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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for ikzf2

Z-value: 1.02

Motif logo

Transcription factors associated with ikzf2

Gene Symbol Gene ID Gene Info
ENSDARG00000069111 IKAROS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IKZF2dr11_v1_chr9_-_40014339_400143390.752.2e-18Click!

Activity profile of ikzf2 motif

Sorted Z-values of ikzf2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_30921246 19.31 ENSDART00000076850
claudin i
chr3_+_39540014 13.54 ENSDART00000074848
zgc:165423
chr20_+_46040666 13.03 ENSDART00000060744
si:dkey-7c18.24
chr6_-_33075576 10.00 ENSDART00000154017
si:dkey-170g13.2
chr16_-_31976269 9.04 ENSDART00000139664
serine/threonine/tyrosine kinase 1
chr25_-_8602437 8.86 ENSDART00000171200
Rh family, C glycoprotein b
chr1_+_1689775 8.85 ENSDART00000048828
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4
chr18_-_17485419 8.28 ENSDART00000018764
forkhead box L1
chr12_-_8070969 7.89 ENSDART00000020995
transmembrane protein 26b
chr18_+_7591381 7.66 ENSDART00000136313
si:dkeyp-1h4.6
chr15_-_46779934 7.49 ENSDART00000085136
chloride channel 2c
chr21_+_11248448 7.24 ENSDART00000142431
AT-rich interaction domain 6
chr16_+_23397785 7.19 ENSDART00000148961
S100 calcium binding protein A10b
chr10_+_36662640 7.09 ENSDART00000063359
uncoupling protein 2
chr15_+_46356879 7.02 ENSDART00000154388
wu:fb18f06
chr16_+_23398369 6.87 ENSDART00000037694
S100 calcium binding protein A10b
chr15_-_33834577 6.36 ENSDART00000163354
matrix metallopeptidase 13b
chr12_+_17106117 6.28 ENSDART00000149990
actin, alpha 2, smooth muscle, aorta
chr9_+_45839260 5.82 ENSDART00000114814
twist2
chr12_-_15205087 5.74 ENSDART00000010068
sulfotransferase family 1, cytosolic sulfotransferase 6
chr18_+_19648275 5.72 ENSDART00000100569
SMAD family member 6b
chr13_-_21672131 5.68 ENSDART00000067537
ELOVL family member 6, elongation of long chain fatty acids like
chr1_+_9966384 5.47 ENSDART00000132607
si:dkeyp-75b4.8
chr6_-_8489810 5.44 ENSDART00000124643
RAS protein activator like 3
chr2_+_45191049 5.35 ENSDART00000165392
chemokine (C-C motif) ligand 20a, duplicate 3
chr8_-_23599096 5.27 ENSDART00000183096
solute carrier family 38, member 5b
chr4_+_18843015 5.16 ENSDART00000152086
ENSDART00000066977
ENSDART00000132567
BCL2 interacting killer
chr16_+_38201840 5.02 ENSDART00000044971
myosin IE, b
chr3_+_14611299 4.83 ENSDART00000140577
tetraspanin 35
chr11_-_21404358 4.81 ENSDART00000129062
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr20_+_16881883 4.81 ENSDART00000130107
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr4_+_76659013 4.66 ENSDART00000147908
ENSDART00000134229
membrane-spanning 4-domains, subfamily A, member 17A.5
chr12_+_23424108 4.64 ENSDART00000077732
BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a
chr18_+_48428713 4.61 ENSDART00000076861
Fli-1 proto-oncogene, ETS transcription factor a
chr20_-_5291012 4.59 ENSDART00000122892
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr11_+_10548171 4.58 ENSDART00000191497
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a
chr4_+_76775837 4.52 ENSDART00000174167
membrane-spanning 4-domains, subfamily A, member 17A.10
chr2_-_37465517 4.52 ENSDART00000139983
si:dkey-57k2.6
chr2_-_48196092 4.47 ENSDART00000139944
secondary ossification center associated regulator of chondrocyte maturation
chr18_+_44703343 4.36 ENSDART00000131510
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, like
chr5_-_41049690 4.34 ENSDART00000174936
ENSDART00000135030
PDZ domain containing 2
chr18_-_7481036 4.26 ENSDART00000101292
si:dkey-238c7.16
chr13_-_31647323 4.19 ENSDART00000135381
SIX homeobox 4a
chr16_+_19732543 4.19 ENSDART00000149901
ENSDART00000052927
twist family bHLH transcription factor 1b
chr22_-_28650442 4.07 ENSDART00000019846
collagen, type VIII, alpha 1b
chr4_+_7508316 3.96 ENSDART00000170924
ENSDART00000170933
ENSDART00000164985
ENSDART00000167571
ENSDART00000158843
ENSDART00000158999
troponin T2e, cardiac
chr24_-_25166720 3.87 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr3_-_20091964 3.83 ENSDART00000029386
ENSDART00000020253
ENSDART00000124326
solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr21_-_26495700 3.80 ENSDART00000109379
CD248 molecule, endosialin b
chr16_-_26140768 3.77 ENSDART00000143960
CD79a molecule, immunoglobulin-associated alpha
chr18_+_8346920 3.76 ENSDART00000083421
carnitine palmitoyltransferase 1B (muscle)
chr9_+_53276356 3.76 ENSDART00000003310
SRY (sex determining region Y)-box 21b
chr16_+_29492749 3.75 ENSDART00000179680
cathepsin K
chr14_-_34605607 3.64 ENSDART00000191608
actin filament associated protein 1-like 1a
chr7_-_35432901 3.54 ENSDART00000026712
matrix metallopeptidase 2
chr20_+_38276690 3.52 ENSDART00000061437
chemokine (C-C motif) ligand 38, duplicate 6
chr5_-_23574234 3.50 ENSDART00000002453
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr7_+_65673885 3.48 ENSDART00000169182
parvin, alpha b
chr4_-_4261673 3.46 ENSDART00000150694
CD9 molecule b
chr3_-_19495814 3.41 ENSDART00000162248

chr14_-_3381303 3.39 ENSDART00000171601
im:7150988
chr3_-_44059902 3.39 ENSDART00000158485
ENSDART00000159088
ENSDART00000165628
interleukin 4 receptor, tandem duplicate 1
chr4_-_4250317 3.36 ENSDART00000103316
CD9 molecule b
chr24_+_39990695 3.33 ENSDART00000040281

chr21_+_25187210 3.31 ENSDART00000101147
ENSDART00000167528
si:dkey-183i3.5
chr6_+_23809163 3.30 ENSDART00000170402
glutamate-ammonia ligase (glutamine synthase) b
chr20_+_29436601 3.30 ENSDART00000136804
formin 1
chr12_-_4841018 3.30 ENSDART00000166500
zgc:163073
chr23_+_45027263 3.29 ENSDART00000058364
high mobility group box 2b
chr16_+_13427967 3.27 ENSDART00000038196
zgc:101640
chr19_-_25519612 3.27 ENSDART00000133150
si:dkey-202e17.1
chr6_-_40899618 3.24 ENSDART00000153949
ENSDART00000021969
zgc:172271
chr20_+_26702377 3.14 ENSDART00000077753
forkhead box C1b
chr14_-_32876280 3.11 ENSDART00000173168
si:rp71-46j2.7
chr8_+_20880848 3.07 ENSDART00000134488
ENSDART00000138605
ENSDART00000192234
si:ch73-196i15.3
chr16_-_31756859 3.06 ENSDART00000149170
ENSDART00000126617
ENSDART00000182722
protein tyrosine phosphatase, non-receptor type 6
chr12_+_22576404 3.06 ENSDART00000172053
capping protein (actin filament), gelsolin-like b
chr8_-_31062811 3.05 ENSDART00000142528
solute carrier family 20, member 1a
chr12_-_22379421 3.04 ENSDART00000187875
si:dkey-38p12.3
chr4_+_4232562 3.03 ENSDART00000177529
small lysine rich protein 1
chr9_+_14010823 3.02 ENSDART00000143837
si:ch211-67e16.3
chr21_-_38852860 3.02 ENSDART00000166101
toll-like receptor 22
chr1_-_24462544 2.99 ENSDART00000184421
ENSDART00000184987
ENSDART00000126950
SH3 domain containing 19
chr21_+_15346363 2.98 ENSDART00000134167
si:dkey-11o15.7
chr7_+_73801377 2.97 ENSDART00000184051
si:ch73-252p3.1
chr10_-_7785930 2.94 ENSDART00000043961
ENSDART00000111058
myeloid-specific peroxidase
chr3_+_32112004 2.93 ENSDART00000105272
zgc:173593
chr8_+_21254192 2.81 ENSDART00000167718
inositol 1,4,5-trisphosphate receptor, type 3
chr7_+_2228276 2.81 ENSDART00000064294
si:dkey-187j14.4
chr11_-_11910225 2.79 ENSDART00000159922
si:ch211-69b7.6
chr23_+_20408227 2.76 ENSDART00000134727
si:rp71-17i16.4
chr7_-_51368681 2.75 ENSDART00000146385
Rho GTPase activating protein 36
chr9_-_8454060 2.74 ENSDART00000110158
insulin receptor substrate 2b
chr10_+_9159279 2.67 ENSDART00000064968
RasGEF domain family, member 1Bb
chr21_+_5800306 2.61 ENSDART00000020603
cyclin G2
chr18_+_48423973 2.58 ENSDART00000184233
ENSDART00000147074
Fli-1 proto-oncogene, ETS transcription factor a
chr16_-_22930925 2.55 ENSDART00000133819
si:dkey-246i14.3
chr16_+_29492937 2.54 ENSDART00000011497
cathepsin K
chr11_-_21404044 2.51 ENSDART00000080116
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr13_-_8446341 2.48 ENSDART00000080382
endothelial PAS domain protein 1b
chr3_+_37707432 2.45 ENSDART00000151236
mitogen-activated protein kinase kinase kinase 14a
chr21_-_21781158 2.43 ENSDART00000113734
chordin-like 2
chr24_+_9744012 2.42 ENSDART00000129656
transmembrane protein 108
chr21_+_27189490 2.41 ENSDART00000125349
BCL2 associated agonist of cell death a
chr2_-_43151358 2.40 ENSDART00000061170
ENSDART00000056161
finTRIM family, member 15
chr25_-_29074064 2.33 ENSDART00000165603
AT rich interactive domain 3B (BRIGHT-like)
chr7_+_44593756 2.31 ENSDART00000125365
si:ch211-189a15.5
chr16_-_38333976 2.31 ENSDART00000031895
CDC42 small effector 1
chr11_-_25418856 2.31 ENSDART00000013714
GATA binding protein 1a
chr24_+_19518570 2.30 ENSDART00000056081
sulfatase 1
chr16_-_22989262 2.29 ENSDART00000191008
si:dkey-246i14.3
chr3_+_22377312 2.29 ENSDART00000155597
Rho GTPase activating protein 27, like
chr14_-_34605804 2.27 ENSDART00000144547
actin filament associated protein 1-like 1a
chr11_+_20899029 2.27 ENSDART00000163029
zgc:162182
chr6_+_35362225 2.26 ENSDART00000133783
ENSDART00000102483
regulator of G protein signaling 4
chr25_-_18470695 2.25 ENSDART00000034377
carboxypeptidase A5
chr8_-_30242706 2.24 ENSDART00000139864
ENSDART00000143809
zgc:162939
chr12_+_38929663 2.24 ENSDART00000156334
si:dkey-239b22.1
chr11_+_25139495 2.21 ENSDART00000168368
si:ch211-25d12.7
chr19_+_11217279 2.20 ENSDART00000181859
si:ch73-109i22.2
chr5_-_34609337 2.18 ENSDART00000145792
hexosaminidase B (beta polypeptide)
chr5_-_28968964 2.17 ENSDART00000184936
ENSDART00000016628
family with sequence similarity 129, member Bb
chr12_+_27232173 2.16 ENSDART00000193714
transmembrane protein 106A
chr20_-_26937453 2.16 ENSDART00000139756
finTRIM family, member 97
chr9_+_33417969 2.15 ENSDART00000024795
G protein-coupled receptor 34b
chr12_+_38878830 2.14 ENSDART00000156926
si:ch211-39f2.3
chr8_+_10304981 2.09 ENSDART00000160766
Pim-1 proto-oncogene, serine/threonine kinase
chr7_-_5125799 2.08 ENSDART00000173390
leukotriene B4 receptor 2a
chr17_+_38255105 2.07 ENSDART00000005296
NK2 transcription factor related, locus 9 (Drosophila)
chr16_-_9980402 2.07 ENSDART00000066372
inhibitor of DNA binding 4
chr23_+_40133136 2.05 ENSDART00000157616
G protein signaling modulator 2, like
chr10_+_44692272 2.05 ENSDART00000157458
ubiquitin C
chr19_+_823945 2.04 ENSDART00000142287
protein phosphatase 1, regulatory subunit 18
chr24_-_25166416 2.04 ENSDART00000111552
ENSDART00000169495
pleckstrin homology-like domain, family B, member 2b
chr8_-_32805214 2.02 ENSDART00000131597
zgc:194839
chr13_+_16279890 1.98 ENSDART00000101775
ENSDART00000057948
annexin A11a
chr19_+_4892281 1.98 ENSDART00000150969
cyclin-dependent kinase 12
chr6_+_39360377 1.96 ENSDART00000028260
ENSDART00000151322
zgc:77517
chr5_+_20428838 1.94 ENSDART00000141118
transmembrane protein 119a
chr25_+_25464630 1.92 ENSDART00000150537
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr6_+_4160579 1.89 ENSDART00000105278
ENSDART00000187932
ENSDART00000111817
tripartite motif containing 25, like
chr3_-_32957702 1.89 ENSDART00000146586
caspase 6, apoptosis-related cysteine peptidase, like 1
chr12_+_34258139 1.89 ENSDART00000153127
suppressor of cytokine signaling 3b
chr23_+_40139765 1.89 ENSDART00000185376
G protein signaling modulator 2, like
chr22_-_17653143 1.87 ENSDART00000089171
histocompatibility (minor) HA-1 b
chr17_-_19626357 1.86 ENSDART00000011432
receptor accessory protein 3a
chr3_+_30980852 1.84 ENSDART00000028529
perforin 1.1
chr14_-_46198373 1.84 ENSDART00000031640
ENSDART00000132966
zgc:113425
chr19_-_27777228 1.84 ENSDART00000046166
adenylate cyclase 2b (brain)
chr14_+_30774515 1.82 ENSDART00000191666
atlastin 3
chr13_-_15994419 1.81 ENSDART00000079724
ENSDART00000042377
ENSDART00000046079
ENSDART00000050481
ENSDART00000016430
IKAROS family zinc finger 1 (Ikaros)
chr6_-_8580857 1.81 ENSDART00000138858
ENSDART00000041142
myosin, heavy chain 11a, smooth muscle
chr14_-_14566417 1.79 ENSDART00000159056
si:dkey-27i16.2
chr2_-_31634978 1.79 ENSDART00000135668
si:ch211-106h4.9
chr11_-_13126505 1.79 ENSDART00000158377
ELOVL fatty acid elongase 1b
chr24_-_26304386 1.78 ENSDART00000175416
otospiralin
chr1_+_14454663 1.76 ENSDART00000005067
recombination signal binding protein for immunoglobulin kappa J region a
chr8_-_25728628 1.75 ENSDART00000127237
forkhead box P3a
chr16_+_25196572 1.74 ENSDART00000141956
TYRO protein tyrosine kinase binding protein
chr14_-_33348221 1.74 ENSDART00000187749
ribosomal protein L39
chr1_+_11659861 1.74 ENSDART00000054787

chr2_-_29994726 1.73 ENSDART00000163350
canopy1
chr24_+_25919809 1.73 ENSDART00000006615
mitogen-activated protein kinase kinase kinase 15
chr9_-_1949915 1.71 ENSDART00000190712
homeobox D3a
chr21_+_26657404 1.71 ENSDART00000129035
ENSDART00000186550
peroxiredoxin 5
chr6_+_54711306 1.70 ENSDART00000074605
plakophilin 1b
chr14_-_1355544 1.70 ENSDART00000060417
centrin 4
chr3_-_34528306 1.70 ENSDART00000023039
septin 9a
chr6_+_30091811 1.67 ENSDART00000088403
melanotransferrin
chr14_+_30774894 1.66 ENSDART00000023054
atlastin 3
chr19_-_27776649 1.65 ENSDART00000135348
adenylate cyclase 2b (brain)
chr11_+_34235372 1.64 ENSDART00000063150
family with sequence similarity 43, member A
chr16_-_28878080 1.62 ENSDART00000149501
si:dkey-239n17.4
chr21_+_20356458 1.61 ENSDART00000135816
phosphodiesterase 6B, cGMP-specific, rod, beta
chr12_-_32066469 1.61 ENSDART00000140685
ENSDART00000062185
RAB40B, member RAS oncogene family
chr12_-_33789006 1.59 ENSDART00000034550
lethal giant larvae homolog 2 (Drosophila)
chr5_+_32882688 1.58 ENSDART00000008807
ENSDART00000185317
ribosomal protein L12
chr11_-_26040594 1.58 ENSDART00000144115
kazrin, periplakin interacting protein b
chr14_-_6666854 1.58 ENSDART00000133031
si:dkeyp-44a8.4
chr23_-_32162810 1.57 ENSDART00000155905
nuclear receptor subfamily 4, group A, member 1
chr23_+_25428513 1.56 ENSDART00000144554
formin-like 3
chr11_+_24716837 1.56 ENSDART00000145217
zgc:153953
chr14_+_30774032 1.53 ENSDART00000139552
atlastin 3
chr23_-_270847 1.50 ENSDART00000191867
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr13_+_25421531 1.50 ENSDART00000158093
calcium homeostasis modulator 2
chr13_-_35908275 1.49 ENSDART00000013961
MYCL proto-oncogene, bHLH transcription factor a
chr9_-_32684008 1.49 ENSDART00000041751
excision repair cross-complementation group 1
chr7_+_19482084 1.48 ENSDART00000173873
si:ch211-212k18.7
chr2_-_58183499 1.46 ENSDART00000172281
ENSDART00000186262
si:ch1073-185p12.2
chr11_+_43740949 1.45 ENSDART00000189296

chr1_+_40740951 1.43 ENSDART00000189780
ENSDART00000080563
HtrA serine peptidase 3a
chr24_-_26622423 1.43 ENSDART00000182044
TRAF2 and NCK interacting kinase b
chr9_-_23994225 1.42 ENSDART00000140346
collagen, type VI, alpha 3
chr17_-_5352924 1.42 ENSDART00000167275
SPT3 homolog, SAGA and STAGA complex component
chr6_+_19950107 1.42 ENSDART00000181632
phosphoinositide-3-kinase, regulatory subunit 5
chr5_-_44286987 1.42 ENSDART00000184112
si:ch73-337l15.2
chr21_+_31253048 1.41 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
argininosuccinate lyase
chr3_+_28576173 1.41 ENSDART00000151189
septin 12
chr9_+_13985567 1.40 ENSDART00000102296
CD28 molecule
chr14_-_15956657 1.38 ENSDART00000169197
fms-related tyrosine kinase 4

Network of associatons between targets according to the STRING database.

First level regulatory network of ikzf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0090131 mesenchyme migration(GO:0090131)
1.8 8.9 GO:0097272 ammonia homeostasis(GO:0097272)
1.7 1.7 GO:0032814 regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816)
1.6 4.8 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
1.3 5.3 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.8 3.4 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
0.8 3.1 GO:2000583 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.7 6.0 GO:1990845 adaptive thermogenesis(GO:1990845)
0.6 1.9 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.6 1.8 GO:0072314 glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.6 2.3 GO:0030224 monocyte differentiation(GO:0030224)
0.5 2.6 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.5 2.5 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
0.5 1.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.5 1.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.5 3.3 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.4 4.6 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 7.6 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.4 19.3 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.4 1.1 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.4 2.5 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.4 7.5 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.4 1.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 1.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 4.4 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.3 2.4 GO:0097106 postsynaptic density organization(GO:0097106)
0.3 9.9 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.3 1.2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.3 2.3 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.3 1.7 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.3 0.8 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.3 7.2 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.3 6.3 GO:0030183 B cell differentiation(GO:0030183)
0.3 1.0 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.2 2.5 GO:1990402 embryonic liver development(GO:1990402)
0.2 0.9 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.2 3.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 6.4 GO:0051923 sulfation(GO:0051923)
0.2 2.9 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
0.2 1.3 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.2 1.9 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.2 9.1 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 0.2 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.2 3.8 GO:0009437 carnitine metabolic process(GO:0009437)
0.2 1.2 GO:0031282 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284)
0.2 1.8 GO:0030859 polarized epithelial cell differentiation(GO:0030859)
0.2 1.0 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.2 4.3 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.7 GO:0018343 protein farnesylation(GO:0018343)
0.2 0.7 GO:0010610 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.2 1.6 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 2.1 GO:0003307 regulation of Wnt signaling pathway involved in heart development(GO:0003307)
0.2 0.7 GO:0019532 oxalate transport(GO:0019532)
0.2 5.2 GO:0055064 chloride ion homeostasis(GO:0055064)
0.2 4.2 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.2 1.2 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.2 2.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.2 6.1 GO:0035138 pectoral fin morphogenesis(GO:0035138)
0.2 4.9 GO:0006826 iron ion transport(GO:0006826)
0.1 0.9 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 3.1 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 5.0 GO:0003094 glomerular filtration(GO:0003094)
0.1 0.6 GO:0032530 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.1 0.9 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.6 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 0.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 6.7 GO:0006937 regulation of muscle contraction(GO:0006937)
0.1 8.2 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 1.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.7 GO:0045899 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.7 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 0.8 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 4.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 0.4 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 3.1 GO:0051014 actin filament severing(GO:0051014)
0.1 5.0 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280)
0.1 2.8 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.1 0.4 GO:0014909 smooth muscle cell migration(GO:0014909)
0.1 1.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 1.3 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 0.8 GO:0090398 cellular senescence(GO:0090398)
0.1 0.3 GO:1900136 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.1 0.4 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 6.8 GO:0048916 posterior lateral line development(GO:0048916)
0.1 3.3 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.1 5.5 GO:0060348 bone development(GO:0060348)
0.1 1.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.8 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 2.7 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 1.3 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 1.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 1.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 1.8 GO:0019835 cytolysis(GO:0019835)
0.1 0.3 GO:0032506 cytokinetic process(GO:0032506)
0.1 0.2 GO:0001112 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 3.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.1 GO:0048264 determination of ventral identity(GO:0048264)
0.1 2.1 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.1 0.7 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.5 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 3.3 GO:0045010 actin nucleation(GO:0045010)
0.1 0.3 GO:0010801 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 2.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 1.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.7 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 1.0 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 2.5 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.7 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 0.9 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.6 GO:0007568 aging(GO:0007568)
0.0 1.9 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 3.3 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.6 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.2 GO:0006203 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleotide catabolic process(GO:0009155) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 3.6 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.6 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 4.5 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.5 GO:0001843 neural tube closure(GO:0001843)
0.0 0.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.6 GO:0007634 optokinetic behavior(GO:0007634)
0.0 2.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 3.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.6 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 0.1 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.7 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 1.1 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 4.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.5 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.3 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.2 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.3 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 2.1 GO:0007626 locomotory behavior(GO:0007626)
0.0 1.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 3.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.9 GO:0051216 cartilage development(GO:0051216)
0.0 0.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.8 GO:0048675 axon extension(GO:0048675)
0.0 0.8 GO:0034968 histone lysine methylation(GO:0034968)
0.0 2.9 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.1 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0033339 pectoral fin development(GO:0033339)
0.0 1.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.3 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.8 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.7 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0019815 B cell receptor complex(GO:0019815)
0.6 2.8 GO:0043034 costamere(GO:0043034)
0.4 5.9 GO:0002102 podosome(GO:0002102)
0.4 6.3 GO:0005869 dynactin complex(GO:0005869)
0.4 1.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.3 7.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 1.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 3.5 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.3 6.2 GO:0045180 basal cortex(GO:0045180)
0.2 0.7 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.2 1.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 2.0 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.2 1.4 GO:0030914 STAGA complex(GO:0030914)
0.2 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.2 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 0.7 GO:0097519 DNA recombinase complex(GO:0097519)
0.2 0.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 19.1 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 5.1 GO:0005861 troponin complex(GO:0005861)
0.1 0.8 GO:0016586 RSC complex(GO:0016586)
0.1 1.4 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 0.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 3.6 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 4.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 5.0 GO:0005902 microvillus(GO:0005902)
0.1 5.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 3.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.4 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.7 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 0.8 GO:0032300 mismatch repair complex(GO:0032300)
0.1 1.9 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.4 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.8 GO:0014704 intercalated disc(GO:0014704)
0.1 2.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 5.2 GO:0030027 lamellipodium(GO:0030027)
0.1 0.4 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 0.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 5.5 GO:0055037 recycling endosome(GO:0055037)
0.1 0.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.6 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 13.8 GO:0005764 lysosome(GO:0005764)
0.0 5.3 GO:0005884 actin filament(GO:0005884)
0.0 5.9 GO:0030017 sarcomere(GO:0030017)
0.0 0.7 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 5.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.7 GO:0005795 Golgi stack(GO:0005795)
0.0 0.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 3.7 GO:0005882 intermediate filament(GO:0005882)
0.0 3.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.5 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 9.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 8.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0010008 endosome membrane(GO:0010008)
0.0 6.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 1.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0032154 cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.2 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.5 4.6 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
1.3 3.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.9 8.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.8 4.6 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.6 5.7 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.6 16.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 3.8 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.5 3.3 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 5.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.4 6.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 4.0 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.4 7.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 8.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 1.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.3 7.0 GO:0070411 I-SMAD binding(GO:0070411)
0.3 4.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.3 2.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 1.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 0.7 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.2 1.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 1.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 2.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 2.7 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 3.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 9.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 2.0 GO:0030332 cyclin binding(GO:0030332)
0.2 3.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 3.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 0.7 GO:1990238 double-stranded DNA endodeoxyribonuclease activity(GO:1990238)
0.2 3.3 GO:0008301 DNA binding, bending(GO:0008301)
0.2 1.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.8 GO:0019215 intermediate filament binding(GO:0019215)
0.2 5.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 1.0 GO:0019809 spermidine binding(GO:0019809)
0.1 1.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 2.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.7 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 3.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 2.0 GO:0031386 protein tag(GO:0031386)
0.1 2.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.3 GO:0031701 angiotensin receptor binding(GO:0031701)
0.1 0.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 5.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.1 3.8 GO:0005109 frizzled binding(GO:0005109)
0.1 0.9 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 2.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.6 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.6 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 2.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.6 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 3.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 9.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 2.9 GO:0004601 peroxidase activity(GO:0004601)
0.1 1.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.9 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.5 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 1.1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 6.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.2 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 1.6 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 8.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 1.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.9 GO:0019902 phosphatase binding(GO:0019902)
0.0 5.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.2 GO:0060090 binding, bridging(GO:0060090)
0.0 7.6 GO:0051015 actin filament binding(GO:0051015)
0.0 12.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 6.4 GO:0003779 actin binding(GO:0003779)
0.0 0.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 11.7 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.0 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.9 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 1.8 GO:0019955 cytokine binding(GO:0019955)
0.0 0.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 5.9 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 7.0 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.1 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 3.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.9 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 4.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 2.1 PID IL5 PATHWAY IL5-mediated signaling events
0.2 3.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 4.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 7.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.4 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 1.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 8.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.6 PID ALK2 PATHWAY ALK2 signaling events
0.1 3.8 PID BCR 5PATHWAY BCR signaling pathway
0.1 1.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 0.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.4 PID MYC PATHWAY C-MYC pathway
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 6.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.4 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.6 7.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.6 6.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.5 3.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.4 2.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 2.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 1.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 6.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 3.8 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 2.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 1.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 3.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 6.6 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 2.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 0.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.9 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 1.0 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 0.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 1.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 0.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.3 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 0.9 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.9 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.1 2.3 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 4.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis