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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for meis3

Z-value: 0.96

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Transcription factors associated with meis3

Gene Symbol Gene ID Gene Info
meis3
ENSDARG00000002795 myeloid ecotropic viral integration site 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
meis3dr11_v1_chr15_-_6863317_68633170.702.6e-15Click!

Activity profile of meis3 motif

Sorted Z-values of meis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_39011514 14.22 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr6_+_3827751 13.91 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr23_-_10177442 13.82 ENSDART00000144280
ENSDART00000129044
krt5
keratin 5
chr6_-_14146979 11.82 ENSDART00000089564
cacnb4b
calcium channel, voltage-dependent, beta 4b subunit
chr15_-_4415917 11.24 ENSDART00000062874
atp1b3b
ATPase Na+/K+ transporting subunit beta 3b
chr15_-_29598679 9.73 ENSDART00000155153
si:ch211-207n23.2
si:ch211-207n23.2
chr5_-_46980651 7.99 ENSDART00000181022
ENSDART00000168038
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr10_+_26667475 7.40 ENSDART00000133281
ENSDART00000147013
si:ch73-52f15.5
si:ch73-52f15.5
chr6_+_33537267 7.37 ENSDART00000040334
pik3r3b
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr5_+_23118470 7.19 ENSDART00000149893
nexmifa
neurite extension and migration factor a
chr6_-_13408680 7.09 ENSDART00000151566
fmnl2b
formin-like 2b
chr1_+_1805294 6.73 ENSDART00000103850
atp1a1a.3
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3
chr6_+_48041759 6.61 ENSDART00000140086
si:dkey-92f12.2
si:dkey-92f12.2
chr17_+_33495194 6.19 ENSDART00000033691
pth2
parathyroid hormone 2
chr9_-_28399071 6.17 ENSDART00000104317
ENSDART00000064343
klf7b
Kruppel-like factor 7b
chr5_+_24245682 6.16 ENSDART00000049003
atp6v1aa
ATPase H+ transporting V1 subunit Aa
chr8_+_25959940 6.10 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
si:dkey-72l14.4
chr23_+_23182037 5.97 ENSDART00000137353
klhl17
kelch-like family member 17
chr8_-_27515540 5.88 ENSDART00000146132
si:ch211-254n4.3
si:ch211-254n4.3
chr21_+_45733871 5.62 ENSDART00000187285
ENSDART00000193018
zgc:77058
zgc:77058
chr21_+_30351256 5.61 ENSDART00000078341
foxi3a
forkhead box I3a
chr18_+_36769758 5.35 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr19_-_30565122 5.33 ENSDART00000185650
hpcal4
hippocalcin like 4
chr15_-_29598444 5.30 ENSDART00000154847
si:ch211-207n23.2
si:ch211-207n23.2
chr23_-_15216654 5.06 ENSDART00000131649
sulf2b
sulfatase 2b
chr20_-_26467307 5.04 ENSDART00000078072
ENSDART00000158213
akap12b
A kinase (PRKA) anchor protein 12b
chr7_-_19369002 5.03 ENSDART00000165680
ntn4
netrin 4
chr19_+_24872159 4.93 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr2_-_32558795 4.88 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr20_-_22798794 4.65 ENSDART00000148084
fip1l1a
FIP1 like 1a (S. cerevisiae)
chr6_-_39631164 4.38 ENSDART00000104042
ENSDART00000136076
atf7b
activating transcription factor 7b
chr2_+_47623202 4.34 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr10_+_26961965 4.27 ENSDART00000089144
vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr19_-_35596207 4.24 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr20_-_26421112 3.95 ENSDART00000183767
ENSDART00000182330
akap12b
A kinase (PRKA) anchor protein 12b
chr20_-_26420939 3.91 ENSDART00000110883
akap12b
A kinase (PRKA) anchor protein 12b
chr16_-_16152199 3.86 ENSDART00000012718
fabp11b
fatty acid binding protein 11b
chr6_-_30210378 3.75 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr11_-_18799827 3.57 ENSDART00000185438
ENSDART00000189116
ENSDART00000180504
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr4_+_20812900 3.50 ENSDART00000005847
nav3
neuron navigator 3
chr8_+_26329482 3.47 ENSDART00000048676
prkar2aa
protein kinase, cAMP-dependent, regulatory, type II, alpha A
chr23_+_23658474 3.28 ENSDART00000162838
agrn
agrin
chr1_-_26026956 3.28 ENSDART00000102346
si:ch211-145b13.6
si:ch211-145b13.6
chr14_-_26436951 3.16 ENSDART00000140173
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr7_-_67214972 3.13 ENSDART00000156861
swap70a
switching B cell complex subunit SWAP70a
chr14_-_17305657 3.11 ENSDART00000168853
jakmip1
janus kinase and microtubule interacting protein 1
chr23_+_21663631 3.10 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr19_+_42693855 3.09 ENSDART00000136873
clasp2
cytoplasmic linker associated protein 2
chr7_-_18881358 3.09 ENSDART00000021502
mllt3
MLLT3, super elongation complex subunit
chr12_+_36413886 3.04 ENSDART00000126325
si:ch211-250n8.1
si:ch211-250n8.1
chr6_+_9107063 3.00 ENSDART00000083820
vps16
vacuolar protein sorting protein 16
chr8_-_1838315 2.97 ENSDART00000114476
ENSDART00000140077
pi4kab
phosphatidylinositol 4-kinase, catalytic, alpha b
chr21_+_30194904 2.95 ENSDART00000137023
ENSDART00000078403
BRD8
si:ch211-59d17.3
chr7_-_31321027 2.81 ENSDART00000186878
CR356242.1

chr5_+_57726425 2.69 ENSDART00000134684
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr3_-_21118969 2.69 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr24_+_12989727 2.63 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr13_-_7233811 2.55 ENSDART00000162026
ninl
ninein-like
chr2_+_6127593 2.50 ENSDART00000184007
fzr1b
fizzy/cell division cycle 20 related 1b
chr9_-_29844596 2.41 ENSDART00000138574
il1rapl1a
interleukin 1 receptor accessory protein-like 1a
chr21_+_25231160 2.40 ENSDART00000063089
ENSDART00000139127
gng8
guanine nucleotide binding protein (G protein), gamma 8
chr19_-_42588510 2.37 ENSDART00000102583
sytl1
synaptotagmin-like 1
chr2_+_27651984 2.35 ENSDART00000126762
tmem68
transmembrane protein 68
chr25_-_22191733 2.33 ENSDART00000067478
pkp3a
plakophilin 3a
chr17_+_7595356 2.30 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr4_-_25908871 2.25 ENSDART00000066949
fgd6
FYVE, RhoGEF and PH domain containing 6
chr5_-_32396929 2.23 ENSDART00000023977
fbxw2
F-box and WD repeat domain containing 2
chr8_-_32506569 2.11 ENSDART00000061792
RFESD (1 of many)
Rieske Fe-S domain containing
chr3_-_45308394 2.09 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr5_-_15283509 1.98 ENSDART00000052712
gnb1l
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
chr23_-_7125494 1.88 ENSDART00000111929
slco4a1
solute carrier organic anion transporter family, member 4A1
chr22_+_30335936 1.83 ENSDART00000059923
mxi1
max interactor 1, dimerization protein
chr23_-_33680265 1.80 ENSDART00000138416
tfcp2
transcription factor CP2
chr10_-_32877348 1.76 ENSDART00000018977
ENSDART00000133421
rabgef1
RAB guanine nucleotide exchange factor (GEF) 1
chr16_+_9400661 1.75 ENSDART00000146174
ice1
KIAA0947-like (H. sapiens)
chr13_+_22295905 1.75 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr25_-_10610961 1.74 ENSDART00000153474
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr8_-_7444390 1.68 ENSDART00000149671
hdac6
histone deacetylase 6
chr23_-_33679579 1.49 ENSDART00000188674
tfcp2
transcription factor CP2
chr17_-_11418513 1.44 ENSDART00000064412
ENSDART00000151847
arid4a
AT rich interactive domain 4A (RBP1-like)
chr16_-_11986321 1.39 ENSDART00000148666
ENSDART00000029121
usp5
ubiquitin specific peptidase 5 (isopeptidase T)
chr5_+_38913621 1.36 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr2_+_36112273 1.34 ENSDART00000191315
traj35
T-cell receptor alpha joining 35
chr18_+_36770166 1.32 ENSDART00000078151
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr25_-_22191983 1.31 ENSDART00000191181
pkp3a
plakophilin 3a
chr20_+_44311448 1.27 ENSDART00000114660
opn8b
opsin 8, group member b
chr19_+_34742706 1.27 ENSDART00000103276
fam206a
family with sequence similarity 206, member A
chr13_+_28702104 1.24 ENSDART00000135481
si:ch211-67n3.9
si:ch211-67n3.9
chr19_+_20713424 1.19 ENSDART00000129730
rab5aa
RAB5A, member RAS oncogene family, a
chr2_-_44183613 1.17 ENSDART00000079596
cadm3
cell adhesion molecule 3
chr14_-_9355177 1.14 ENSDART00000138535
fam46d
family with sequence similarity 46, member D
chr14_-_51014292 1.09 ENSDART00000029797
faf2
Fas associated factor family member 2
chr15_-_23442891 1.06 ENSDART00000059376
ube4a
ubiquitination factor E4A (UFD2 homolog, yeast)
chr17_-_15667198 1.00 ENSDART00000142972
ENSDART00000132571
ENSDART00000189936
manea
mannosidase, endo-alpha
chr11_-_20987378 0.99 ENSDART00000110140
taf4a
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_-_30839338 0.98 ENSDART00000139707
gdf7
growth differentiation factor 7
chr6_+_15762647 0.96 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr3_+_22443313 0.93 ENSDART00000156450
wnk4b
WNK lysine deficient protein kinase 4b
chr8_-_18225968 0.86 ENSDART00000135504
si:ch211-241d21.5
si:ch211-241d21.5
chr22_-_22231720 0.86 ENSDART00000160165
ap3d1
adaptor-related protein complex 3, delta 1 subunit
chr10_-_33379850 0.85 ENSDART00000186924
ska2
spindle and kinetochore associated complex subunit 2
chr9_+_7358749 0.80 ENSDART00000081660
ihha
Indian hedgehog homolog a
chr8_-_7444155 0.79 ENSDART00000148993
hdac6
histone deacetylase 6
chr2_-_27651674 0.73 ENSDART00000177402
tgs1
trimethylguanosine synthase 1
chr8_-_25569920 0.66 ENSDART00000136869
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr24_-_30091937 0.65 ENSDART00000148249
plppr4b
phospholipid phosphatase related 4b
chr24_+_17349177 0.64 ENSDART00000176338
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr7_+_65673885 0.54 ENSDART00000169182
parvab
parvin, alpha b
chr5_+_37091626 0.45 ENSDART00000161054
tagln2
transgelin 2
chr7_-_30174882 0.44 ENSDART00000110409
frmd5
FERM domain containing 5
chr2_-_39090258 0.42 ENSDART00000134270
ENSDART00000145268
NMNAT3
si:ch73-170l17.1
chr8_-_41519064 0.41 ENSDART00000098578
ENSDART00000112214
golga1
golgin A1
chr6_+_9952678 0.31 ENSDART00000019325
cyp20a1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr2_-_44183451 0.26 ENSDART00000111246
cadm3
cell adhesion molecule 3
chr5_-_37341044 0.24 ENSDART00000084675
wdr44
WD repeat domain 44
chr8_+_144154 0.23 ENSDART00000164099
snx2
sorting nexin 2
chr16_+_24971717 0.21 ENSDART00000156958
fpr1
formyl peptide receptor 1
chr25_+_19670273 0.13 ENSDART00000073472
zgc:113426
zgc:113426
chr12_+_47122104 0.11 ENSDART00000184248
CABZ01088982.1

chr17_-_11417904 0.09 ENSDART00000103228
arid4a
AT rich interactive domain 4A (RBP1-like)
chr11_-_38513978 0.08 ENSDART00000123381
si:ch211-117k10.3
si:ch211-117k10.3
chr22_+_17214389 0.03 ENSDART00000187083
ENSDART00000159468
ENSDART00000129109
ENSDART00000090107
nrd1b
nardilysin b (N-arginine dibasic convertase)

Network of associatons between targets according to the STRING database.

First level regulatory network of meis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
4.3 12.9 GO:0032060 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
1.8 7.2 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.4 5.6 GO:0009957 epidermal cell fate specification(GO:0009957)
1.2 24.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
1.1 3.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.8 6.2 GO:0021634 optic nerve formation(GO:0021634)
0.7 4.3 GO:0044241 lipid digestion(GO:0044241)
0.6 7.4 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.5 4.9 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.5 4.6 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.5 2.6 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.4 2.5 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.4 1.2 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.4 5.1 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.4 6.1 GO:0032418 lysosome localization(GO:0032418)
0.3 3.0 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.3 3.3 GO:0018120 peptidyl-arginine ADP-ribosylation(GO:0018120)
0.3 11.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.3 2.7 GO:0070475 rRNA base methylation(GO:0070475)
0.3 3.8 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.3 3.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.3 3.5 GO:0072576 liver morphogenesis(GO:0072576)
0.2 3.1 GO:0042572 retinol metabolic process(GO:0042572)
0.2 3.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 3.1 GO:0034453 microtubule anchoring(GO:0034453)
0.2 6.6 GO:0006998 nuclear envelope organization(GO:0006998)
0.2 0.9 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.2 5.0 GO:0070831 basement membrane assembly(GO:0070831)
0.2 2.4 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.1 0.9 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.8 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.1 14.5 GO:0031101 fin regeneration(GO:0031101)
0.1 1.4 GO:0071711 basement membrane organization(GO:0071711)
0.1 6.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.2 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.0 3.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 2.5 GO:0006476 protein deacetylation(GO:0006476)
0.0 6.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 3.6 GO:0007043 cell-cell junction assembly(GO:0007043)
0.0 1.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 3.1 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 1.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 2.3 GO:1990266 neutrophil migration(GO:1990266)
0.0 4.2 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.9 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:1990745 EARP complex(GO:1990745)
1.3 13.8 GO:0045095 keratin filament(GO:0045095)
1.1 11.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.6 3.0 GO:0033263 CORVET complex(GO:0033263)
0.4 3.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 6.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 6.6 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3 4.9 GO:0071564 npBAF complex(GO:0071564)
0.3 1.2 GO:0098842 postsynaptic early endosome(GO:0098842)
0.3 4.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 5.0 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.2 3.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 3.6 GO:0030057 desmosome(GO:0030057)
0.2 11.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 3.1 GO:0045180 basal cortex(GO:0045180)
0.1 7.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.0 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 8.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0043195 terminal bouton(GO:0043195)
0.0 2.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 4.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.4 GO:0070382 exocytic vesicle(GO:0070382)
0.0 5.1 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.9 2.7 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.8 2.4 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.7 6.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.6 2.5 GO:0042903 tubulin deacetylase activity(GO:0042903) acetylspermidine deacetylase activity(GO:0047611)
0.6 11.2 GO:0001671 ATPase activator activity(GO:0001671)
0.6 6.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 6.6 GO:0043495 protein anchor(GO:0043495)
0.5 2.5 GO:1990757 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.5 3.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 3.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 11.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 12.9 GO:0051018 protein kinase A binding(GO:0051018)
0.4 3.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.4 6.2 GO:0030546 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.3 3.3 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 5.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 3.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 4.4 GO:0035497 cAMP response element binding(GO:0035497)
0.2 7.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 5.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 4.3 GO:0031267 small GTPase binding(GO:0031267)
0.1 3.1 GO:0050811 GABA receptor binding(GO:0050811)
0.1 8.0 GO:0005178 integrin binding(GO:0005178)
0.1 3.3 GO:0043236 laminin binding(GO:0043236)
0.1 0.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 2.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 2.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.8 GO:0005113 patched binding(GO:0005113)
0.1 3.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.0 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 6.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 8.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 8.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.6 GO:0045296 cadherin binding(GO:0045296)
0.0 1.7 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.7 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 3.1 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 7.9 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.2 NABA COLLAGENS Genes encoding collagen proteins
0.2 8.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 6.7 PID AP1 PATHWAY AP-1 transcription factor network
0.1 2.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.8 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 3.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 8.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 5.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 4.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase