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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for mycb

Z-value: 0.68

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Transcription factors associated with mycb

Gene Symbol Gene ID Gene Info
ENSDARG00000007241 MYC proto-oncogene, bHLH transcription factor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mycbdr11_v1_chr2_+_32016516_320165160.488.3e-07Click!

Activity profile of mycb motif

Sorted Z-values of mycb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_50999675 8.53 ENSDART00000158064
ENSDART00000165746
ENSDART00000163917
ENSDART00000172038
ENSDART00000169048
ENSDART00000164775
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr2_+_50999477 6.44 ENSDART00000190111
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr16_+_23960933 6.03 ENSDART00000146077
apolipoprotein Eb
chr21_+_11969603 5.93 ENSDART00000142247
ENSDART00000140652
motilin-like
chr14_-_12822 5.84 ENSDART00000180650
ENSDART00000188819
muscle segment homeobox 1a
chr10_+_29850330 5.22 ENSDART00000168898
heat shock protein 8
chr4_-_2945306 5.19 ENSDART00000128934
ENSDART00000019518
AE binding protein 2
chr16_+_23960744 4.87 ENSDART00000058965
apolipoprotein Eb
chr20_+_54079341 4.80 ENSDART00000060444
ribosomal protein S29
chr8_+_44783424 4.71 ENSDART00000025875
si:ch1073-459j12.1
chr10_+_29849977 4.68 ENSDART00000180242
heat shock protein 8
chr14_+_22076596 4.60 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
solute carrier family 43 (amino acid system L transporter), member 1a
chr13_-_280652 4.60 ENSDART00000193627
solute carrier family 30 (zinc transporter), member 6
chr13_-_18345854 4.50 ENSDART00000080107
si:dkey-228d14.5
chr15_+_6652396 4.48 ENSDART00000192813
ENSDART00000157678
NOP53 ribosome biogenesis factor
chr16_+_23961276 4.45 ENSDART00000192754
apolipoprotein Eb
chr22_-_26834043 4.44 ENSDART00000087202
si:dkey-44g23.5
chr22_+_6293563 4.42 ENSDART00000063416
ribonuclease like 2
chr11_-_30636163 4.39 ENSDART00000140516
zgc:153665
chr8_-_46386024 4.29 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
glutaminyl-tRNA synthetase
chr16_-_38629208 4.17 ENSDART00000126705
eukaryotic translation initiation factor 3, subunit E, a
chr13_-_280827 4.14 ENSDART00000144819
solute carrier family 30 (zinc transporter), member 6
chr7_+_20344032 3.96 ENSDART00000144948
ENSDART00000138786
plac8 onzin related protein 1
chr10_+_29260096 3.94 ENSDART00000088973
synaptotagmin-like 2a
chr22_-_607812 3.88 ENSDART00000145983
cyclin-dependent kinase inhibitor 1A
chr21_+_26071874 3.66 ENSDART00000003001
ENSDART00000146573
ribosomal protein L23a
chr9_-_56272465 3.61 ENSDART00000039235
lymphocyte cytosolic protein 1 (L-plastin)
chr24_-_42090635 3.59 ENSDART00000166413
signal sequence receptor, alpha
chr6_-_58975010 3.57 ENSDART00000144911
ENSDART00000144514
methionyl-tRNA synthetase
chr5_-_8765428 3.56 ENSDART00000167793
MYB binding protein (P160) 1a
chr25_+_37443194 3.52 ENSDART00000163178
ENSDART00000190262
solute carrier family 10, member 3
chr2_-_42375275 3.49 ENSDART00000026339
GTP binding protein 4
chr25_+_29474982 3.35 ENSDART00000130410
interleukin 17 receptor E-like
chr21_-_45382112 3.34 ENSDART00000151029
ENSDART00000151335
ENSDART00000151687
ENSDART00000075438
CDKN2A interacting protein N-terminal like
chr6_-_13114406 3.27 ENSDART00000188015
zgc:194469
chr19_-_24555935 3.19 ENSDART00000132660
ENSDART00000162801
polymerase (RNA) III (DNA directed) polypeptide G like a
chr8_-_23599096 3.12 ENSDART00000183096
solute carrier family 38, member 5b
chr22_+_835728 3.12 ENSDART00000003325
DENN/MADD domain containing 2Db
chr13_-_35907768 3.11 ENSDART00000147522
MYCL proto-oncogene, bHLH transcription factor a
chr19_+_791538 3.07 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr25_+_245438 2.96 ENSDART00000004689
zgc:92481
chr6_-_39080630 2.93 ENSDART00000021520
ENSDART00000128308
eukaryotic translation initiation factor 4Bb
chr19_-_24555623 2.89 ENSDART00000176022
polymerase (RNA) III (DNA directed) polypeptide G like a
chr15_-_36533322 2.88 ENSDART00000156466
ENSDART00000121755
si:dkey-262k9.4
chr1_-_54972170 2.80 ENSDART00000150548
ENSDART00000038330
KH-type splicing regulatory protein
chr1_-_54971968 2.79 ENSDART00000140016
KH-type splicing regulatory protein
chr9_-_11587070 2.55 ENSDART00000030995
uridine monophosphate synthetase
chr5_-_16475374 2.45 ENSDART00000134274
ENSDART00000136004
piwi-like RNA-mediated gene silencing 2
chr20_+_25445826 2.45 ENSDART00000012581
phosphoribosylformylglycinamidine synthase
chr5_-_3927692 2.43 ENSDART00000146840
ENSDART00000058346
complement component 1, q subcomponent binding protein
chr11_-_21304452 2.42 ENSDART00000163008
si:dkey-85p17.3
chr9_-_12888082 2.37 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
chr20_+_54666222 2.35 ENSDART00000166592

chr12_-_4301234 2.33 ENSDART00000152377
ENSDART00000152521
carbonic anhydrase XVb
chr1_-_19648227 2.32 ENSDART00000054574
polymerase (RNA) I polypeptide E
chr11_+_3959495 2.31 ENSDART00000122953
guanine nucleotide binding protein-like 3 (nucleolar)
chr11_+_77526 2.31 ENSDART00000193521

chr21_+_17768174 2.29 ENSDART00000141380
retinoid X receptor, alpha a
chr4_+_90048 2.29 ENSDART00000166440
low density lipoprotein receptor-related protein 6
chr17_+_51627209 2.28 ENSDART00000056886
zgc:113142
chr7_-_35126374 2.27 ENSDART00000141211
hydroxysteroid (11-beta) dehydrogenase 2
chr2_+_39618951 2.25 ENSDART00000077108
zgc:136870
chr20_+_25625872 2.24 ENSDART00000078385
phosphoribosyl pyrophosphate amidotransferase
chr13_-_293250 2.21 ENSDART00000138581
chitin synthase 1
chr18_+_5543677 2.16 ENSDART00000146161
ENSDART00000136189
nicotinamide nucleotide transhydrogenase 2
chr15_-_17099560 2.15 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr1_+_31674297 2.13 ENSDART00000044214
WW domain binding protein 1-like b
chr12_+_33975065 2.12 ENSDART00000036649
sideroflexin 2
chr5_-_54714789 2.11 ENSDART00000063357
cyclin B1
chr21_+_4509483 2.02 ENSDART00000025612
phytanoyl-CoA dioxygenase domain containing 1
chr15_+_42235449 1.96 ENSDART00000114801
ENSDART00000182053
sphingosine-1-phosphate phosphatase 2
chr13_+_15702142 1.94 ENSDART00000135960
tRNA methyltransferase 61A
chr24_+_36317544 1.90 ENSDART00000048640
ENSDART00000156096
pseudouridylate synthase 3
chr5_-_54714525 1.89 ENSDART00000150138
ENSDART00000150070
cyclin B1
chr23_+_38159715 1.86 ENSDART00000137969
zgc:112994
chr20_+_46660339 1.80 ENSDART00000016530
adenylate cyclase 3b
chr8_-_13678415 1.76 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
chr13_-_35892051 1.73 ENSDART00000145884
transforming, acidic coiled-coil containing protein 3
chr3_-_40955780 1.70 ENSDART00000130130
cytochrome P450, family 3, subfamily c, polypeptide 3
chr3_+_57991074 1.70 ENSDART00000076077
myeloid-associated differentiation marker-like 2
chr10_-_39283883 1.69 ENSDART00000023831
cryptochrome circadian clock 5
chr19_+_1005933 1.66 ENSDART00000191953
zinc finger, DHHC-type containing 3b
chr5_+_3927989 1.65 ENSDART00000030125
zinc finger, HIT-type containing 3
chr15_-_44052927 1.64 ENSDART00000166209
wu:fb44b02
chr5_+_72194444 1.64 ENSDART00000165436
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
chr13_+_31402067 1.62 ENSDART00000019202
tudor domain containing 9
chr4_+_5193198 1.56 ENSDART00000067388
fibroblast growth factor 23
chr21_-_30408775 1.53 ENSDART00000101037
NHP2 ribonucleoprotein homolog (yeast)
chr15_+_17621375 1.45 ENSDART00000158352
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr2_+_258698 1.37 ENSDART00000181330
ENSDART00000181645
PH domain and leucine rich repeat protein phosphatase 1
chr2_-_24369087 1.36 ENSDART00000081237
plasmalemma vesicle associated protein a
chr20_-_25645150 1.36 ENSDART00000063137
si:dkeyp-117h8.4
chr20_-_52882881 1.35 ENSDART00000111078
wu:fi04e12
chr4_-_14192254 1.35 ENSDART00000143804
pseudouridylate synthase 7-like
chr23_-_21534455 1.32 ENSDART00000139092
regulator of chromosome condensation 2
chr12_+_30586599 1.31 ENSDART00000124920
ENSDART00000126984
nebulin-related anchoring protein
chr11_+_6456146 1.30 ENSDART00000036939
growth arrest and DNA-damage-inducible, beta a
chr11_+_42478184 1.29 ENSDART00000089963
zgc:110286
chr8_+_26059677 1.28 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr24_+_16905188 1.28 ENSDART00000066760
chaperonin containing TCP1, subunit 5 (epsilon)
chr3_+_24595922 1.28 ENSDART00000169405
si:dkey-68o6.5
chr1_-_35916247 1.26 ENSDART00000181541
SMAD family member 1
chr9_+_41821613 1.26 ENSDART00000097295
collagen type XVIII alpha 1 chain a
chr7_+_1550966 1.22 ENSDART00000177863
ENSDART00000126840
SPT16 homolog, facilitates chromatin remodeling subunit
chr21_-_14832369 1.21 ENSDART00000144859
pseudouridylate synthase 1
chr1_-_26675969 1.19 ENSDART00000054184
tRNA methyltransferase O
chr20_-_54259780 1.17 ENSDART00000172631
FK506 binding protein 3
chr9_-_21460164 1.14 ENSDART00000133469
zinc finger, MYM-type 2
chr6_-_10752937 1.13 ENSDART00000135093
Obg-like ATPase 1
chr3_-_8765165 1.10 ENSDART00000191131

chr14_-_28568107 1.08 ENSDART00000042850
ENSDART00000145502
preproinsulin b
chr12_-_20350629 1.07 ENSDART00000066384
hemoglobin beta embryonic-2
chr3_+_28939759 1.06 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr17_+_51682429 1.06 ENSDART00000004379
nucleolar protein 10
chr14_+_4796168 1.05 ENSDART00000041468
adaptor-related protein complex 1 associated regulatory protein
chr1_+_5485799 1.04 ENSDART00000022307
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr13_+_25199849 1.01 ENSDART00000139209
ENSDART00000130876
adaptor-related protein complex 3, mu 1 subunit
chr13_-_4992395 1.00 ENSDART00000102651
nucleolar and coiled-body phosphoprotein 1
chr1_-_26676391 1.00 ENSDART00000152492
tRNA methyltransferase O
chr9_+_1339194 1.00 ENSDART00000186976
ENSDART00000014766
caspase 8, apoptosis-related cysteine peptidase, like 2
chr13_-_3516473 0.99 ENSDART00000146240
parkin RBR E3 ubiquitin protein ligase
chr2_-_37803614 0.99 ENSDART00000154124
nuclear factor of activated T cells 4
chr23_-_21535040 0.92 ENSDART00000010647
regulator of chromosome condensation 2
chr11_-_12800945 0.91 ENSDART00000191178
taxilin gamma
chr11_+_2198831 0.91 ENSDART00000160515
homeobox C6b
chr9_+_1339549 0.89 ENSDART00000082478
caspase 8, apoptosis-related cysteine peptidase, like 2
chr22_+_5118361 0.89 ENSDART00000168371
ENSDART00000170222
ENSDART00000158846
muscle-specific beta 1 integrin binding protein
chr19_-_35229336 0.88 ENSDART00000054274
microtubule-actin crosslinking factor 1a
chr25_+_10909850 0.87 ENSDART00000186021

chr9_+_38158570 0.85 ENSDART00000059549
ENSDART00000133060
nucleolar protein interacting with the FHA domain of MKI67
chr1_-_29061285 0.85 ENSDART00000053933
ENSDART00000142350
ENSDART00000192615
gem (nuclear organelle) associated protein 8
chr9_+_27720428 0.83 ENSDART00000112415
leucine carboxyl methyltransferase 2
chr13_+_48359573 0.82 ENSDART00000161959
ENSDART00000165311
mutS homolog 6 (E. coli)
chr7_+_69449814 0.81 ENSDART00000109644
CTD nuclear envelope phosphatase 1b
chr23_-_38160024 0.80 ENSDART00000087112
prefoldin subunit 4
chr11_-_12801157 0.78 ENSDART00000103449
taxilin gamma
chr9_-_27391908 0.78 ENSDART00000135221
nucleolus and neural progenitor protein
chr5_-_60885935 0.78 ENSDART00000128350
RAD51 paralog D
chr14_+_20941038 0.78 ENSDART00000182539
zgc:66433
chr10_-_14929630 0.76 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
SMAD family member 2
chr2_-_20715094 0.76 ENSDART00000155439
dual specificity phosphatase 12
chr3_+_23029934 0.75 ENSDART00000110343
N-acetylglutamate synthase
chr10_+_16036573 0.75 ENSDART00000188757
lamin B1
chr25_+_3328487 0.73 ENSDART00000181143
lactate dehydrogenase Bb
chr21_+_19517492 0.73 ENSDART00000123168
ENSDART00000187993
granzyme K
chr9_+_29985010 0.69 ENSDART00000020743
cms1 ribosomal small subunit homolog (yeast)
chr18_-_5850683 0.67 ENSDART00000082087
NIP7, nucleolar pre-rRNA processing protein
chr4_+_18824959 0.66 ENSDART00000146141
ENSDART00000040424
solute carrier family 26 (anion exchanger), member 3
chr19_-_8940068 0.66 ENSDART00000043507
circadian associated repressor of transcription a
chr11_+_25485774 0.65 ENSDART00000026249
guanine nucleotide binding protein-like 3 (nucleolar)-like
chr14_+_16287968 0.65 ENSDART00000106593
pre-mRNA processing factor 19
chr24_-_16905018 0.64 ENSDART00000066759
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr10_+_16036246 0.63 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lamin B1
chr16_-_45398408 0.62 ENSDART00000004052
ral guanine nucleotide dissociation stimulator-like 2
chr22_+_28969071 0.61 ENSDART00000163427
Pim proto-oncogene, serine/threonine kinase, related 95
chr13_-_45022301 0.56 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
KH domain containing, RNA binding, signal transduction associated 1a
chr6_-_54078623 0.55 ENSDART00000154076
hyaluronoglucosaminidase 1
chr20_-_25631256 0.53 ENSDART00000048164
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_-_26964348 0.52 ENSDART00000103955
zinc finger and BTB domain containing 12, tandem duplicate 2
chr3_+_23488652 0.51 ENSDART00000126282
nuclear receptor subfamily 1, group d, member 1
chr9_+_12887491 0.49 ENSDART00000102386
si:ch211-167j6.4
chr13_-_25199260 0.45 ENSDART00000057605
adenosine kinase a
chr16_+_16969060 0.45 ENSDART00000182819
ENSDART00000191876
si:ch211-120k19.1
ribosomal protein L18
chr9_+_907459 0.41 ENSDART00000034850
ENSDART00000144114
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr21_+_19852532 0.41 ENSDART00000180572
FYN binding protein b
chr8_-_13419049 0.40 ENSDART00000133656
Pim proto-oncogene, serine/threonine kinase, related 101
chr8_-_2246143 0.40 ENSDART00000135835
si:dkeyp-117b11.3
chr13_-_9061944 0.39 ENSDART00000164186
ENSDART00000102051
si:dkey-112g5.12
chr8_-_13471916 0.39 ENSDART00000146558
Pim proto-oncogene, serine/threonine kinase, related 105
chr24_+_39518774 0.38 ENSDART00000132939
defective in cullin neddylation 1 domain containing 3
chr14_-_31059218 0.38 ENSDART00000111691
ENSDART00000021379
ENSDART00000113479
muscleblind-like splicing regulator 3
chr21_-_11199366 0.37 ENSDART00000167666
DnaJ (Hsp40) homolog, subfamily C, member 21
chr13_+_25761279 0.35 ENSDART00000177818
ENSDART00000002863
neurogenin 3
chr16_+_16968682 0.28 ENSDART00000111074
si:ch211-120k19.1
chr23_+_8679216 0.27 ENSDART00000111368
regulator of G protein signaling 19
chr10_+_428269 0.26 ENSDART00000140715
zinc finger, DHHC-type containing 8a
chr5_+_68807170 0.25 ENSDART00000017849
hairy and enhancer of split related-7
chr17_-_29771639 0.25 ENSDART00000086201
Usher syndrome 2A (autosomal recessive, mild)
chr7_+_41322407 0.25 ENSDART00000114076
ENSDART00000139093
DPH2 homolog (S. cerevisiae)
chr4_-_38033800 0.24 ENSDART00000159662
si:dkeyp-82b4.4
chr13_+_39277178 0.24 ENSDART00000113259
si:dkey-85a20.4
chr5_-_31875645 0.21 ENSDART00000098160
transmembrane protein 119b
chr9_-_11676491 0.21 ENSDART00000022358
zinc finger CCCH-type containing 15
chr6_-_16456093 0.18 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr7_+_33136545 0.18 ENSDART00000173485
intelectin 2
chr5_-_1999417 0.18 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
chr20_-_48470599 0.16 ENSDART00000166857

chr19_-_791016 0.16 ENSDART00000037515
misato 1, mitochondrial distribution and morphology regulator
chr18_+_5850837 0.15 ENSDART00000013150
component of oligomeric golgi complex 8
chr23_-_21534738 0.14 ENSDART00000134587
regulator of chromosome condensation 2
chr21_+_45510448 0.13 ENSDART00000160494
ENSDART00000167914
folliculin interacting protein 1
chr2_-_5199431 0.10 ENSDART00000063384
prohibitin 2a
chr6_+_12462079 0.10 ENSDART00000192029
ENSDART00000065385
nuclear receptor subfamily 4, group A, member 2b
chr20_+_35998073 0.10 ENSDART00000140457
opsin 5
chr5_-_61609448 0.09 ENSDART00000133426
si:dkey-261j4.5
chr4_+_36489448 0.08 ENSDART00000143181
zinc finger protein 1149
chr4_-_890220 0.08 ENSDART00000022668
crystallin beta-gamma domain containing 1b
chr13_-_9367647 0.07 ENSDART00000083362
ENSDART00000144146
si:dkey-33c12.4
chr3_-_23575007 0.07 ENSDART00000155282
ENSDART00000087726
insulin-like growth factor 2 mRNA binding protein 1
chr4_-_64709908 0.07 ENSDART00000161032
si:dkey-9i5.2

Network of associatons between targets according to the STRING database.

First level regulatory network of mycb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:0071831 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
1.6 9.9 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.8 3.1 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.8 1.5 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.7 2.2 GO:1902102 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.6 6.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.6 3.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.6 2.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.6 2.4 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.5 2.2 GO:0006740 NADPH regeneration(GO:0006740)
0.5 2.5 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.5 2.3 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.4 4.0 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.4 2.2 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.4 2.9 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.4 4.0 GO:0072078 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.3 8.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 2.3 GO:0034650 cortisol metabolic process(GO:0034650)
0.3 8.7 GO:0006829 zinc II ion transport(GO:0006829)
0.3 0.8 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.3 0.8 GO:0006290 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 1.6 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.3 1.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.3 3.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 2.3 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.2 15.0 GO:0006414 translational elongation(GO:0006414)
0.2 1.3 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.2 3.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 4.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 6.1 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.2 0.8 GO:0042148 strand invasion(GO:0042148)
0.2 1.6 GO:0072501 cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 0.8 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 1.3 GO:1904035 epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
0.2 5.8 GO:0043049 otic placode formation(GO:0043049)
0.2 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 0.8 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.2 0.6 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.2 3.6 GO:0051639 actin filament network formation(GO:0051639)
0.2 4.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 0.9 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.1 1.3 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.8 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 1.3 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 3.9 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 3.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.0 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.1 1.2 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.1 1.7 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 2.3 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.1 0.5 GO:0044209 AMP salvage(GO:0044209)
0.1 1.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 2.3 GO:0032526 response to retinoic acid(GO:0032526)
0.1 3.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 0.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 1.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 2.2 GO:0030488 tRNA methylation(GO:0030488)
0.1 1.2 GO:0008354 germ cell migration(GO:0008354)
0.1 0.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 1.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.7 GO:0009651 response to salt stress(GO:0009651)
0.0 0.8 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 4.5 GO:0010506 regulation of autophagy(GO:0010506)
0.0 7.4 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 1.3 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.8 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 0.2 GO:0045117 azole transport(GO:0045117)
0.0 4.2 GO:0048511 rhythmic process(GO:0048511)
0.0 0.3 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.8 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.4 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0016038 absorption of visible light(GO:0016038)
0.0 1.7 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 1.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 3.6 GO:0001755 neural crest cell migration(GO:0001755)
0.0 1.3 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.2 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 3.1 GO:0045055 regulated exocytosis(GO:0045055)
0.0 0.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
2.1 15.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.3 4.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.8 4.2 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.5 2.4 GO:1990923 PET complex(GO:1990923)
0.5 2.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 1.9 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.4 1.5 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.4 5.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 6.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 2.2 GO:0030428 cell septum(GO:0030428)
0.3 0.8 GO:0032301 MutSalpha complex(GO:0032301)
0.2 0.8 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 0.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2 3.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.6 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 4.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 1.2 GO:0035101 FACT complex(GO:0035101)
0.1 0.9 GO:0032019 mitochondrial cloud(GO:0032019)
0.1 0.8 GO:0032797 SMN complex(GO:0032797)
0.1 1.3 GO:0014704 intercalated disc(GO:0014704)
0.1 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 4.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.8 GO:0016272 prefoldin complex(GO:0016272)
0.1 3.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 23.6 GO:0005730 nucleolus(GO:0005730)
0.1 4.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.5 GO:0043186 P granule(GO:0043186)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 3.9 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0030018 Z disc(GO:0030018)
0.0 12.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 2.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.1 GO:0005764 lysosome(GO:0005764)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.9 4.5 GO:0008097 5S rRNA binding(GO:0008097)
0.7 9.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.6 4.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.6 3.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.6 1.7 GO:0003913 DNA photolyase activity(GO:0003913)
0.6 5.6 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.5 2.2 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.5 1.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.5 3.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 2.9 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.4 2.1 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.3 15.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 8.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 3.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 2.4 GO:0034584 piRNA binding(GO:0034584)
0.3 3.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 2.2 GO:0004100 chitin synthase activity(GO:0004100)
0.3 0.8 GO:0032138 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.3 2.4 GO:0008494 translation activator activity(GO:0008494)
0.3 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 0.8 GO:0034618 arginine binding(GO:0034618)
0.2 4.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 1.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 1.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 1.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 2.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.2 3.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 0.9 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.1 1.0 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 1.1 GO:0016936 galactoside binding(GO:0016936)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 2.3 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 2.0 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.2 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1 0.5 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 1.1 GO:0031720 haptoglobin binding(GO:0031720)
0.1 2.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.7 GO:0019843 rRNA binding(GO:0019843)
0.1 4.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 2.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 4.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.1 GO:0019894 kinesin binding(GO:0019894)
0.0 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 3.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 1.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 3.4 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.1 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.0 5.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.6 GO:0008143 poly(A) binding(GO:0008143)
0.0 2.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 1.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 3.7 GO:0005179 hormone activity(GO:0005179)
0.0 2.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.7 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 2.4 GO:0008134 transcription factor binding(GO:0008134)
0.0 6.1 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 12.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 1.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.3 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.7 PID AURORA A PATHWAY Aurora A signaling
0.1 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.0 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.6 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 7.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 4.0 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 5.6 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.3 7.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 3.9 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 1.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 1.6 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 2.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 2.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 4.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.1 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 2.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.2 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 1.1 REACTOME SIGNALING BY FGFR1 MUTANTS Genes involved in Signaling by FGFR1 mutants
0.0 1.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA