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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irf4a+irf4b

Z-value: 1.14

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Transcription factors associated with irf4a+irf4b

Gene Symbol Gene ID Gene Info
irf4a
ENSDARG00000006560 interferon regulatory factor 4a
irf4b
ENSDARG00000055374 interferon regulatory factor 4b
irf4b
ENSDARG00000115381 interferon regulatory factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf4bdr11_v1_chr20_+_26556174_265561740.593.8e-10Click!
irf4adr11_v1_chr2_-_879800_8798000.205.7e-02Click!

Activity profile of irf4a+irf4b motif

Sorted Z-values of irf4a+irf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_22552678 14.35 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr19_-_7110617 12.77 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr4_-_17669881 11.11 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr7_+_19482877 9.54 ENSDART00000077868
si:ch211-212k18.7
si:ch211-212k18.7
chr19_-_15420678 9.50 ENSDART00000151454
ENSDART00000027697
serinc2
serine incorporator 2
chr7_+_19483277 9.02 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr16_+_19637384 8.68 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr9_-_32837860 8.61 ENSDART00000142227
mxe
myxovirus (influenza virus) resistance E
chr16_+_48753664 8.47 ENSDART00000155148
si:ch73-31d8.2
si:ch73-31d8.2
chr4_-_12795436 8.43 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr9_+_23765587 8.35 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr16_+_29492937 8.17 ENSDART00000011497
ctsk
cathepsin K
chr2_-_37140423 8.06 ENSDART00000144220
tspan37
tetraspanin 37
chr23_-_30045661 7.66 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr4_-_26107841 7.46 ENSDART00000172012
si:ch211-244b2.4
si:ch211-244b2.4
chr15_-_40175894 7.06 ENSDART00000156632
si:ch211-281l24.3
si:ch211-281l24.3
chr4_-_12795030 6.91 ENSDART00000150427
b2m
beta-2-microglobulin
chr1_-_7570181 6.62 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr14_-_33585809 6.41 ENSDART00000023540
sash3
SAM and SH3 domain containing 3
chr16_+_46497149 6.06 ENSDART00000135151
ENSDART00000058324
rpz4
rapunzel 4
chr19_+_791538 5.95 ENSDART00000146554
ENSDART00000138406
tmem79a
transmembrane protein 79a
chr7_-_34192834 5.94 ENSDART00000125131
smad6a
SMAD family member 6a
chr21_+_45626136 5.83 ENSDART00000158742
irf1b
interferon regulatory factor 1b
chr15_+_34069746 5.79 ENSDART00000163513
arl4aa
ADP-ribosylation factor-like 4aa
chr12_-_23658888 5.79 ENSDART00000088319
map3k8
mitogen-activated protein kinase kinase kinase 8
chr24_-_11467549 5.78 ENSDART00000082264
pxdc1b
PX domain containing 1b
chr10_+_8101729 5.77 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr7_-_26579465 5.73 ENSDART00000173820
si:dkey-62k3.6
si:dkey-62k3.6
chr11_+_10984293 5.67 ENSDART00000065933
itgb6
integrin, beta 6
chr7_-_19614916 5.56 ENSDART00000169029
zgc:194655
zgc:194655
chr14_+_33329761 5.56 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr1_+_38153944 5.45 ENSDART00000135666
galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr1_+_31674297 5.40 ENSDART00000044214
wbp1lb
WW domain binding protein 1-like b
chr8_-_27687095 5.32 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr14_+_33329420 5.23 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr9_-_23765480 5.03 ENSDART00000027212
si:ch211-219a4.6
si:ch211-219a4.6
chr24_-_11467004 4.93 ENSDART00000144316
pxdc1b
PX domain containing 1b
chr3_-_29941357 4.72 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr22_-_17474583 4.37 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr3_+_25191467 4.37 ENSDART00000156956
ENSDART00000154799
il2rb
interleukin 2 receptor, beta
chr22_-_17474781 4.23 ENSDART00000186817
si:ch211-197g15.8
si:ch211-197g15.8
chr7_+_19615056 4.17 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
si:ch211-212k18.15
chr21_+_25793970 3.97 ENSDART00000101217
CLDN4 (1 of many)
zgc:136892
chr18_+_44532370 3.92 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr2_-_13333932 3.89 ENSDART00000150238
ENSDART00000168258
si:dkey-185p13.1
vps4b
si:dkey-185p13.1
vacuolar protein sorting 4b homolog B (S. cerevisiae)
chr4_+_11464255 3.84 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr25_-_774350 3.83 ENSDART00000166321
ENSDART00000160386
IRAK4
interleukin 1 receptor associated kinase 4
chr18_+_17624295 3.79 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr15_-_41734639 3.75 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr13_+_24263049 3.74 ENSDART00000135992
ENSDART00000088005
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr9_+_42269059 3.51 ENSDART00000113435
si:dkey-10c21.1
si:dkey-10c21.1
chr5_-_69716501 3.50 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr21_-_37933833 3.44 ENSDART00000184138
ENSDART00000177664
FO704750.1

chr4_+_68562464 3.40 ENSDART00000192954
BX548011.4

chr22_-_30999000 3.38 ENSDART00000109841
ssuh2.3
ssu-2 homolog, tandem duplicate 3
chr18_+_44532668 3.31 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr10_+_5060191 3.22 ENSDART00000145908
ENSDART00000122397
carm1l
coactivator-associated arginine methyltransferase 1, like
chr12_-_35936329 3.18 ENSDART00000166634
rnf213b
ring finger protein 213b
chr25_+_16646113 3.14 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr4_-_6373735 3.14 ENSDART00000140100
MDFIC
si:ch73-156e19.1
chr15_-_17071328 3.13 ENSDART00000122617
si:ch211-24o10.6
si:ch211-24o10.6
chr25_+_28862660 2.86 ENSDART00000154681
si:ch211-106e7.2
si:ch211-106e7.2
chr23_-_29553430 2.84 ENSDART00000157773
ENSDART00000126384
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr25_+_15997957 2.78 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr17_+_35362851 2.75 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr18_+_44532199 2.66 ENSDART00000135386
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr2_+_2818645 2.56 ENSDART00000163587
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr18_+_44532883 2.56 ENSDART00000121994
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr11_-_42472941 2.54 ENSDART00000166624
arf4b
ADP-ribosylation factor 4b
chr2_-_24554416 2.49 ENSDART00000052061
cnn2
calponin 2
chr25_-_3034668 2.47 ENSDART00000053405
scamp2
secretory carrier membrane protein 2
chr2_-_55797318 2.32 ENSDART00000158147
calr3b
calreticulin 3b
chr6_-_18400548 2.31 ENSDART00000179797
ENSDART00000164891
trim25
tripartite motif containing 25
chr7_-_20464133 2.29 ENSDART00000078192
cnpy4
canopy4
chr1_-_35924495 2.29 ENSDART00000184424
smad1
SMAD family member 1
chr8_+_45361775 2.20 ENSDART00000015193
chmp4bb
charged multivesicular body protein 4Bb
chr9_+_34089156 2.19 ENSDART00000000005
ccdc80
coiled-coil domain containing 80
chr4_-_18434924 2.11 ENSDART00000190271
socs2
suppressor of cytokine signaling 2
chr25_-_483808 2.05 ENSDART00000104720
si:ch1073-385f13.3
si:ch1073-385f13.3
chr10_+_28160265 2.03 ENSDART00000022484
rnft1
ring finger protein, transmembrane 1
chr15_+_2421729 1.97 ENSDART00000082294
ENSDART00000156428
hephl1a
hephaestin-like 1a
chr5_+_21922534 1.95 ENSDART00000148092
si:ch73-92i20.1
si:ch73-92i20.1
chr10_+_4046448 1.89 ENSDART00000123086
ENSDART00000052268
pitpnb
phosphatidylinositol transfer protein, beta
chr13_+_22476742 1.85 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr9_+_23003208 1.82 ENSDART00000021060
eaf2
ELL associated factor 2
chr20_-_3911546 1.82 ENSDART00000169787
cnksr3
cnksr family member 3
chr20_-_51547464 1.81 ENSDART00000099486
disp1
dispatched homolog 1 (Drosophila)
chr20_-_25436389 1.79 ENSDART00000153266
itsn2a
intersectin 2a
chr15_-_41749364 1.73 ENSDART00000155464
ftr73
finTRIM family, member 73
chr3_+_36127287 1.60 ENSDART00000058605
ENSDART00000182500
scpep1
serine carboxypeptidase 1
chr15_+_2421432 1.60 ENSDART00000193772
hephl1a
hephaestin-like 1a
chr20_-_35012093 1.53 ENSDART00000062761
cnstb
consortin, connexin sorting protein b
chr13_-_50200348 1.52 ENSDART00000038391
pkz
protein kinase containing Z-DNA binding domains
chr16_+_27383717 1.50 ENSDART00000132329
ENSDART00000136256
stx17
syntaxin 17
chr24_-_26885897 1.46 ENSDART00000180512
fndc3bb
fibronectin type III domain containing 3Bb
chr8_-_51340773 1.45 ENSDART00000060633
kansl3
KAT8 regulatory NSL complex subunit 3
chr19_-_19871211 1.45 ENSDART00000170980
evx1
even-skipped homeobox 1
chr1_-_55750208 1.38 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr18_-_24988645 1.33 ENSDART00000136434
ENSDART00000085735
chd2
chromodomain helicase DNA binding protein 2
chr10_+_7703251 1.29 ENSDART00000165134
ggcx
gamma-glutamyl carboxylase
chr7_+_17908235 1.24 ENSDART00000077113
mta2
metastasis associated 1 family, member 2
chr22_+_19365220 1.22 ENSDART00000132781
ENSDART00000135672
ENSDART00000153630
si:dkey-21e2.12
si:dkey-21e2.12
chr6_+_22068589 1.21 ENSDART00000151205
aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr15_-_43995028 1.19 ENSDART00000172485
ENSDART00000186320
nlrc3l
NLR family, CARD domain containing 3-like
chr1_-_714626 1.18 ENSDART00000161072
adamts5
ADAM metallopeptidase with thrombospondin type 1 motif 5
chr23_-_29553691 1.04 ENSDART00000053804
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr12_+_48319221 0.99 ENSDART00000126362
anapc16
anaphase promoting complex subunit 16
chr21_-_40049642 0.90 ENSDART00000124416
med31
mediator complex subunit 31
chr2_-_43739740 0.87 ENSDART00000113849
kif5ba
kinesin family member 5B, a
chr13_-_50200042 0.87 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains
chr15_-_21702317 0.84 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr5_+_66063807 0.82 ENSDART00000122405
jak2b
Janus kinase 2b
chr12_-_28975705 0.79 ENSDART00000129173
znf646
zinc finger protein 646
chr22_-_8692305 0.79 ENSDART00000181602
CR450686.4

chr24_-_3407507 0.76 ENSDART00000132648
nck1b
NCK adaptor protein 1b
chr2_-_26620803 0.74 ENSDART00000003946
ENSDART00000126826
tmem59
transmembrane protein 59
chr15_-_29556757 0.59 ENSDART00000060049
hspa13
heat shock protein 70 family, member 13
chr3_-_4501026 0.54 ENSDART00000163052
zgc:162198
zgc:162198
chr17_-_23603263 0.50 ENSDART00000079559
ifit16
interferon-induced protein with tetratricopeptide repeats 16
chr10_-_5821584 0.50 ENSDART00000166388
il6st
interleukin 6 signal transducer
chr21_-_22543611 0.45 ENSDART00000177084
myo5b
myosin VB
chr22_+_38914983 0.44 ENSDART00000085701
senp5
SUMO1/sentrin specific peptidase 5
chr25_-_37489917 0.42 ENSDART00000160688
psma1
proteasome subunit alpha 1
chr19_-_791016 0.39 ENSDART00000037515
msto1
misato 1, mitochondrial distribution and morphology regulator
chr19_-_42462491 0.39 ENSDART00000131715
psmb4
proteasome subunit beta 4
chr5_+_35502290 0.36 ENSDART00000191222
CR762390.1

chr9_+_51147764 0.33 ENSDART00000188480
ifih1
interferon induced with helicase C domain 1
chr3_-_26171668 0.24 ENSDART00000113890
rabep2
rabaptin, RAB GTPase binding effector protein 2
chr5_+_31959954 0.23 ENSDART00000142826
myo1hb
myosin IHb
chr3_-_49554912 0.18 ENSDART00000159392
CR847534.1

chr18_-_23874929 0.16 ENSDART00000134910
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr2_+_15586632 0.12 ENSDART00000164903
BX510342.1

chr11_-_30508843 0.12 ENSDART00000101667
ENSDART00000179930
map4k3a
mitogen-activated protein kinase kinase kinase kinase 3a
chr5_+_28260158 0.09 ENSDART00000181434
ncaph
non-SMC condensin I complex, subunit H
chr20_+_13781779 0.06 ENSDART00000142999
ENSDART00000152471
lpgat1
lysophosphatidylglycerol acyltransferase 1
chr8_+_38564942 0.06 ENSDART00000085371
rfk
riboflavin kinase
chr20_-_38525467 0.05 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr1_-_7582859 0.04 ENSDART00000110696
mxb
myxovirus (influenza) resistance B
chr15_-_1835189 0.00 ENSDART00000154369
taf15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Network of associatons between targets according to the STRING database.

First level regulatory network of irf4a+irf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 19.1 GO:0045824 negative regulation of innate immune response(GO:0045824)
1.1 5.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.9 2.8 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.9 2.6 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.8 5.9 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.8 6.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.8 8.1 GO:0050688 regulation of defense response to virus(GO:0050688)
0.7 2.2 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.6 3.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.6 4.7 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.5 1.5 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.5 8.7 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.4 13.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.4 2.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.4 2.0 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.4 1.2 GO:0042560 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.2 1.2 GO:0014005 microglia development(GO:0014005)
0.2 1.3 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 5.7 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.2 5.7 GO:0017121 phospholipid scrambling(GO:0017121)
0.2 3.6 GO:0006825 copper ion transport(GO:0006825)
0.2 0.5 GO:0042546 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.2 1.4 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 1.4 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.1 2.2 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 1.8 GO:0042694 muscle cell fate specification(GO:0042694)
0.1 0.9 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.8 GO:0014812 muscle cell migration(GO:0014812)
0.1 3.9 GO:0042476 odontogenesis(GO:0042476)
0.1 0.4 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 8.2 GO:0060348 bone development(GO:0060348)
0.1 2.5 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 2.3 GO:0061515 myeloid cell development(GO:0061515)
0.1 12.4 GO:0008544 epidermis development(GO:0008544)
0.1 14.4 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 4.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 0.5 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.1 11.1 GO:0042742 defense response to bacterium(GO:0042742)
0.1 1.9 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 2.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 2.0 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 13.2 GO:0072594 establishment of protein localization to organelle(GO:0072594)
0.1 2.3 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 3.1 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.1 3.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.5 GO:0097352 autophagosome maturation(GO:0097352)
0.0 8.7 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 5.3 GO:0001756 somitogenesis(GO:0001756)
0.0 2.0 GO:0051607 defense response to virus(GO:0051607)
0.0 5.9 GO:0045055 regulated exocytosis(GO:0045055)
0.0 0.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 4.6 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 6.5 GO:0030041 actin filament polymerization(GO:0030041)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 1.2 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.0 5.4 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 8.3 GO:0006886 intracellular protein transport(GO:0006886)
0.0 0.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 1.8 GO:0016197 endosomal transport(GO:0016197)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.4 GO:0043034 costamere(GO:0043034)
2.6 15.3 GO:0042612 MHC class I protein complex(GO:0042612)
1.9 5.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.8 15.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.5 13.6 GO:0005839 proteasome core complex(GO:0005839)
0.4 8.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 8.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 20.8 GO:0031902 late endosome membrane(GO:0031902)
0.3 3.1 GO:0031010 ISWI-type complex(GO:0031010)
0.2 1.8 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 5.3 GO:0043186 P granule(GO:0043186)
0.1 0.9 GO:0070847 core mediator complex(GO:0070847)
0.1 5.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.4 GO:0044545 NSL complex(GO:0044545)
0.1 20.0 GO:0005764 lysosome(GO:0005764)
0.1 2.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 7.6 GO:0005884 actin filament(GO:0005884)
0.0 1.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.5 GO:0031201 SNARE complex(GO:0031201)
0.0 5.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 5.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 3.6 GO:0005730 nucleolus(GO:0005730)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
1.3 3.8 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.9 2.8 GO:0009041 uridylate kinase activity(GO:0009041)
0.7 13.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 2.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.6 3.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.5 5.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.5 3.2 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.4 8.2 GO:0070411 I-SMAD binding(GO:0070411)
0.4 1.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 1.5 GO:0071253 connexin binding(GO:0071253)
0.4 3.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 5.6 GO:0031386 protein tag(GO:0031386)
0.3 1.3 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.3 2.6 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.3 1.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 1.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 1.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 2.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.3 5.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 4.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 5.7 GO:0005178 integrin binding(GO:0005178)
0.1 1.8 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 1.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 13.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 8.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 10.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 4.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 3.3 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 6.4 GO:0051015 actin filament binding(GO:0051015)
0.0 10.8 GO:0005525 GTP binding(GO:0005525)
0.0 1.3 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.8 GO:0060090 binding, bridging(GO:0060090)
0.0 2.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 14.0 GO:0004672 protein kinase activity(GO:0004672)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.5 17.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.5 5.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 2.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 3.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 2.3 PID ALK2 PATHWAY ALK2 signaling events
0.2 3.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.9 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 2.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 7.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.0 PID P73PATHWAY p73 transcription factor network
0.0 3.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.7 8.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.5 3.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3 5.8 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 4.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 6.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 2.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 3.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 2.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 5.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 5.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.9 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.0 0.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins