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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mybl2b

Z-value: 0.74

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Transcription factors associated with mybl2b

Gene Symbol Gene ID Gene Info
ENSDARG00000032264 v-myb avian myeloblastosis viral oncogene homolog-like 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mybl2bdr11_v1_chr11_+_1551603_15516630.398.2e-05Click!

Activity profile of mybl2b motif

Sorted Z-values of mybl2b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_43656125 4.52 ENSDART00000136392
ENSDART00000192805
ENSDART00000181960
si:ch211-263m18.4
si:dkey-229d11.5
chr17_+_1632294 4.14 ENSDART00000191959
signal recognition particle 14
chr2_+_6253246 3.89 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr9_-_34308113 3.86 ENSDART00000137806
glycoprotein A33 (transmembrane)
chr9_-_23253870 3.56 ENSDART00000143657
ENSDART00000169911
aminocarboxymuconate semialdehyde decarboxylase
chr6_-_32349153 3.38 ENSDART00000140004
angiopoietin-like 3
chr10_+_16501699 3.21 ENSDART00000121864
solute carrier family 27 (fatty acid transporter), member 6
chr4_-_2380173 3.06 ENSDART00000177727
nucleosome assembly protein 1-like 1
chr6_+_9191981 2.98 ENSDART00000150916
zgc:112392
chr2_+_38025260 2.77 ENSDART00000075905
heterogeneous nuclear ribonucleoprotein C
chr1_-_23293261 2.64 ENSDART00000122648
UDP-glucose 6-dehydrogenase
chr6_-_55297274 2.51 ENSDART00000184283
ubiquitin-conjugating enzyme E2C
chr22_-_23590069 2.43 ENSDART00000172067
coagulation factor XIII, B polypeptide
chr1_-_8020589 2.41 ENSDART00000143881
si:dkeyp-9d4.2
chr19_-_47571456 2.31 ENSDART00000158071
ENSDART00000165841
ribonucleotide reductase M2 polypeptide
chr10_-_35257458 2.25 ENSDART00000143890
ENSDART00000139107
ENSDART00000082445
proline rich 11
chr16_+_42667560 2.23 ENSDART00000023452
dpy-19-like 1, like (H. sapiens)
chr10_-_26202766 2.10 ENSDART00000136393
FH2 domain containing 3
chr4_+_13568469 2.04 ENSDART00000171235
ENSDART00000136152
calumenin a
chr12_-_4220713 2.04 ENSDART00000129427
vitamin K epoxide reductase complex, subunit 1
chr6_-_49078263 2.01 ENSDART00000032982
solute carrier family 5 (iodide transporter), member 8-like
chr24_+_20325312 2.00 ENSDART00000007997
acetyl-CoA acyltransferase 1
chr20_+_51479263 1.85 ENSDART00000148798
toll-like receptor 5a
chr9_-_36924388 1.84 ENSDART00000059756
v-ral simian leukemia viral oncogene homolog Ba (ras related)
chr15_+_17074185 1.69 ENSDART00000046648
cleft lip and palate associated transmembrane protein 1
chr3_+_32080403 1.63 ENSDART00000124943
aldehyde dehydrogenase 16 family, member A1
chr8_+_26226044 1.58 ENSDART00000186503
WD repeat domain 6
chr9_-_2892250 1.55 ENSDART00000140695
cell division cycle associated 7a
chr15_+_17030473 1.51 ENSDART00000129407
perilipin 2
chr1_-_354115 1.51 ENSDART00000141590
ENSDART00000098627
protein S
chr13_-_50139916 1.48 ENSDART00000099475
nidogen 1a
chr2_-_51757328 1.44 ENSDART00000189286
si:ch211-9d9.1
chr19_+_43579786 1.39 ENSDART00000138404
si:ch211-199g17.2
chr3_-_36823643 1.38 ENSDART00000131340
ENSDART00000185075
ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2
chr9_-_2892045 1.38 ENSDART00000137201
cell division cycle associated 7a
chr19_-_46566430 1.33 ENSDART00000166668
exostosin glycosyltransferase 1b
chr22_+_14117078 1.31 ENSDART00000013575
basic leucine zipper and W2 domains 1a
chr5_+_42951852 1.31 ENSDART00000097615
MOB kinase activator 1Ba
chr25_-_37331513 1.29 ENSDART00000111862
low density lipoprotein receptor class A domain containing 3
chr24_-_12832499 1.28 ENSDART00000182027
ENSDART00000039312
importin 4
chr2_+_9970942 1.25 ENSDART00000153063
SEC22 homolog B, vesicle trafficking protein a
chr19_-_41213718 1.24 ENSDART00000077121
pyruvate dehydrogenase kinase, isozyme 4
chr7_+_17106160 1.24 ENSDART00000190048
ENSDART00000180004
ENSDART00000013409
protein arginine methyltransferase 3
chr8_-_47206399 1.23 ENSDART00000060877
peptidylprolyl isomerase H (cyclophilin H)
chr22_-_5655680 1.23 ENSDART00000159629
minichromosome maintenance complex component 2
chr24_-_21150100 1.21 ENSDART00000154249
ENSDART00000193256
GRAM domain containing 1c
chr19_+_31904836 1.18 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tumor protein D52
chr20_+_13781779 1.17 ENSDART00000142999
ENSDART00000152471
lysophosphatidylglycerol acyltransferase 1
chr19_-_24555935 1.16 ENSDART00000132660
ENSDART00000162801
polymerase (RNA) III (DNA directed) polypeptide G like a
chr8_+_23382568 1.12 ENSDART00000129167
microtubule-associated protein, RP/EB family, member 1a
chr15_+_17030941 1.10 ENSDART00000062069
perilipin 2
chr15_-_17074393 1.09 ENSDART00000155526
si:ch211-24o10.6
chr15_+_17031111 1.08 ENSDART00000175378
perilipin 2
chr25_-_16552135 1.08 ENSDART00000125836
si:ch211-266k8.4
chr19_-_24555623 1.08 ENSDART00000176022
polymerase (RNA) III (DNA directed) polypeptide G like a
chr20_+_21595244 1.08 ENSDART00000010643
estrogen receptor 2a
chr23_-_40766518 1.05 ENSDART00000127420
si:dkeyp-27c8.2
chr3_+_14641962 1.05 ENSDART00000091070
zgc:158403
chr1_+_23559478 1.02 ENSDART00000133659
non-SMC condensin I complex, subunit G
chr5_-_1869982 1.00 ENSDART00000055878
RNA terminal phosphate cyclase-like 1
chr20_+_51478939 0.99 ENSDART00000149758
toll-like receptor 5a
chr10_+_22782522 0.98 ENSDART00000079498
ENSDART00000145558
si:ch211-237l4.6
chr5_+_6796291 0.98 ENSDART00000166868
ENSDART00000165308
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr6_+_3473657 0.97 ENSDART00000011785
RAD54 like
chr21_-_1635268 0.97 ENSDART00000151258
zgc:152948
chr2_+_25315591 0.97 ENSDART00000161386
fibronectin type III domain containing 3Ba
chr1_-_49225890 0.97 ENSDART00000111598
chemokine (C-X-C motif) ligand 18b
chr8_-_47206114 0.97 ENSDART00000147606
ENSDART00000060883
ENSDART00000060880
peptidylprolyl isomerase H (cyclophilin H)
chr3_-_5394800 0.95 ENSDART00000181938
si:ch73-106l15.2
chr16_+_52343905 0.89 ENSDART00000131051
interferon lambda receptor 1
chr6_+_52212927 0.88 ENSDART00000143458
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a
chr10_+_35257651 0.87 ENSDART00000028940
serine/threonine/tyrosine interacting-like 1
chr22_+_10166407 0.86 ENSDART00000092104
PX domain containing serine/threonine kinase
chr6_+_57741039 0.86 ENSDART00000169175
syntrophin alpha 1
chr9_+_18829360 0.86 ENSDART00000006514
general transcription factor IIF, polypeptide 2b
chr10_+_43406796 0.85 ENSDART00000184337
ENSDART00000183034
ENSDART00000180623
ENSDART00000132486
RAS p21 protein activator (GTPase activating protein) 1b
chr5_-_67499279 0.85 ENSDART00000128050
si:dkey-251i10.3
chr18_-_26797723 0.83 ENSDART00000008013
SEC11 homolog A, signal peptidase complex subunit
chr5_+_59234421 0.82 ENSDART00000045518
PRKR interacting protein 1
chr4_-_72643171 0.82 ENSDART00000130126

chr7_+_1579510 0.82 ENSDART00000190525
SPT16 homolog, facilitates chromatin remodeling subunit
chr8_-_16675464 0.81 ENSDART00000191982
oxysterol binding protein-like 9
chr9_+_22782027 0.81 ENSDART00000090816
replication timing regulatory factor 1
chr13_+_45524475 0.80 ENSDART00000074567
ENSDART00000019113
macoilin 1b
chr9_+_14023386 0.79 ENSDART00000140199
ENSDART00000124267
si:ch211-67e16.4
chr16_+_25066880 0.79 ENSDART00000154084
im:7147486
chr14_+_41345175 0.77 ENSDART00000086104
NADPH oxidase 1
chr19_-_11336782 0.77 ENSDART00000131014
septin 7a
chr10_-_45029041 0.77 ENSDART00000167878
polymerase (DNA directed), mu
chr2_+_26655744 0.76 ENSDART00000174928
aspartate beta-hydroxylase
chr21_+_6212844 0.75 ENSDART00000150301
formin binding protein 1b
chr21_+_34119759 0.75 ENSDART00000024750
ENSDART00000128242
high mobility group box 3b
chr10_-_26985231 0.75 ENSDART00000050585
zinc finger, HIT-type containing 2
chr2_-_9696283 0.73 ENSDART00000165712
selenoprotein T, 1a
chr21_-_5799122 0.73 ENSDART00000129351
ENSDART00000151202
cyclin I
chr19_+_4968947 0.73 ENSDART00000003634
ENSDART00000134808
StAR-related lipid transfer (START) domain containing 3
chr7_+_1579236 0.72 ENSDART00000172830
SPT16 homolog, facilitates chromatin remodeling subunit
chr18_+_328689 0.70 ENSDART00000167841
synovial sarcoma translocation gene on chromosome 18-like 2
chr25_-_3192405 0.69 ENSDART00000104835
Hermansky-Pudlak syndrome 5
chr3_-_33941319 0.68 ENSDART00000026090
ENSDART00000111878
general transcription factor IIF, polypeptide 1
chr25_-_13403726 0.67 ENSDART00000056723
GINS complex subunit 3
chr11_+_23760470 0.67 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
neurofascin homolog (chicken) a
chr4_-_12790886 0.66 ENSDART00000182535
ENSDART00000067131
ENSDART00000186426
interleukin-1 receptor-associated kinase 3
chr4_-_1684335 0.61 ENSDART00000019144
ENSDART00000113360
AT rich interactive domain 2 (ARID, RFX-like)
chr18_-_399554 0.61 ENSDART00000164374
ENSDART00000186311
ENSDART00000181816
ENSDART00000181892
si:ch211-79l17.1
chr17_+_5846202 0.60 ENSDART00000189713
fibronectin type III domain containing 4b
chr4_+_72205923 0.60 ENSDART00000181075
zgc:165515
chr18_-_18587745 0.59 ENSDART00000191973
splicing factor 3b, subunit 3
chr10_-_16868211 0.58 ENSDART00000171755
stomatin (EPB72)-like 2
chr12_+_19138452 0.57 ENSDART00000141346
ENSDART00000066397
PHD finger protein 5A
chr14_+_1365097 0.57 ENSDART00000083797
ENSDART00000176087
TBC1 domain family, member 9 (with GRAM domain)
chr7_+_19738665 0.57 ENSDART00000089333
triokinase/FMN cyclase
chr3_-_33941875 0.57 ENSDART00000047660
general transcription factor IIF, polypeptide 1
chr5_+_4366431 0.56 ENSDART00000168560
ENSDART00000149185
spermidine/spermine N1-acetyltransferase 1a, duplicate 2
chr8_+_23381892 0.55 ENSDART00000180950
ENSDART00000063010
ENSDART00000074241
ENSDART00000142783
microtubule-associated protein, RP/EB family, member 1a
chr13_+_15701849 0.51 ENSDART00000003517
tRNA methyltransferase 61A
chr4_-_26035770 0.51 ENSDART00000124514
ubiquitin specific peptidase 44
chr3_+_46444999 0.51 ENSDART00000186530
si:ch211-66e2.3
chr3_+_46444625 0.49 ENSDART00000108686
si:ch211-66e2.3
chr3_-_9444749 0.49 ENSDART00000182191

chr12_+_26706745 0.49 ENSDART00000141401
Rho GTPase activating protein 12b
chr9_+_37320222 0.48 ENSDART00000100622
solute carrier family 15 (oligopeptide transporter), member 2
chr5_+_25084385 0.47 ENSDART00000134526
ENSDART00000111863
PAXX, non-homologous end joining factor
chr6_-_36795111 0.47 ENSDART00000160669
ENSDART00000104256
ENSDART00000187751
ENSDART00000161928
ENSDART00000183264
optic atrophy 1 (autosomal dominant)
chr17_-_31819837 0.46 ENSDART00000160281
abraxas 2b, BRISC complex subunit
chr20_-_26047741 0.46 ENSDART00000141626
ENSDART00000112714
ENSDART00000152102
ENSDART00000078535
ENSDART00000151874
general transcription factor IIH, polypeptide 5
chr17_-_45383699 0.45 ENSDART00000141182
transmembrane protein 206
chr11_-_40519886 0.45 ENSDART00000172819
migration and invasion inhibitory protein
chr16_-_31342356 0.44 ENSDART00000136648
maestro heat-like repeat family member 1
chr2_-_1622641 0.44 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr7_-_24994568 0.43 ENSDART00000002961
REST corepressor 2
chr5_-_61797220 0.43 ENSDART00000079855
im:7138535
chr14_-_733565 0.42 ENSDART00000158097
toll-like receptor 1
chr2_-_51507540 0.41 ENSDART00000166605
ENSDART00000161093
polymeric immunoglobulin receptor-like 2.3
chr12_+_4220353 0.41 ENSDART00000133675
mitogen-activated protein kinase 7
chr2_-_37632896 0.40 ENSDART00000008302
insulin receptor a
chr7_-_33130552 0.40 ENSDART00000127006
meiosis-specific nuclear structural 1
chr20_-_284865 0.40 ENSDART00000104806
WNT1 inducible signaling pathway protein 3
chr18_+_29898955 0.40 ENSDART00000064080
centromere protein N
chr21_-_41838284 0.39 ENSDART00000141067
chaperonin containing TCP1, subunit 6A (zeta 1)
chr7_-_63637644 0.39 ENSDART00000145168
si:ch211-208g1.1
chr16_-_7214513 0.38 ENSDART00000150005
si:ch73-341k19.1
chr24_-_25166416 0.36 ENSDART00000111552
ENSDART00000169495
pleckstrin homology-like domain, family B, member 2b
chr7_+_62004048 0.36 ENSDART00000181818
small integral membrane protein 20
chr23_+_6795531 0.36 ENSDART00000092131
si:ch211-117c9.5
chr5_+_32882688 0.35 ENSDART00000008807
ENSDART00000185317
ribosomal protein L12
chr2_+_8649293 0.35 ENSDART00000081442
ENSDART00000186024
far upstream element (FUSE) binding protein 1
chr10_+_3145707 0.35 ENSDART00000160046
hypermethylated in cancer 2
chr10_+_43037064 0.35 ENSDART00000160159
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr9_+_14023942 0.34 ENSDART00000142749
si:ch211-67e16.4
chr4_-_5831036 0.33 ENSDART00000166232
forkhead box M1
chr4_-_73572030 0.32 ENSDART00000121652
zinc finger protein 1015
chr5_-_32882162 0.32 ENSDART00000085769
leucine rich repeat and sterile alpha motif containing 1
chr8_-_12432604 0.31 ENSDART00000133350
ENSDART00000140699
ENSDART00000101174
TNF receptor-associated factor 1
chr3_-_60175470 0.31 ENSDART00000156597
si:ch73-364h19.1
chr24_-_25166720 0.30 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr18_-_18821929 0.30 ENSDART00000178875
alanyl-tRNA synthetase
chr20_+_42563618 0.28 ENSDART00000153441
insulin-like growth factor 2 receptor
chr2_-_51511494 0.28 ENSDART00000161392
ENSDART00000160877
si:ch211-9d9.8
chr1_+_27808916 0.28 ENSDART00000102335
paraspeckle component 1
chr7_+_33130639 0.27 ENSDART00000142450
ENSDART00000173967
ENSDART00000173832
zgc:153219
si:ch211-194p6.7
chr6_+_29693492 0.27 ENSDART00000114172
phosphodiesterase 6D, cGMP-specific, rod, delta
chr3_+_13929860 0.27 ENSDART00000164179
synaptonemal complex central element protein 2
chr17_-_22573311 0.26 ENSDART00000141523
ENSDART00000140022
ENSDART00000079390
ENSDART00000188644
exonuclease 1
chr23_+_36308717 0.26 ENSDART00000131711
heterogeneous nuclear ribonucleoprotein A1b
chr7_-_37858569 0.26 ENSDART00000129156
ENSDART00000173552
ENSDART00000178306
adenylate cyclase 7
chr22_+_1431743 0.24 ENSDART00000182871
Danio rerio si:dkeyp-53d3.6 (si:dkeyp-53d3.6), mRNA.
chr24_-_41180149 0.23 ENSDART00000019975
activin A receptor type 2Ba
chr24_+_3963684 0.23 ENSDART00000182959
ENSDART00000185926
ENSDART00000167043
ENSDART00000033394
phosphofructokinase, platelet a
chr22_-_8006342 0.23 ENSDART00000162028
sc:d217
chr7_-_17337233 0.19 ENSDART00000050236
ENSDART00000102141
novel immune-type receptor 8
chr25_+_34938317 0.19 ENSDART00000042678
vacuolar protein sorting 4a homolog A (S. cerevisiae)
chr20_-_22798794 0.19 ENSDART00000148084
FIP1 like 1a (S. cerevisiae)
chr5_-_61588998 0.19 ENSDART00000050912
peroxisomal biogenesis factor 12
chr22_-_15578402 0.18 ENSDART00000062986
hematopoietic SH2 domain containing
chr7_-_24994722 0.16 ENSDART00000131671
REST corepressor 2
chr11_-_24015845 0.15 ENSDART00000191783
chitinase, acidic.3
chr17_+_12408405 0.15 ENSDART00000154827
ENSDART00000048440
ENSDART00000156429
ketohexokinase
chr19_+_16068445 0.14 ENSDART00000138709
glucocorticoid modulatory element binding protein 1
chr18_+_5308392 0.13 ENSDART00000179072
deoxyuridine triphosphatase
chr21_+_30355767 0.13 ENSDART00000189948

chr23_+_6795709 0.13 ENSDART00000149136
si:ch211-117c9.5
chr2_+_307665 0.13 ENSDART00000082083
zgc:113452
chr2_+_22495274 0.12 ENSDART00000167915
leucine rich repeat containing 8 VRAC subunit Da
chr14_-_4043818 0.12 ENSDART00000179870
sorting nexin 25
chr19_+_7124337 0.12 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr6_+_49995781 0.12 ENSDART00000075009
eukaryotic translation initiation factor 2, subunit 2 beta
chr23_-_10722664 0.09 ENSDART00000146526
ENSDART00000129022
ENSDART00000104985
forkhead box P1a
chr24_+_5912635 0.09 ENSDART00000153736
Pim proto-oncogene, serine/threonine kinase, related 63
chr8_+_25761654 0.09 ENSDART00000137899
ENSDART00000062403
transmembrane protein 9
chr22_+_24157807 0.09 ENSDART00000159165
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr5_+_43870389 0.08 ENSDART00000141002
zgc:112966
chr16_+_19536614 0.07 ENSDART00000112894
ENSDART00000079201
ENSDART00000139357
sp8 transcription factor b
chr5_-_45894802 0.06 ENSDART00000097648
cytokine receptor family member b6
chr5_-_69212184 0.06 ENSDART00000053963
methionine adenosyltransferase II, alpha b
chr25_+_4979446 0.05 ENSDART00000154131
ENSDART00000155537
si:ch73-265h17.1
chr17_-_40879108 0.04 ENSDART00000010362
SPT7-like STAGA complex gamma subunit
chr16_-_28268201 0.02 ENSDART00000121671
ENSDART00000141911
si:dkey-12j5.1
chr9_-_950004 0.01 ENSDART00000168917
secretin receptor
chr2_+_10006839 0.00 ENSDART00000160304
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b

Network of associatons between targets according to the STRING database.

First level regulatory network of mybl2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.4 GO:0055091 phospholipid homeostasis(GO:0055091)
0.7 2.2 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.7 2.8 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.7 2.0 GO:0042373 vitamin K metabolic process(GO:0042373)
0.6 3.6 GO:0046874 quinolinate biosynthetic process(GO:0019805) quinolinate metabolic process(GO:0046874)
0.5 1.5 GO:0042730 fibrinolysis(GO:0042730)
0.4 2.6 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.4 3.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.3 1.2 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.3 0.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 1.9 GO:1902292 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 4.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 3.9 GO:2000344 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 0.9 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 2.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.7 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.2 2.0 GO:0042537 benzene-containing compound metabolic process(GO:0042537)
0.2 0.8 GO:0023041 neuronal signal transduction(GO:0023041)
0.2 0.8 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.6 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.1 1.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 2.8 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.1 0.7 GO:0032655 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1 0.5 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1 1.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.7 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 0.7 GO:0048069 eye pigmentation(GO:0048069)
0.1 1.0 GO:0006108 malate metabolic process(GO:0006108)
0.1 1.0 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.8 GO:0042554 superoxide anion generation(GO:0042554)
0.1 3.5 GO:0001878 response to yeast(GO:0001878)
0.1 0.6 GO:0019563 glycerol catabolic process(GO:0019563)
0.1 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 1.0 GO:0000479 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.1 2.9 GO:0048538 thymus development(GO:0048538)
0.1 3.2 GO:0015908 fatty acid transport(GO:0015908)
0.1 1.2 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 0.4 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.1 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 2.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.9 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 2.6 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.2 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.2 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 1.2 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 1.3 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.4 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.0 GO:0071222 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.0 0.4 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.2 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.2 GO:0061615 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.3 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.6 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.3 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.6 GO:0030301 cholesterol transport(GO:0030301)
0.0 0.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.8 GO:0000723 telomere maintenance(GO:0000723) telomere organization(GO:0032200)
0.0 0.3 GO:0070193 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.7 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.2 GO:0006032 chitin catabolic process(GO:0006032)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.8 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 2.5 GO:0006814 sodium ion transport(GO:0006814)
0.0 1.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.9 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.3 2.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.3 2.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.5 GO:0035101 FACT complex(GO:0035101)
0.1 0.7 GO:0000811 GINS complex(GO:0000811)
0.1 1.0 GO:0000796 condensin complex(GO:0000796)
0.1 0.5 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.1 0.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.7 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.1 1.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 3.7 GO:0005811 lipid particle(GO:0005811)
0.1 0.5 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.6 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 1.7 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.4 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 2.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.7 GO:0045180 basal cortex(GO:0045180)
0.0 0.7 GO:0031082 BLOC complex(GO:0031082)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.9 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.7 2.6 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.5 2.0 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.5 2.0 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.5 3.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4 3.9 GO:0035804 structural constituent of egg coat(GO:0035804)
0.3 1.3 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.3 2.3 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 1.2 GO:0001096 TFIIF-class transcription factor binding(GO:0001096)
0.2 1.0 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.0 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.2 0.8 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.5 GO:1901612 cardiolipin binding(GO:1901612)
0.2 1.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.1 GO:1903924 estradiol binding(GO:1903924)
0.1 1.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 2.0 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.6 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 1.2 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.5 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1 2.0 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.3 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.1 0.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.4 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.1 0.6 GO:0019809 spermidine binding(GO:0019809)
0.1 4.0 GO:0031491 nucleosome binding(GO:0031491)
0.1 3.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.3 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 1.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.5 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 0.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 0.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 1.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.8 GO:0019003 GDP binding(GO:0019003)
0.0 1.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.8 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.0 3.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.8 GO:0016849 phosphorus-oxygen lyase activity(GO:0016849)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 3.1 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.9 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 2.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID ATR PATHWAY ATR signaling pathway
0.0 2.3 PID E2F PATHWAY E2F transcription factor network
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.7 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.5 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 3.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 2.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 2.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.6 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 1.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 2.8 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.1 2.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 3.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 3.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 3.3 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex