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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mta3

Z-value: 0.26

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Transcription factors associated with mta3

Gene Symbol Gene ID Gene Info
ENSDARG00000054903 metastasis associated 1 family, member 3
ENSDARG00000113436 metastasis associated 1 family, member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mta3dr11_v1_chr12_+_25223843_25223873-0.028.5e-01Click!

Activity profile of mta3 motif

Sorted Z-values of mta3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_2578026 1.46 ENSDART00000065821
zona pellucida glycoprotein 3, tandem duplicate 2
chr7_+_1467863 1.25 ENSDART00000173433
ER membrane protein complex subunit 4
chr5_-_54712159 1.23 ENSDART00000149207
cyclin B1
chr18_-_45736 1.08 ENSDART00000148373
ENSDART00000148950
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_-_46010 0.99 ENSDART00000052641
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr22_-_193234 0.87 ENSDART00000131067
F-box protein 42
chr12_-_290413 0.66 ENSDART00000152496
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr2_-_22535 0.65 ENSDART00000157877

chr1_+_15062 0.60 ENSDART00000169005
centrosomal protein 97
chr5_-_23800376 0.47 ENSDART00000134184
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr3_+_16566361 0.46 ENSDART00000132869
ENSDART00000080771
solute carrier family 6, member 16a
chr21_+_44581654 0.44 ENSDART00000187201
ENSDART00000180360
ENSDART00000191543
ENSDART00000180039
ENSDART00000186308
transmembrane protein 164
chr14_-_237130 0.42 ENSDART00000164988
biorientation of chromosomes in cell division 1-like 1
chr21_+_45712247 0.40 ENSDART00000163982
calcium modulating ligand
chr22_+_26703026 0.39 ENSDART00000158756
CREB binding protein a
chr13_+_1100197 0.36 ENSDART00000139560
protein phosphatase 3, regulatory subunit B, alpha a
chr5_+_20453874 0.36 ENSDART00000124545
ENSDART00000008402
squamous cell carcinoma antigen recognized by T cells 3
chr22_+_344763 0.35 ENSDART00000181934

chr12_+_13348918 0.35 ENSDART00000181373
ribonuclease type III, nuclear
chr16_-_17207754 0.34 ENSDART00000063804
wu:fj39g12
chr11_-_20956309 0.34 ENSDART00000188659

chr7_+_1579236 0.33 ENSDART00000172830
SPT16 homolog, facilitates chromatin remodeling subunit
chr20_-_14665002 0.29 ENSDART00000152816
secernin 2
chr5_+_45139196 0.28 ENSDART00000113738
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_-_12270226 0.28 ENSDART00000180473
plakophilin 4
chr14_-_572742 0.21 ENSDART00000168951
fibroblast growth factor 2
chr23_-_24825863 0.20 ENSDART00000112493
synaptotagmin VIa
chr14_-_2369849 0.20 ENSDART00000180422
ENSDART00000189731
ENSDART00000111748
protocadherin b
chr7_+_1579510 0.20 ENSDART00000190525
SPT16 homolog, facilitates chromatin remodeling subunit
chr11_+_44579865 0.19 ENSDART00000173425
nidogen 1b
chr20_-_54435287 0.18 ENSDART00000148632
YY1 transcription factor b
chr7_-_6592142 0.17 ENSDART00000160137
potassium inwardly-rectifying channel, subfamily J, member 10a
chr16_-_280835 0.14 ENSDART00000190541

chr9_-_1434484 0.14 ENSDART00000093412
oxysterol binding protein-like 6
chr5_+_66433287 0.14 ENSDART00000170757
kinetochore associated 1
chr12_-_14551077 0.13 ENSDART00000188717

chr13_+_31545812 0.12 ENSDART00000076527
protein phosphatase, Mg2+/Mn2+ dependent, 1Aa
chr25_-_35143360 0.11 ENSDART00000188033
zgc:165555
chr11_-_32723851 0.11 ENSDART00000155592
protocadherin 17
chr17_-_25630822 0.11 ENSDART00000126201
ENSDART00000105503
ENSDART00000151878
RAB3 GTPase activating protein subunit 2 (non-catalytic)
chr4_-_13255700 0.11 ENSDART00000162277
ENSDART00000026593
glutamate receptor interacting protein 1
chr11_-_44543082 0.09 ENSDART00000099568
G protein-coupled receptor 137Bb
chr7_+_17560808 0.08 ENSDART00000159699
ENSDART00000165724
ENSDART00000129017
ENSDART00000101955
novel immune-type receptor 1b
chr23_+_2825940 0.07 ENSDART00000135781
phospholipase C, gamma 1
chr22_-_7809904 0.07 ENSDART00000182269
ENSDART00000097201
ENSDART00000138522
si:ch73-44m9.3
si:ch73-44m9.1
chr5_-_25123807 0.07 ENSDART00000183171
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_+_29909870 0.06 ENSDART00000150324
zinc finger protein 1111
chr3_-_5228137 0.06 ENSDART00000137105
myosin, heavy chain 9b, non-muscle
chr4_-_34799395 0.06 ENSDART00000170744
si:dkey-146m20.13
chr8_+_43056153 0.05 ENSDART00000186377
prion protein a
chr22_-_367569 0.02 ENSDART00000041895
SSU72 homolog, RNA polymerase II CTD phosphatase

Network of associatons between targets according to the STRING database.

First level regulatory network of mta3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0006601 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.2 1.3 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.1 1.2 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.4 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.1 1.5 GO:2000344 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.5 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.5 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting(GO:0035477)
0.0 0.2 GO:0036268 swimming(GO:0036268)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0030323 respiratory tube development(GO:0030323) lung development(GO:0030324)
0.0 0.2 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.1 GO:0070650 actin filament bundle distribution(GO:0070650)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 1.3 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.5 GO:0035101 FACT complex(GO:0035101)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0032977 membrane insertase activity(GO:0032977)
0.1 1.5 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 2.1 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.3 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.7 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.5 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 2.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives