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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for klf15+si:ch211-117k10.3

Z-value: 1.02

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Transcription factors associated with klf15+si:ch211-117k10.3

Gene Symbol Gene ID Gene Info
si_ch211-117k10.3
ENSDARG00000090914 si_ch211-117k10.3
klf15
ENSDARG00000091127 Kruppel-like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-117k10.3dr11_v1_chr11_-_38513978_38513978-0.594.9e-10Click!
klf15dr11_v1_chr23_-_35195908_351959080.512.0e-07Click!

Activity profile of klf15+si:ch211-117k10.3 motif

Sorted Z-values of klf15+si:ch211-117k10.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_38110779 27.00 ENSDART00000147783
crp
c-reactive protein, pentraxin-related
chr4_+_55758103 23.18 ENSDART00000185964
CT583728.23

chr19_+_48117995 20.08 ENSDART00000170865
nme2b.1
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
chr3_-_16289826 12.92 ENSDART00000131972
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr5_-_16351306 11.34 ENSDART00000168643
CABZ01088700.1

chr1_-_44638058 10.58 ENSDART00000081835
slc43a1b
solute carrier family 43 (amino acid system L transporter), member 1b
chr5_+_27525477 10.54 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr18_-_26715655 9.87 ENSDART00000181497
malt3
MALT paracaspase 3
chr5_-_69621227 9.05 ENSDART00000178543
aldh2.2
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr18_-_26715156 8.94 ENSDART00000142043
malt3
MALT paracaspase 3
chr2_+_7192966 8.76 ENSDART00000142735
si:ch211-13f8.1
si:ch211-13f8.1
chr7_+_1449999 8.24 ENSDART00000173864
si:cabz01101003.1
si:cabz01101003.1
chr22_-_5918670 8.08 ENSDART00000141373
si:rp71-36a1.1
si:rp71-36a1.1
chr11_+_11719575 8.05 ENSDART00000003891
jupa
junction plakoglobin a
chr9_-_8314028 7.74 ENSDART00000102739
si:ch211-145c1.1
si:ch211-145c1.1
chr4_-_68569527 7.38 ENSDART00000192091
BX548011.5

chr6_+_36821621 7.19 ENSDART00000104157
tmem45a
transmembrane protein 45a
chr15_-_28618502 6.95 ENSDART00000086902
slc6a4a
solute carrier family 6 (neurotransmitter transporter), member 4a
chr8_-_53488832 6.87 ENSDART00000191801
chdh
choline dehydrogenase
chr24_-_32582378 6.66 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr20_-_7080427 6.53 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
si:ch211-121a2.2
chr2_-_51700709 6.37 ENSDART00000188601
tgm1l1
transglutaminase 1 like 1
chr11_-_40504170 6.28 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr24_-_4450238 5.87 ENSDART00000066835
fzd8a
frizzled class receptor 8a
chr6_-_442163 5.46 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
grap2b
GRB2-related adaptor protein 2b
chr21_-_43117327 5.30 ENSDART00000122352
p4ha2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr24_+_28525507 5.28 ENSDART00000191121
arhgap29a
Rho GTPase activating protein 29a
chr17_-_4395373 5.14 ENSDART00000015923
klhl10a
kelch-like family member 10a
chr7_-_55454406 5.07 ENSDART00000108646
piezo1
piezo-type mechanosensitive ion channel component 1
chr12_+_10443785 4.80 ENSDART00000029133
snu13b
SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5)
chr5_+_9382301 4.73 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr15_-_23376541 4.62 ENSDART00000078570
c1qtnf5
C1q and TNF related 5
chr5_-_71838520 4.44 ENSDART00000174396
CU927890.1

chr25_-_34284144 4.29 ENSDART00000188109
gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_-_16990896 4.17 ENSDART00000152402
ifit12
interferon-induced protein with tetratricopeptide repeats 12
chr5_+_22067570 4.10 ENSDART00000045574
shisa2a
shisa family member 2a
chr2_+_24781026 4.07 ENSDART00000145692
pde4ca
phosphodiesterase 4C, cAMP-specific a
chr23_+_7518294 4.06 ENSDART00000081536
hck
HCK proto-oncogene, Src family tyrosine kinase
chr25_+_150570 4.05 ENSDART00000170892
adam10b
ADAM metallopeptidase domain 10b
chr12_-_4540564 4.05 ENSDART00000106566
CABZ01030107.1

chr18_+_46151505 3.95 ENSDART00000015034
ENSDART00000141287
blvrb
biliverdin reductase B
chr10_-_24961310 3.87 ENSDART00000037303
si:ch211-214k5.3
si:ch211-214k5.3
chr16_+_9713850 3.86 ENSDART00000164103
ecm1b
extracellular matrix protein 1b
chr21_-_45086170 3.85 ENSDART00000188963
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr10_-_40333319 3.80 ENSDART00000150479
taar20a
trace amine associated receptor 20a
chr6_-_43677125 3.68 ENSDART00000150128
foxp1b
forkhead box P1b
chr10_-_9115383 3.52 ENSDART00000139324
si:dkeyp-41f9.3
si:dkeyp-41f9.3
chr19_-_2707048 3.47 ENSDART00000166112
il6
interleukin 6 (interferon, beta 2)
chr24_-_11467004 3.41 ENSDART00000144316
pxdc1b
PX domain containing 1b
chr6_-_29377092 3.39 ENSDART00000078665
tmem131
transmembrane protein 131
chr21_+_41649336 3.39 ENSDART00000164694
ENSDART00000181539
ppp2r2bb
protein phosphatase 2, regulatory subunit B, beta b
chr21_+_11244068 3.29 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr22_+_7738966 3.22 ENSDART00000147073
si:ch73-44m9.5
si:ch73-44m9.5
chr7_+_44445595 2.98 ENSDART00000108766
cdh5
cadherin 5
chr6_+_52918537 2.95 ENSDART00000174229
or137-1
odorant receptor, family H, subfamily 137, member 1
chr14_+_34495216 2.89 ENSDART00000147756
wnt8a
wingless-type MMTV integration site family, member 8a
chr10_+_44719697 2.87 ENSDART00000158087
scarb1
scavenger receptor class B, member 1
chr2_-_7246338 2.84 ENSDART00000186735
zgc:153115
zgc:153115
chr22_-_1168291 2.81 ENSDART00000167724
si:ch1073-181h11.4
si:ch1073-181h11.4
chr16_-_31976269 2.79 ENSDART00000139664
styk1
serine/threonine/tyrosine kinase 1
chr11_+_6010177 2.77 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
gtpbp3
GTP binding protein 3, mitochondrial
chr4_+_65306260 2.66 ENSDART00000167558
si:dkey-14o6.8
si:dkey-14o6.8
chr12_+_5530247 2.66 ENSDART00000114637
ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr4_-_73572030 2.64 ENSDART00000121652
znf1015
zinc finger protein 1015
chr18_+_32780450 2.63 ENSDART00000168399
olfcg7
olfactory receptor C family, g7
chr16_+_7991274 2.57 ENSDART00000179704
ano10a
anoctamin 10a
chr4_+_9057427 2.54 ENSDART00000113867
slc41a2b
solute carrier family 41 (magnesium transporter), member 2b
chr25_+_25464630 2.50 ENSDART00000150537
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr14_-_9522364 2.49 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr4_-_75505048 2.43 ENSDART00000163665
si:dkey-71l4.5
si:dkey-71l4.5
chr20_-_48516765 2.41 ENSDART00000150200
si:zfos-223e1.2
si:zfos-223e1.2
chr22_-_24285432 2.39 ENSDART00000164083
si:ch211-117l17.4
si:ch211-117l17.4
chr6_-_53326421 2.31 ENSDART00000191740
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr6_+_23712911 2.25 ENSDART00000167795
zgc:158654
zgc:158654
chr3_-_36690348 2.24 ENSDART00000192513
myh11b
myosin, heavy chain 11b, smooth muscle
chr8_-_52938439 2.22 ENSDART00000168185
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr18_-_51015718 2.13 ENSDART00000190698
LO018598.1

chr20_-_16972351 2.09 ENSDART00000148312
ENSDART00000186702
si:ch73-74h11.1
si:ch73-74h11.1
chr8_+_8947623 1.90 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr22_-_4872418 1.86 ENSDART00000132360
si:ch73-256j6.6
si:ch73-256j6.6
chr8_-_13722682 1.82 ENSDART00000142052
si:dkey-258f14.2
si:dkey-258f14.2
chr10_+_33382858 1.77 ENSDART00000063662
mdh2
malate dehydrogenase 2, NAD (mitochondrial)
chr6_-_42003780 1.69 ENSDART00000032527
cav3
caveolin 3
chr24_+_42131564 1.65 ENSDART00000153854
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr10_+_5645887 1.63 ENSDART00000171426
pdzph1
PDZ and pleckstrin homology domains 1
chr7_-_71331690 1.60 ENSDART00000149682
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr2_-_23479714 1.59 ENSDART00000167291
si:ch211-14p21.3
si:ch211-14p21.3
chr23_-_40817792 1.57 ENSDART00000136343
si:dkeyp-27c8.1
si:dkeyp-27c8.1
chr13_-_45523026 1.45 ENSDART00000020663
rhd
Rh blood group, D antigen
chr5_-_30074332 1.41 ENSDART00000147963
bco2a
beta-carotene oxygenase 2a
chr14_+_48960078 1.36 ENSDART00000165514
mif
macrophage migration inhibitory factor
chr9_-_39968820 1.35 ENSDART00000100311
IKZF2
si:zfos-1425h8.1
chr15_-_18223769 1.32 ENSDART00000139966
or131-1
odorant receptor, family H, subfamily 131, member 1
chr3_+_52467879 1.26 ENSDART00000156039
adgre5a
adhesion G protein-coupled receptor E5a
chr13_+_18663600 1.18 ENSDART00000141647
selenou1a
selenoprotein U 1a
chr19_-_46037835 1.17 ENSDART00000163815
nup153
nucleoporin 153
chr2_+_44977889 1.14 ENSDART00000144024
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr22_-_24284961 1.11 ENSDART00000141230
si:ch211-117l17.4
si:ch211-117l17.4
chr17_+_53418445 1.06 ENSDART00000097631
slc9a1b
solute carrier family 9 member A1b
chr8_+_35356944 0.90 ENSDART00000143243
si:dkeyp-14d3.1
si:dkeyp-14d3.1
chr8_-_34762163 0.90 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr17_+_33313566 0.88 ENSDART00000045040
si:ch211-132f19.7
si:ch211-132f19.7
chr14_-_15154695 0.84 ENSDART00000160677
uvssa
UV-stimulated scaffold protein A
chr9_-_50000144 0.80 ENSDART00000123416
scn1a
sodium channel, voltage-gated, type I, alpha
chr7_-_71331499 0.77 ENSDART00000081245
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr1_+_7414318 0.66 ENSDART00000127426
si:ch73-383l1.1
si:ch73-383l1.1
chr22_-_17474583 0.65 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr21_+_15601100 0.62 ENSDART00000180558
ENSDART00000145454
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr22_-_6777976 0.61 ENSDART00000187946
CT583625.5

chr18_+_33725576 0.53 ENSDART00000146816
si:dkey-145c18.5
si:dkey-145c18.5
chr4_-_11064073 0.49 ENSDART00000150760
si:dkey-21h14.8
si:dkey-21h14.8
chr21_-_3201027 0.46 ENSDART00000161256
zbtb7c
zinc finger and BTB domain containing 7C
chr22_-_13042992 0.37 ENSDART00000028787
ahr1b
aryl hydrocarbon receptor 1b
chr22_+_12477996 0.29 ENSDART00000177704
CR847870.3

chr7_+_13918349 0.27 ENSDART00000172772
ENSDART00000173384
si:cabz01059983.1
si:cabz01059983.1
chr21_+_7188943 0.18 ENSDART00000172174
agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr3_+_35611625 0.16 ENSDART00000190995
traf7
TNF receptor-associated factor 7
chr14_+_45596583 0.14 ENSDART00000110429
zgc:194285
zgc:194285
chr8_-_23776399 0.11 ENSDART00000114800
INAVA
si:ch211-163l21.4
chr2_+_43469241 0.07 ENSDART00000142078
ENSDART00000098265
nrp1b
neuropilin 1b
chr23_+_36308717 0.07 ENSDART00000131711
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr16_+_11029762 0.06 ENSDART00000091183
erfl3
Ets2 repressor factor like 3
chr2_-_48512450 0.01 ENSDART00000160132
CR391991.1

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15+si:ch211-117k10.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0019695 choline metabolic process(GO:0019695)
2.0 5.9 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
1.7 6.9 GO:0051610 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
1.6 8.0 GO:0002159 desmosome assembly(GO:0002159)
1.3 20.1 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
1.0 5.1 GO:0003173 ventriculo bulbo valve development(GO:0003173) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
1.0 2.9 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
1.0 2.9 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.8 2.5 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.5 3.0 GO:0001955 blood vessel maturation(GO:0001955) regulation of establishment of cell polarity(GO:2000114)
0.5 3.5 GO:0006953 acute-phase response(GO:0006953)
0.4 10.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.3 3.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.3 6.4 GO:0018149 peptide cross-linking(GO:0018149)
0.3 2.3 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.3 10.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 5.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.2 4.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 1.7 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.2 1.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.8 GO:0006108 malate metabolic process(GO:0006108)
0.1 4.8 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 4.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 3.9 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.1 9.0 GO:0042493 response to drug(GO:0042493)
0.1 1.9 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 8.8 GO:0007098 centrosome cycle(GO:0007098)
0.1 2.8 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.8 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 2.2 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 1.1 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.7 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 4.2 GO:0051607 defense response to virus(GO:0051607)
0.0 0.9 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.4 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.4 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 7.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 1.2 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 1.7 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.9 GO:0046058 cAMP biosynthetic process(GO:0006171) cAMP metabolic process(GO:0046058)
0.0 4.1 GO:0045087 innate immune response(GO:0045087)
0.0 1.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 1.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0097189 apoptotic body(GO:0097189)
0.8 4.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.5 10.1 GO:0030057 desmosome(GO:0030057)
0.1 4.6 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 3.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 5.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.6 GO:0035060 brahma complex(GO:0035060)
0.1 8.8 GO:0016324 apical plasma membrane(GO:0016324)
0.1 3.0 GO:0016342 catenin complex(GO:0016342)
0.0 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 6.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 4.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 2.2 GO:0016459 myosin complex(GO:0016459)
0.0 2.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 19.1 GO:0005615 extracellular space(GO:0005615)
0.0 4.2 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0005335 serotonin:sodium symporter activity(GO:0005335) serotonin transmembrane transporter activity(GO:0015222)
1.3 4.0 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.9 8.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.7 12.9 GO:0033691 sialic acid binding(GO:0033691)
0.7 20.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.6 9.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.6 2.9 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.5 8.8 GO:0005080 protein kinase C binding(GO:0005080)
0.5 27.0 GO:0015485 cholesterol binding(GO:0015485)
0.5 16.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.4 1.7 GO:0071253 connexin binding(GO:0071253)
0.4 5.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.4 1.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.3 6.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 1.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 10.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 1.9 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 4.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 2.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.2 5.1 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 18.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 8.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 1.1 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 4.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.7 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 2.9 GO:0005109 frizzled binding(GO:0005109)
0.1 2.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 1.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 3.8 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 6.9 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 4.1 GO:0070851 growth factor receptor binding(GO:0070851)
0.1 4.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 3.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.9 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 3.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 7.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.4 GO:0003724 RNA helicase activity(GO:0003724)
0.0 2.2 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 3.4 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 34.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.4 2.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 3.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 1.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 1.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.7 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 27.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 3.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.3 4.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 4.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 3.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.2 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 1.7 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4