSDART00000001649
actn3b
actinin alpha 3b
chr25_+_14087045 2.82 ENSDART00000155770
actc1c
actin, alpha, cardiac muscle 1c
chr13_+_10945337 2.64 ENSDART00000091845
abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr12_-_35830625 2.24 ENSDART00000180028
CU459056.1

chr2_-_1486023 2.21 ENSDART00000113774
si:ch211-188c16.1
si:ch211-188c16.1
chr13_-_10945288 2.20 ENSDART00000114315
ENSDART00000164667
ENSDART00000159482
abcg8
ATP-binding cassette, sub-family G (WHITE), member 8
chr7_+_69019851 2.07 ENSDART00000162891
CABZ01057488.1

chr10_-_21362320 1.94 ENSDART00000189789
avd
avidin
chr18_+_45781516 1.93 ENSDART00000168840
rpl35a
ribosomal protein L35a
chr24_+_16985181 1.91 ENSDART00000135580
eif2s3
eukaryotic translation initiation factor 2, subunit 3 gamma
chr10_-_21362071 1.86 ENSDART00000125167
avd
avidin
chr18_+_45781115 1.82 ENSDART00000151699
ENSDART00000179887
rpl35a
ribosomal protein L35a
chr12_+_20641471 1.79 ENSDART00000133654
calcoco2
calcium binding and coiled-coil domain 2
chr12_+_20641102 1.73 ENSDART00000152964
calcoco2
calcium binding and coiled-coil domain 2
chr17_+_16090436 1.55 ENSDART00000136059
ENSDART00000138734
znf395a
zinc finger protein 395a
chr5_+_34623107 1.54 ENSDART00000184126
enc1
ectodermal-neural cortex 1
chr23_+_4709607 1.50 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
raf1a
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr10_-_13343831 1.49 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr13_-_12602920 1.44 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr10_+_11261576 1.43 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr4_-_9891874 1.37 ENSDART00000067193
adm2a
adrenomedullin 2a
chr7_+_21272833 1.33 ENSDART00000052942
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr6_-_43677125 1.30 ENSDART00000150128
foxp1b
forkhead box P1b
chr17_+_20589553 1.29 ENSDART00000154447
si:ch73-288o11.4
si:ch73-288o11.4
chr17_+_30369396 1.25 ENSDART00000076611
greb1
growth regulation by estrogen in breast cancer 1
chr1_+_19303241 1.21 ENSDART00000129970
si:dkeyp-118a3.2
si:dkeyp-118a3.2
chr5_+_71802014 1.21 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr4_+_77971104 1.21 ENSDART00000188609
zgc:113921
zgc:113921
chr18_+_14619544 1.18 ENSDART00000010821
utp4
UTP4, small subunit processome component
chr5_-_30620625 1.17 ENSDART00000098273
tcnl
transcobalamin like
chr25_-_35599887 1.14 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr12_+_47698356 1.11 ENSDART00000112010
lzts2b
leucine zipper, putative tumor suppressor 2b
chr22_-_22301672 1.04 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr22_-_27296889 0.95 ENSDART00000155724
si:dkey-208m12.3
si:dkey-208m12.3
chr12_+_48803098 0.92 ENSDART00000074768
ppifb
peptidylprolyl isomerase Fb
chr9_-_27398369 0.91 ENSDART00000186499
tex30
testis expressed 30
chr12_+_16168342 0.90 ENSDART00000079326
ENSDART00000170024
lrp2b
low density lipoprotein receptor-related protein 2b
chr4_-_779796 0.88 ENSDART00000128743
tmem214
transmembrane protein 214
chr25_+_13620555 0.88 ENSDART00000163642
si:ch211-172l8.4
si:ch211-172l8.4
chr20_-_9095105 0.84 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr6_+_24398907 0.84 ENSDART00000167482
tgfbr3
transforming growth factor, beta receptor III
chr24_+_13316737 0.83 ENSDART00000191658
SBSPON
somatomedin B and thrombospondin type 1 domain containing
chr8_-_12867128 0.83 ENSDART00000142201
slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr18_-_15551360 0.81 ENSDART00000159915
ENSDART00000172690
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr9_+_1139378 0.80 ENSDART00000170033
slc15a1a
solute carrier family 15 (oligopeptide transporter), member 1a
chr11_+_705727 0.79 ENSDART00000165366
timp4.2
TIMP metallopeptidase inhibitor 4, tandem duplicate 2
chr10_-_31015535 0.78 ENSDART00000146116
panx3
pannexin 3
chr13_-_2440622 0.77 ENSDART00000102767
ENSDART00000172616
fbxo9
F-box protein 9
chr3_-_50443607 0.74 ENSDART00000074036
rcvrna
recoverin a
chr20_-_46128590 0.73 ENSDART00000123744
taar1b
trace amine associated receptor 1b
chr2_+_105748 0.71 ENSDART00000169601
CABZ01098670.1

chr17_+_51682429 0.70 ENSDART00000004379
nol10
nucleolar protein 10
chr15_+_28318005 0.70 ENSDART00000175860
myo1cb
myosin Ic, paralog b
chr23_+_28809002 0.70 ENSDART00000134121
ENSDART00000183661
pex14
peroxisomal biogenesis factor 14
chr24_+_7800486 0.69 ENSDART00000145504
ptprh
protein tyrosine phosphatase, receptor type, h
chr6_+_7414215 0.65 ENSDART00000049339
sox21a
SRY (sex determining region Y)-box 21a
chr4_-_13548806 0.64 ENSDART00000067155
il22
interleukin 22
chr13_-_5252559 0.61 ENSDART00000181652
si:dkey-78p8.1
si:dkey-78p8.1
chr12_-_4243268 0.58 ENSDART00000131275
zgc:92313
zgc:92313
chr11_-_45141309 0.58 ENSDART00000181736
cant1b
calcium activated nucleotidase 1b
chr8_+_25034544 0.57 ENSDART00000123300
ngrn
neugrin, neurite outgrowth associated
chr22_-_22301929 0.49 ENSDART00000142027
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr4_+_16715267 0.48 ENSDART00000143849
pkp2
plakophilin 2
chr17_+_31914877 0.47 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr15_-_40246396 0.47 ENSDART00000063777
kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr23_+_39461989 0.46 ENSDART00000184761
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr6_+_9898683 0.41 ENSDART00000005573
tmem237b
transmembrane protein 237b
chr8_+_7801060 0.40 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr4_+_70151160 0.39 ENSDART00000111816
si:dkey-3h2.4
si:dkey-3h2.4
chr20_+_15600167 0.36 ENSDART00000171991
faslg
Fas ligand (TNF superfamily, member 6)
chr2_-_36500347 0.36 ENSDART00000110528
BX901889.1

chr23_+_39462208 0.34 ENSDART00000136707
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr11_-_2838699 0.34 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr3_-_36602069 0.33 ENSDART00000165414
rrn3
RRN3 homolog, RNA polymerase I transcription factor
chr23_-_36857964 0.33 ENSDART00000188822
ENSDART00000134061
ENSDART00000093061
hipk1a
homeodomain interacting protein kinase 1a
chr19_+_5480327 0.31 ENSDART00000148794
jupb
junction plakoglobin b
chr25_-_3058687 0.28 ENSDART00000149117
ENSDART00000137950
si:ch1073-296i8.2
si:ch1073-296i8.2
chr8_-_12867434 0.27 ENSDART00000081657
slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr4_-_2545310 0.26 ENSDART00000150619
ENSDART00000140760
e2f7
E2F transcription factor 7
chr9_+_24008879 0.24 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
mlphb
melanophilin b
chr5_-_16218777 0.24 ENSDART00000141698
kremen1
kringle containing transmembrane protein 1
chr17_+_25481466 0.20 ENSDART00000139451
aim1a
crystallin beta-gamma domain containing 1a
chr17_+_44697604 0.18 ENSDART00000156625
pgfb
placental growth factor b
chr21_+_8276989 0.18 ENSDART00000028265
nr5a1b
nuclear receptor subfamily 5, group A, member 1b
chr7_+_7696665 0.15 ENSDART00000091099
ino80b
INO80 complex subunit B
chr18_+_2228737 0.14 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr5_+_56023186 0.12 ENSDART00000156230
fzd9a
frizzled class receptor 9a
chr24_-_36680261 0.08 ENSDART00000059507
ccr10
chemokine (C-C motif) receptor 10
chr3_-_31079186 0.07 ENSDART00000145636
ENSDART00000140569
ELOB (1 of many)
elob
elongin B
elongin B
chr2_+_38373272 0.05 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr15_-_43284021 0.04 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr8_-_13046089 0.04 ENSDART00000137784
si:dkey-208b23.5
si:dkey-208b23.5

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb7a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.3 0.8 GO:0019417 sulfur oxidation(GO:0019417)
0.2 4.8 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 1.1 GO:0051013 microtubule severing(GO:0051013)
0.1 0.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.5 GO:0051876 pigment granule dispersal(GO:0051876)
0.1 0.8 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 0.8 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 1.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.8 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.8 GO:0002934 desmosome organization(GO:0002934)
0.1 0.9 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 0.7 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 0.7 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 1.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.3 GO:0032877 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.1 3.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.2 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.0 1.3 GO:0021983 pituitary gland development(GO:0021983)
0.0 2.2 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.4 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 0.8 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 1.4 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.2 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 1.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.0 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.3 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.8 GO:0007528 neuromuscular junction development(GO:0007528)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0033186 CAF-1 complex(GO:0033186)
0.4 1.9 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 0.7 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 3.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.9 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.5 GO:0014704 intercalated disc(GO:0014704)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 1.1 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.7 GO:0005902 microvillus(GO:0005902)
0.0 1.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.4 GO:0035869 ciliary transition zone(GO:0035869)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0009374 biotin binding(GO:0009374)
0.2 1.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.8 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 0.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.9 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.8 GO:0022829 wide pore channel activity(GO:0022829)
0.0 4.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.6 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.9 GO:0042562 hormone binding(GO:0042562)
0.0 1.5 GO:0019838 growth factor binding(GO:0019838)
0.0 0.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.7 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.2 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 1.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 5.7 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines