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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for isl2a+isl2b

Z-value: 0.59

Motif logo

Transcription factors associated with isl2a+isl2b

Gene Symbol Gene ID Gene Info
ENSDARG00000003971 ISL LIM homeobox 2a
ENSDARG00000053499 ISL LIM homeobox 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
isl2bdr11_v1_chr7_+_29992889_299928890.223.2e-02Click!
isl2adr11_v1_chr25_-_32751982_327519820.094.0e-01Click!

Activity profile of isl2a+isl2b motif

Sorted Z-values of isl2a+isl2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_45094599 4.28 ENSDART00000155479
si:rp71-77l1.1
chr18_+_30847237 4.14 ENSDART00000012374
forkhead box F1
chr25_+_21833287 3.78 ENSDART00000187606
creatine kinase, mitochondrial 1
chr15_+_46356879 3.76 ENSDART00000154388
wu:fb18f06
chr20_-_5291012 3.50 ENSDART00000122892
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr15_+_46357080 3.49 ENSDART00000155571
ENSDART00000156541
wu:fb18f06
chr15_-_2640966 3.42 ENSDART00000063320
claudin e
chr12_+_17154655 3.28 ENSDART00000028003
ankyrin repeat domain 22
chr19_+_1688727 2.83 ENSDART00000115136
ENSDART00000166744
DENN/MADD domain containing 3a
chr24_-_26310854 2.62 ENSDART00000080113
apolipoprotein Db
chr20_+_41021054 2.45 ENSDART00000146052
mannosidase, alpha, class 1A, member 1
chr21_+_25236297 2.43 ENSDART00000112783
transmembrane protein 45B
chr23_-_33350990 2.41 ENSDART00000144831
si:ch211-226m16.2
chr15_-_46779934 2.33 ENSDART00000085136
chloride channel 2c
chr5_+_58550291 2.15 ENSDART00000184983
ENSDART00000044803
POU class 2 homeobox 3
chr8_+_52637507 2.13 ENSDART00000163830
si:dkey-90l8.3
chr25_+_3994823 2.06 ENSDART00000154020
EPS8 like 2
chr21_-_44081540 2.02 ENSDART00000130833

chr17_+_15433518 1.98 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr22_-_16154771 1.90 ENSDART00000009464
solute carrier family 30 (zinc transporter), member 7
chr22_+_19552987 1.87 ENSDART00000105315
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr1_+_52792439 1.75 ENSDART00000123972
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr6_-_35046735 1.75 ENSDART00000143649
UDP-N-acetylglucosamine pyrophosphorylase 1
chr18_-_48547564 1.72 ENSDART00000138607
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr17_+_15433671 1.72 ENSDART00000149568
fatty acid binding protein 7, brain, a
chr23_-_31645760 1.71 ENSDART00000035031
serum/glucocorticoid regulated kinase 1
chr18_-_15932704 1.69 ENSDART00000127769
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr21_+_11385031 1.64 ENSDART00000040598
carboxyl ester lipase, tandem duplicate 2
chr8_-_50147948 1.63 ENSDART00000149010
haptoglobin
chr14_-_4145594 1.61 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr13_-_36391496 1.52 ENSDART00000100217
ENSDART00000140243
actinin, alpha 1
chr7_+_66822229 1.51 ENSDART00000112109
lymphatic vessel endothelial hyaluronic receptor 1a
chr16_+_54209504 1.47 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr3_-_25268751 1.45 ENSDART00000139423
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a
chr7_+_22657566 1.45 ENSDART00000141048
plac8 onzin related protein 5
chr5_-_19861766 1.44 ENSDART00000088904
glycolipid transfer protein a
chr11_+_24002503 1.42 ENSDART00000164702
chitinase, acidic.2
chr19_-_5769728 1.41 ENSDART00000133106
si:ch211-264f5.6
chr11_+_24001993 1.39 ENSDART00000168215
chitinase, acidic.2
chr13_-_33639050 1.37 ENSDART00000133073
ribosome binding protein 1a
chr10_+_29850330 1.34 ENSDART00000168898
heat shock protein 8
chr3_+_26342768 1.25 ENSDART00000163832
si:ch211-156b7.4
chr10_-_45210184 1.22 ENSDART00000167128
poly (ADP-ribose) glycohydrolase, like
chr21_-_35419486 1.22 ENSDART00000138529
si:dkeyp-23e4.3
chr12_-_4532066 1.21 ENSDART00000092687
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr5_+_69785990 1.14 ENSDART00000162057
ENSDART00000166893
lysine methyltransferase 5Ab
chr19_+_16015881 1.14 ENSDART00000187135
CTP synthase 1a
chr2_+_36112273 1.13 ENSDART00000191315
T-cell receptor alpha joining 35
chr5_+_60590796 1.13 ENSDART00000159859
transmembrane protein 132E
chr22_-_5252005 1.12 ENSDART00000132942
ENSDART00000081801
nicalin
chr6_-_12588044 1.11 ENSDART00000047896
solute carrier family 15 (oligopeptide transporter), member 1b
chr16_-_39477746 1.10 ENSDART00000102525
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
chr6_-_16717878 1.10 ENSDART00000153552
nodal modulator
chr1_-_9641845 1.08 ENSDART00000121490
ENSDART00000159411
UDP glucuronosyltransferase 5 family, polypeptide B2
UDP glucuronosyltransferase 5 family, polypeptide B3
chr25_-_21031007 1.07 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr23_+_36460239 1.06 ENSDART00000172441
LIM domain and actin binding 1a
chr16_+_23303859 1.03 ENSDART00000006093
solute carrier family 50 (sugar efflux transporter), member 1
chr15_-_43284021 1.02 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr15_+_36115955 1.02 ENSDART00000032702
somatostatin 1, tandem duplicate 2
chr8_+_25913787 1.01 ENSDART00000190257
ENSDART00000062515
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H
chr2_+_2169337 1.00 ENSDART00000179939
HIG1 hypoxia inducible domain family, member 1A
chr4_-_17669881 0.96 ENSDART00000066997
DNA-damage regulated autophagy modulator 1
chr24_+_12989727 0.94 ENSDART00000126842
ENSDART00000129309
hypothetical protein FLJ11011-like (H. sapiens)
chr12_+_18899396 0.91 ENSDART00000105858
X-ray repair complementing defective repair in Chinese hamster cells 6
chr5_+_69786215 0.88 ENSDART00000165956
lysine methyltransferase 5Ab
chr5_+_56023186 0.87 ENSDART00000156230
frizzled class receptor 9a
chr16_-_17072440 0.87 ENSDART00000002493
ENSDART00000178443
tumor necrosis factor receptor superfamily, member 1a
chr12_+_16168342 0.85 ENSDART00000079326
ENSDART00000170024
low density lipoprotein receptor-related protein 2b
chr15_+_25438714 0.84 ENSDART00000154164
apoptosis-inducing factor, mitochondrion-associated, 4
chr23_-_36724575 0.83 ENSDART00000159560
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr22_-_10165446 0.83 ENSDART00000142012
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_55873178 0.82 ENSDART00000019936
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
chr2_-_38284648 0.82 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr21_+_27513859 0.81 ENSDART00000065420
phosphofurin acidic cluster sorting protein 1a
chr6_+_39905021 0.80 ENSDART00000064904
endonuclease, polyU-specific
chr12_+_22560067 0.80 ENSDART00000172066
polymerase (RNA) II (DNA directed) polypeptide A
chr22_-_36530902 0.78 ENSDART00000056188
info polymerase (RNA) II (DNA directed) polypeptide H
chr3_+_3681116 0.78 ENSDART00000109618
ADP-ribosyltransferase 4 (Dombrock blood group)
chr3_+_28939759 0.78 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr3_+_14388010 0.77 ENSDART00000171726
ENSDART00000165452
transmembrane protein 56b
chr21_+_45841731 0.76 ENSDART00000038657
fatty acid hydroxylase domain containing 2
chr14_+_21722235 0.76 ENSDART00000183667
syntaxin 3A
chr9_+_24008879 0.73 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
melanophilin b
chr4_-_77218637 0.72 ENSDART00000174325
proteasome subunit beta 10
chr7_-_48665305 0.71 ENSDART00000190507
cyclin-dependent kinase inhibitor 1Ca
chr24_-_6078222 0.71 ENSDART00000146830
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr12_+_10062953 0.71 ENSDART00000148689
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr13_-_30996072 0.70 ENSDART00000181661
WDFY family member 4
chr3_-_19368435 0.70 ENSDART00000132987
sphingosine-1-phosphate receptor 5a
chr25_+_35212919 0.70 ENSDART00000180127
anoctamin 5a
chr19_+_7424347 0.65 ENSDART00000004622
splicing factor 3b, subunit 4
chr21_+_7100442 0.63 ENSDART00000163869
protein phosphatase 1, regulatory subunit 26
chr13_+_7049823 0.61 ENSDART00000178997
ENSDART00000161443
ribonuclease T2
chr6_-_34838397 0.59 ENSDART00000060169
ENSDART00000169605
mesoderm induction early response 1a, transcriptional regulator
chr18_+_17537344 0.59 ENSDART00000025782
nucleoporin 93
chr24_+_19415124 0.59 ENSDART00000186931
sulfatase 1
chr20_+_25586099 0.58 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr18_+_13275735 0.57 ENSDART00000148127
phospholipase C, gamma 2
chr13_+_646700 0.56 ENSDART00000006892
tumor protein p53 binding protein, 2a
chr22_-_17482282 0.56 ENSDART00000105453
si:ch211-197g15.7
chr3_+_7808459 0.55 ENSDART00000162374
hook microtubule-tethering protein 2
chr3_+_32553714 0.54 ENSDART00000165638
paired box 10
chr17_-_16422654 0.54 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr8_-_11324143 0.54 ENSDART00000008215
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr15_-_21702317 0.54 ENSDART00000155824
si:dkey-40g16.6
chr3_-_26787430 0.53 ENSDART00000087047
RAB40c, member RAS oncogene family
chr19_+_31904836 0.53 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tumor protein D52
chr21_-_35534401 0.52 ENSDART00000112308
si:dkeyp-23e4.3
chr9_+_21793565 0.52 ENSDART00000134915
REV1, polymerase (DNA directed)
chr19_+_16016038 0.51 ENSDART00000131319
CTP synthase 1a
chr18_+_17537975 0.51 ENSDART00000179783
nucleoporin 93
chr23_-_18024543 0.51 ENSDART00000139695
peptidase M20 domain containing 1, tandem duplicate 1
chr2_-_59205393 0.51 ENSDART00000056417
ENSDART00000182452
ENSDART00000141876
finTRIM family, member 30
chr7_+_39166460 0.50 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
midkine a
chr11_-_45138857 0.50 ENSDART00000166501
calcium activated nucleotidase 1b
chr12_-_9516981 0.49 ENSDART00000106285
si:ch211-207i20.3
chr7_-_2047639 0.48 ENSDART00000173892
si:cabz01007794.1
chr16_-_48400639 0.46 ENSDART00000159372
eukaryotic translation initiation factor 3, subunit H, a
chr8_+_31717175 0.46 ENSDART00000013434
3-oxoacid CoA transferase 1a
chr11_+_29856032 0.46 ENSDART00000079150
gastrin-releasing peptide receptor
chr2_+_10771787 0.46 ENSDART00000187782
growth factor independent 1A transcription repressor a
chr24_-_12770357 0.44 ENSDART00000060826
importin 4
chr10_-_34916208 0.44 ENSDART00000187371
cyclin A1
chr7_+_24573721 0.43 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr6_-_8311044 0.43 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr21_-_10886709 0.40 ENSDART00000134408
si:dkey-277m11.2
chr4_-_75158035 0.39 ENSDART00000174353

chr19_+_33093577 0.38 ENSDART00000180317
family with sequence similarity 91, member A1
chr24_-_32173754 0.38 ENSDART00000048633
tRNA aspartic acid methyltransferase 1
chr4_-_1801519 0.38 ENSDART00000188604
ENSDART00000135749
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr11_-_29737088 0.37 ENSDART00000159828
si:ch211-218g23.6
chr9_+_32069989 0.37 ENSDART00000139540
si:dkey-83m22.7
chr4_-_46915962 0.34 ENSDART00000169555
si:ch211-134c10.1
chr3_+_32532645 0.34 ENSDART00000055312
ENSDART00000150981
nitric oxide synthase interacting protein
chr15_+_1766734 0.34 ENSDART00000168250
cullin 3b
chr4_-_49582758 0.34 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
chr10_+_44956660 0.34 ENSDART00000169225
ENSDART00000189298
interleukin 1, beta
chr1_+_55608520 0.33 ENSDART00000152307
adhesion G protein-coupled receptor E18
chr16_+_11660839 0.33 ENSDART00000193911
ENSDART00000143683
si:dkey-250k15.10
chr7_-_50410524 0.33 ENSDART00000083346
huntingtin interacting protein K
chr2_-_293793 0.33 ENSDART00000082091
si:ch73-40a17.3
chr16_-_28658341 0.33 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr21_-_37194839 0.32 ENSDART00000175126
fibroblast growth factor receptor 4
chr1_+_55758257 0.32 ENSDART00000139312
trans-2,3-enoyl-CoA reductase b
chr6_+_40951227 0.28 ENSDART00000156660
POZ (BTB) and AT hook containing zinc finger 1
chr6_+_12527725 0.28 ENSDART00000149328
serine/threonine kinase 24b (STE20 homolog, yeast)
chr3_+_32532000 0.28 ENSDART00000165909
nitric oxide synthase interacting protein
chr21_-_35325466 0.27 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ubiquitin-like domain containing CTD phosphatase 1
chr10_-_43771447 0.27 ENSDART00000052307
arrestin domain containing 3b
chr5_+_32076109 0.26 ENSDART00000051357
ENSDART00000144510
zinc finger, matrin-type 5
chr18_+_43891051 0.26 ENSDART00000024213
chemokine (C-X-C motif) receptor 5
chr3_-_54846444 0.25 ENSDART00000074010
UBA-like domain containing 1b
chr13_+_15657911 0.24 ENSDART00000134972
ENSDART00000138991
ENSDART00000133342
MAP/microtubule affinity-regulating kinase 3a
chr1_-_669717 0.24 ENSDART00000160564
cysteine/tyrosine-rich 1
chr25_+_22320738 0.23 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr7_-_66868543 0.23 ENSDART00000149680
adenosine monophosphate deaminase 3a
chr4_-_9909371 0.23 ENSDART00000102656
si:dkey-22l11.6
chr2_-_22927958 0.23 ENSDART00000141621
myosin VIIBb
chr2_+_10878406 0.22 ENSDART00000091497
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr5_-_42083363 0.22 ENSDART00000162596
chemokine (C-X-C motif) ligand 11, duplicate 5
chr5_+_22791686 0.21 ENSDART00000014806
neuronal PAS domain protein 2
chr23_+_31981796 0.20 ENSDART00000187080
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr21_+_43172506 0.17 ENSDART00000121725
zinc finger, CCHC domain containing 10
chr2_-_293036 0.15 ENSDART00000171629
si:ch73-40a17.3
chr22_-_17482810 0.15 ENSDART00000171293
si:ch211-197g15.7
chr16_-_10223741 0.15 ENSDART00000188099
si:rp71-15i12.1
chr21_+_4256291 0.15 ENSDART00000148138
leucine rich repeat containing 8 VRAC subunit Aa
chr7_+_60079302 0.15 ENSDART00000051524
ethanolamine-phosphate phospho-lyase
chr23_+_9353552 0.15 ENSDART00000163298

chr8_+_31716872 0.14 ENSDART00000161121
3-oxoacid CoA transferase 1a
chr17_-_2834764 0.14 ENSDART00000024027
bradykinin receptor B1
chr11_-_10456387 0.13 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr2_-_10877765 0.12 ENSDART00000100607
cell division cycle 7 homolog (S. cerevisiae)
chr11_+_31324335 0.11 ENSDART00000088093
signal-induced proliferation-associated 1 like 2
chr9_+_54039006 0.09 ENSDART00000112441
toll-like receptor 7
chr23_+_32406461 0.09 ENSDART00000179878
si:ch211-66i15.5
chr2_+_20605925 0.09 ENSDART00000191510
olfactomedin-like 2Bb
chr17_-_4245902 0.09 ENSDART00000151851
growth differentiation factor 3
chr7_-_7797654 0.09 ENSDART00000084503
ENSDART00000192779
ENSDART00000173079
tRNA methyltransferase 10B
chr24_-_3477103 0.08 ENSDART00000143723
isopentenyl-diphosphate delta isomerase 1
chr21_+_11749097 0.08 ENSDART00000102408
ENSDART00000102404
elongation factor, RNA polymerase II, 2
chr2_-_1622641 0.07 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr1_-_50859053 0.07 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr13_-_42560662 0.07 ENSDART00000124898

chr16_-_21140097 0.05 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
chr11_-_10456553 0.04 ENSDART00000169509
ENSDART00000185574
ENSDART00000188276
epithelial cell transforming 2
chr23_-_3511630 0.03 ENSDART00000019667
ring finger protein 114
chr17_-_29224908 0.00 ENSDART00000156288
si:dkey-28g23.6
chr19_+_24872159 0.00 ENSDART00000158490
si:ch211-195b13.1

Network of associatons between targets according to the STRING database.

First level regulatory network of isl2a+isl2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.2 GO:0006032 chitin catabolic process(GO:0006032)
0.5 2.3 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.4 1.7 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.4 1.2 GO:0002369 T cell cytokine production(GO:0002369)
0.4 2.0 GO:0000012 single strand break repair(GO:0000012)
0.3 2.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.3 3.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.3 3.8 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3 0.9 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.2 1.3 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.2 1.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 2.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 0.9 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.2 1.0 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.2 0.8 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 0.8 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 1.6 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 1.8 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.5 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.1 1.1 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.6 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 1.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 0.3 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1 2.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0015871 choline transport(GO:0015871)
0.1 1.1 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 0.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.0 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.8 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.6 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 0.1 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 1.5 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 2.6 GO:0007568 aging(GO:0007568)
0.1 0.4 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 2.3 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 0.6 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.8 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.1 3.4 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 1.9 GO:0006829 zinc II ion transport(GO:0006829)
0.1 1.1 GO:0043687 protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687)
0.1 0.6 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.8 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 1.2 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.0 0.6 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.5 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 3.6 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.5 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.0 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.5 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 3.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.2 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.8 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.6 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0097268 cytoophidium(GO:0097268)
0.3 1.8 GO:0016589 NURF complex(GO:0016589)
0.2 0.6 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.1 0.4 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.1 1.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.8 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.1 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.5 GO:0001726 ruffle(GO:0001726)
0.0 0.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 3.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.7 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.5 1.6 GO:0004771 sterol esterase activity(GO:0004771)
0.5 5.2 GO:0004568 chitinase activity(GO:0004568)
0.4 1.7 GO:0003883 CTP synthase activity(GO:0003883)
0.4 1.8 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.3 1.2 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.3 3.8 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.3 1.1 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 3.7 GO:0005504 fatty acid binding(GO:0005504)
0.2 2.5 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.2 0.6 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.2 0.5 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.2 0.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 0.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.2 1.1 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 2.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.6 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.3 GO:0015562 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.1 0.8 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 1.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.8 GO:0016936 galactoside binding(GO:0016936)
0.1 0.2 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.1 1.6 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 1.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.4 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 2.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.8 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.9 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.1 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0032190 acrosin binding(GO:0032190)
0.0 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.8 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.2 GO:0099604 ligand-gated calcium channel activity(GO:0099604)
0.0 0.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 2.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.5 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.5 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.7 GO:0017022 myosin binding(GO:0017022)
0.0 0.7 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 4.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.7 GO:0042562 hormone binding(GO:0042562)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 4.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.5 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.8 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 1.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 1.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.6 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.6 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling