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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for lhx5

Z-value: 0.68

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Transcription factors associated with lhx5

Gene Symbol Gene ID Gene Info
ENSDARG00000057936 LIM homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx5dr11_v1_chr21_-_15929041_159290410.815.1e-23Click!

Activity profile of lhx5 motif

Sorted Z-values of lhx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_44601331 12.18 ENSDART00000161514
zgc:165508
chr4_+_9669717 11.58 ENSDART00000004604
si:dkey-153k10.9
chr17_+_15433671 10.28 ENSDART00000149568
fatty acid binding protein 7, brain, a
chr6_-_11768198 10.11 ENSDART00000183463
membrane-associated ring finger (C3HC4) 7
chr21_-_20939488 10.04 ENSDART00000039043
regulator of G protein signaling 7 binding protein b
chr17_+_15433518 10.04 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr3_-_49566364 9.55 ENSDART00000161507
zgc:153426
chr19_+_31771270 8.74 ENSDART00000147474
stathmin 2b
chr25_-_19420949 8.69 ENSDART00000181338
microtubule-associated protein 1Ab
chr11_+_30057762 8.12 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr4_-_5019113 8.08 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr6_+_7444899 7.73 ENSDART00000053775
ADP-ribosylation factor 3b
chr16_-_28856112 7.61 ENSDART00000078543
synaptotagmin XIb
chr2_-_9059955 7.25 ENSDART00000022768
adenylate kinase 5
chr9_+_24159280 6.82 ENSDART00000184624
ENSDART00000178422
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr12_+_1139690 6.59 ENSDART00000160442

chr12_+_7497882 6.37 ENSDART00000134608
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr12_+_45200744 6.17 ENSDART00000098932
WW domain binding protein 2
chr24_+_24461341 6.14 ENSDART00000147658
basic helix-loop-helix family, member e22
chr11_-_1509773 6.04 ENSDART00000050762
phosphatase and actin regulator 3b
chr9_+_54039006 5.83 ENSDART00000112441
toll-like receptor 7
chr19_-_26869103 5.77 ENSDART00000089699
proline-rich transmembrane protein 1
chr17_-_16965809 5.61 ENSDART00000153697
neurexin 3a
chr2_+_20430366 5.39 ENSDART00000155108
si:ch211-153l6.6
chr24_-_7697274 5.34 ENSDART00000186077
synaptotagmin Vb
chr24_+_24461558 5.33 ENSDART00000182424
basic helix-loop-helix family, member e22
chr13_-_29421331 5.19 ENSDART00000150228
choline O-acetyltransferase a
chr5_-_31901468 5.13 ENSDART00000147814
ENSDART00000141446
coronin, actin binding protein, 1Cb
chr3_-_48716422 4.93 ENSDART00000164979
si:ch211-114m9.1
chr9_+_7998794 4.87 ENSDART00000138167
myosin XVI
chr20_+_19512727 4.78 ENSDART00000063696
all-trans retinoic acid-induced differentiation factor
chr25_-_9805269 4.63 ENSDART00000192048
leucine rich repeat containing 4C
chr13_+_11440389 4.58 ENSDART00000186463
zinc finger and BTB domain containing 18
chr10_-_2524917 4.53 ENSDART00000188642

chr12_+_25600685 4.47 ENSDART00000077157
SIX homeobox 3b
chr5_-_21422390 4.31 ENSDART00000144198
teneurin transmembrane protein 1
chr5_-_67911111 4.26 ENSDART00000051833
GS homeobox 1
chr21_-_17482465 4.25 ENSDART00000004548
BarH-like homeobox 1b
chr12_+_18681477 4.25 ENSDART00000127981
ENSDART00000143979
regulator of G protein signaling 9b
chr2_+_2223837 4.20 ENSDART00000101038
ENSDART00000129354
transmembrane inner ear
chr23_+_16638639 4.19 ENSDART00000143545
syntaphilin b
chr1_+_29858032 4.11 ENSDART00000054066
zic family member 2 (odd-paired homolog, Drosophila) b
chr22_-_28226948 4.10 ENSDART00000147686
si:dkey-222p3.1
chr16_-_41515662 3.71 ENSDART00000166201
ENSDART00000127243
sialic acid binding Ig-like lectin 15, like
chr5_-_6377865 3.64 ENSDART00000031775
zgc:73226
chr9_+_24159725 3.63 ENSDART00000137756
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr24_+_17260001 3.60 ENSDART00000066765
bmi1 polycomb ring finger oncogene 1a
chr10_-_2524297 3.48 ENSDART00000192475

chr4_-_2219705 3.34 ENSDART00000131046
si:ch73-278m9.1
chr21_+_30502002 3.33 ENSDART00000043727
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr9_+_38074082 3.32 ENSDART00000017833
calcium channel, voltage-dependent, beta 4a subunit
chr24_-_38657683 3.32 ENSDART00000154843
si:ch1073-164k15.3
chr1_+_6172786 3.30 ENSDART00000126468
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr4_-_75158035 3.30 ENSDART00000174353

chr16_-_41004731 3.23 ENSDART00000102591
si:dkey-201i6.2
chr21_+_34976600 3.20 ENSDART00000191672
ENSDART00000139635
RNA binding motif protein 11
chr15_-_20949692 3.16 ENSDART00000185548
tubulin folding cofactor E-like a
chr16_+_2820340 3.15 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
chr17_+_28533102 3.13 ENSDART00000156218
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr24_-_35767501 3.12 ENSDART00000105680
ENSDART00000042290
ENSDART00000166264
dystrobrevin, alpha
chr4_-_5018705 3.09 ENSDART00000154025
striatin interacting protein 2
chr12_-_17712393 3.07 ENSDART00000143534
ENSDART00000010144
parvalbumin 2
chr24_+_17260329 3.05 ENSDART00000129554
bmi1 polycomb ring finger oncogene 1a
chr24_-_11309477 3.01 ENSDART00000137257
myosin VIIA and Rab interacting protein
chr1_+_6862917 2.96 ENSDART00000182953
erb-b2 receptor tyrosine kinase 4a
chr16_-_28658341 2.95 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr5_-_38094130 2.95 ENSDART00000131831
si:ch211-284e13.4
chr6_+_52350443 2.92 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
chr11_-_44801968 2.90 ENSDART00000161846
microtubule-associated protein 1 light chain 3 gamma
chr23_+_41800052 2.87 ENSDART00000141484
prodynorphin
chr2_-_30668580 2.86 ENSDART00000087270
catenin (cadherin-associated protein), delta 2b
chr10_+_45089820 2.86 ENSDART00000175481
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr15_-_18162647 2.84 ENSDART00000012064
PIH1 domain containing 2
chr20_-_48485354 2.72 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr5_+_21144269 2.70 ENSDART00000028087
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr8_-_30979494 2.63 ENSDART00000138959
si:ch211-251j10.3
chr18_+_46382484 2.57 ENSDART00000024202
ENSDART00000142790
dynein assembly factor with WDR repeat domains 1
chr3_+_39853788 2.55 ENSDART00000154869
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr9_-_38398789 2.54 ENSDART00000188384
zinc finger protein 142
chr3_-_11624694 2.50 ENSDART00000127157
hepatic leukemia factor a
chr10_-_43721530 2.49 ENSDART00000025366
centrin 3
chr22_-_13466246 2.49 ENSDART00000134035
contactin associated protein-like 5b
chr5_+_13427826 2.46 ENSDART00000083359
SEC14-like lipid binding 8
chr8_+_36500061 2.42 ENSDART00000185840
solute carrier family 7, member 4
chr12_+_36416173 2.42 ENSDART00000190278
unkempt family zinc finger
chr8_+_36500308 2.37 ENSDART00000098701
solute carrier family 7, member 4
chr25_-_25058508 2.33 ENSDART00000087570
ENSDART00000178891

chr21_-_22635245 2.27 ENSDART00000115224
ENSDART00000101782
nectin cell adhesion molecule 1a
chr17_+_16564921 2.26 ENSDART00000151904
forkhead box N3
chr2_-_17393216 2.20 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr22_-_11614973 2.19 ENSDART00000063135
phosphate cytidylyltransferase 2, ethanolamine
chr6_-_21582444 2.18 ENSDART00000151339
si:dkey-43k4.3
chr20_-_53981626 2.16 ENSDART00000023550
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr7_+_24023653 2.14 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr6_+_49551614 2.11 ENSDART00000022581
RAB22A, member RAS oncogene family
chr20_-_13774826 2.10 ENSDART00000063831
opsin 8, group member c
chr17_-_40956035 2.02 ENSDART00000124715
si:dkey-16j16.4
chr15_-_46718759 2.01 ENSDART00000085926
ENSDART00000154577
zgc:162872
chr24_-_33873451 1.95 ENSDART00000159840
acid-sensing (proton-gated) ion channel 1c
chr17_-_16422654 1.94 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr6_-_57539141 1.93 ENSDART00000156967
itchy E3 ubiquitin protein ligase a
chr23_-_18707418 1.88 ENSDART00000144668
ENSDART00000141205
ENSDART00000016765
zgc:103759
chr15_+_34592215 1.86 ENSDART00000099776
tetraspanin 13a
chr9_+_48761455 1.84 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr17_-_200316 1.80 ENSDART00000190561

chr23_-_17509656 1.71 ENSDART00000148423
DnaJ (Hsp40) homolog, subfamily C, member 5ab
chr10_+_16225117 1.70 ENSDART00000169885
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr10_-_34916208 1.68 ENSDART00000187371
cyclin A1
chr9_+_2574122 1.67 ENSDART00000166326
ENSDART00000191822
si:ch73-167c12.2
chr16_+_28932038 1.66 ENSDART00000149480
natriuretic peptide receptor 1b
chr1_-_15797663 1.66 ENSDART00000177122
sarcoglycan zeta
chr15_-_14552101 1.63 ENSDART00000171169
numb homolog (Drosophila)-like
chr22_-_34995333 1.61 ENSDART00000110900
Kv channel interacting protein 2
chr17_-_25831569 1.60 ENSDART00000148743
hedgehog acyltransferase
chr19_+_5480327 1.59 ENSDART00000148794
junction plakoglobin b
chr20_+_52389858 1.58 ENSDART00000185863
ENSDART00000166651
Rho GTPase activating protein 39
chr20_+_32552912 1.56 ENSDART00000009691
Scm polycomb group protein like 4
chr17_+_43595692 1.55 ENSDART00000156271
cilia and flagella associated protein 99
chr7_-_57509447 1.54 ENSDART00000051973
ENSDART00000147036
sirtuin 3
chr17_-_4245902 1.54 ENSDART00000151851
growth differentiation factor 3
chr10_-_43404027 1.52 ENSDART00000086227
EGF-like repeats and discoidin I-like domains 3b
chr5_-_48664522 1.48 ENSDART00000083229
metallo-beta-lactamase domain containing 2
chr15_-_22074315 1.45 ENSDART00000149830
dopamine receptor D2a
chr4_-_1801519 1.45 ENSDART00000188604
ENSDART00000135749
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr6_-_50730749 1.43 ENSDART00000157153
ENSDART00000110441
phosphatidylinositol glycan anchor biosynthesis, class U
chr17_+_49281597 1.42 ENSDART00000155599
zgc:113176
chr7_-_71829649 1.39 ENSDART00000160449
calcium channel, voltage-dependent, beta 2a
chr25_+_3994823 1.38 ENSDART00000154020
EPS8 like 2
chr15_-_21014270 1.33 ENSDART00000154019
si:ch211-212c13.10
chr11_-_45141309 1.32 ENSDART00000181736
calcium activated nucleotidase 1b
chr24_-_7995960 1.31 ENSDART00000186594
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr4_+_2482046 1.30 ENSDART00000103371
zinc finger, DHHC-type containing 17
chr5_-_54672763 1.28 ENSDART00000159009
sperm associated antigen 8
chr24_+_20969358 1.28 ENSDART00000129675
dopamine receptor D3
chr15_-_40267485 1.28 ENSDART00000152253
potassium inwardly-rectifying channel, subfamily J, member 13
chr1_+_41498188 1.27 ENSDART00000191934
ENSDART00000146310
deltex 4, E3 ubiquitin ligase
chr19_-_47323267 1.26 ENSDART00000190077

chr2_+_11923615 1.26 ENSDART00000126118
TROVE domain family, member 2
chr21_-_39327223 1.26 ENSDART00000115097
apoptosis-inducing factor, mitochondrion-associated, 5
chr16_-_42965192 1.25 ENSDART00000113714
metaxin 1a
chr23_+_31405497 1.25 ENSDART00000053546
SH3 domain binding glutamate-rich protein like 2
chr23_-_2901167 1.23 ENSDART00000165955
ENSDART00000190616
zinc fingers and homeoboxes 3
chr2_-_16217344 1.22 ENSDART00000152031
Rho guanine nucleotide exchange factor (GEF) 4
chr8_+_7801060 1.19 ENSDART00000161618
transcription factor binding to IGHM enhancer 3a
chr4_+_5255041 1.19 ENSDART00000137966
coiled-coil domain containing 167
chr14_-_48765262 1.19 ENSDART00000166463
CCR4-NOT transcription complex, subunit 6b
chr15_+_9861973 1.18 ENSDART00000170945
si:dkey-13m3.2
chr11_-_22371105 1.16 ENSDART00000146873
transmembrane protein 183A
chr3_-_7546740 1.15 ENSDART00000128960
zmp:0000001003
chr15_+_857148 1.13 ENSDART00000156949
si:dkey-7i4.13
chr22_+_26853254 1.10 ENSDART00000182487
transmembrane protein 186
chr2_-_17392799 1.09 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr5_-_13251907 1.08 ENSDART00000176774
ENSDART00000030553
DNA topoisomerase III beta
chr23_-_20051369 1.08 ENSDART00000049836
biglycan b
chr5_+_12888260 1.02 ENSDART00000175916
galactose-3-O-sulfotransferase 1a
chr23_+_26946429 0.99 ENSDART00000185564
calcium channel, voltage-dependent, beta 3b
chr21_+_43172506 0.99 ENSDART00000121725
zinc finger, CCHC domain containing 10
chr11_-_6068375 0.99 ENSDART00000167672
ENSDART00000122262
BRISC and BRCA1 A complex member 1
chr21_+_25802190 0.98 ENSDART00000128987
neurofibromin 2b (merlin)
chr18_+_5172848 0.97 ENSDART00000190642

chr6_-_40029423 0.96 ENSDART00000103230
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr1_+_54124209 0.96 ENSDART00000187730

chr20_-_2949028 0.94 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cyclin-dependent kinase 19
chr22_-_36530902 0.92 ENSDART00000056188
info polymerase (RNA) II (DNA directed) polypeptide H
chr1_+_51039558 0.91 ENSDART00000024743
dpy-30 histone methyltransferase complex regulatory subunit
chr11_-_6069081 0.91 ENSDART00000008980
BRISC and BRCA1 A complex member 1
chr22_-_14739491 0.90 ENSDART00000133385
low density lipoprotein receptor-related protein 1Ba
chr16_+_54209504 0.90 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr4_-_73447058 0.89 ENSDART00000172042
si:ch73-120g24.4
chr11_-_26832685 0.88 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr5_-_32396929 0.88 ENSDART00000023977
F-box and WD repeat domain containing 2
chr16_-_7793457 0.88 ENSDART00000113483
tripartite motif containing 71, E3 ubiquitin protein ligase
chr5_+_32076109 0.88 ENSDART00000051357
ENSDART00000144510
zinc finger, matrin-type 5
chr25_-_13490744 0.88 ENSDART00000056721
lactate dehydrogenase D
chr24_-_31425799 0.86 ENSDART00000157998
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr17_+_22577472 0.86 ENSDART00000045099
Yip1 domain family, member 4
chr8_+_50953776 0.85 ENSDART00000013870
zgc:56596
chr8_-_13046089 0.83 ENSDART00000137784
si:dkey-208b23.5
chr23_-_18024543 0.82 ENSDART00000139695
peptidase M20 domain containing 1, tandem duplicate 1
chr1_+_35985813 0.80 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
chr6_-_58764672 0.80 ENSDART00000154322
sterol O-acyltransferase 2
chr1_-_31534089 0.80 ENSDART00000007770
ladybird homeobox 1b
chr23_+_27051919 0.79 ENSDART00000054237
prostaglandin E synthase 3a (cytosolic)
chr19_+_32158010 0.77 ENSDART00000005255
mitochondrial ribosomal protein L53
chr23_-_18567088 0.76 ENSDART00000192371
selenophosphate synthetase 2
chr23_-_1660708 0.76 ENSDART00000175138

chr5_-_41494831 0.75 ENSDART00000051081
eukaryotic translation elongation factor 2, like 2
chr15_+_9327252 0.75 ENSDART00000144381
sarcoglycan, gamma
chr18_+_8320165 0.73 ENSDART00000092053
choline kinase beta
chr8_-_25569920 0.72 ENSDART00000136869
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr22_+_2751887 0.70 ENSDART00000133652
si:dkey-20i20.11
chr5_-_42083363 0.70 ENSDART00000162596
chemokine (C-X-C motif) ligand 11, duplicate 5
chr3_+_7808459 0.70 ENSDART00000162374
hook microtubule-tethering protein 2
chr16_-_27677930 0.67 ENSDART00000145991
transforming growth factor beta regulator 4
chr17_+_38476300 0.66 ENSDART00000123298
StAR-related lipid transfer (START) domain containing 9
chr19_+_40069524 0.66 ENSDART00000151365
ENSDART00000140926
zinc finger, MYM-type 4
chr4_+_19700308 0.66 ENSDART00000027919
paired box 4
chr24_+_12989727 0.66 ENSDART00000126842
ENSDART00000129309
hypothetical protein FLJ11011-like (H. sapiens)
chr23_+_17509794 0.65 ENSDART00000148457
GID complex subunit 8 homolog b (S. cerevisiae)
chr8_-_11834599 0.63 ENSDART00000190986
Rap guanine nucleotide exchange factor (GEF) 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.7 5.2 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
1.3 10.4 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
1.2 4.9 GO:0099563 modification of synaptic structure(GO:0099563)
1.2 4.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
1.0 3.1 GO:0021611 facial nerve formation(GO:0021611)
0.8 4.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.8 2.5 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.8 2.3 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.7 11.2 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.7 3.7 GO:0045124 regulation of bone resorption(GO:0045124)
0.6 4.1 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.6 2.8 GO:0000012 single strand break repair(GO:0000012)
0.6 3.3 GO:1902023 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.5 6.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.5 1.8 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.4 4.8 GO:0034394 protein localization to cell surface(GO:0034394)
0.4 2.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 3.6 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.4 2.7 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.4 17.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 15.7 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 1.3 GO:0051876 pigment granule dispersal(GO:0051876)
0.3 1.6 GO:0002159 desmosome assembly(GO:0002159)
0.3 1.5 GO:1904086 regulation of epiboly involved in gastrulation with mouth forming second(GO:1904086)
0.3 2.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.3 0.9 GO:0006089 lactate metabolic process(GO:0006089)
0.3 1.4 GO:1901908 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 3.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.3 1.9 GO:0070207 protein homotrimerization(GO:0070207)
0.3 0.8 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.3 4.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.2 1.9 GO:0072425 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.2 4.5 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.2 1.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 1.3 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2 0.8 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.2 2.2 GO:0034605 cellular response to heat(GO:0034605)
0.2 4.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 0.9 GO:0010586 miRNA metabolic process(GO:0010586)
0.2 6.2 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.2 1.9 GO:0016074 snoRNA metabolic process(GO:0016074)
0.2 4.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 2.1 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.2 2.9 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 1.7 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.1 2.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 1.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.6 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 0.4 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 1.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.7 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 2.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 4.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.1 0.8 GO:0034434 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.1 0.9 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 2.9 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 0.7 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 6.0 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.1 0.6 GO:0007589 body fluid secretion(GO:0007589)
0.1 4.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 2.9 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 1.1 GO:0006265 DNA topological change(GO:0006265)
0.1 0.8 GO:0006278 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.1 7.4 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 1.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.6 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.1 1.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 1.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 2.1 GO:0007602 phototransduction(GO:0007602)
0.0 3.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.6 GO:0006415 translational termination(GO:0006415)
0.0 0.5 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.7 GO:1990798 pancreas regeneration(GO:1990798)
0.0 2.9 GO:0006865 amino acid transport(GO:0006865)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.7 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 1.6 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 11.9 GO:0009968 negative regulation of signal transduction(GO:0009968)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.6 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.3 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.6 GO:0036269 swimming behavior(GO:0036269)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 9.4 GO:0006886 intracellular protein transport(GO:0006886)
0.0 0.6 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 6.0 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.3 GO:0032543 mitochondrial translation(GO:0032543)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0097255 R2TP complex(GO:0097255)
0.6 1.7 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.4 5.3 GO:0031045 dense core granule(GO:0031045)
0.3 4.2 GO:0044295 axonal growth cone(GO:0044295)
0.3 6.6 GO:0035102 PRC1 complex(GO:0035102)
0.3 3.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 1.9 GO:0070552 BRISC complex(GO:0070552)
0.2 8.7 GO:0030426 growth cone(GO:0030426)
0.2 3.6 GO:0009925 basal plasma membrane(GO:0009925)
0.2 1.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.6 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 2.1 GO:0070187 telosome(GO:0070187)
0.1 17.1 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.9 GO:0071818 BAT3 complex(GO:0071818)
0.1 8.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.6 GO:0030057 desmosome(GO:0030057)
0.1 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.9 GO:0000421 autophagosome membrane(GO:0000421)
0.1 2.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 4.9 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.7 GO:0098978 glutamatergic synapse(GO:0098978)
0.1 1.9 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 1.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 11.6 GO:0030424 axon(GO:0030424)
0.1 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.9 GO:0098858 actin-based cell projection(GO:0098858)
0.0 8.1 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 12.4 GO:0043005 neuron projection(GO:0043005)
0.0 0.8 GO:0044447 axoneme part(GO:0044447)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 5.7 GO:0045202 synapse(GO:0045202)
0.0 0.2 GO:0044545 NSL complex(GO:0044545)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 20.3 GO:0005504 fatty acid binding(GO:0005504)
1.1 3.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
1.0 3.0 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.8 2.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.7 2.7 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.6 1.9 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.6 1.9 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.5 3.3 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.5 3.3 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.5 1.8 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.4 5.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 1.9 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.4 2.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.3 1.4 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.3 6.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 13.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 2.9 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.9 GO:0031628 opioid receptor binding(GO:0031628)
0.2 6.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 1.7 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 0.8 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 2.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2 1.7 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 0.5 GO:0001635 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.2 6.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 4.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 9.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 8.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 3.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.3 GO:0016208 AMP binding(GO:0016208)
0.1 1.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.4 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.9 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.1 4.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.5 GO:0070403 NAD+ binding(GO:0070403)
0.1 4.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.9 GO:0035198 miRNA binding(GO:0035198)
0.1 1.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.8 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.0 GO:0008443 6-phosphofructo-2-kinase activity(GO:0003873) phosphofructokinase activity(GO:0008443)
0.1 0.9 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.5 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 1.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 3.0 GO:0017022 myosin binding(GO:0017022)
0.1 2.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 25.5 GO:0015631 tubulin binding(GO:0015631)
0.1 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 2.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.6 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 7.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 2.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 2.9 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 12.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 2.9 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.6 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 1.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 8.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 1.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 7.7 GO:0005525 GTP binding(GO:0005525)
0.0 0.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.8 GO:0004527 exonuclease activity(GO:0004527)
0.0 3.3 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.7 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 7.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.9 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 2.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 1.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 0.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.9 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 3.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.7 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.6 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus