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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for klf7a+klf7b

Z-value: 0.34

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Transcription factors associated with klf7a+klf7b

Gene Symbol Gene ID Gene Info
klf7b
ENSDARG00000043821 Kruppel-like factor 7b
klf7a
ENSDARG00000073857 Kruppel-like factor 7a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf7bdr11_v1_chr9_-_28399071_283990710.581.3e-09Click!
klf7adr11_v1_chr1_-_6494384_64943840.463.7e-06Click!

Activity profile of klf7a+klf7b motif

Sorted Z-values of klf7a+klf7b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_17441734 2.26 ENSDART00000153729
snx19b
sorting nexin 19b
chr23_-_12015139 1.95 ENSDART00000110627
ENSDART00000193988
ENSDART00000184528
si:dkey-178k16.1
si:dkey-178k16.1
chr2_-_14390627 1.95 ENSDART00000172367
sgip1b
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr19_+_23982466 1.85 ENSDART00000080673
syt11a
synaptotagmin XIa
chr16_+_53519048 1.82 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr7_-_2039060 1.65 ENSDART00000173879
si:cabz01007794.1
si:cabz01007794.1
chr23_-_12014931 1.49 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr5_-_35252761 1.26 ENSDART00000051278
tnpo1
transportin 1
chr19_+_31404686 1.25 ENSDART00000078459
pip4p2
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr16_+_33163858 1.22 ENSDART00000101943
rragca
Ras-related GTP binding Ca
chr5_+_32791245 1.00 ENSDART00000077189
ier5l
immediate early response 5-like
chr8_-_22288258 0.98 ENSDART00000140978
ENSDART00000100046
si:ch211-147a11.3
si:ch211-147a11.3
chr19_-_30422239 0.96 ENSDART00000043554
ppp1r10
protein phosphatase 1, regulatory subunit 10
chr19_-_30422035 0.96 ENSDART00000144265
ppp1r10
protein phosphatase 1, regulatory subunit 10
chr19_+_43669122 0.87 ENSDART00000139151
si:ch211-193k19.1
si:ch211-193k19.1
chr1_+_14073891 0.86 ENSDART00000021693
ank2a
ankyrin 2a, neuronal
chr8_+_44475793 0.85 ENSDART00000190118
si:ch73-211l2.3
si:ch73-211l2.3
chr6_+_30668098 0.84 ENSDART00000112294
ttc22
tetratricopeptide repeat domain 22
chr8_+_54013199 0.83 ENSDART00000158497
CABZ01079663.1

chr24_-_21487609 0.82 ENSDART00000191325
atp8a2
ATPase phospholipid transporting 8A2
chr20_+_20731633 0.77 ENSDART00000191952
ENSDART00000165224
ppp1r13bb
protein phosphatase 1, regulatory subunit 13Bb
chr2_+_54844755 0.76 ENSDART00000170428
rnf126
ring finger protein 126
chr21_+_8427059 0.73 ENSDART00000143151
dennd1a
DENN/MADD domain containing 1A
chr22_+_980290 0.73 ENSDART00000065377
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr1_+_16574312 0.68 ENSDART00000187067
mtus1b
microtubule associated tumor suppressor 1b
chr20_+_20731052 0.67 ENSDART00000047662
ppp1r13bb
protein phosphatase 1, regulatory subunit 13Bb
chr18_-_6943577 0.67 ENSDART00000132399
si:dkey-266m15.6
si:dkey-266m15.6
chr17_+_43843536 0.65 ENSDART00000164097
FO704777.1

chr11_-_16115804 0.65 ENSDART00000143436
ENSDART00000157928
rpf1
ribosome production factor 1 homolog
chr15_+_5132439 0.64 ENSDART00000010350
pgm2l1
phosphoglucomutase 2-like 1
chr11_-_16215470 0.63 ENSDART00000185744
rab7
RAB7, member RAS oncogene family
chr2_-_42035250 0.61 ENSDART00000056460
ENSDART00000140788
gbp1
guanylate binding protein 1
chr1_+_39990547 0.61 ENSDART00000112150
sod3b
superoxide dismutase 3, extracellular b
chr17_-_37795865 0.61 ENSDART00000025853
zfp36l1a
zinc finger protein 36, C3H type-like 1a
chr7_-_30087048 0.59 ENSDART00000112743
nmbb
neuromedin Bb
chr10_-_41157135 0.57 ENSDART00000134851
aak1b
AP2 associated kinase 1b
chr1_+_26012668 0.51 ENSDART00000182428
BX323448.1

chr3_-_28872756 0.49 ENSDART00000138840
eef2kmt
eukaryotic elongation factor 2 lysine methyltransferase
chr19_+_19511394 0.46 ENSDART00000172410
jazf1a
JAZF zinc finger 1a
chr7_+_24081167 0.46 ENSDART00000141749
acin1b
apoptotic chromatin condensation inducer 1b
chr16_-_13921589 0.43 ENSDART00000023543
rcvrn2
recoverin 2
chr21_-_20120543 0.41 ENSDART00000065664
dusp4
dual specificity phosphatase 4
chr5_-_26795438 0.38 ENSDART00000146124
si:ch211-102c2.7
si:ch211-102c2.7
chr24_+_22021675 0.38 ENSDART00000081234
ropn1l
rhophilin associated tail protein 1-like
chr25_+_35683956 0.37 ENSDART00000149768
kif21a
kinesin family member 21A
chr11_-_2594045 0.35 ENSDART00000114079
nab2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr15_-_12229874 0.29 ENSDART00000165159
dscaml1
Down syndrome cell adhesion molecule like 1
chr13_+_40334727 0.25 ENSDART00000074950
slc25a28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr20_+_18741089 0.25 ENSDART00000183218
fam167ab
family with sequence similarity 167, member Ab
chr5_+_15202495 0.19 ENSDART00000144915
tbx1
T-box 1
chr2_-_23172708 0.19 ENSDART00000041365
prrx1a
paired related homeobox 1a
chr18_-_26894732 0.17 ENSDART00000147735
ENSDART00000188938
BX470164.1
si:dkey-24l11.2

si:dkey-24l11.2
chr8_-_45759137 0.13 ENSDART00000123878
ppiaa
peptidylprolyl isomerase Aa (cyclophilin A)
chr7_-_37563883 0.06 ENSDART00000148805
nod2
nucleotide-binding oligomerization domain containing 2
chr6_-_10034145 0.01 ENSDART00000185999
nudt15
nudix (nucleoside diphosphate linked moiety X)-type motif 15

Network of associatons between targets according to the STRING database.

First level regulatory network of klf7a+klf7b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.2 GO:0003156 regulation of organ formation(GO:0003156)
0.1 0.6 GO:0000303 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 1.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 3.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.4 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 1.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.6 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 0.8 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0086002 cardiac muscle cell action potential involved in contraction(GO:0086002)
0.0 0.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.3 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.7 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.8 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.7 GO:0030136 clathrin-coated vesicle(GO:0030136)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 1.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.6 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 1.4 GO:0002039 p53 binding(GO:0002039)
0.1 0.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 1.3 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 0.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.6 GO:0019843 rRNA binding(GO:0019843)
0.0 3.0 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases