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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for irx6a

Z-value: 0.44

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Transcription factors associated with irx6a

Gene Symbol Gene ID Gene Info
irx6a
ENSDARG00000034420 iroquois homeobox 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx6adr11_v1_chr7_-_35516251_355162510.456.5e-06Click!

Activity profile of irx6a motif

Sorted Z-values of irx6a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_35382482 3.99 ENSDART00000135284
vsnl1a
visinin-like 1a
chr16_+_25316973 3.89 ENSDART00000086409
dync1i1
dynein, cytoplasmic 1, intermediate chain 1
chr6_+_3827751 3.79 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr17_-_26719821 3.39 ENSDART00000186813
calm1a
calmodulin 1a
chr13_+_43247936 3.23 ENSDART00000126850
ENSDART00000165331
smoc2
SPARC related modular calcium binding 2
chr13_+_23677949 3.07 ENSDART00000144215
pcnxl2
pecanex-like 2 (Drosophila)
chr8_-_6943155 2.98 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr18_+_5549672 2.75 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr18_+_910992 2.38 ENSDART00000161206
ENSDART00000167229
pkma
pyruvate kinase M1/2a
chr16_+_1803462 2.37 ENSDART00000183974
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr15_-_9419472 2.28 ENSDART00000122117
sacs
sacsin molecular chaperone
chr5_-_33460959 2.24 ENSDART00000085636
si:ch211-182d3.1
si:ch211-182d3.1
chr21_-_12036134 1.95 ENSDART00000031658
tpgs2
tubulin polyglutamylase complex subunit 2
chr25_+_7671640 1.79 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr24_-_15263142 1.70 ENSDART00000183176
ENSDART00000006930
rttn
rotatin
chr15_+_11381532 1.61 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr15_+_33991928 1.60 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr5_-_48268049 1.35 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr5_+_13427826 1.21 ENSDART00000083359
sec14l8
SEC14-like lipid binding 8
chr7_+_10701770 1.17 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr7_-_44672095 1.15 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr6_-_12788539 1.14 ENSDART00000156415
dock9b
dedicator of cytokinesis 9b
chr15_-_14375452 1.14 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
dpf1
D4, zinc and double PHD fingers family 1
chr9_+_23748342 1.08 ENSDART00000019053
faima
Fas apoptotic inhibitory molecule a
chr15_-_2857961 1.08 ENSDART00000033263
ankrd49
ankyrin repeat domain 49
chr9_-_14108896 1.07 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr14_-_47963115 1.03 ENSDART00000003826
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr16_+_22649855 1.00 ENSDART00000143043
chrnb2b
cholinergic receptor, nicotinic, beta 2b
chr23_-_32944796 0.99 ENSDART00000190388
plxna2
plexin A2
chr23_-_3721444 0.91 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr8_-_11832771 0.90 ENSDART00000193412
ENSDART00000184720
ENSDART00000139947
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr9_+_23748133 0.89 ENSDART00000180758
faima
Fas apoptotic inhibitory molecule a
chr21_-_45871866 0.85 ENSDART00000161716
larp1
La ribonucleoprotein domain family, member 1
chr4_+_22613625 0.80 ENSDART00000131161
sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr24_-_28229618 0.78 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a
chr21_+_40498628 0.77 ENSDART00000163454
coro6
coronin 6
chr20_-_43723860 0.75 ENSDART00000122051
mixl1
Mix paired-like homeobox
chr23_+_45027263 0.74 ENSDART00000058364
hmgb2b
high mobility group box 2b
chr6_+_49901465 0.72 ENSDART00000023515
chmp4ba
charged multivesicular body protein 4Ba
chr20_-_13774826 0.72 ENSDART00000063831
opn8c
opsin 8, group member c
chr4_+_9028819 0.70 ENSDART00000102893
aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr22_+_2937485 0.69 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr19_+_26923274 0.68 ENSDART00000148439
ENSDART00000148877
nelfe
negative elongation factor complex member E
chr1_+_961607 0.68 ENSDART00000184660
n6amt1
N-6 adenine-specific DNA methyltransferase 1
chr19_-_17526735 0.67 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr21_+_20549395 0.65 ENSDART00000181633
efna5a
ephrin-A5a
chr6_+_27304503 0.64 ENSDART00000154759
espnla
espin like a
chr12_-_35095414 0.64 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr17_-_14705039 0.61 ENSDART00000154281
ENSDART00000123550
ptp4a2a
protein tyrosine phosphatase type IVA, member 2a
chr18_+_19990412 0.60 ENSDART00000155054
ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr20_-_38610360 0.57 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr2_+_54804385 0.57 ENSDART00000172309
twsg1a
twisted gastrulation BMP signaling modulator 1a
chr19_+_27342479 0.55 ENSDART00000184687
ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr8_+_29986265 0.55 ENSDART00000148258
ptch1
patched 1
chr22_+_31207226 0.53 ENSDART00000180016
grip2b
glutamate receptor interacting protein 2b
chr9_-_2945008 0.53 ENSDART00000183452
zak
sterile alpha motif and leucine zipper containing kinase AZK
chr24_-_26981848 0.52 ENSDART00000183198
stag1b
stromal antigen 1b
chr4_-_18841071 0.50 ENSDART00000140722
cbll1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr21_+_23108420 0.47 ENSDART00000192394
ENSDART00000088459
htr3b
5-hydroxytryptamine (serotonin) receptor 3B
chr8_+_28259347 0.43 ENSDART00000110857
fam212b
family with sequence similarity 212, member B
chr5_-_69538058 0.42 ENSDART00000097251
zgc:153044
zgc:153044
chr10_+_8629275 0.37 ENSDART00000129643
aplnrb
apelin receptor b
chr22_+_2431585 0.35 ENSDART00000167758
zgc:171435
zgc:171435
chr12_+_34854562 0.34 ENSDART00000130366
si:dkey-21c1.4
si:dkey-21c1.4
chr13_-_12389748 0.34 ENSDART00000141606
commd8
COMM domain containing 8
chr17_+_8899016 0.31 ENSDART00000150214
psmc1a
proteasome 26S subunit, ATPase 1a
chr14_-_26392146 0.30 ENSDART00000037999
b4galt7
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr15_-_3976035 0.30 ENSDART00000168061
si:ch73-309g22.1
si:ch73-309g22.1
chr15_-_23522653 0.29 ENSDART00000144685
hmbsb
hydroxymethylbilane synthase, b
chr10_-_28117740 0.24 ENSDART00000134491
med13a
mediator complex subunit 13a
chr3_-_12970418 0.20 ENSDART00000158747
pdgfab
platelet-derived growth factor alpha polypeptide b
chr15_-_5178899 0.19 ENSDART00000132148
or126-4
odorant receptor, family E, subfamily 126, member 4
chr23_+_29885019 0.18 ENSDART00000167059
aurkaip1
aurora kinase A interacting protein 1
chr14_-_30747686 0.16 ENSDART00000008373
fosl1a
FOS-like antigen 1a
chr6_+_6802582 0.14 ENSDART00000189422
dtd1
D-tyrosyl-tRNA deacylase 1
chr6_-_131401 0.12 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr12_+_4222854 0.12 ENSDART00000144881
mapk7
mitogen-activated protein kinase 7
chr22_+_2492397 0.10 ENSDART00000181596
CU570894.2

chr24_+_10202718 0.07 ENSDART00000126668
pou6f2
POU class 6 homeobox 2
chr14_-_10492072 0.05 ENSDART00000182525
lpar4
lysophosphatidic acid receptor 4
chr12_+_36891483 0.03 ENSDART00000048927
cox10
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
chr21_+_43882274 0.00 ENSDART00000075672
sra1
steroid receptor RNA activator 1
chr17_-_5352924 0.00 ENSDART00000167275
supt3h
SPT3 homolog, SAGA and STAGA complex component
chr16_+_26741319 0.00 ENSDART00000183552
rad54b
RAD54 homolog B (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of irx6a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.7 2.8 GO:0006740 NADPH regeneration(GO:0006740)
0.4 1.2 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.3 1.0 GO:0003403 optic vesicle formation(GO:0003403)
0.3 1.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 0.7 GO:0009397 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.2 0.9 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 2.0 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.2 0.7 GO:0042706 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 0.7 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 3.4 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 0.6 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 1.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.8 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 0.4 GO:1903589 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.1 1.2 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 3.2 GO:0042476 odontogenesis(GO:0042476)
0.1 0.3 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 0.7 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.1 0.5 GO:0048635 cardioblast differentiation(GO:0010002) negative regulation of muscle organ development(GO:0048635)
0.0 0.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.7 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.5 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 3.9 GO:0010970 establishment of localization by movement along microtubule(GO:0010970)
0.0 2.4 GO:0006096 glycolytic process(GO:0006096)
0.0 1.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 1.3 GO:0060914 heart formation(GO:0060914)
0.0 1.8 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.8 GO:0001706 endoderm formation(GO:0001706)
0.0 0.6 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.7 GO:0007602 phototransduction(GO:0007602)
0.0 0.8 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 1.6 GO:0021782 glial cell development(GO:0021782)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 0.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.7 GO:0032021 NELF complex(GO:0032021)
0.1 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.0 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.1 GO:0071565 nBAF complex(GO:0071565)
0.0 3.1 GO:0005604 basement membrane(GO:0005604)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.5 GO:0008278 cohesin complex(GO:0008278)
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.7 2.8 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.4 2.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 3.9 GO:0045503 dynein light chain binding(GO:0045503)
0.2 0.7 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.2 0.9 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.2 0.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 2.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.5 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 1.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 3.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.4 GO:0060182 apelin receptor activity(GO:0060182)
0.1 0.5 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.1 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.7 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.1 GO:0016208 AMP binding(GO:0016208)
0.0 1.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 4.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis