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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irx2a

Z-value: 0.83

Motif logo

Transcription factors associated with irx2a

Gene Symbol Gene ID Gene Info
ENSDARG00000001785 iroquois homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx2adr11_v1_chr16_-_563235_5632350.666.2e-13Click!

Activity profile of irx2a motif

Sorted Z-values of irx2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_31282161 12.77 ENSDART00000010774
zic family member 2 (odd-paired homolog, Drosophila), a
chr6_+_27146671 10.83 ENSDART00000156792
kinesin family member 1Aa
chr24_-_7632187 8.52 ENSDART00000041714
ATPase H+ transporting V0 subunit a1b
chr2_+_47581997 8.07 ENSDART00000112579
secretogranin II (chromogranin C), b
chr2_-_13216269 7.26 ENSDART00000149947
BCL2, apoptosis regulator b
chr6_-_54845622 6.93 ENSDART00000048887
cysteine and glycine-rich protein 1b
chr17_-_20897250 6.66 ENSDART00000088106
ankyrin 3b
chr5_-_4493502 6.50 ENSDART00000067593
ENSDART00000190221
zgc:153704
chr7_+_23875269 6.47 ENSDART00000101406
RAB39B, member RAS oncogene family b
chr19_+_30387999 6.35 ENSDART00000145396
tetraspanin 13b
chr2_+_47582681 6.16 ENSDART00000187579
secretogranin II (chromogranin C), b
chr12_+_9761685 5.86 ENSDART00000189522
protein phosphatase 1, regulatory subunit 9Bb
chr16_-_43025885 5.79 ENSDART00000193146
ENSDART00000157302
si:dkey-7j14.5
chr3_+_54849083 5.79 ENSDART00000008988
ENSDART00000078221
mahogunin, ring finger 1b
chr12_-_10275320 5.76 ENSDART00000170078
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr6_-_54845083 5.59 ENSDART00000148815
cysteine and glycine-rich protein 1b
chr2_+_22795494 5.43 ENSDART00000042255
RAB6B, member RAS oncogene family b
chr24_+_14713776 5.36 ENSDART00000134475
ganglioside induced differentiation associated protein 1
chr23_-_28141419 5.19 ENSDART00000133039
tachykinin 3a
chr1_+_20635190 5.10 ENSDART00000145418
ENSDART00000148518
ENSDART00000139461
ENSDART00000102969
ENSDART00000166479
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr16_+_34479064 5.09 ENSDART00000159965
si:ch211-255i3.4
chr8_+_25959940 5.09 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
chr7_-_18656069 5.07 ENSDART00000021559
coronin, actin binding protein, 1B
chr19_+_30388186 4.84 ENSDART00000103474
tetraspanin 13b
chr9_-_32730487 4.69 ENSDART00000147795
oligodendrocyte transcription factor 1
chr5_-_22621417 4.67 ENSDART00000138716
zgc:113208
chr2_-_36932253 4.50 ENSDART00000124217
microtubule-associated protein 1Sb
chr6_+_12326267 4.43 ENSDART00000155101
si:dkey-276j7.3
chr5_+_31214341 4.40 ENSDART00000133432
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr12_+_26632448 4.33 ENSDART00000185762
Rho GTPase activating protein 12b
chr6_-_18698006 4.24 ENSDART00000170128
rhomboid, veinlet-like 3 (Drosophila)
chr2_+_38924975 4.22 ENSDART00000109219
RAS (RAD and GEM)-like GTP binding 2
chr17_-_35881841 4.21 ENSDART00000110040
SRY (sex determining region Y)-box 11a
chr5_+_21931124 4.05 ENSDART00000137627
si:ch73-92i20.1
chr23_+_4299887 3.94 ENSDART00000132604
l(3)mbt-like 1a (Drosophila)
chr7_-_34339845 3.92 ENSDART00000173816
MAP-kinase activating death domain
chr23_-_39849155 3.91 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr11_-_21585176 3.75 ENSDART00000045391
SLIT-ROBO Rho GTPase activating protein 2
chr20_+_38201644 3.74 ENSDART00000022694
EH-domain containing 3
chr1_+_41666611 3.68 ENSDART00000145789
F-box protein 41
chr20_+_26349002 3.59 ENSDART00000152842
spectrin repeat containing, nuclear envelope 1a
chr8_-_25011157 3.55 ENSDART00000078795
adenosylhomocysteinase-like 1
chr3_-_33494163 3.54 ENSDART00000020342
small G protein signaling modulator 3
chr22_-_28226948 3.52 ENSDART00000147686
si:dkey-222p3.1
chr3_-_43821381 3.52 ENSDART00000166021
stannin
chr8_+_23147218 3.49 ENSDART00000030920
ENSDART00000141175
ENSDART00000146264
GID complex subunit 8 homolog a (S. cerevisiae)
chr4_+_8168514 3.48 ENSDART00000150830
ninjurin 2
chr16_-_52821023 3.01 ENSDART00000074718
spire-type actin nucleation factor 1b
chr7_-_5431841 2.99 ENSDART00000173073
Rho guanine nucleotide exchange factor (GEF) 11
chr3_+_28831450 2.90 ENSDART00000055422
fleer
chr21_-_2248239 2.87 ENSDART00000169448
si:ch73-299h12.1
chr9_+_41024973 2.87 ENSDART00000014660
ENSDART00000144467
ORMDL sphingolipid biosynthesis regulator 1
chr1_+_52518176 2.87 ENSDART00000003278
tachykinin receptor 3-like
chr25_-_36286186 2.85 ENSDART00000182398
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10b
chr14_+_32022272 2.83 ENSDART00000105760
zic family member 6
chr16_-_22022456 2.82 ENSDART00000140175
si:dkey-71b5.3
chr12_+_27024676 2.76 ENSDART00000153104
male-specific lethal 1 homolog b (Drosophila)
chr21_-_4032650 2.75 ENSDART00000151648
netrin g2b
chr21_+_21339311 2.71 ENSDART00000137693
ENSDART00000161820
succinate dehydrogenase complex assembly factor 1
si:ch211-191j22.3
chr19_+_34311374 2.67 ENSDART00000086617
gamma-aminobutyric acid (GABA) B receptor, 2
chr1_+_15226268 2.66 ENSDART00000109911
heparan-alpha-glucosaminide N-acetyltransferase
chr2_+_47582488 2.66 ENSDART00000149967
secretogranin II (chromogranin C), b
chr21_+_723998 2.64 ENSDART00000160956
ornithine decarboxylase antizyme 1b
chr19_-_42416696 2.63 ENSDART00000086961
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr6_+_28205284 2.62 ENSDART00000160707
ENSDART00000190509
smx5
si:ch73-14h10.2
chr22_+_2715815 2.58 ENSDART00000042770
zinc finger protein 1163
chr2_-_42864472 2.57 ENSDART00000134139
adenylate cyclase 8 (brain)
chr11_+_38332419 2.55 ENSDART00000005864
si:dkey-166c18.1
chr2_-_4797512 2.53 ENSDART00000160765
tyrosine kinase, non-receptor, 2b
chr21_-_32467799 2.52 ENSDART00000007675
ENSDART00000133099
zgc:123105
chr19_+_7549854 2.52 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr16_-_25393699 2.48 ENSDART00000149445
par-6 family cell polarity regulator gamma a
chr19_+_42735211 2.45 ENSDART00000139109
cytoplasmic linker associated protein 2
chr23_+_23658474 2.43 ENSDART00000162838
agrin
chr21_-_4244514 2.37 ENSDART00000065880
uridine-cytidine kinase 1
chr18_-_29961784 2.36 ENSDART00000135601
ENSDART00000140661
si:ch73-103b9.2
chr22_-_354592 2.36 ENSDART00000155769
transmembrane protein 240b
chr19_+_10832092 2.34 ENSDART00000191851
translocase of outer mitochondrial membrane 40 homolog, like
chr6_-_19340889 2.33 ENSDART00000181407
MIF4G domain containing a
chr24_-_37955993 2.33 ENSDART00000041805
meteorin, glial cell differentiation regulator
chr17_-_20897407 2.31 ENSDART00000149481
ankyrin 3b
chr15_+_5321612 2.27 ENSDART00000174345
odorant receptor, family A, subfamily 113, member 1
chr8_-_25566347 2.24 ENSDART00000138289
ENSDART00000078022
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr19_-_41069573 2.17 ENSDART00000111982
ENSDART00000193142
sarcoglycan, epsilon
chr7_+_50109239 2.16 ENSDART00000021605
si:dkey-6l15.1
chr1_-_11878845 2.15 ENSDART00000163971
ENSDART00000123431
IQ motif containing E
chr5_-_12560569 2.10 ENSDART00000133587
WD repeat and SOCS box containing 2
chr21_+_5915041 2.10 ENSDART00000151370
proline dehydrogenase (oxidase) 1a
chr9_+_54417141 2.04 ENSDART00000056810
dopamine receptor D1b
chr6_-_10776254 2.04 ENSDART00000184008
G protein-coupled receptor 155b
chr25_-_13676682 2.03 ENSDART00000090226
zinc finger protein 319b
chr21_+_6961635 1.98 ENSDART00000137281
si:ch211-93g21.2
chr2_-_44038698 1.96 ENSDART00000079582
ENSDART00000146804
kirre like nephrin family adhesion molecule 1b
chr11_+_12811906 1.95 ENSDART00000123445
regulator of telomere elongation helicase 1
chr16_+_24681177 1.95 ENSDART00000058956
ENSDART00000189335
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr7_+_13582256 1.95 ENSDART00000158477
ankyrin repeat and death domain containing 1A
chr5_+_36650096 1.94 ENSDART00000111414
alkB homolog 6
chr21_-_2238277 1.93 ENSDART00000165754
si:dkey-50i6.6
chr5_+_31860043 1.91 ENSDART00000036235
ENSDART00000140541
iron-sulfur cluster assembly enzyme b
chr20_-_33790003 1.91 ENSDART00000020183
family with sequence similarity 102, member B, b
chr17_+_32571584 1.88 ENSDART00000087565
eva-1 homolog A (C. elegans)
chr14_-_25985698 1.88 ENSDART00000172909
ENSDART00000123053
antioxidant 1 copper chaperone
chr2_+_30739680 1.88 ENSDART00000101861
transcription elongation factor A (SII), 1
chr13_-_24825691 1.87 ENSDART00000142745
STE20-like kinase a
chr7_+_39624728 1.87 ENSDART00000173847
ENSDART00000173845
protein tyrosine phosphatase, non-receptor type 5
chr22_-_15010688 1.87 ENSDART00000139892
extracellular leucine-rich repeat and fibronectin type III domain containing 2a
chr22_+_21972824 1.83 ENSDART00000183708
ENSDART00000133739
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 3
chr25_+_7671640 1.82 ENSDART00000145367
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr2_-_10014821 1.80 ENSDART00000185525

chr2_+_30960351 1.79 ENSDART00000141575
lipin 2
chr4_+_77060861 1.77 ENSDART00000174271
ENSDART00000174393
ENSDART00000150450
si:dkey-240n22.8
chr6_-_18698456 1.75 ENSDART00000166587
rhomboid, veinlet-like 3 (Drosophila)
chr21_-_2232640 1.74 ENSDART00000157754
zgc:113343
chr16_+_32131568 1.73 ENSDART00000171454
sphingosine kinase 2
chr3_+_26223376 1.72 ENSDART00000128284
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr20_-_17259573 1.70 ENSDART00000166397

chr8_+_26226044 1.67 ENSDART00000186503
WD repeat domain 6
chr7_-_32599669 1.67 ENSDART00000173752
potassium voltage-gated channel, shaker-related subfamily, member 4
chr14_-_48765262 1.64 ENSDART00000166463
CCR4-NOT transcription complex, subunit 6b
chr19_+_9533008 1.62 ENSDART00000104607
family with sequence similarity 131, member Ba
chr6_-_37749711 1.61 ENSDART00000078324
non imprinted in Prader-Willi/Angelman syndrome 1
chr5_+_28973264 1.59 ENSDART00000005638
syntaxin binding protein 1b
chr13_-_15793585 1.59 ENSDART00000145914
ENSDART00000010286
BCL2 associated athanogene 5
chr6_-_19341184 1.57 ENSDART00000168236
ENSDART00000167674
MIF4G domain containing a
chr22_+_35516440 1.56 ENSDART00000184191
hydroxylysine kinase, tandem duplicate 2
chr6_-_18698669 1.55 ENSDART00000168554
ENSDART00000175205
rhomboid, veinlet-like 3 (Drosophila)
chr18_-_34156765 1.52 ENSDART00000059400
c18h3orf33 homolog (H. sapiens)
chr16_+_54210554 1.52 ENSDART00000172622
X-ray repair complementing defective repair in Chinese hamster cells 1
chr17_+_5793248 1.47 ENSDART00000153743
retinitis pigmentosa 1-like 1a
chr12_+_28854410 1.44 ENSDART00000152991
nuclear factor, erythroid 2-like 1b
chr19_-_20446756 1.43 ENSDART00000140711
TBC1 domain family, member 5
chr1_-_18336878 1.41 ENSDART00000054674
melatonin receptor 1A a
chr5_+_28972935 1.40 ENSDART00000193274
syntaxin binding protein 1b
chr22_-_11606078 1.39 ENSDART00000146026
phosphate cytidylyltransferase 2, ethanolamine
chr19_+_34742706 1.38 ENSDART00000103276
family with sequence similarity 206, member A
chr2_+_35854242 1.37 ENSDART00000134918
DEAH (Asp-Glu-Ala-His) box helicase 9
chr3_+_27786601 1.36 ENSDART00000086994
N-acetyltransferase 15 (GCN5-related, putative)
chr15_-_915635 1.33 ENSDART00000179821
si:dkey-7i4.21
chr4_-_16706776 1.32 ENSDART00000079461
DENN/MADD domain containing 5B
chr6_-_22146258 1.31 ENSDART00000181700
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr8_+_68864 1.30 ENSDART00000164574
proline rich 16
chr1_-_13968153 1.30 ENSDART00000103383
E74-like factor 2b (ets domain transcription factor)
chr4_+_14343706 1.29 ENSDART00000142845
prolactin 2
chr1_+_44941031 1.29 ENSDART00000141145
si:dkey-9i23.16
chr23_+_38940700 1.28 ENSDART00000065331
spalt-like transcription factor 4
chr4_-_3023182 1.28 ENSDART00000127894
pleckstrin homology domain containing, family A member 5
chr7_+_27898091 1.28 ENSDART00000186451
ENSDART00000173510
tubby bipartite transcription factor
chr11_-_23697217 1.27 ENSDART00000124810
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr11_-_41130239 1.26 ENSDART00000173268
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr14_+_31496543 1.24 ENSDART00000170683
PHD finger protein 6
chr17_+_43468732 1.21 ENSDART00000055487
charged multivesicular body protein 3
chr4_+_25912654 1.19 ENSDART00000109508
ENSDART00000134218
vezatin, adherens junctions transmembrane protein
chr22_+_10440991 1.19 ENSDART00000064805
centromere protein P
chr6_-_13200585 1.15 ENSDART00000185321
eukaryotic translation elongation factor 1 beta 2
chr16_+_10413551 1.12 ENSDART00000032877
ENSDART00000172827
INO80 complex subunit E
chr5_+_30998764 1.10 ENSDART00000185783
ENSDART00000147874
ankyrin repeat and FYVE domain containing 1
chr12_+_2870671 1.07 ENSDART00000165225
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b
chr13_+_32636197 1.04 ENSDART00000141057
si:ch211-206k20.5
chr3_+_17951790 1.03 ENSDART00000164663
ATP citrate lyase a
chr4_+_76404572 1.03 ENSDART00000174020

chr14_+_12142828 1.02 ENSDART00000012438
heat shock protein 9
chr10_-_33379850 0.98 ENSDART00000186924
spindle and kinetochore associated complex subunit 2
chr17_-_9995667 0.96 ENSDART00000148463
sorting nexin 6
chr3_+_38793499 0.95 ENSDART00000083394
potassium voltage-gated channel subfamily J member 19a
chr6_-_18249760 0.93 ENSDART00000192037
APC11 anaphase promoting complex subunit 11 homolog (yeast)
chr25_-_21609645 0.91 ENSDART00000087817
si:dkey-81e3.1
chr1_+_8304904 0.88 ENSDART00000168631
calcium channel, voltage-dependent, T type, alpha 1H subunit b
chr5_+_41496490 0.87 ENSDART00000039369
Fanconi anemia, complementation group G
chr12_-_9516981 0.87 ENSDART00000106285
si:ch211-207i20.3
chr23_-_27442544 0.86 ENSDART00000019521
disco-interacting protein 2 homolog Ba
chr4_-_17263210 0.86 ENSDART00000147853
lymphoid-restricted membrane protein
chr5_-_18897482 0.85 ENSDART00000010101
ENSDART00000099434
acetoacetyl-CoA synthetase
chr13_-_26799244 0.82 ENSDART00000036419
vaccinia related kinase 2
chr3_+_57997980 0.80 ENSDART00000168477
ENSDART00000193840
pyrroline-5-carboxylate reductase 1a
chr5_+_20257225 0.78 ENSDART00000127919
slingshot protein phosphatase 1a
chr22_-_8725768 0.75 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
chr21_-_37435162 0.74 ENSDART00000133585
family with sequence similarity 114, member A2
chr5_+_69868911 0.74 ENSDART00000014649
ENSDART00000188215
ENSDART00000167385
UDP glucuronosyltransferase 2 family, polypeptide A5
chr6_-_32314913 0.70 ENSDART00000051779
autophagy related 4C, cysteine peptidase
chr25_-_35996141 0.63 ENSDART00000149074
spalt-like transcription factor 1b
chr15_-_24178893 0.63 ENSDART00000077980
pipecolic acid oxidase
chr2_+_31806602 0.60 ENSDART00000086608
RAN binding protein 9
chr21_+_45223194 0.60 ENSDART00000150902
si:ch73-269m14.3
chr25_-_34845302 0.59 ENSDART00000039485
GABA(A) receptor-associated protein like 2
chr8_+_10823069 0.58 ENSDART00000081341
mitogen-activated protein kinase 13
chr7_-_24644893 0.52 ENSDART00000048921
GP1 homolog, RAB6A GEF complex partner 1
chr19_-_7441948 0.52 ENSDART00000003544
GA binding protein transcription factor, beta subunit 2a
chr7_-_17779644 0.52 ENSDART00000128504
si:dkey-106g10.7
chr7_+_24153070 0.48 ENSDART00000076735
low density lipoprotein receptor-related protein 10
chr21_+_22423286 0.47 ENSDART00000133190
calcyphosine-like b
chr2_+_31308587 0.46 ENSDART00000027090
clusterin-like 1 (retinal)
chr3_-_13437799 0.46 ENSDART00000126455
ENSDART00000074068
deoxyhypusine synthase
chr6_+_14980761 0.45 ENSDART00000087782
mitochondrial ribosomal protein S9
chr5_+_33281105 0.44 ENSDART00000011337
surfeit 1
chr18_-_14691727 0.43 ENSDART00000010129
peptide deformylase, mitochondrial
chr7_-_5711197 0.43 ENSDART00000134367
si:dkey-10h3.2
chr22_-_10440688 0.40 ENSDART00000111962
nucleolar protein 8
chr8_+_23009662 0.39 ENSDART00000030885
uridine-cytidine kinase 1-like 1a
chr21_-_29119560 0.36 ENSDART00000147367
hepatitis A virus cellular receptor 2
chr6_-_39218609 0.36 ENSDART00000133305
osteosarcoma amplified 9, endoplasmic reticulum lectin

Network of associatons between targets according to the STRING database.

First level regulatory network of irx2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 12.8 GO:0021846 cell proliferation in forebrain(GO:0021846)
1.0 5.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.0 2.9 GO:0042940 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
0.9 2.6 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.8 5.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.8 2.4 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.7 3.7 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.7 2.9 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.6 8.5 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.6 3.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 2.7 GO:0097032 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.4 5.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.4 16.9 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.4 4.2 GO:0046548 retinal rod cell development(GO:0046548)
0.4 2.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 2.9 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.4 3.0 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.4 2.9 GO:0036372 opsin transport(GO:0036372)
0.4 2.5 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.3 2.8 GO:0044211 CTP salvage(GO:0044211)
0.3 5.1 GO:0032418 lysosome localization(GO:0032418)
0.3 5.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 10.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 1.5 GO:0000012 single strand break repair(GO:0000012)
0.3 2.0 GO:0042311 vasodilation(GO:0042311)
0.3 0.9 GO:0035046 pronuclear migration(GO:0035046)
0.3 7.3 GO:0097192 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.2 1.9 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.2 2.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.2 1.8 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.2 2.0 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.2 1.7 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.2 1.2 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 12.5 GO:0045214 sarcomere organization(GO:0045214)
0.2 2.6 GO:0016199 axon midline choice point recognition(GO:0016199)
0.2 2.6 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.2 4.5 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.2 4.2 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.2 5.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 0.6 GO:0006554 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.2 1.1 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.1 3.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 2.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 4.7 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 2.4 GO:0034453 microtubule anchoring(GO:0034453)
0.1 3.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 1.3 GO:0042407 cristae formation(GO:0042407)
0.1 4.2 GO:0001763 morphogenesis of a branching structure(GO:0001763)
0.1 2.8 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.9 GO:2000758 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 1.6 GO:0015693 magnesium ion transport(GO:0015693)
0.1 2.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 3.0 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.1 2.0 GO:0039022 pronephric duct development(GO:0039022) nephric duct development(GO:0072176)
0.1 1.9 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 2.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.8 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 1.6 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.1 1.8 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 3.7 GO:0032456 endocytic recycling(GO:0032456)
0.1 0.9 GO:0051984 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of chromosome segregation(GO:0051984) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.1 3.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.0 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.1 1.0 GO:0042026 protein refolding(GO:0042026)
0.1 1.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 3.5 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 8.5 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 1.3 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 3.0 GO:0006414 translational elongation(GO:0006414)
0.0 1.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 5.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 2.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 1.2 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.6 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.9 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956) positive regulation of regulated secretory pathway(GO:1903307)
0.0 3.3 GO:0021510 spinal cord development(GO:0021510)
0.0 1.3 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.4 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 4.3 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 3.5 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 4.0 GO:0050804 modulation of synaptic transmission(GO:0050804)
0.0 1.7 GO:0010469 regulation of receptor activity(GO:0010469)
0.0 0.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.5 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 1.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.2 GO:0002031 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 0.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 2.6 GO:0006914 autophagy(GO:0006914)
0.0 1.3 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.7 2.9 GO:0035339 SPOTS complex(GO:0035339)
0.6 2.9 GO:0005879 axonemal microtubule(GO:0005879)
0.4 5.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.4 2.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.4 2.9 GO:0097225 sperm midpiece(GO:0097225)
0.3 4.4 GO:0033270 paranode region of axon(GO:0033270)
0.3 2.7 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.3 2.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 2.3 GO:0072487 MSL complex(GO:0072487)
0.2 2.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 19.9 GO:0030141 secretory granule(GO:0030141)
0.2 3.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 3.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 4.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 1.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 3.5 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.8 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 10.8 GO:0005871 kinesin complex(GO:0005871)
0.1 10.8 GO:0031968 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.3 GO:0061617 MICOS complex(GO:0061617)
0.1 2.4 GO:0045180 basal cortex(GO:0045180)
0.1 1.2 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.9 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.1 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 3.9 GO:0030018 Z disc(GO:0030018)
0.0 5.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 5.3 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.7 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.1 GO:0043514 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 1.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 4.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 4.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 4.9 GO:0005938 cell cortex(GO:0005938)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 9.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0005769 early endosome(GO:0005769)
0.0 4.8 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.0 2.9 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.8 5.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.7 2.0 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.7 2.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.6 1.7 GO:0017050 D-erythro-sphingosine kinase activity(GO:0017050)
0.6 8.5 GO:0051117 ATPase binding(GO:0051117)
0.5 2.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.5 2.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 12.5 GO:0042805 actinin binding(GO:0042805)
0.4 3.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 3.9 GO:0008494 translation activator activity(GO:0008494)
0.4 2.9 GO:0004995 tachykinin receptor activity(GO:0004995)
0.4 1.9 GO:0016531 copper chaperone activity(GO:0016531)
0.3 2.8 GO:0004849 uridine kinase activity(GO:0004849)
0.3 2.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 10.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 1.6 GO:0019202 amino acid kinase activity(GO:0019202)
0.3 4.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 3.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.8 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 5.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 4.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 1.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 0.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 1.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 3.7 GO:0031267 small GTPase binding(GO:0031267)
0.2 2.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.2 1.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 1.7 GO:0031420 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.1 2.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.4 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 1.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 1.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 1.7 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 2.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 3.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 3.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 6.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 15.3 GO:0051015 actin filament binding(GO:0051015)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 6.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0042164 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 0.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.8 GO:0016878 acid-thiol ligase activity(GO:0016878)
0.0 2.7 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 11.5 GO:0003924 GTPase activity(GO:0003924)
0.0 4.9 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 4.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 5.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 32.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 5.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 5.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 3.0 ST GA13 PATHWAY G alpha 13 Pathway
0.1 3.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 0.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 3.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 2.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 4.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 2.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.5 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 3.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.9 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 1.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.9 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 2.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation