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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for klf5l+klf6a+klf6b

Z-value: 0.37

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Transcription factors associated with klf5l+klf6a+klf6b

Gene Symbol Gene ID Gene Info
klf5l
ENSDARG00000018757 Kruppel-like factor 5 like
klf6a
ENSDARG00000029072 Kruppel-like factor 6a
klf6b
ENSDARG00000038561 Kruppel-like factor 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf6adr11_v1_chr24_-_4148914_4148915-0.422.1e-05Click!
klf6bdr11_v1_chr2_+_48074243_48074243-0.242.2e-02Click!
klf5ldr11_v1_chr21_-_38153824_38153824-0.161.1e-01Click!

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_32526263 4.63 ENSDART00000150897
si:ch73-367p23.2
si:ch73-367p23.2
chr17_-_2584423 3.99 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr21_-_30293224 3.77 ENSDART00000101051
slbp2
stem-loop binding protein 2
chr22_+_396840 3.60 ENSDART00000163198
capzb
capping protein (actin filament) muscle Z-line, beta
chr6_-_60104628 3.38 ENSDART00000057463
ENSDART00000169188
pmepa1
prostate transmembrane protein, androgen induced 1
chr21_-_5056812 2.59 ENSDART00000139713
ENSDART00000140859
zgc:77838
zgc:77838
chr13_-_12021566 2.56 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr12_-_47648538 2.51 ENSDART00000108477
fh
fumarate hydratase
chr22_+_1006573 2.39 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr6_-_9952103 2.36 ENSDART00000065475
zp2l2
zona pellucida glycoprotein 2, like 2
chr7_-_46019756 2.28 ENSDART00000162583
zgc:162297
zgc:162297
chr21_+_6613772 1.74 ENSDART00000159645
col5a1
procollagen, type V, alpha 1
chr13_+_33688474 1.47 ENSDART00000161465
CABZ01087953.1

chr5_-_23800376 1.47 ENSDART00000134184
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr16_+_34111919 1.44 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr1_-_59232267 1.41 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr18_-_127558 1.40 ENSDART00000149556
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr11_+_45461853 1.23 ENSDART00000173409
sos1
son of sevenless homolog 1 (Drosophila)
chr24_-_41180149 1.22 ENSDART00000019975
acvr2ba
activin A receptor type 2Ba
chr25_+_2229301 1.17 ENSDART00000180198
pparab
peroxisome proliferator-activated receptor alpha b
chr8_-_4100365 1.17 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr20_-_49889111 1.08 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr6_-_10788065 0.99 ENSDART00000190968
wipf1b
WAS/WASL interacting protein family, member 1b
chr24_+_20559009 0.96 ENSDART00000131677
hhatlb
hedgehog acyltransferase like, b
chr7_-_45852270 0.94 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
chr21_-_24865454 0.87 ENSDART00000142907
igsf9bb
immunoglobulin superfamily, member 9Bb
chr18_+_660578 0.86 ENSDART00000161203
CELF6
si:dkey-205h23.2
chr22_+_344763 0.84 ENSDART00000181934
CU914780.1

chr17_-_12712776 0.83 ENSDART00000064511
il17a/f1
interleukin 17a/f1
chr24_+_36452927 0.83 ENSDART00000168181
zgc:114120
zgc:114120
chr19_+_7636941 0.78 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cgnb
cingulin b
chr20_+_2039518 0.76 ENSDART00000043157
CABZ01088134.1

chr7_-_32980017 0.75 ENSDART00000113744
pkp3b
plakophilin 3b
chr10_-_44026369 0.72 ENSDART00000185456
crybb1
crystallin, beta B1
chr9_-_3496548 0.70 ENSDART00000102876
cybrd1
cytochrome b reductase 1
chr2_+_38225427 0.69 ENSDART00000141614
si:ch211-14a17.11
si:ch211-14a17.11
chr19_+_4892281 0.69 ENSDART00000150969
cdk12
cyclin-dependent kinase 12
chr7_-_23768234 0.68 ENSDART00000173981
si:ch211-200p22.4
si:ch211-200p22.4
chr8_+_43056153 0.65 ENSDART00000186377
prnpa
prion protein a
chr19_+_19756425 0.65 ENSDART00000167606
hoxa3a
homeobox A3a
chr13_+_23214100 0.63 ENSDART00000163393
sorbs1
sorbin and SH3 domain containing 1
chr13_-_50200042 0.62 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains
chr14_+_46291022 0.61 ENSDART00000074099
cabp2b
calcium binding protein 2b
chr21_-_24865217 0.58 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr9_+_13999620 0.53 ENSDART00000143229
cd28l
cd28-like molecule
chr20_-_7176809 0.53 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr21_-_37733571 0.52 ENSDART00000176214
mpp1
membrane protein, palmitoylated 1
chr4_+_57093908 0.50 ENSDART00000170198
si:ch211-238e22.5
si:ch211-238e22.5
chr6_+_27514465 0.41 ENSDART00000128985
ENSDART00000079397
ryk
receptor-like tyrosine kinase
chr15_-_38202630 0.40 ENSDART00000183772
rhoga
ras homolog family member Ga
chr7_-_25126212 0.40 ENSDART00000173588
MAJIN
si:dkey-23i12.11
chr11_-_11965033 0.39 ENSDART00000193683
abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr15_-_45538773 0.34 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr20_+_700616 0.33 ENSDART00000168166
senp6a
SUMO1/sentrin specific peptidase 6a
chr13_-_23611960 0.29 ENSDART00000146216
prim2
DNA primase subunit 2
chr24_+_24726956 0.29 ENSDART00000144574
ENSDART00000066628
mtfr1
mitochondrial fission regulator 1
chr25_-_6629281 0.27 ENSDART00000112782
cspg4
chondroitin sulfate proteoglycan 4
chr8_+_36621598 0.27 ENSDART00000180389
magixb
MAGI family member, X-linked b
chr6_-_7109063 0.24 ENSDART00000148548
nhej1
nonhomologous end-joining factor 1
chr16_-_51254694 0.22 ENSDART00000148894
serpinb14
serpin peptidase inhibitor, clade B (ovalbumin), member 14
chr1_+_59538755 0.20 ENSDART00000166354
sp6
Sp6 transcription factor
chr14_-_237130 0.19 ENSDART00000164988
bod1l1
biorientation of chromosomes in cell division 1-like 1
chr21_-_37733287 0.16 ENSDART00000157826
mpp1
membrane protein, palmitoylated 1
chr20_-_1268863 0.15 ENSDART00000109321
ENSDART00000027119
lats1
large tumor suppressor kinase 1
chr3_+_1223824 0.14 ENSDART00000065922
wbp2nl
WBP2 N-terminal like
chr2_+_59015878 0.14 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr3_+_17634952 0.12 ENSDART00000191833
rab5c
RAB5C, member RAS oncogene family
chr5_-_37252111 0.12 ENSDART00000185110
lrch2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr15_+_20543770 0.11 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr6_-_54078623 0.09 ENSDART00000154076
hyal1
hyaluronoglucosaminidase 1
chr10_-_38456382 0.07 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr4_+_53119675 0.05 ENSDART00000167470
si:dkey-8o9.2
si:dkey-8o9.2
chr6_+_12503849 0.03 ENSDART00000149529
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr8_+_8298439 0.02 ENSDART00000170566
srpk3
SRSF protein kinase 3
chr20_+_18703108 0.01 ENSDART00000181188
eif5
eukaryotic translation initiation factor 5
chr17_+_37253706 0.01 ENSDART00000076004
tmem62
transmembrane protein 62
chr5_-_44496805 0.00 ENSDART00000110076
gas1a
growth arrest-specific 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.5 3.8 GO:0040016 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) embryonic cleavage(GO:0040016)
0.5 3.4 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.4 3.6 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.4 1.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.3 1.0 GO:0050748 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.3 2.5 GO:0006108 malate metabolic process(GO:0006108)
0.2 4.0 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 0.7 GO:0010039 response to iron ion(GO:0010039)
0.2 1.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.6 GO:0060017 parathyroid gland development(GO:0060017)
0.1 1.5 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.3 GO:0090230 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.1 0.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 2.6 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 1.2 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 1.4 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0046620 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.0 1.0 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.5 GO:0042129 regulation of T cell proliferation(GO:0042129)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.4 1.7 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.3 GO:1990077 primosome complex(GO:1990077)
0.1 1.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.7 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 0.7 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 3.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 2.4 GO:0000785 chromatin(GO:0000785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0070412 R-SMAD binding(GO:0070412)
0.4 4.0 GO:0035804 structural constituent of egg coat(GO:0035804)
0.2 0.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 3.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 0.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 3.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 1.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 2.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.7 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 2.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 1.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 2.0 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 2.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 1.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis